J Tuomisto

Summary

Affiliation: National Public Health Institute
Country: Finland

Publications

  1. ncbi [Doctors suffering from contradictory opinions about environmental health problems]
    Jouko Tuomisto
    Kansanterveyslaitos, Kuopio
    Duodecim 120:1643-4. 2004
  2. pmc Dioxin cancer risk--example of hormesis?
    Jouko Tuomisto
    Department of Environmental Health, National Public Health Institute, Kuopio, Finland
    Dose Response 3:332-41. 2005
  3. ncbi Does mechanistic understanding help in risk assessment--the example of dioxins
    Jouko Tuomisto
    National Public Health Institute KTL, Department of Environmental Health, Centre for Environmental Health Risk Analysis, P O Box 95, FIN 70701 Kuopio, Finland
    Toxicol Appl Pharmacol 207:2-10. 2005
  4. ncbi [Dioxin and health--from molecular biology to preventive care]
    Jouko Tuomisto
    Kansanterveyslaitos, ympäristöterveyden osasto, Kuopio
    Duodecim 120:1664-72. 2004
  5. ncbi Is the precautionary principle used to cover up ignorance?
    Jouko Tuomisto
    Centre of Environmental Health Risk Analysis, Department of Environmental Health, National Public Health Institute, P O B 95, FIN 70701 Kuopio, Finland
    Basic Clin Pharmacol Toxicol 95:49-52. 2004
  6. ncbi Maternal smoking during pregnancy and testicular cancer in the sons: a nested case-control study and a meta-analysis
    Jouko Tuomisto
    Department of Environmental Health, THL National Institute for Health and Welfare, Formerly National Public Health Institute, P O Box 95, Kuopio FI 70701, Finland
    Eur J Cancer 45:1640-8. 2009
  7. pmc Protecting our unborn children: how to measure exposure to thousands of chemicals?
    J Tuomisto
    Department of Environmental Health, KTL National Public Health Institute, PO Box 95, FIN 70701, Kuopio, Finland
    Arch Dis Child 91:627-8. 2006
  8. ncbi Environmental health in the east Baltic region--pesticides and persistent organic compounds
    J Tuomisto
    Laboratory of Toxicology, Division of Environmental Health, National Public Health Institute, Kuopio, Finland
    Scand J Work Environ Health 25:65-71. 1999
  9. ncbi Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on liver phosphoenolpyruvate carboxykinase (PEPCK) activity, glucose homeostasis and plasma amino acid concentrations in the most TCDD-susceptible and the most TCDD-resistant rat strains
    M Viluksela
    National Public Health Institute, Laboratory of Toxicology, P O Box 95, FIN 70701 Kuopio, Finland
    Arch Toxicol 73:323-36. 1999
  10. ncbi Structure-activity relationships and dose responses of polychlorinated dibenzo-p-dioxins for short-term effects in 2,3,7,8-tetrachlorodibenzo-p-dioxin-resistant and -sensitive rat strains
    Ulla Simanainen
    Department of Environmental Health, National Public Health Institute, Kuopio, Finland
    Toxicol Appl Pharmacol 181:38-47. 2002

Detail Information

Publications55

  1. ncbi [Doctors suffering from contradictory opinions about environmental health problems]
    Jouko Tuomisto
    Kansanterveyslaitos, Kuopio
    Duodecim 120:1643-4. 2004
  2. pmc Dioxin cancer risk--example of hormesis?
    Jouko Tuomisto
    Department of Environmental Health, National Public Health Institute, Kuopio, Finland
    Dose Response 3:332-41. 2005
    ..This is also supported by the similar J-shaped dose responses in animal studies...
  3. ncbi Does mechanistic understanding help in risk assessment--the example of dioxins
    Jouko Tuomisto
    National Public Health Institute KTL, Department of Environmental Health, Centre for Environmental Health Risk Analysis, P O Box 95, FIN 70701 Kuopio, Finland
    Toxicol Appl Pharmacol 207:2-10. 2005
    ..The highly controversial risk assessment of dioxins is used to exemplify the difficulties of excessively straightforward risk analysis process...
  4. ncbi [Dioxin and health--from molecular biology to preventive care]
    Jouko Tuomisto
    Kansanterveyslaitos, ympäristöterveyden osasto, Kuopio
    Duodecim 120:1664-72. 2004
  5. ncbi Is the precautionary principle used to cover up ignorance?
    Jouko Tuomisto
    Centre of Environmental Health Risk Analysis, Department of Environmental Health, National Public Health Institute, P O B 95, FIN 70701 Kuopio, Finland
    Basic Clin Pharmacol Toxicol 95:49-52. 2004
    ..Improvement is especially needed in such cases where the risks of different management options must be compared...
  6. ncbi Maternal smoking during pregnancy and testicular cancer in the sons: a nested case-control study and a meta-analysis
    Jouko Tuomisto
    Department of Environmental Health, THL National Institute for Health and Welfare, Formerly National Public Health Institute, P O Box 95, Kuopio FI 70701, Finland
    Eur J Cancer 45:1640-8. 2009
    ..Its results agree with our meta-analysis of seven previous epidemiological studies (total number of 2149 cases, 2762 controls) using indirect exposure assessment (OR 1.0; 95% CI 0.88, 1.12)...
  7. pmc Protecting our unborn children: how to measure exposure to thousands of chemicals?
    J Tuomisto
    Department of Environmental Health, KTL National Public Health Institute, PO Box 95, FIN 70701, Kuopio, Finland
    Arch Dis Child 91:627-8. 2006
  8. ncbi Environmental health in the east Baltic region--pesticides and persistent organic compounds
    J Tuomisto
    Laboratory of Toxicology, Division of Environmental Health, National Public Health Institute, Kuopio, Finland
    Scand J Work Environ Health 25:65-71. 1999
    ..Thus the overall risk caused by pesticide residues and persistent organic compounds in the Baltic countries and northwestern Russia is low, but local sites of concern exist...
  9. ncbi Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on liver phosphoenolpyruvate carboxykinase (PEPCK) activity, glucose homeostasis and plasma amino acid concentrations in the most TCDD-susceptible and the most TCDD-resistant rat strains
    M Viluksela
    National Public Health Institute, Laboratory of Toxicology, P O Box 95, FIN 70701 Kuopio, Finland
    Arch Toxicol 73:323-36. 1999
    ....
  10. ncbi Structure-activity relationships and dose responses of polychlorinated dibenzo-p-dioxins for short-term effects in 2,3,7,8-tetrachlorodibenzo-p-dioxin-resistant and -sensitive rat strains
    Ulla Simanainen
    Department of Environmental Health, National Public Health Institute, Kuopio, Finland
    Toxicol Appl Pharmacol 181:38-47. 2002
    ..Type I effects are similar in both strains, and type II effects show decreased efficacy of toxic response in relation with the altered H/W-type AHR...
  11. ncbi Hepatic Ah-receptor levels and the effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on hepatic microsomal monooxygenase activities in a TCDD-susceptible and -resistant rat strain
    R Pohjanvirta
    Department of Environmental Hygiene and Toxicology, National Public Health Institute, Kuopio, Finland
    Toxicol Appl Pharmacol 92:131-40. 1988
    ..The parameters measured in the present study are causally unrelated to the mechanism of lethal action of TCDD in these rat strains...
  12. ncbi Effects of TCDD on vitamin A status and liver microsomal enzyme activities in a TCDD-susceptible and a TCDD-resistant rat strain
    R Pohjanvirta
    National Public Health Institute, Department of Environmental Hygiene and Toxicology, Kuopio, Finland
    Food Chem Toxicol 28:197-203. 1990
    ..These findings show that the correlations between TCDD lethality and changes in vitamin A status found among species of laboratory animals do not hold for Long-Evans and Han/Wistar strains of rat...
  13. ncbi 2,3,7,8-Tetrachlorodibenzo-p-dioxin-induced anorexia and wasting syndrome in rats: aggravation after ventromedial hypothalamic lesion
    J T Tuomisto
    National Public Health Institute, Department of Toxicology, Kuopio, Finland
    Eur J Pharmacol 293:309-17. 1995
    ..Thus, TCDD seems to affect the same regulation chain that is involved in the lesioning of the ventromedial hypothalamus. TCDD might serve as a tool in studying different mechanisms of long-term food intake and body weight regulation...
  14. ncbi Restructured transactivation domain in hamster AH receptor
    M Korkalainen
    Laboratory of Toxicology, National Public Health Institute, Kuopio, FIN 70701, Finland
    Biochem Biophys Res Commun 273:272-81. 2000
    ..Because of the additional material in the transactivation domain, hamster AHR protein is larger than that in rats or mice, but the pattern of AHR mRNA expression in tissues is similar...
  15. ncbi Point mutation in intron sequence causes altered carboxyl-terminal structure in the aryl hydrocarbon receptor of the most 2,3,7,8-tetrachlorodibenzo-p-dioxin-resistant rat strain
    R Pohjanvirta
    National Public Health Institute, Department of Environmental Medicine, FIN 70701 Kuopio, Finland
    Mol Pharmacol 54:86-93. 1998
    ..These findings suggest that there is a relatively small region in the AhR trans-activation domain that may be capable of providing selectivity to its function...
  16. ncbi The AH receptor of the most dioxin-sensitive species, guinea pig, is highly homologous to the human AH receptor
    M Korkalainen
    Laboratory of Toxicology, National Public Health Institute, Kuopio, FIN 70701, Finland
    Biochem Biophys Res Commun 285:1121-9. 2001
    ..The closest homolog of the Guinea pig receptor turned out to be the human AHR, which may be relevant for dioxin risk assessment...
  17. ncbi Seasonal exposure to NO2 and respiratory symptoms in preschool children
    K Mukala
    Unit of Environmental Epidemiology, National Public Health Institute Kuopio, Finland
    J Expo Anal Environ Epidemiol 6:197-210. 1996
    ..Thus the areal difference in these symptoms was partly, but not completely, due to the difference in exposure to NO2...
  18. ncbi Adult 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure and effects on male reproductive organs in three differentially TCDD-susceptible rat lines
    Ulla Simanainen
    National Public Health Institute, Department of Environmental Health, P O Box 95, FIN 70701 Kuopio, Finland
    Toxicol Sci 81:401-7. 2004
    ..The fact that the influence of resistance alleles on spermatogenesis is different from that on androgenic status indicates that the effect of TCDD on sperm numbers is not fully related to decreased serum testosterone...
  19. ncbi Effects of epidermal growth factor receptor deficiency and 2,3,7,8-tetrachlorodibenzo-p-dioxin on fetal development in mice
    Hanna M Miettinen
    Laboratory of Toxicology, Department of Environmental Health, National Public Health Institute, P O Box 95, FIN 70701 Kuopio, Finland
    Toxicol Lett 150:285-91. 2004
    ..In conclusion, EGFR signaling is not required for TCDD-induced cleft palate or hydronephrosis but TCDD appears to counteract the effect of EGFR deficiency on eye opening...
  20. ncbi Finnish research programme on environmental health 1998--2001
    Soile Juuti
    Finnish Research Programme on Environmental Health SYTTY, National Public Health Institute, Kuopio
    Scand J Work Environ Health 30:5-6. 2004
  21. ncbi Effect of TCDD on mRNA expression of genes encoding bHLH/PAS proteins in rat hypothalamus
    Merja Korkalainen
    National Public Health Institute, Department of Environmental Health, P O Box 95, FIN 70701 Kuopio, Finland
    Toxicology 208:1-11. 2005
    ..Thus, although the changes found do not account for the wasting syndrome, expression of all principal genes of the AHR-signalling pathway in rat hypothalamus make it a candidate target for TCDD...
  22. ncbi Effects of in utero and lactational TCDD exposure on bone development in differentially sensitive rat lines
    Hanna M Miettinen
    National Public Health Institute, Department of Environmental Health, FIN 70701 Kuopio, Finland
    Toxicol Sci 85:1003-12. 2005
    ..The dioxin-resistance alleles, Ahr(hw) and B(hw) increase the resistance to these defects...
  23. ncbi Polychlorinated dibenzo-p-dioxins, dibenzofurans, and biphenyls in the general population in Finland
    Hannu Kiviranta
    Department of Environmental Health, National Public Health Institute, P O Box 95, FI 70701 Kuopio, Finland
    Chemosphere 60:854-69. 2005
    ..Age, lactation, place of residence, and fish consumption frequencies were significant predictors in the models...
  24. ncbi Assessment by c-Fos immunostaining of changes in brain neural activity induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and leptin in rats
    Sanna Lensu
    National Public Health Institute, Department of Environmental Health, P O B 95, FI 70701 Kuopio, Finland
    Basic Clin Pharmacol Toxicol 98:363-71. 2006
    ..Although the present findings are not suggestive of a primary role for the hypothalamus in the wasting syndrome, a time-course study covering also the feeding-active dark hours is warranted for their verification...
  25. ncbi Differences in acute toxicity syndromes of 2,3,7,8-tetrachlorodibenzo-p-dioxin and 1,2,3,4,7,8-hexachlorodibenzo-p-dioxin in rats
    Marjo Niittynen
    Department of Environmental Health, National Public Health Institute, PO Box 95, FI 70701 Kuopio, Finland
    Toxicology 235:39-51. 2007
    ....
  26. ncbi Pattern of male reproductive system effects after in utero and lactational 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure in three differentially TCDD-sensitive rat lines
    Ulla Simanainen
    National Public Health Institute, Department of Environmental Health, Kuopio, Finland
    Toxicol Sci 80:101-8. 2004
    ..Thus, the intraspecies genetic differences in C-terminal transactivation domain of AHR appear to modify the sensitivity to only certain dioxin-induced male reproductive effects...
  27. ncbi Postnatal development of resistance to short-term high-dose toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin in TCDD-resistant and -semiresistant rats
    Ulla Simanainen
    Laboratory of Toxicology, Department of Environmental Health, National Public Health Institute, FIN 70701 Kuopio, Finland
    Toxicol Appl Pharmacol 196:11-9. 2004
    ..This difference in the time course of resistance development suggests that there are basic differences in pathways mediating resistance in lines A and B rats...
  28. ncbi Effect of in utero and lactational 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure on rat molar development: the role of exposure time
    Hanna M Miettinen
    National Public Health Institute, Department of Environmental Health, P O Box 95, FIN 70701 Kuopio, Finland
    Toxicol Appl Pharmacol 184:57-66. 2002
    ..Response to TCDD was increased if the exposure was started several days before this critical window of sensitivity or if it was continued thereafter. Dental epithelium is the likely target of TCDD...
  29. ncbi 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced accumulation of biliverdin and hepatic peliosis in rats
    Marjo Niittynen
    Department of Environmental Health, Laboratory of Toxicology, National Public Health Institute, Box 95, FIN 70701 Kuopio, Finland
    Toxicol Sci 71:112-23. 2003
    ....
  30. ncbi Dose-response analysis of short-term effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin in three differentially susceptible rat lines
    Ulla Simanainen
    National Public Health Institute, Department of Environmental Health, P O Box 95, FIN 70701 Kuopio, Finland
    Toxicol Appl Pharmacol 187:128-36. 2003
    ..Both H/W-type resistance alleles also decreased the potency of TCDD. However, the potency differences in short-term toxicity seem not to explain, at least alone, the differences seen in acute lethality among the rat lines...
  31. ncbi Identification of novel splice variants of ARNT and ARNT2 in the rat
    Merja Korkalainen
    National Public Health Institute, Laboratory of Toxicology, Department of Environmental Health, P O Box 95, Neulaniementie 4, FIN 70701 Kuopio, Finland
    Biochem Biophys Res Commun 303:1095-100. 2003
    ..However, the regulation of ARNT and ARNT2 activities may be more intricate than previously assumed...
  32. pmc Polychlorinated dibenzo-p-dioxins, dibenzofurans, and biphenyls in fishermen in Finland
    Hannu Kiviranta
    National Public Health Institute, Department of Environmental Health, Kuopio, Finland
    Environ Health Perspect 110:355-61. 2002
    ..Age was the only significant predictor of ln WHO(PCDD/F)-TEq, whereas age, amount of fish eaten, and place of residence were significant predictors of ln WHO(PCB)-TEq, and ln total WHO-TEq...
  33. ncbi Soft-tissue sarcoma and dioxin: A case-control study
    Jouni T Tuomisto
    Department of Environmental Health, National Public Health Institute, PO Box 95, FIN 70701 Kuopio, Finland
    Int J Cancer 108:893-900. 2004
    ..The results imply that dioxin does not increase the risk of soft-tissue sarcoma at the present population levels...
  34. ncbi Primary structure and inducibility by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) of aryl hydrocarbon receptor repressor in a TCDD-sensitive and a TCDD-resistant rat strain
    Merja Korkalainen
    National Public Health Institute, Department of Environmental Health, P O Box 95, FIN 70701 Kuopio, Finland
    Biochem Biophys Res Commun 315:123-31. 2004
    ..However, simultaneous measurement of CYP1A1 mRNA reinforced the view that AHRR is an important determinant of tissue-specific responsiveness to TCDD...
  35. pmc Associations between congenital cryptorchidism in newborn boys and levels of dioxins and PCBs in placenta
    H E Virtanen
    Departments of Physiology and Paediatrics, University of Turku, Turku, Finland
    Int J Androl 35:283-93. 2012
    ..In conclusion, no association between placenta levels of dioxins or PCBs and congenital cryptorchidism was found. Significant country differences in chemical levels were observed...
  36. pmc Environmental chemicals and changes in sex ratio: analysis over 250 years in finland
    T Vartiainen
    National Public Health Institute, Department of Environmental Hygiene, Kuopio, Finland Department of Environmental Sciences, University of Kuopio, Kuopio, Finland
    Environ Health Perspect 107:813-5. 1999
    ..Moreover the trends are similar to those observed in other countries with worse pollution and much greater pesticide use...
  37. ncbi Personal NO2 exposures of preschool children in Helsinki
    S Alm
    Division of Environmental Health, KTL National Public Health Institute, Kuopio, Finland
    J Expo Anal Environ Epidemiol 8:79-100. 1998
    ..In the absence of personal exposure measurements, both stationary measurements and questionnaire information are useful in estimating variations in personal exposures...
  38. ncbi Comparison of acute toxicities of indolo[3,2-b]carbazole (ICZ) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in TCDD-sensitive rats
    R Pohjanvirta
    National Public Health Institute, Laboratory of Toxicology, PO Box 95, FIN 70701 Kuopio, Finland
    Food Chem Toxicol 40:1023-32. 2002
    ..Thus, the present study does not support the view that dietary exposure to ICZ would present a hazard of AHR-mediated adverse health effects to humans...
  39. ncbi In utero/lactational 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure impairs molar tooth development in rats
    H Kattainen
    Department of Environmental Health, National Public Health Institute, Kuopio, FIN-70701, Finland
    Toxicol Appl Pharmacol 174:216-24. 2001
    ..03 microg/kg in line A and at 0.1 microg/kg in lines B and C. The results indicate that impaired tooth development is one of the most sensitive endpoints of TCDD-induced toxicity...
  40. ncbi Liver tumor-promoting activity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in TCDD-sensitive and TCDD-resistant rat strains
    M Viluksela
    Laboratory of Toxicology, National Public Health Institute, Kuopio, Finland
    Cancer Res 60:6911-20. 2000
    ..Understanding the role of transactivation domain of the aryl hydrocarbon receptor in carcinogenesis is therefore likely to improve dioxin risk assessment...
  41. pmc The 2005 World Health Organization reevaluation of human and Mammalian toxic equivalency factors for dioxins and dioxin-like compounds
    Martin van den Berg
    World Health Organization Collaborating Centre for Research on Environmental Health Risk Assessment and Institute for Risk Assessment Sciences, Science and University Medical Center, Universiteit Utrecht, The Netherlands
    Toxicol Sci 93:223-41. 2006
    ..These included the use of a probabilistic methodology to determine TEFs that better describe the associated levels of uncertainty and "systemic" TEFs for blood and adipose tissue and TEQ for body burden...
  42. ncbi Aryl hydrocarbon receptor regulates distinct dioxin-dependent and dioxin-independent gene batteries
    Nathalie Tijet
    Department of Pharmacology, Medical Sciences Building, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    Mol Pharmacol 69:140-53. 2006
    ..Overall, our study identifies a wide range of genes that depend on the AHR, either for constitutive expression or for response to TCDD...
  43. pmc Flame retardants in placenta and breast milk and cryptorchidism in newborn boys
    Katharina Maria Main
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Environ Health Perspect 115:1519-26. 2007
    ..Polybrominated diphenyl ethers (PBDEs) are widely used in Western countries...
  44. ncbi Follow-up study of cancer incidence after chlorophenol exposure in a community in southern Finland
    Pentti Lampi
    Päijät Häme Social and Health Group, Keskussairaalankatu 7, FI 15850 Lahti, Finland
    Scand J Work Environ Health 34:230-3. 2008
    ..The present article reports a follow-up of cancer risk in the same study area during a 20-year period after the closing of the old water intake plant, which was contaminated by chlorophenols...
  45. ncbi Interference by 2,3,7,8-tetrachlorodibenzo-p-dioxin with cultured mouse submandibular gland branching morphogenesis involves reduced epidermal growth factor receptor signaling
    Anu Kiukkonen
    Department of Pedodontics and Orthodontics, Institute of Dentistry, University of Helsinki, Helsinki, Finland
    Toxicol Appl Pharmacol 212:200-11. 2006
    ..Together with the failure of EGF and FN at morphogenesis-stimulating concentrations to compensate for the effect of TCDD this implies that TCDD toxicity to developing salivary gland involves reduced EGF receptor signaling...
  46. ncbi Expression of the mediators of dioxin toxicity, aryl hydrocarbon receptor (AHR) and the AHR nuclear translocator (ARNT), is developmentally regulated in mouse teeth
    Carin Sahlberg
    Department of Pedodontics and Orthodontics, Institute of Dentistry, University of Helsinki, Finland
    Int J Dev Biol 46:295-300. 2002
    ..The coexpression of AHR and ARNT during early tooth development as well as during the information and mineralization of the dental matrices is suggestive of the AHR-ARNT pathway as a mediator of dental toxicity of TCDD...
  47. ncbi Risk-benefit analysis of eating farmed salmon
    Jouni T Tuomisto
    Science 305:476-7; author reply 476-7. 2004
  48. pmc Developmental dental aberrations after the dioxin accident in Seveso
    Satu Alaluusua
    Department of Pedodontics and Orthodontics, Institute of Dentistry, University of Helsinki, Helsinki, Finland
    Environ Health Perspect 112:1313-8. 2004
    ..The results support our hypothesis that dioxins can interfere with human organogenesis...
  49. ncbi Dioxin-responsive AHRE-II gene battery: identification by phylogenetic footprinting
    Paul C Boutros
    Department of Pharmacology, University of Toronto, Toronto, Ont, Canada M5S 1A8
    Biochem Biophys Res Commun 321:707-15. 2004
    ..Collectively, these results demonstrate that the AHRE-II induction mechanism is employed by multiple genes and provide the first categorization of the gene battery of a ligand-activated coactivator...
  50. ncbi Response of the incisor tooth to 2,3,7,8-tetrachlorodibenzo-p-dioxin in a dioxin-resistant and a dioxin-sensitive rat strain
    Anu Kiukkonen
    Department of Pedodontics and Orthodontics, Institute of Dentistry, Mannerheimintie 172, FIN 00014 University of Helsinki, Finland
    Toxicol Sci 69:482-9. 2002
    ..Similar responses in both strains implied that the impaired formation of the incisor tooth, at least of its mesenchymal elements, is not associated with the differential resistance of H/W and L-E rats to TCDD acute lethality...
  51. ncbi Altered retinoid metabolism in female Long-Evans and Han/Wistar rats following long-term 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-treatment
    Nick Fletcher
    Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Toxicol Sci 86:264-72. 2005
    ..Furthermore, 9-cis-4-oxo-13,14-dihydro-RA was identified as a novel and sensitive indicator of TCDD exposure, in a resistant and sensitive rat strain, thereby extending the database of low-dose TCDD effects...
  52. ncbi Bone resorption by aryl hydrocarbon receptor-expressing osteoclasts is not disturbed by TCDD in short-term cultures
    Joanna Ilvesaro
    Department of Anatomy and Cell Biology, FIN 90014 University of Oulu, Finland
    Life Sci 77:1351-66. 2005
    ..These data indicate that even though TCDD-treated bones show decreased mechanical strength and size, this is not a direct result from increased osteoclastic bone resorption...
  53. ncbi Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and leptin on hypothalamic mRNA expression of factors participating in food intake regulation in a TCDD-sensitive and a TCDD-resistant rat strain
    Jere Lindén
    Department of Food and Environmental Hygiene, Faculty of Veterinary Medicine, P O Box 66, FIN 00014 University of Helsinki, Helsinki, Finland
    J Biochem Mol Toxicol 19:139-48. 2005
    ..However, the fact that TCDD mainly affected orexigenic factors and the temporal differences in response found between the rat strains warrant further research...
  54. ncbi [Risks of acrylamide in the food stuffs seem to be low]
    Jouko Tuomisto
    Duodecim 119:1019-20. 2003
  55. ncbi Toxicological implications of polymorphisms in receptors for xenobiotic chemicals: the case of the aryl hydrocarbon receptor
    Allan B Okey
    Department of Pharmacology, Medical Sciences Building, University of Toronto, Toronto, Ontario, Canada
    Toxicol Appl Pharmacol 207:43-51. 2005
    ..dioxin-resistant rat strains and lines. Polymorphisms exist in the human AH receptor, but thus far they have not been shown to have any substantial effect on human responses to AHR-ligands...