T Ruutu

Summary

Affiliation: Helsinki University Central Hospital
Country: Finland

Publications

  1. doi request reprint Improved survival with ursodeoxycholic acid prophylaxis in allogeneic stem cell transplantation: long-term follow-up of a randomized study
    Tapani Ruutu
    Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland Electronic address
    Biol Blood Marrow Transplant 20:135-8. 2014
  2. doi request reprint Prophylaxis and treatment of GVHD after allogeneic haematopoietic SCT: a survey of centre strategies by the European Group for Blood and Marrow Transplantation
    T Ruutu
    Department of Medicine, Division of Haematology, Helsinki University Central Hospital, Helsinki, Finland
    Bone Marrow Transplant 47:1459-64. 2012
  3. ncbi request reprint Ursodeoxycholic acid for the prevention of hepatic complications in allogeneic stem cell transplantation
    Tapani Ruutu
    Department of Medicine, Division of Hematology, Helsinki University Central Hospital, POB 340, FIN 00029 HUS, Helsinki, Finland
    Blood 100:1977-83. 2002
  4. ncbi request reprint Oral treatment of acute myeloid leukaemia with etoposide, thioguanine, and idarubicin (ETI) in elderly patients: a prospective randomised comparison with intravenous cytarabine, idarubicin, and thioguanine in the second and third treatment cycle
    T Ruutu
    Eur J Haematol 72:38-44. 2004
  5. ncbi request reprint Use of intrathecal prophylaxis in allogeneic haematopoietic stem cell transplantation for malignant blood diseases: a survey of the European Group for Blood and Marrow Transplantation (EBMT)
    T Ruutu
    Department of Medicine, Helsinki University Central Hospital, POB 340, FIN 00029 HUS, Helsinki, Finland
    Bone Marrow Transplant 35:121-4. 2005
  6. ncbi request reprint Diagnostic criteria for hematopoietic stem cell transplant-associated microangiopathy: results of a consensus process by an International Working Group
    Tapani Ruutu
    Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland
    Haematologica 92:95-100. 2007
  7. ncbi request reprint Thrombotic thrombocytopenic purpura after allogeneic stem cell transplantation: a survey of the European Group for Blood and Marrow Transplantation (EBMT)
    Tapani Ruutu
    Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland
    Br J Haematol 118:1112-9. 2002
  8. pmc Reduced-toxicity conditioning with treosulfan and fludarabine in allogeneic hematopoietic stem cell transplantation for myelodysplastic syndromes: final results of an international prospective phase II trial
    Tapani Ruutu
    Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland
    Haematologica 96:1344-50. 2011
  9. doi request reprint Low incidence of invasive aspergillosis in allogeneic stem cell transplant recipients receiving amphotericin B inhalation prophylaxis
    A Nihtinen
    Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland
    Transpl Infect Dis 14:24-32. 2012
  10. ncbi request reprint Candidaemia in allogeneic stem cell transplant recipients: low risk without fluconazole prophylaxis
    E Jantunen
    Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland
    Bone Marrow Transplant 34:891-5. 2004

Detail Information

Publications62

  1. doi request reprint Improved survival with ursodeoxycholic acid prophylaxis in allogeneic stem cell transplantation: long-term follow-up of a randomized study
    Tapani Ruutu
    Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland Electronic address
    Biol Blood Marrow Transplant 20:135-8. 2014
    ..These long-term results continue to support the useful role of UDCA in the prevention of transplant-related complications in allogeneic transplantation...
  2. doi request reprint Prophylaxis and treatment of GVHD after allogeneic haematopoietic SCT: a survey of centre strategies by the European Group for Blood and Marrow Transplantation
    T Ruutu
    Department of Medicine, Division of Haematology, Helsinki University Central Hospital, Helsinki, Finland
    Bone Marrow Transplant 47:1459-64. 2012
    ..On the basis of these findings, EBMT is developing a consensus process aiming at a standardized strategy...
  3. ncbi request reprint Ursodeoxycholic acid for the prevention of hepatic complications in allogeneic stem cell transplantation
    Tapani Ruutu
    Department of Medicine, Division of Hematology, Helsinki University Central Hospital, POB 340, FIN 00029 HUS, Helsinki, Finland
    Blood 100:1977-83. 2002
    ..In conclusion, UDCA administration reduced hepatic problems and severe acute GVHD and improved survival. These results suggest a role for UDCA in the prevention of transplant-related complications in allogeneic transplantation...
  4. ncbi request reprint Oral treatment of acute myeloid leukaemia with etoposide, thioguanine, and idarubicin (ETI) in elderly patients: a prospective randomised comparison with intravenous cytarabine, idarubicin, and thioguanine in the second and third treatment cycle
    T Ruutu
    Eur J Haematol 72:38-44. 2004
    ..In conclusion, treatment with oral ETI resulted in a similar antileukaemic effect as obtained with mainly i.v. TAI, with less toxicity and reduced need for hospitalisation...
  5. ncbi request reprint Use of intrathecal prophylaxis in allogeneic haematopoietic stem cell transplantation for malignant blood diseases: a survey of the European Group for Blood and Marrow Transplantation (EBMT)
    T Ruutu
    Department of Medicine, Helsinki University Central Hospital, POB 340, FIN 00029 HUS, Helsinki, Finland
    Bone Marrow Transplant 35:121-4. 2005
    ..Based on the rarity of isolated CNS relapse after allogeneic stem cell transplantation, EBMT does not recommend routine i.t. prophylaxis to patients without prior CNS involvement...
  6. ncbi request reprint Diagnostic criteria for hematopoietic stem cell transplant-associated microangiopathy: results of a consensus process by an International Working Group
    Tapani Ruutu
    Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland
    Haematologica 92:95-100. 2007
    ..An International Working Group was formed to develop a consensus formulation of criteria for diagnosing clinically significant TAM...
  7. ncbi request reprint Thrombotic thrombocytopenic purpura after allogeneic stem cell transplantation: a survey of the European Group for Blood and Marrow Transplantation (EBMT)
    Tapani Ruutu
    Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland
    Br J Haematol 118:1112-9. 2002
    ..TTP is a relatively frequent complication of allogeneic stem cell transplantation and it is associated with high mortality, though death is usually caused by multiple factors...
  8. pmc Reduced-toxicity conditioning with treosulfan and fludarabine in allogeneic hematopoietic stem cell transplantation for myelodysplastic syndromes: final results of an international prospective phase II trial
    Tapani Ruutu
    Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland
    Haematologica 96:1344-50. 2011
    ..The rationale for this study was to investigate the efficacy and safety of this regimen prospectively in patients with a primary myelodysplastic syndrome...
  9. doi request reprint Low incidence of invasive aspergillosis in allogeneic stem cell transplant recipients receiving amphotericin B inhalation prophylaxis
    A Nihtinen
    Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland
    Transpl Infect Dis 14:24-32. 2012
    ..Mortality of patients with IA was high. The overall survival of patients was significantly higher in Period II, indicating the advances made in SCT therapy over the 10-year period...
  10. ncbi request reprint Candidaemia in allogeneic stem cell transplant recipients: low risk without fluconazole prophylaxis
    E Jantunen
    Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland
    Bone Marrow Transplant 34:891-5. 2004
    ..Thus, systematic prophylaxis against Candida infections might not be indicated. The prognosis of established infections is still poor due to comorbid conditions, notably GVHD...
  11. doi request reprint Invasive Aspergillus infections in allo-SCT recipients: environmental sampling, nasal and oral colonization and galactomannan testing
    A Nihtinen
    Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland
    Bone Marrow Transplant 45:333-8. 2010
    ..The GM ELISA test remained negative in one of two patients with IA and does not seem useful in a population of patients with a low incidence of IA...
  12. doi request reprint Factors influencing the performance level of Candida mannan antigen testing in allogeneic stem cell transplant recipients not receiving fluconazole prophylaxis
    A Nihtinen
    Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland
    Transpl Infect Dis 13:266-72. 2011
    ..5 ng/mL, and a single positive result does not seem to predict IC. Multiple positive results might predict IC, as 6 out of 9 samples were positive in the only patient with IC, the first one 7 weeks before positive blood cultures...
  13. ncbi request reprint Central nervous system aspergillosis in allogeneic stem cell transplant recipients
    E Jantunen
    Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland
    Bone Marrow Transplant 31:191-6. 2003
    ..CNS aspergillosis is not uncommon in allogeneic SCT recipients. Clinical manifestations are usually dramatic and progress quickly. Earlier and more effective treatment of IA is needed to prevent dissemination of infection into the CNS...
  14. ncbi request reprint Epstein-Barr viral load and disease prediction in a large cohort of allogeneic stem cell transplant recipients
    S M Aalto
    Department of Virology, Haartman Institute, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
    Clin Infect Dis 45:1305-9. 2007
    ..We wanted to determine the clinical significance and predictability of Epstein-Barr virus (EBV) infections among a large cohort of recipients of allogeneic, unselected stem cell transplants...
  15. ncbi request reprint Quality of life and factors related to perceived satisfaction with quality of life after allogeneic bone marrow transplantation
    H Heinonen
    Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland
    Ann Hematol 80:137-43. 2001
    ..One year after BMT, 75.6% of the BMT recipients were able to work, 67.8% of the patients were actively participating in work/school and 7.8% were unemployed...
  16. ncbi request reprint Tetravalent meningococcal polysaccharide vaccine is immunogenic in adult allogeneic BMT recipients
    T Parkkali
    Division of Haematology, Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland
    Bone Marrow Transplant 27:79-84. 2001
    ..Vaccination against Neisseria meningitidis should be considered, especially in the event of travelling or military service > or = 8 months after BMT...
  17. ncbi request reprint Serum osteoprotegerin and receptor activator of nuclear factor-kappaB ligand (RANKL) concentrations in allogeneic stem cell transplant-recipients: a role in bone loss?
    K Kananen
    Division of Endocrinology, Department of Medicine, Helsinki University Central Hospital, 00290, Helsinki, Finland
    Osteoporos Int 17:724-30. 2006
    ..Receptor activator of nuclear factor-kappaB ligand (RANKL) increases osteoclast activity, while osteoprotegerin (OPG) neutralizes RANKL. A deficiency of OPG or an excess of RANKL may contribute to post-SCT bone loss...
  18. ncbi request reprint Aspergillus infections in allogeneic stem cell transplant recipients: have we made any progress?
    E Jantunen
    Department of Medicine, Kuopio University Hospital, Kuopio, Finland
    Bone Marrow Transplant 30:925-9. 2002
    ..Further studies in this field will focus on the role of various cytokines and combinations of antifungal agents...
  19. ncbi request reprint High incidence of PTLD after non-T-cell-depleted allogeneic haematopoietic stem cell transplantation as a consequence of intensive immunosuppressive treatment
    E Juvonen
    Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland
    Bone Marrow Transplant 32:97-102. 2003
    ..In conclusion, in transplantations from an HLA-identical donor with a non-T-cell-depleted graft, the risk of PTLD correlated strongly with the intensity of the immunosuppressive treatment...
  20. ncbi request reprint Allogeneic blood stem cell transplantation following non-myeloablative conditioning for hypereosinophilic syndrome
    E Juvonen
    Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland
    Bone Marrow Transplant 29:457-8. 2002
    ..The present study shows that stem cell transplantation after non-myeloablative conditioning may have curative potential for HES...
  21. ncbi request reprint Opsonophagocytic activity against Streptococcus pneumoniae type 19F in allogeneic BMT recipients before and after vaccination with pneumococcal polysaccharide vaccine
    T Parkkali
    Department of Medicine, Helsinki University, Central Hospital, Finland
    Bone Marrow Transplant 27:207-11. 2001
    ..There is a need to study new Pnc conjugate vaccines in multi-dose schedules for their capacity to elicit higher specific antibody concentrations with high OPA in BMT recipients...
  22. ncbi request reprint Collection of autologous blood for bone marrow donation: how useful is it?
    T Parkkali
    Department of Medicine, Helsinki University Central Hospital, PO Box 340, Helsinki FIN 00029 HUS, Finland
    Bone Marrow Transplant 35:1035-9. 2005
    ..The post-donation Hb concentrations do not decrease to levels detrimental to healthy persons whether autologous blood is transfused or not...
  23. doi request reprint The EBMT-ELN working group recommendations on the prophylaxis and treatment of GvHD: a change-control analysis
    T Ruutu
    Comprehensive Cancer Center, Stem Cell Transplantation Unit, Helsinki University Hospital, Helsinki, Finland
    Bone Marrow Transplant . 2016
    ..It also identified some of the weaknesses to be addressed when releasing recommendations in the future.Bone Marrow Transplantation advance online publication, 28 November 2016; doi:10.1038/bmt.2016.298...
  24. doi request reprint Second allogeneic transplantation for relapse of malignant disease: retrospective analysis of outcome and predictive factors by the EBMT
    T Ruutu
    Comprehensive Cancer Center, Helsinki University Hospital, Helsinki, Finland
    Bone Marrow Transplant 50:1542-50. 2015
    ..The present findings do not support the usefulness of changing the donor for the second transplantation. ..
  25. ncbi request reprint A randomized study on donor immunization with tetanus-diphtheria, Haemophilus influenzae type b and inactivated poliovirus vaccines to improve the recipient responses to the same vaccines after allogeneic bone marrow transplantation
    T Parkkali
    Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland
    Bone Marrow Transplant 39:179-88. 2007
    ..Especially patients whose donors have low-specific antibody concentrations may benefit from donor vaccination with protein and conjugate vaccines...
  26. ncbi request reprint The utility of intensified environmental surveillance for pathogenic moulds in a stem cell transplantation ward during construction work to monitor the efficacy of HEPA filtration
    A Nihtinen
    Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland
    Bone Marrow Transplant 40:457-60. 2007
    ..In conclusion, the HEPA filters seemed to have performed well in preventing an aspergillosis outbreak...
  27. ncbi request reprint Radiologically guided fine needle lung biopsies in the evaluation of focal pulmonary lesions in allogeneic stem cell transplant recipients
    E Jantunen
    Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland
    Bone Marrow Transplant 29:353-6. 2002
    ..Radiologically guided FNLB is feasible in allogeneic SCT recipients and has a low complication rate. The diagnostic yield is high especially for IPA...
  28. ncbi request reprint The predictive value of vascular risk factors and gender for the development of thrombotic complications in essential thrombocythemia
    R Jantunen
    Department of Medicine, Helsinki University Central Hospital, P. O. Box 340, 00029 HYKS, Helsinki, Finland
    Ann Hematol 80:74-8. 2001
    ..According to the present findings, the male gender should be regarded as a risk factor when deciding about the indication for treatment. Smoking should be discouraged especially among women with ET...
  29. ncbi request reprint Non-transferrin-bound iron during allogeneic stem cell transplantation
    L Sahlstedt
    Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland
    Br J Haematol 113:836-8. 2001
    ..High transferrin saturation levels were associated with the appearance of NTBI with a threshold at 80% saturation. Prevention of the potential deleterious effects of NTBI might reduce transplantation-related morbidity...
  30. ncbi request reprint Inhibition of erythroid and granulocyte-macrophage colony formation by non-transferrin-bound iron in vitro: protective effect of apotransferrin
    Eeva Juvonen
    Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland
    Eur J Haematol 79:126-31. 2007
    ..The aim of the study was to investigate in vitro the effect of free iron on erythroid and granulocyte-macrophage colony formation and the effect of binding free iron with apotransferrin...
  31. ncbi request reprint Effective binding of free iron by a single intravenous dose of human apotransferrin in haematological stem cell transplant patients
    Leila Sahlstedt
    Department of Medicine, Helsinki University Central Hospital, Finland
    Br J Haematol 119:547-53. 2002
    ..Repeated apotransferrin infusions might completely eliminate NTBI and iron-induced toxicity during myeloablative therapy...
  32. doi request reprint Effect of fluconazole prophylaxis on the incidence of invasive candida infections and bacteraemias in patients with acute leukaemia
    Anne Nihtinen
    Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland
    Eur J Haematol 80:391-6. 2008
    ..A retrospective single-centre study was conducted to investigate the effect of fluconazole prophylaxis on the incidence and the species of invasive candida infections and on the number of bacteraemias...
  33. ncbi request reprint Retrospective evaluation of serum Epstein Barr virus DNA levels in 406 allogeneic stem cell transplant patients
    Eeva Juvonen
    Helsinki University Central Hospital, Department of Medicine, Helsinki, Finland
    Haematologica 92:819-25. 2007
    ..We studied the frequency and outcome of serum EBV DNA levels in patients transplanted with an unmanipulated graft from an HLA-identical donor...
  34. ncbi request reprint Human herpesvirus 6 antigenaemia in allogeneic stem cell transplant recipients: impact on clinical course and association with other beta-herpesviruses
    Liisa Volin
    Department of Medicine, Helsinki University Central Hospital, PO Box 340, FIN 00029 HUS, Helsinki, Finland
    Br J Haematol 126:690-6. 2004
    ..Fifteen patients had acute GVHD diagnosed. Acute GVHD manifested statistically significantly (P = 0.034) earlier in the nine patients with HHV-6B antigenaemia compared with the six patients who were HHV-6B negative...
  35. ncbi request reprint Gender-associated differences in the quality of life after allogeneic BMT
    H Heinonen
    Dept of Medicine, Helsinki University Central Hospital, Helsinki, Finland
    Bone Marrow Transplant 28:503-9. 2001
    ..The present results indicated that important gender differences exist among allogeneic BMT recipients which need to be addressed when designing post-treatment intervention programs for BMT recipients...
  36. doi request reprint Early thrombin generation and impaired fibrinolysis after SCT associate with acute GVHD
    A Pinomäki
    Coagulation Disorders, Helsinki University Central Hospital, Helsinki, Finland
    Bone Marrow Transplant 45:730-7. 2010
    ....
  37. ncbi request reprint Erratum to "Apotransferrin administration prevents growth of Staphylococcus epidermidis in serum of stem cell transplant patients by binding of free iron". [FEMS Immunol. Med Microbiol. 37 (2003) 45-51]
    Leni von Bonsdorff
    Finnish Red Cross Blood Transfusion Service, Helsinki, Finland
    FEMS Immunol Med Microbiol 40:173-80. 2004
    ..The results suggest that exogenous apotransferrin might protect stem cell transplant patients against infections by S. epidermidis and possibly other opportunistic pathogens...
  38. ncbi request reprint Effect of repeated apotransferrin administrations on serum iron parameters in patients undergoing myeloablative conditioning and allogeneic stem cell transplantation
    Jaakko Parkkinen
    Finnish Red Cross Blood Transfusion Service, Helsinki, Finland
    Br J Haematol 135:228-34. 2006
    ..Complete iron binding with apotransferrin would apparently require very high apotransferrin doses...
  39. doi request reprint Prophylaxis and treatment of GVHD: EBMT-ELN working group recommendations for a standardized practice
    T Ruutu
    Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland
    Bone Marrow Transplant 49:168-73. 2014
    ....
  40. doi request reprint Non-transferrin-bound iron in haematological patients during chemotherapy and conditioning for autologous stem cell transplantation
    Leila Sahlstedt
    Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland
    Eur J Haematol 83:455-9. 2009
    ....
  41. ncbi request reprint Recovery of bone mass and normalization of bone turnover in long-term survivors of allogeneic bone marrow transplantation
    K Kananen
    Division of Endocrinology, Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland
    Bone Marrow Transplant 29:33-9. 2002
    ..More attention should be paid to the vitamin D status of all recipients and to possible hypogonadism of male patients...
  42. ncbi request reprint Stress among allogeneic bone marrow transplantation patients
    Heikki Heinonen
    Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland
    Patient Educ Couns 56:62-71. 2005
    ..A number of stressors generated by the patients were quite novel, and identified important information likely to be useful in clinical settings as well as subsequent research with this high-risk population...
  43. ncbi request reprint Prevention of bone loss after allogeneic stem cell transplantation by calcium, vitamin D, and sex hormone replacement with or without pamidronate
    Kristiina Kananen
    Division of Endocrinology, Department of Medicine, Helsinki University Central Hospital, FIN 00290 Helsinki, Finland
    J Clin Endocrinol Metab 90:3877-85. 2005
    ..In controlled studies, bisphosphonates have been used to prevent bone loss after solid organ transplantations but not in conjunction with stem cell transplantation (SCT)...
  44. ncbi request reprint Aberrant expression of HOXA9, DEK, CBL and CSF1R in acute myeloid leukemia
    Silvia Casas
    Department of Pathology, Haartman Institute, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland
    Leuk Lymphoma 44:1935-41. 2003
    ..Furthermore, an association was found between the AML-M2 subtype and lower expression of CBL, CSF1R or HOXA9, and between the AML-M5 subtype and CBL or CSF1R overexpression...
  45. ncbi request reprint Long-term outcome of intensive chemotherapy for adults with de novo acute myeloid leukaemia (AML): the nationwide AML-92 study by the Finnish Leukaemia Group
    Pirjo Koistinen
    Department of Medicine, Oulu University Hospital, Oulu, Finland
    Eur J Haematol 78:477-86. 2007
    ..To investigate the long-term outcome of idarubicin- and cytarabine-based intensive chemotherapy in adult acute myeloid leukaemia (AML)...
  46. ncbi request reprint The predictive value of megakaryocytic and erythroid colony formation and platelet function tests on the risk of thromboembolic and bleeding complications in essential thrombocythaemia
    Riitta Niittyvuopio
    Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland
    Eur J Haematol 72:245-51. 2004
    ..In conclusion, spontaneous colony formation indicated an increased risk of thrombohaemorragic events but the platelet function test had no predictive value for these complications...
  47. ncbi request reprint Lymphotoxin beta expression is high in chronic lymphocytic leukemia but low in small lymphocytic lymphoma: a quantitative real-time reverse transcriptase polymerase chain reaction analysis
    Balint Nagy
    Departments of Pathology and Medical Genetics, Haartman Institute and Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland
    Haematologica 88:654-8. 2003
    ..3, has an important role in the formation of germinal center reactions and regulation of immune response and apoptosis. Our aim was to determine LTB gene expression in different hematologic neoplasias...
  48. ncbi request reprint Lymphoproliferative disease after allogeneic stem cell transplantation--pre-emptive diagnosis by quantification of Epstein-Barr virus DNA in serum
    Sanna M Aalto
    Department of Virology, Haartman Institute, University of Helsinki and Helsinki University Central Hospital, FIN 00290 Helsinki, Finland
    J Clin Virol 28:275-83. 2003
    ..Lymphoproliferative disease (PTLD) is a life-threatening complication of organ transplantation. In matched, allogeneic, non-T-cell-depleted stem-cell transplantations (SCT) the disease develops early but has been thought to be rare...
  49. ncbi request reprint Marrow versus peripheral blood for geno-identical allogeneic stem cell transplantation in acute myelocytic leukemia: influence of dose and stem cell source shows better outcome with rich marrow
    Norbert C Gorin
    Centre International Greffes de Moelle, Hopital Saint Antoine, AP HP, Paris, France
    Blood 102:3043-51. 2003
    ..64; 95% CI, 0.44-0.92; P =.016). The present study in patients with AML receiving allografts in first remission indicates a better outcome with BM as compared to PB, when the dose of BM infused is rich...
  50. ncbi request reprint Filgrastim-mobilized peripheral blood progenitor cells versus bone marrow transplantation for treating leukemia: 3-year results from the EBMT randomized trial
    Norbert Schmitz
    Department of Hematology, AK St Georg, Lohmuehlenstrasse 5, 20099 Hamburg, Germany
    Haematologica 90:643-8. 2005
    ....
  51. ncbi request reprint Development of leukemia in donor cells after allogeneic stem cell transplantation--a survey of the European Group for Blood and Marrow Transplantation (EBMT)
    Bernd Hertenstein
    Hannover Medical School, Department of Hematology and Oncology, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Haematologica 90:969-75. 2005
    ..DCL is an extremely rare complication of allogeneic SCT in which treatment attempts with chemotherapy and a second SCT are justified. Donors are not at an increased risk of developing hematologic malignancies...
  52. ncbi request reprint Retrospective comparison of bone marrow and granulocyte colony-stimulating factor-mobilized peripheral blood progenitor cells for allogeneic stem cell transplantation using HLA identical sibling donors in myelodysplastic syndromes
    Philippe Guardiola
    Service de Greffe de Moelle, Hopital Saint Louis, Paris, France
    Blood 99:4370-8. 2002
    ....
  53. ncbi request reprint Common polymorphisms in critical genes of innate immunity do not contribute to the risk for chronic disseminated candidiasis in adult leukemia patients
    Eun Hwa Choi
    Section of Genomic Variation, Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Med Mycol 43:349-53. 2005
    ..Common variants in the six studied genes most likely do not contribute to the risk for chronic disseminated candidiasis in patients with acute leukemia...
  54. ncbi request reprint Transplants of umbilical-cord blood or bone marrow from unrelated donors in adults with acute leukemia
    Vanderson Rocha
    Hopital Saint Louis, Assistance Publique des Hôpitaux de Paris and Paris University, Paris, France
    N Engl J Med 351:2276-85. 2004
    ..Promising results of cord-blood transplants from unrelated donors have been reported in adults...
  55. ncbi request reprint Transplantation of mobilized peripheral blood cells to HLA-identical siblings with standard-risk leukemia
    Norbert Schmitz
    Department of Internal Medicine II, University of Kiel, Germany
    Blood 100:761-7. 2002
    ..Long-term observation of patients with different diseases and stages of disease is necessary to ultimately define the role of both sources of stem cells...
  56. ncbi request reprint Allogeneic hematopoietic stem cell transplantation for chronic myeloid leukemia in Europe 2006: transplant activity, long-term data and current results. An analysis by the Chronic Leukemia Working Party of the European Group for Blood and Marrow Transplan
    Alois Gratwohl
    Hematology, University Hospital Basel, Switzerland
    Haematologica 91:513-21. 2006
    ..HSCT remains an important treatment option for patients with CML. The data describe the current status of this option and the outcome a patient can expect today. They provide an objective basis for decision making...
  57. doi request reprint Prospective oral mucositis audit: oral mucositis in patients receiving high-dose melphalan or BEAM conditioning chemotherapy--European Blood and Marrow Transplantation Mucositis Advisory Group
    Nicole Blijlevens
    Department of Hematology, University Medical Center St Radboud, PO Box 9101 6500 HB Nijmegen, The Netherlands
    J Clin Oncol 26:1519-25. 2008
    ....
  58. ncbi request reprint Retrospective comparison of reduced-intensity conditioning and conventional high-dose conditioning for allogeneic hematopoietic stem cell transplantation using HLA-identical sibling donors in myelodysplastic syndromes
    Rodrigo Martino
    Division of Clinical Hematology, Hopital de la Sant Creu i Sant Pau, Autonomous University of Barcelona, Spain
    Blood 108:836-46. 2006
    ....
  59. ncbi request reprint Apotransferrin administration prevents growth of Staphylococcus epidermidis in serum of stem cell transplant patients by binding of free iron
    Leni von Bonsdorff
    Finnish Red Cross Blood Transfusion Service, Kivihaantie 7, 00310 Helsinki, Finland
    FEMS Immunol Med Microbiol 37:45-51. 2003
    ..The results suggest that exogenous apotransferrin might protect stem cell transplant patients against infections by S. epidermidis and possibly other opportunistic pathogens...
  60. ncbi request reprint Relevance of bone marrow cell dose on allogeneic transplantation outcomes for patients with acute myeloid leukemia in first complete remission: results of a European survey
    Vanderson Rocha
    Hematopoietic Stem Cell Transplant Unit, Hopital Saint Louis, and Service d Hématologie, CHU Saint Antoine and European Data Management Office, Institut des Cordeliers, Paris, France
    J Clin Oncol 20:4324-30. 2002
    ..Bone marrow cell dose has been reported to be an important factor in alloBMT; however, its true impact on relapse incidence (RI), leukemia-free survival (LFS), and nonrelapse mortality (NRM) in a large cohort of patients is unknown...
  61. ncbi request reprint Graft-versus-host disease and outcome in HLA-identical sibling transplantations for chronic myeloid leukemia
    Alois Gratwohl
    Division of Hematology, Department of Internal Medicine, Kantonsspital Basel, Basel, Switzerland
    Blood 100:3877-86. 2002
    ..These data clarify the role of GvHD in posttransplantation outcome. Considerations for long-term outcome are essential when short-term data of interventions on GvHD are analyzed...
  62. ncbi request reprint Association between chronic disseminated candidiasis in adult acute leukemia and common IL4 promoter haplotypes
    Eun Hwa Choi
    Section of Genomic Variation, Pediatric Oncology Branch, National Cancer Institute NIH, Advanced Technology Center, Gaithersburg, MD 20892 4605, USA
    J Infect Dis 187:1153-6. 2003
    ..16), whereas another common haplotype (-1098T/-589T/-33T) appeared to be protective against CDC (P= .018; OR, 0.47). Genetic variants of IL4 could contribute to the development of CDC in patients with acute leukemia...