M Finel

Summary

Affiliation: University of Helsinki
Country: Finland

Publications

  1. ncbi request reprint Genetic inactivation of the H(+)-translocating NADH:ubiquinone oxidoreductase of Paracoccus denitrificans is facilitated by insertion of the ndh gene from Escherichia coli
    M Finel
    Department of Medical Chemistry, University of Helsinki, Finland
    FEBS Lett 393:81-5. 1996
  2. ncbi request reprint Catalytic activity of complex I in cell lines that possess replacement mutations in the ND genes in Leber's hereditary optic neuropathy
    A Majander
    Department of Medical Chemistry, University of Helsinki, Finland
    Eur J Biochem 239:201-7. 1996
  3. ncbi request reprint Analysis of the pathogenic human mitochondrial mutation ND1/3460, and mutations of strictly conserved residues in its vicinity, using the bacterium Paracoccus denitrificans
    V Zickermann
    Helsinki Bioenergetics Group, Department of Medical Chemistry, University of Helskinki, Finland
    Biochemistry 37:11792-6. 1998
  4. ncbi request reprint Purification of the 45 kDa, membrane bound NADH dehydrogenase of Escherichia coli (NDH-2) and analysis of its interaction with ubiquinone analogues
    K Bjorklof
    Helsinki Bioenergetics Group, Department of Medical Chemistry, University of Helsinki, P O Box 8, Siltavuorenpenger 10, FIN 00014, Helsinki, Finland
    FEBS Lett 467:105-10. 2000
  5. ncbi request reprint Studies on the proton-translocating NADH:ubiquinone oxidoreductases of mitochondria and Escherichia coli using the inhibitor 1,10-phenanthroline
    M Finel
    Helsinki Bioenergetics Group, Department of Medical Chemistry, University of Helsinki, Finland
    FEBS Lett 339:142-6. 1994
  6. ncbi request reprint Cytochrome o (bo) is a proton pump in Paracoccus denitrificans and Escherichia coli
    A Puustinen
    Department of Medical Chemistry, University of Helsinki, Finland
    FEBS Lett 249:163-7. 1989

Collaborators

  • Marten Wikstrom
  • V Zickermann
  • K Bjorklof
  • A Majander
  • B Barquera
  • E Nikoskelainen
  • M L Savontaus
  • A Puustinen
  • M Virkki

Detail Information

Publications6

  1. ncbi request reprint Genetic inactivation of the H(+)-translocating NADH:ubiquinone oxidoreductase of Paracoccus denitrificans is facilitated by insertion of the ndh gene from Escherichia coli
    M Finel
    Department of Medical Chemistry, University of Helsinki, Finland
    FEBS Lett 393:81-5. 1996
    ..Hence, this mutant expressed active and membrane-bound NDH2, and lacked NDH1 activity...
  2. ncbi request reprint Catalytic activity of complex I in cell lines that possess replacement mutations in the ND genes in Leber's hereditary optic neuropathy
    A Majander
    Department of Medical Chemistry, University of Helsinki, Finland
    Eur J Biochem 239:201-7. 1996
    ..The efficiency of these changes and the level of kinetic limitation of respiration by Complex I in each tissue are proposed to determine the clinical development of the disease...
  3. ncbi request reprint Analysis of the pathogenic human mitochondrial mutation ND1/3460, and mutations of strictly conserved residues in its vicinity, using the bacterium Paracoccus denitrificans
    V Zickermann
    Helsinki Bioenergetics Group, Department of Medical Chemistry, University of Helskinki, Finland
    Biochemistry 37:11792-6. 1998
    ..The results suggest that the mutated residues play an important role in ubiquinone reduction by Complex I...
  4. ncbi request reprint Purification of the 45 kDa, membrane bound NADH dehydrogenase of Escherichia coli (NDH-2) and analysis of its interaction with ubiquinone analogues
    K Bjorklof
    Helsinki Bioenergetics Group, Department of Medical Chemistry, University of Helsinki, P O Box 8, Siltavuorenpenger 10, FIN 00014, Helsinki, Finland
    FEBS Lett 467:105-10. 2000
    ..The latter observation is in agreement with possible evolutionary relation between NDH-2 and water-soluble enzymes such as dihydrolipoamide dehydrogenase. There is currently no clear indication of how NDH-2 binds to biological membranes...
  5. ncbi request reprint Studies on the proton-translocating NADH:ubiquinone oxidoreductases of mitochondria and Escherichia coli using the inhibitor 1,10-phenanthroline
    M Finel
    Helsinki Bioenergetics Group, Department of Medical Chemistry, University of Helsinki, Finland
    FEBS Lett 339:142-6. 1994
    ..EPR spectroscopy of membranous E. coli NDH1 shows that two slow- and one fast-relaxing Fe-S clusters become detectable upon reduction by NADH in the presence of OP. However, none of them resembles the mitochondrial cluster 2...
  6. ncbi request reprint Cytochrome o (bo) is a proton pump in Paracoccus denitrificans and Escherichia coli
    A Puustinen
    Department of Medical Chemistry, University of Helsinki, Finland
    FEBS Lett 249:163-7. 1989
    ..coli from which cytochrome d was deleted. These observations show that the cytochrome o complex is a proton pump much like cytochrome aa3 to which it is structurally related...