Kaisa Silander

Summary

Affiliation: National Public Health Institute
Country: Finland

Publications

  1. pmc Gender differences in genetic risk profiles for cardiovascular disease
    Kaisa Silander
    Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland
    PLoS ONE 3:e3615. 2008
  2. ncbi Evaluating whole genome amplification via multiply-primed rolling circle amplification for SNP genotyping of samples with low DNA yield
    Kaisa Silander
    Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland
    Twin Res Hum Genet 8:368-75. 2005
  3. pmc Association of a nonsynonymous variant of DAOA with visuospatial ability in a bipolar family sample
    Pia Soronen
    Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland
    Biol Psychiatry 64:438-42. 2008
  4. doi Identification of susceptibility loci at 7q31 and 9p13 for bipolar disorder in an isolated population
    Outi M Palo
    FIMM, Institute for Molecular Medicine and National Institute for Health and Welfare, Helsinki, Finland
    Am J Med Genet B Neuropsychiatr Genet 153:723-35. 2010
  5. pmc Combined effects of thrombosis pathway gene variants predict cardiovascular events
    Kirsi Auro
    0Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland
    PLoS Genet 3:e120. 2007
  6. ncbi The role of DTNBP1, NRG1, and AKT1 in the genetics of schizophrenia in Finland
    Joni A Turunen
    Department of Molecular Medicine, National Public Health Institute, Biomedicum, P O Box 104, FI 00251, Helsinki, Finland
    Schizophr Res 91:27-36. 2007
  7. ncbi Variation in the selenoprotein S gene locus is associated with coronary heart disease and ischemic stroke in two independent Finnish cohorts
    Mervi Alanne
    Department of Molecular Medicine, KTL National Public Health Institute, Biomedicum, Helsinki, Finland
    Hum Genet 122:355-65. 2007
  8. pmc Association of AKT1 with verbal learning, verbal memory, and regional cortical gray matter density in twins
    Olli P H Pietiläinen
    FIMM, Institute for Molecular Medicine Finland and National Public Health Institute, Biomedicum, Helsinki, Finland
    Am J Med Genet B Neuropsychiatr Genet 150:683-92. 2009
  9. ncbi Association of distinct allelic haplotypes of DISC1 with psychotic and bipolar spectrum disorders and with underlying cognitive impairments
    Outi M Palo
    Department of Molecular Medicine, National Public Health Insitute, Helsinki, Finland
    Hum Mol Genet 16:2517-28. 2007
  10. pmc The impact of newly identified loci on coronary heart disease, stroke and total mortality in the MORGAM prospective cohorts
    Juha Karvanen
    Department of Health Promotion and Chronic Disease Prevention, National Public Health Institute, Helsinki, Finland
    Genet Epidemiol 33:237-46. 2009

Detail Information

Publications31

  1. pmc Gender differences in genetic risk profiles for cardiovascular disease
    Kaisa Silander
    Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland
    PLoS ONE 3:e3615. 2008
    ..We aimed to estimate whether the genetic risk profiles of coronary heart disease (CHD), ischemic stroke and the composite end-point of CVD differ between the genders...
  2. ncbi Evaluating whole genome amplification via multiply-primed rolling circle amplification for SNP genotyping of samples with low DNA yield
    Kaisa Silander
    Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland
    Twin Res Hum Genet 8:368-75. 2005
    ..Thus, WGA is applicable for low DNA yield samples, especially if using pooled WGA samples. A higher rate of genotyping errors requires that increased attention be paid to genotyping quality control, and caution when interpreting results...
  3. pmc Association of a nonsynonymous variant of DAOA with visuospatial ability in a bipolar family sample
    Pia Soronen
    Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland
    Biol Psychiatry 64:438-42. 2008
    ..Bipolar disorder and schizophrenia are hypothesized to share some genetic background...
  4. doi Identification of susceptibility loci at 7q31 and 9p13 for bipolar disorder in an isolated population
    Outi M Palo
    FIMM, Institute for Molecular Medicine and National Institute for Health and Welfare, Helsinki, Finland
    Am J Med Genet B Neuropsychiatr Genet 153:723-35. 2010
    ..The loci on the centromeric region of 9p13 and the telomeric region of 7q31 may represent susceptibility loci for mood disorder in the Finnish population...
  5. pmc Combined effects of thrombosis pathway gene variants predict cardiovascular events
    Kirsi Auro
    0Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland
    PLoS Genet 3:e120. 2007
    ..These results suggest that variants in these four thrombosis genes contribute to arterial cardiovascular events at population level...
  6. ncbi The role of DTNBP1, NRG1, and AKT1 in the genetics of schizophrenia in Finland
    Joni A Turunen
    Department of Molecular Medicine, National Public Health Institute, Biomedicum, P O Box 104, FI 00251, Helsinki, Finland
    Schizophr Res 91:27-36. 2007
    ..Furthermore, results do not support a major role for NRG1, but we cannot completely exclude a minor role of this gene in the Finnish population...
  7. ncbi Variation in the selenoprotein S gene locus is associated with coronary heart disease and ischemic stroke in two independent Finnish cohorts
    Mervi Alanne
    Department of Molecular Medicine, KTL National Public Health Institute, Biomedicum, Helsinki, Finland
    Hum Genet 122:355-65. 2007
    ..This observation should stimulate further investigations of the role of this gene and protein in the pathogenesis of CVD...
  8. pmc Association of AKT1 with verbal learning, verbal memory, and regional cortical gray matter density in twins
    Olli P H Pietiläinen
    FIMM, Institute for Molecular Medicine Finland and National Public Health Institute, Biomedicum, Helsinki, Finland
    Am J Med Genet B Neuropsychiatr Genet 150:683-92. 2009
    ..The established association of the same allelic variant of AKT1 with both cognitive and neuroanatomical aberrations could suggest that AKT1 exerts its effect on verbal learning and memory via neural networks involving prefrontal cortex...
  9. ncbi Association of distinct allelic haplotypes of DISC1 with psychotic and bipolar spectrum disorders and with underlying cognitive impairments
    Outi M Palo
    Department of Molecular Medicine, National Public Health Insitute, Helsinki, Finland
    Hum Mol Genet 16:2517-28. 2007
    ..Finding of alternative associating haplotypes in the same set of BPD families gives evidence for allelic heterogeneity within DISC1, eventually leading to heterogeneity in the clinical outcome as well...
  10. pmc The impact of newly identified loci on coronary heart disease, stroke and total mortality in the MORGAM prospective cohorts
    Juha Karvanen
    Department of Health Promotion and Chronic Disease Prevention, National Public Health Institute, Helsinki, Finland
    Genet Epidemiol 33:237-46. 2009
    ..1) were associated with blood pressure. These findings underline the need for replication studies in prospective settings and confirm the candidacy of several SNPs that may play a role in the etiology of cardiovascular disease...
  11. pmc Risk alleles of USF1 gene predict cardiovascular disease of women in two prospective studies
    Kati Komulainen
    Department of Molecular Medicine, National Public Health Institute, Biomedicum, Helsinki, Finland
    PLoS Genet 2:e69. 2006
    ....
  12. doi Further evidence for the role of ENPP1 in obesity: association with morbid obesity in Finns
    Kaisa Valli-Jaakola
    Department of Medicine and Research Program for Molecular Medicine, University of Helsinki, Helsinki, Finland
    Obesity (Silver Spring) 16:2113-9. 2008
    ..In this study, we did not find association between the frequently studied ENPP1 K121Q variant, nor SNPs in the MCR or POMC genes and obesity or type 2 diabetes...
  13. pmc Genetic association and interaction analysis of USF1 and APOA5 on lipid levels and atherosclerosis
    Pirkka Pekka Laurila
    Public Health Genomics Unit, National Institute for Health and Welfare and Institute for Molecular Medicine, Helsinki, Finland
    Arterioscler Thromb Vasc Biol 30:346-52. 2010
    ..No detailed studies about the effect of APOA5 on atherosclerotic lesion formation have been conducted, nor has its potential interaction with USF1 been examined...
  14. doi An association analysis of circadian genes in anxiety disorders
    Tessa Sipilä
    Research Program of Molecular Neurology, University of Helsinki, Helsinki, Finland
    Biol Psychiatry 67:1163-70. 2010
    ..We tested this hypothesis with a genetic association analysis...
  15. doi Contribution of adenosine related genes to the risk of depression with disturbed sleep
    Natalia Gass
    Department of Physiology, Institute of Biomedicine, University of Helsinki, Helsinki, Finland
    J Affect Disord 126:134-9. 2010
    ..One of the key substances regulating sleep is adenosine. We hypothesized that variations in polymorphic sites of adenosine related genes may predispose to depression with sleep disturbances...
  16. doi Genome-wide association study of sleep duration in the Finnish population
    Hanna M Ollila
    Public Health Genomics Unit and Institute for Molecular Medicine FIMM, National Institute for Health and Welfare, Helsinki, Finland Institute of Biomedicine, Physiology, University of Helsinki, Helsinki, Finland Department of Psychiatry, University of Helsinki, Helsinki, Finland
    J Sleep Res 23:609-18. 2014
    ..However, additional studies are needed in order to understand the roles of KLF6 and PCDH7 in sleep regulation. ..
  17. ncbi Families with the risk allele of DISC1 reveal a link between schizophrenia and another component of the same molecular pathway, NDE1
    William Hennah
    Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland
    Hum Mol Genet 16:453-62. 2007
    ..Notably, this and other converging lines of evidence underline the importance of DISC1-related functional pathways in the etiology of schizophrenia...
  18. doi C-reactive protein-associated genetic variants and cancer risk: findings from FINRISK 1992, FINRISK 1997 and Health 2000 studies
    Katriina Heikkilä
    the National Institute for Health and Welfare, Helsinki, Finland
    Eur J Cancer 47:404-12. 2011
    ..In order to examine this, we investigated whether genetic variants that are associated with circulating CRP concentrations are associated with cancer risk...
  19. ncbi Effect of short-term carbohydrate overfeeding and long-term weight loss on liver fat in overweight humans
    Ksenia Sevastianova
    Minerva Foundation Institute for Medical Research, Helsinki, Finland
    Am J Clin Nutr 96:727-34. 2012
    ..Cross-sectional studies have identified a high intake of simple sugars as an important dietary factor predicting nonalcoholic fatty liver disease (NAFLD)...
  20. ncbi The enhancement of homogenous mass extension reaction: comparison of two enzymes
    Päivi Tikka-Kleemola
    The Finnish Genome Center, P O Box 63, 00014 University of Helsinki, Helsinki, Finland
    Mol Cell Probes 21:216-21. 2007
    ..Further, using TERMIPol enabled successful genotyping (>93%) of several SNPs that failed (<80% success) when using ThermoSequenase...
  21. doi Assessment of the neuropeptide S system in anxiety disorders
    Jonas Donner
    Research Program of Molecular Neurology, Biomedicum Helsinki, Helsinki, Finland
    Biol Psychiatry 68:474-83. 2010
    ..We addressed here the role of NPS and NPSR1 as susceptibility genes for human anxiety disorders...
  22. doi Whole genome amplification with Phi29 DNA polymerase to enable genetic or genomic analysis of samples of low DNA yield
    Kaisa Silander
    National Public Health Institute, Helsinki, Finland
    Methods Mol Biol 439:1-18. 2008
    ..This chapter reviews the various applications in which whole genome amplified DNA can be used, the types of commercial kits available, and the quality control steps necessary before using the DNA in the genetic studies...
  23. ncbi Analysis of genetic variation in the GenomEUtwin project
    Kaisa Silander
    Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland
    Twin Res 6:391-8. 2003
    ..All genotyping data will be stored in a common database established specifically for the GenomEUtwin project, from where it can be accessed by the twin research centres that provided the samples for genotyping...
  24. ncbi Active and low-active forms of serum phospholipid transfer protein in a normal Finnish population sample
    Minna T Jänis
    Department of Molecular Medicine, National Public Health Institute, Biomedicum, Helsinki, Finland
    J Lipid Res 45:2303-9. 2004
    ..The present data on PLTP activity and concentration reveal novel connections of the two PLTP forms to lipid and carbohydrate metabolism...
  25. pmc High-throughput screening for evidence of association by using mass spectrometry genotyping on DNA pools
    Karen L Mohlke
    Genome Technology Branch, National Human Genome Research Institute, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 99:16928-33. 2002
    ..Based on these data and assuming pools of 500 individuals, we conclude that at significance level 0.05 we would have 95% (82%) power to detect population allele frequency differences of 0.07 for control allele frequencies of 0.10 (0.50)...
  26. pmc The SLC6A14 gene shows evidence of association with obesity
    Elina Suviolahti
    Department of Human Genetics, University of California, Los Angeles, USA
    J Clin Invest 112:1762-72. 2003
    ..003). The SLC6A14 gene is an interesting novel candidate for obesity because it encodes an amino acid transporter, which potentially regulates tryptophan availability for serotonin synthesis and thus possibly affects appetite control...
  27. ncbi Genetic variation near the hepatocyte nuclear factor-4 alpha gene predicts susceptibility to type 2 diabetes
    Kaisa Silander
    Genome Technology Branch, National Human Genome Research Institute, Bethesda, Maryland, USA
    Diabetes 53:1141-9. 2004
    ....
  28. ncbi Variation in three single nucleotide polymorphisms in the calpain-10 gene not associated with type 2 diabetes in a large Finnish cohort
    Tasha E Fingerlin
    Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, Michigan 48109 2029, USA
    Diabetes 51:1644-8. 2002
    ..We conclude that variation in these three SNPs in the calpain-10 gene is unlikely to confer susceptibility to type 2 diabetes in this Finnish cohort...
  29. ncbi Variation in resistin gene promoter not associated with polycystic ovary syndrome
    Margrit Urbanek
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Diabetes 52:214-7. 2003
    ..3 and PCOS. Instead, this association is most likely due to a gene or genetic element in this region that has not been identified...
  30. ncbi A large set of Finnish affected sibling pair families with type 2 diabetes suggests susceptibility loci on chromosomes 6, 11, and 14
    Kaisa Silander
    Genome Technology Branch, National Human Genome Research Institute, Bethesda, Maryland, USA
    Diabetes 53:821-9. 2004
    ....
  31. pmc Subsets of Finns with high HDL to total cholesterol ratio show evidence for linkage to type 2 diabetes on chromosome 6q
    Corina Shtir
    Division of Biostatistics, Department of Preventive Medicine, Keck School of Medicine of USC, Los Angeles, CA 90089, USA
    Hum Hered 63:17-25. 2007
    ..The purpose of this study was to examine carefully heterogeneity underlying evidence for linkage to type 2 diabetes (T2DM) on chromosome 6q from two sets of FUSION families...