O Vaarala

Summary

Affiliation: National Public Health Institute
Country: Finland

Publications

  1. ncbi Gut and the induction of immune tolerance in type 1 diabetes
    O Vaarala
    Department of Biochemistry, National Public Health Institute, Helsinki, Finland
    Diabetes Metab Res Rev 15:353-61. 1999
  2. ncbi Relation between T-cell responses to glutamate decarboxylase and coxsackievirus B4 in patients with insulin-dependent diabetes mellitus
    P Klemetti
    Department of Biochemistry, National Public Health Institute, and Hospital for Children and Adolescents, University of Helsinki, Finland
    J Clin Virol 14:95-105. 1999
  3. ncbi Cow's milk formula feeding induces primary immunization to insulin in infants at genetic risk for type 1 diabetes
    O Vaarala
    Department of Biochemistry, National Public Health Institute, Helsinki, Finland
    Diabetes 48:1389-94. 1999
  4. pmc Immune activation in the small intestine in patients with rheumatoid arthritis
    R Nissinen
    National Public Health Institute, Department of Molecular Medicine, Biomedicum, PO Box 104, 00251 Helsinki, Finland
    Ann Rheum Dis 63:1327-30. 2004
  5. pmc Infiltration of forkhead box P3-expressing cells in small intestinal mucosa in coeliac disease but not in type 1 diabetes
    M Tiittanen
    Department of Viral Diseases and Immunology, Laboratory for Immunology, National Public Health Institute, Helsinki, Finland
    Clin Exp Immunol 152:498-507. 2008
  6. pmc Dietary intervention in infancy and later signs of beta-cell autoimmunity
    Mikael Knip
    Hospital for Children and Adolescents, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
    N Engl J Med 363:1900-8. 2010
  7. ncbi Genetic and phenotypic diversity of echovirus 30 strains and pathogenesis of type 1 diabetes
    A Paananen
    Enterovirus Laboratory, National Public Health Institute, Helsinki, Finland
    J Med Virol 79:945-55. 2007
  8. doi High level of fecal calprotectin at age 2 months as a marker of intestinal inflammation predicts atopic dermatitis and asthma by age 6
    L Orivuori
    Institute of Clinical Medicine, University of Helsinki, Helsinki, Finland Department of Vaccination and Immune Protection, National Institute for Health and Welfare, Helsinki, Finland
    Clin Exp Allergy 45:928-39. 2015
  9. doi Scientific rationale for the Finnish Allergy Programme 2008-2018: emphasis on prevention and endorsing tolerance
    L C Von Hertzen
    Skin and Allergy Hospital, Helsinki University Central Hospital, Helsinki, Finland
    Allergy 64:678-701. 2009
  10. pmc Monocyte-derived dendritic cells from Crohn's disease patients exhibit decreased ability to activate T helper type 17 responses in memory cells
    J K Nieminen
    Immune Response Unit, Department of Vaccination and Immune Protection, National Institute for Health and Welfare, Helsinki, Finland
    Clin Exp Immunol 177:190-202. 2014

Collaborators

Detail Information

Publications21

  1. ncbi Gut and the induction of immune tolerance in type 1 diabetes
    O Vaarala
    Department of Biochemistry, National Public Health Institute, Helsinki, Finland
    Diabetes Metab Res Rev 15:353-61. 1999
    ..In this review, the possible role of the gut immune system in the development of beta-cell autoimmunity and Type 1 diabetes is discussed with special reference to the putative therapeutic implications...
  2. ncbi Relation between T-cell responses to glutamate decarboxylase and coxsackievirus B4 in patients with insulin-dependent diabetes mellitus
    P Klemetti
    Department of Biochemistry, National Public Health Institute, and Hospital for Children and Adolescents, University of Helsinki, Finland
    J Clin Virol 14:95-105. 1999
    ..A possible connection between glutamate decarboxylase (GAD) autoimmunity and enterovirus infections in IDDM has been suggested to be based on a homology region between GAD and the non-structural protein 2C of coxsackievirus B4 (CVB4)...
  3. ncbi Cow's milk formula feeding induces primary immunization to insulin in infants at genetic risk for type 1 diabetes
    O Vaarala
    Department of Biochemistry, National Public Health Institute, Helsinki, Finland
    Diabetes 48:1389-94. 1999
    ..This immune response to insulin may later be diverted into autoaggressive immunity against beta-cells in some individuals, as indicated by our findings in children with diabetes-associated autoantibodies...
  4. pmc Immune activation in the small intestine in patients with rheumatoid arthritis
    R Nissinen
    National Public Health Institute, Department of Molecular Medicine, Biomedicum, PO Box 104, 00251 Helsinki, Finland
    Ann Rheum Dis 63:1327-30. 2004
    ....
  5. pmc Infiltration of forkhead box P3-expressing cells in small intestinal mucosa in coeliac disease but not in type 1 diabetes
    M Tiittanen
    Department of Viral Diseases and Immunology, Laboratory for Immunology, National Public Health Institute, Helsinki, Finland
    Clin Exp Immunol 152:498-507. 2008
    ..The increased intestinal expression of IL-18 mRNA in patients with T1D adds evidence in favour of the hypothesis that T1D is associated with derangements in the gut immune system...
  6. pmc Dietary intervention in infancy and later signs of beta-cell autoimmunity
    Mikael Knip
    Hospital for Children and Adolescents, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
    N Engl J Med 363:1900-8. 2010
    ..We tested the hypothesis that supplementing breast milk with highly hydrolyzed milk formula would decrease the cumulative incidence of diabetes-associated autoantibodies in such children...
  7. ncbi Genetic and phenotypic diversity of echovirus 30 strains and pathogenesis of type 1 diabetes
    A Paananen
    Enterovirus Laboratory, National Public Health Institute, Helsinki, Finland
    J Med Virol 79:945-55. 2007
    ..This finding does not support a previous proposition of aberrant antibody responses to E-30 in diabetic patients. It is concluded that identification of the genetic counterparts of pathogenicity of E-30 strains requires further studies...
  8. doi High level of fecal calprotectin at age 2 months as a marker of intestinal inflammation predicts atopic dermatitis and asthma by age 6
    L Orivuori
    Institute of Clinical Medicine, University of Helsinki, Helsinki, Finland Department of Vaccination and Immune Protection, National Institute for Health and Welfare, Helsinki, Finland
    Clin Exp Allergy 45:928-39. 2015
    ..Gut microbiota and intestinal inflammation regulate the development of immune-mediated diseases, such as allergies. Fecal calprotectin is a biomarker of intestinal inflammation...
  9. doi Scientific rationale for the Finnish Allergy Programme 2008-2018: emphasis on prevention and endorsing tolerance
    L C Von Hertzen
    Skin and Allergy Hospital, Helsinki University Central Hospital, Helsinki, Finland
    Allergy 64:678-701. 2009
    ..In this review, the scientific rationale for the Finnish Allergy Programme 2008-2018 is outlined. The focus is on tolerance and how to endorse tolerance at the population level...
  10. pmc Monocyte-derived dendritic cells from Crohn's disease patients exhibit decreased ability to activate T helper type 17 responses in memory cells
    J K Nieminen
    Immune Response Unit, Department of Vaccination and Immune Protection, National Institute for Health and Welfare, Helsinki, Finland
    Clin Exp Immunol 177:190-202. 2014
    ..The increased mucosal Th1 and Th17 responses, which may contribute to the pathogenesis, could be the consequences of primary defects in the innate immunity. ..
  11. doi Soluble immunoglobulin A in breast milk is inversely associated with atopic dermatitis at early age: the PASTURE cohort study
    L Orivuori
    Department of Vaccination and Immune Protection, National Institute for Health and Welfare, Helsinki, Finland
    Clin Exp Allergy 44:102-12. 2014
    ..The role of breastfeeding for the development of atopic diseases in childhood is contradictory. This might be due to differences in the composition of breast milk and levels of antimicrobial and anti-inflammatory components...
  12. doi No association between vitamin D and β-cell autoimmunity in Finnish and Estonian children
    L Reinert-Hartwall
    Department of Vaccination and Immune Protection, National Institute for Health and Welfare, Helsinki, Finland
    Diabetes Metab Res Rev 30:749-60. 2014
    ....
  13. ncbi Coxsackievirus immunization delays onset of diabetes in non-obese diabetic mice
    B Davydova
    Enterovirus Laboratory, National Public Health Institute KTL, Helsinki, Finland
    J Med Virol 69:510-20. 2003
    ....
  14. ncbi Antibodies to oxidised LDL
    O Vaarala
    Department of Biochemistry, National Public Health Institute, Helsinki, Finland
    Lupus 9:202-5. 2000
    ..These antibodies can be considered as markers of the pathogenic determinants of atherosclerosis, such as enhanced lipid oxidation, proinflammatory stage and impaired vasodilatation...
  15. doi Probiotics in infancy induce protective immune profiles that are characteristic for chronic low-grade inflammation
    E Marschan
    The Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland
    Clin Exp Allergy 38:611-8. 2008
    ..Probiotics are widely studied both in the treatment and prevention of allergic diseases, but their mode of action is poorly known...
  16. doi Maternal diet during pregnancy and lactation and cow's milk allergy in offspring
    J Tuokkola
    Children s Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
    Eur J Clin Nutr 70:554-9. 2016
    ..There are few human studies on the topic, especially focusing on food allergies. We sought to study the associations between maternal diet during pregnancy and lactation and cow's milk allergy (CMA) in offspring...
  17. ncbi Relation of inflammation to vascular function in patients with coronary heart disease
    J Sinisalo
    Department of Medicine, Division of Cardiology, The Helsinki University Central Hospital, Meilahti 15krs, Haartmaninkatu 4, FIN 00290, Helsinki, Finland
    Atherosclerosis 149:403-11. 2000
    ..It is possible that endothelial dysfunction in coronary heart disease patients is related to the chronic inflammation or infection coexisting with atherosclerosis...
  18. pmc Cytokine and chemokine receptor profile of peripheral blood mononuclear cells during treatment with infliximab in patients with active rheumatoid arthritis
    R Nissinen
    National Public Health Institute, Department of Molecular Medicine, Biomedicum, PO Box 104, 00251 Helsinki, Finland
    Ann Rheum Dis 63:681-7. 2004
    ..To analyse immunological changes during treatment with a monoclonal anti-tumour necrosis factor alpha (TNFalpha) antibody, infliximab, in patients with rheumatoid arthritis (RA)...
  19. ncbi Effect of coincident enterovirus infection and cows' milk exposure on immunisation to insulin in early infancy
    O Vaarala
    Department of Molecular Medicine, National Public Health Institute, Biomedicum, Helsinki, Finland
    Diabetologia 45:531-4. 2002
    ..As gut-associated lymphoid tissue is also the primary replication site of enteroviruses, we tested whether enterovirus infections could modify the development of immune response to dietary insulin in early infancy...
  20. ncbi Immunologic and hematologic properties of antibodies to prothrombin and plasminogen in a mouse model
    M Puurunen
    Department of Health and Disability, National Public Health Institute, Helsinki, Finland
    Lupus 10:108-15. 2001
    ..Antibodies to prothrombin and plasminogen have different functional profiles, immunisation with prothrombin leads to prolonged blood clotting time, and immunisation with plasminogen induces antibodies interfering with fibrinolysis...
  21. ncbi Autoantibodies to modified LDLs and other phospholipid-protein complexes as markers of cardiovascular diseases
    O Vaarala
    Department of Biochemistry, National Public Health Institute, Mannerheimintie 166, 00300 Helsinki, Finland
    J Intern Med 247:381-4. 2000
    ..These autoantibodies can be used as markers of atherosclerosis but their possible pathogenic role in the athero- and thrombogenesis needs further studies...