R Kaaja

Summary

Affiliation: Helsinki University Central Hospital
Country: Finland

Publications

  1. pmc Low-molecular-weight heparin for prevention of placenta-mediated pregnancy complications: protocol for a systematic review and individual patient data meta-analysis (AFFIRM)
    Marc A Rodger
    The Ottawa Hospital, Centre for Practice Changing Research, 501 Smyth Road, Box 201, Ottawa, ON K1H 8 L6, Canada
    Syst Rev 3:69. 2014
  2. ncbi request reprint [Risk factor of coronary artery disease in women]
    Risto Kaaja
    HYKS n naistenklinikka PL 140, 00029 HUS
    Duodecim 119:2436-43. 2003
  3. ncbi request reprint Manifestations of chronic disease during pregnancy
    Risto J Kaaja
    Department of Obstetrics and Gynecology, Helsinki University Hospital, Helsinki, Finland
    JAMA 294:2751-7. 2005
  4. doi request reprint Vascular complications in diabetic pregnancy
    R Kaaja
    Turku University Satakunta Central Hospital, Finland
    Thromb Res 127:S53-5. 2011
  5. ncbi request reprint [Pregnancy, window to women's health]
    Risto Kaaja
    HYKS, HUS
    Duodecim 121:978-84. 2005
  6. ncbi request reprint Peripartum cardiomyopathy
    R Kaaja
    Department of Obstetrics and Gynecology, Helsinki University Hospital, Helsinki, Finland
    Minerva Cardioangiol 54:331-6. 2006
  7. ncbi request reprint Progression of retinopathy in type 1 diabetic women during pregnancy
    Risto Kaaja
    Department of Obstetrics and Gynecology, Helsinki University Hospital, Haartmaninkatu 2, 00290, Helsinki, Finland
    Curr Diabetes Rev 3:85-93. 2007
  8. ncbi request reprint Effects of sympatholytic therapy on insulin sensitivity indices in hypertensive postmenopausal women
    R Kaaja
    Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, Finland
    Int J Clin Pharmacol Ther 45:394-401. 2007
  9. ncbi request reprint Treatment of postpartum thrombotic microangiopathy with plasma exchange using cryosupernatant as replacement
    Katja Lampinen
    Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Finland
    Acta Obstet Gynecol Scand 83:175-9. 2004
  10. ncbi request reprint Pre-eclampsia but not pregnancy-induced hypertension is a risk factor for diabetic nephropathy in type 1 diabetic women
    D Gordin
    Folkhalsan Research Center, Biomedicum Helsinki, University of Helsinki, and Department of Medicine, Helsinki University Central Hospital, Finland
    Diabetologia 50:516-22. 2007

Collaborators

Detail Information

Publications72

  1. pmc Low-molecular-weight heparin for prevention of placenta-mediated pregnancy complications: protocol for a systematic review and individual patient data meta-analysis (AFFIRM)
    Marc A Rodger
    The Ottawa Hospital, Centre for Practice Changing Research, 501 Smyth Road, Box 201, Ottawa, ON K1H 8 L6, Canada
    Syst Rev 3:69. 2014
    ..The project is called AFFIRM, An individual patient data meta-analysis oF low-molecular-weight heparin For prevention of placenta-medIated pRegnancy coMplications...
  2. ncbi request reprint [Risk factor of coronary artery disease in women]
    Risto Kaaja
    HYKS n naistenklinikka PL 140, 00029 HUS
    Duodecim 119:2436-43. 2003
  3. ncbi request reprint Manifestations of chronic disease during pregnancy
    Risto J Kaaja
    Department of Obstetrics and Gynecology, Helsinki University Hospital, Helsinki, Finland
    JAMA 294:2751-7. 2005
    ..Physiologic changes of pregnancy include insulin resistance, thrombophilia, immunosuppression, and hypervolemia. These changes may herald the development of disease in later life...
  4. doi request reprint Vascular complications in diabetic pregnancy
    R Kaaja
    Turku University Satakunta Central Hospital, Finland
    Thromb Res 127:S53-5. 2011
    ..Women with diabetes should be evaluated before pregnancy for microangiopathies, treated and followed closely during pregnancy by obstetrician, internist/diabetologue, cardiologist and ophthalmologist and nephrologist...
  5. ncbi request reprint [Pregnancy, window to women's health]
    Risto Kaaja
    HYKS, HUS
    Duodecim 121:978-84. 2005
  6. ncbi request reprint Peripartum cardiomyopathy
    R Kaaja
    Department of Obstetrics and Gynecology, Helsinki University Hospital, Helsinki, Finland
    Minerva Cardioangiol 54:331-6. 2006
    ..In less than 50% of PPCM patients, left ventricular function normalizes with pharmacologic therapy. However, subsequent pregnancies are often associated with recurrence of left ventricular systolic dysfunction...
  7. ncbi request reprint Progression of retinopathy in type 1 diabetic women during pregnancy
    Risto Kaaja
    Department of Obstetrics and Gynecology, Helsinki University Hospital, Haartmaninkatu 2, 00290, Helsinki, Finland
    Curr Diabetes Rev 3:85-93. 2007
    ..However, pregnancy seems to have no long-term detrimental effects as regards the progression of DR unless it has proceeded to pre-proliferative and proliferative phases...
  8. ncbi request reprint Effects of sympatholytic therapy on insulin sensitivity indices in hypertensive postmenopausal women
    R Kaaja
    Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, Finland
    Int J Clin Pharmacol Ther 45:394-401. 2007
    ....
  9. ncbi request reprint Treatment of postpartum thrombotic microangiopathy with plasma exchange using cryosupernatant as replacement
    Katja Lampinen
    Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Finland
    Acta Obstet Gynecol Scand 83:175-9. 2004
    ..This small analysis lends weight to early plasma exchange with cryosupernatant as part of the treatment of postpartum HUS/TTP and suggests that persistent thrombocytopenia is a signal of more serious disease...
  10. ncbi request reprint Pre-eclampsia but not pregnancy-induced hypertension is a risk factor for diabetic nephropathy in type 1 diabetic women
    D Gordin
    Folkhalsan Research Center, Biomedicum Helsinki, University of Helsinki, and Department of Medicine, Helsinki University Central Hospital, Finland
    Diabetologia 50:516-22. 2007
    ..Our aim was to study whether pre-eclampsia and pregnancy-induced hypertension are predictors of diabetic nephropathy in type 1 diabetic women...
  11. doi request reprint Oral inflammatory burden and preterm birth
    Aura Heimonen
    Institute of Dentistry, University of Helsinki, Helsinki, Finland
    J Periodontol 80:884-91. 2009
    ..Earlier studies on the association between oral inflammation and preterm birth limited the inflammation source to periodontal disease. This might have caused an underestimation of the total inflammatory burden from the oral cavity...
  12. ncbi request reprint Macular blood flow during pregnancy in patients with early diabetic retinopathy measured by blue-field entoptic simulation
    T Hellstedt
    Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Finland
    Graefes Arch Clin Exp Ophthalmol 234:659-63. 1996
    ....
  13. ncbi request reprint Evidence of high circulating testosterone in women with prior preeclampsia
    H Laivuori
    Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Finland
    J Clin Endocrinol Metab 83:344-7. 1998
    ..A history of preeclampsia an average of 17 yr earlier thus appears to be associated with elevated levels of testosterone, which may contribute to the increased risk of vascular morbidity in such women...
  14. ncbi request reprint Thromboprophylaxis with low molecular weight heparin (dalteparin) in pregnancy
    V Pettila
    Department of Obstetrics and Gynaecology, Helsinki University Central Hospital, Finland
    Thromb Res 96:275-82. 1999
    ..Recurrence of venous thromboembolism and safety of treatments were assessed. Dalteparin administered once daily was safe and effective in thromboprophylaxis during pregnancy and postpartum...
  15. ncbi request reprint Increased thromboxane production in women with a history of venous thromboembolic event: effect of heparins
    R Kaaja
    Department of Obstetrics and Gynaecology, Helsinki University Hospital, Helsinki, Finland
    Br J Haematol 114:655-9. 2001
    ..Thus, women with a history of venous thromboembolic events have thromboxane dominance during and after pregnancy, but this dominance can be eliminated through the use of heparins...
  16. doi request reprint Factor V Leiden as a risk factor for preterm birth--a population-based nested case-control study
    L M Hiltunen
    Department of Hemostasis, Finnish Red Cross Blood Service, Helsinki, Finland
    J Thromb Haemost 9:71-8. 2011
    ..Genetic thrombophilia can theoretically contribute to the induction of preterm delivery, but the role of thrombophilia as risk factor is unclear...
  17. ncbi request reprint Progression of retinopathy during pregnancy in type 1 diabetic women treated with insulin lispro
    Sirpa Loukovaara
    Department of Ophthalmology, Helsinki University Central Hospital, Helsinki, Finland
    Diabetes Care 26:1193-8. 2003
    ..To evaluate the progression of retinopathy during pregnancy and postpartum in (insulin-dependent) women with type 1 diabetes treated with insulin lispro or with regular human insulin...
  18. ncbi request reprint Plasma homocysteine levels elevated and inversely related to insulin sensitivity in preeclampsia
    H Laivuori
    Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Finland
    Obstet Gynecol 93:489-93. 1999
    ..To study the plasma levels of homocysteine in preeclampsia and relate them to insulin sensitivity...
  19. ncbi request reprint 677 C-->T polymorphism of the methylenetetrahydrofolate reductase gene and preeclampsia
    H Laivuori
    Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, Finland
    Obstet Gynecol 96:277-80. 2000
    ..To evaluate C to T substitution at nucleotide 677 of N(5), N(10)-methylenetetrahydrofolate reductase gene in women with prior preeclamptic or normotensive pregnancies...
  20. ncbi request reprint Diurnal blood glucose profiles in women with gestational diabetes with or without hypertension
    A Leinonen
    Department of Obstetrics and Gynaecology, Helsinki University Hospital, Haartmanninkatu 2, 00029 HUCH, Helsinki, Finland
    Diabet Med 21:1181-4. 2004
    ..The aim of the study was to establish whether diurnal blood glucose profiles differed in women with gestational diabetes (GDM) with different forms of hypertensive complications...
  21. doi request reprint Vascular complications in diabetic pregnancy
    R Kaaja
    Obstetric physician, Associate Professor, Helsinki University Hospital, Helsinki, Finland
    Thromb Res 123:S1-3. 2009
    ..Women with Type 1 diabetes should be evaluated before pregnancy for microangiopathies, treated and followed closely during pregnancy by obstetrician and internist/diabetologue...
  22. doi request reprint Pre-eclampsia is a risk factor of carotid artery atherosclerosis
    L Haukkamaa
    Department of Obstetrics and Gynaecology, Helsinki University Central Hospital, Helsinki, Finland
    Cerebrovasc Dis 27:599-607. 2009
    ..The aim of this study was to examine whether women with a history of pre-eclampsia more often show signs of atherosclerosis compared with 2 control groups...
  23. ncbi request reprint Inflammatory markers and retinopathy in pregnancies complicated with type I diabetes
    S Loukovaara
    Department of Ophthalmology, Helsinki University, Central Hospital Helsinki, Haartmaninkatu 4 C, FIN 00290 Helsinki, Finland
    Eye (Lond) 19:422-30. 2005
    ....
  24. ncbi request reprint Clinical cure of severe, early onset preeclampsia with low molecular weight heparin therapy in primigravida with hyperreactio luteinalis and thrombophilia
    Terhi Saisto
    Department of Obstetrics and Gynaecology, Helsinki University Central Hospital, PO Box 140, FIN 00290 HUS Helsinki, Finland
    Hum Reprod 19:725-8. 2004
    ..Inherited thrombophilia, spontaneous hyperreactio luteinalis and PE may be associated phenomena...
  25. ncbi request reprint Norepinephrine, adrenocorticotropin, cortisol and beta-endorphin in women suffering from fear of labor: responses to the cold pressor test during and after pregnancy
    Terhi Saisto
    Department of Obstetrics and Gynecology, Helsinki University Central Hospital, PO Box 140, Haartmaninkatu 2, FIN 00290 HUS, Helsinki, Finland
    Acta Obstet Gynecol Scand 83:19-26. 2004
    ..Women suffering from fear of labor have reduced pain tolerance during a cold pressor test (CPT) during and after pregnancy...
  26. ncbi request reprint Retinal capillary blood flow in diabetic and nondiabetic women during pregnancy and postpartum period
    Sirpa Loukovaara
    Department of Ophthalmology, Helsinki University Central Hospital, Helsinki, Finland
    Invest Ophthalmol Vis Sci 44:1486-91. 2003
    ..To evaluate the response of retinal capillary circulation to pregnancy in women with diabetes and to correlate microcirculatory changes with progression of retinopathy during pregnancy...
  27. doi request reprint Detection of pregnancies with high risk of fetal macrosomia among women with gestational diabetes mellitus
    Lauri Suhonen
    Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, Finland
    Acta Obstet Gynecol Scand 87:940-5. 2008
    ..To compare the frequency of fetal macrosomia and Erb's palsy in two groups of women with gestational diabetes mellitus (GDM) and in healthy controls...
  28. ncbi request reprint Macular capillary blood flow velocity by blue-field entoptoscopy in diabetic and healthy women during pregnancy and the postpartum period
    Sirpa Loukovaara
    Department of Ophthalmology, Helsinki University Central Hospital, Haartmaninkatu 4 C, 00290 Helsinki, Finland
    Graefes Arch Clin Exp Ophthalmol 240:977-82. 2002
    ..To study macular capillary blood flow velocity in diabetic and healthy women during pregnancy and the postpartum period...
  29. doi request reprint Parity and mortality in cases of childhood-onset diabetes mellitus
    L Sjoberg
    University of Helsinki, Department of Public Health, Helsinki, Finland
    Diabetes Metab Res Rev 32:607-14. 2016
    ..This study aims to assess the association between parity and mortality in adults with childhood-onset type 1 diabetes (T1D) and their matched controls...
  30. doi request reprint The effect of hysterectomy or levonorgestrel-releasing intrauterine system on cardiovascular disease risk factors in menorrhagia patients: a 10-year follow-up of a randomised trial
    S Heliövaara-Peippo
    Department of Obstetrics and Gynaecology, Helsinki University Hospital, Helsinki, Finland
    Maturitas 69:354-8. 2011
    ..To compare, whether women with menorrhagia, treated with either hysterectomy or LNG-IUS, differ in their cardiovascular risk profile during 10-year follow-up...
  31. ncbi request reprint Treatment of gestational diabetes with short- or long-acting insulin and neonatal outcome: a pilot study
    Maritta Pöyhönen-Alho
    Department of Obstetrics and Gynecology, Helsinki District University Central Hospital, Jorvi Hospital, Espoo, Finland
    Acta Obstet Gynecol Scand 81:258-9. 2002
  32. ncbi request reprint Adiponectin concentrations in maternal serum: elevated in preeclampsia but unrelated to insulin sensitivity
    Eero Kajantie
    Hospital of Children and Adolescents and Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Finland
    J Soc Gynecol Investig 12:433-9. 2005
    ..We studied whether serum adiponectin is related to insulin sensitivity in preeclamptic and normotensive pregnant women...
  33. ncbi request reprint Is there any link between insulin resistance and inflammation in established preeclampsia?
    Risto Kaaja
    Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Finland
    Metabolism 53:1433-5. 2004
    ..We conclude that insulin resistance and the inflammatory markers studied were not associated in established preeclampsia...
  34. ncbi request reprint Pregnancy in essential thrombocythaemia: experience with 40 pregnancies
    Riitta Niittyvuopio
    Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland
    Eur J Haematol 73:431-6. 2004
    ..Treatment with low-dose acetylsalicylic acid (ASA) alone during pregnancy or platelet-lowering drugs before or during pregnancy reduced the risk of complications...
  35. doi request reprint Fertility in people with childhood-onset type 1 diabetes
    L Sjoberg
    Hjelt Institute, Department of Public Health, University of Helsinki, Helsinki, Finland
    Diabetologia 56:78-81. 2013
    ..To assess the number of live births in a population-based, retrospective cohort of women and men with childhood-onset type 1 diabetes, and matched controls...
  36. doi request reprint Decreased variation of inflammatory markers in gestational diabetes
    Maritta Pöyhönen-Alho
    Department of Obstetrics and Gynaecology, Helsinki University Central Hospital Jorvi Hospital, Helsinki, Finland
    Diabetes Metab Res Rev 27:269-76. 2011
    ..We aimed to study the association of the sympathetic nervous system and sub-clinical inflammation in women with gestational diabetes...
  37. doi request reprint Postpartum oral health parameters in women with preterm birth
    Aura Heimonen
    Institute of Dentistry, University of Helsinki, and Department of Oral and Maxillofacial Diseases, Helsinki University Central Hospital, Helsinki, Finland
    Acta Odontol Scand 66:334-41. 2008
    ....
  38. doi request reprint Blood group AB and factor V Leiden as risk factors for pre-eclampsia: a population-based nested case-control study
    Leena M Hiltunen
    Department of Hemostasis, Finnish Red Cross Blood Service, Helsinki, Finland
    Thromb Res 124:167-73. 2009
    ..ABO blood group has been associated with thrombotic disorders and pre-eclampsia. We assessed ABO blood group, seven thrombophilia associated polymorphisms, and anti-beta2-glycoprotein I antibodies as risk factors for pre-eclampsia...
  39. ncbi request reprint Risk for subsequent coronary artery disease after preeclampsia
    Leena Haukkamaa
    Department of Obstetrics and Gynecology, Helsinki University Hospital, Helsinki, Finland
    Am J Cardiol 93:805-8. 2004
    ..Our study showed that hypertension, diabetes, hypercholesterolemia, advanced age, smoking, and preeclampsia are independent risk factors for subsequent coronary artery disease...
  40. doi request reprint Free fatty acid profiles in preeclampsia
    Pia M Villa
    Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, Finland
    Prostaglandins Leukot Essent Fatty Acids 81:17-21. 2009
    ..009), was unrelated to total or any individual FFA concentration. We concluded that preeclamptic women have higher circulating FFA concentrations, which despite insulin resistance are suppressed by oral glucose loading...
  41. doi request reprint Hormonal and metabolic characteristics of premenopausal women with a history of preeclamptic pregnancy
    Anna Tuuri
    Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, Finland
    Acta Obstet Gynecol Scand 89:1331-7. 2010
    ..To investigate whether women with a history of preeclampsia have more signs of hyperandrogenism and insulin resistance in the premenopausal period than women with history of normotensive pregnancies...
  42. ncbi request reprint Postpartum bone mineral density in women treated for thromboprophylaxis with unfractionated heparin or LMW heparin
    Ville Pettila
    Department of Anaesthesiology and Intensive Care Medicine, Helsinki University Central Hospital, Finland
    Thromb Haemost 87:182-6. 2002
    ..Therefore we recommend use of dalteparin instead of UF heparin for long-term thromboprophylaxis during and after pregnancy...
  43. ncbi request reprint Plasma exchange in severe postpartum HELLP syndrome
    J G Forster
    Department of Anesthesiology and Intensive Care Medicine, Helsinki University Central Hospital, Finland
    Acta Anaesthesiol Scand 46:955-8. 2002
    ..Plasma exchange was a major part of the treatment regime in our patient. Early plasma exchange may be considered as an adjuvant therapy in severe and progressive postpartum HELLP syndrome...
  44. ncbi request reprint Reduced pain tolerance during and after pregnancy in women suffering from fear of labor
    T Saisto
    Department of Obstetrics and Gynecology, Helsinki University Central Hospital, P O Box 140, Haartmaninkatu 2, FIN 00029 HUS, Finland
    Pain 93:123-7. 2001
    ..6.60+/-2.6, P=0.001). Patients with fear of labor were characterized by pain intolerance also in circumstances other than labor. This fact may indicate enhanced sensitivity to pain-causing mechanisms in women who develop fear of labor...
  45. ncbi request reprint Predictors and risk factors of pre-eclampsia
    R Kaaja
    Department of Obstetrics and Gynecology, Helsinki University Hospital, Helsinki, Finland
    Minerva Ginecol 60:421-9. 2008
    ..Large-scale prospective studies, assessing these markers, are important to advance progress in reducing maternal and perinatal morbidity and relieving the heavy burden of pre-eclampsia...
  46. doi request reprint Imbalance of the autonomic nervous system at night in women with gestational diabetes
    M Pöyhönen-Alho
    Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, Finland
    Diabet Med 27:988-94. 2010
    ..Because activity of the sympathetic nervous system tends to be relatively stable in the nocturnal hours, we performed the study at night...
  47. ncbi request reprint Pregnancy-associated recurrent liver necrosis in patient with antiphospholipid syndrome
    V M Ulander
    Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, Finland
    Lupus 15:889-91. 2006
    ..We describe a rare case of recurrent liver necrosis postpartum in two consecutive pregnancies of woman with systemic lupus erythematosus (SLE) and positive antiphospholipid antibodies (aPL) who underwent complete recovery...
  48. ncbi request reprint Thrombophilia: a new potential risk factor for cervical insufficiency
    Veli Matti Ulander
    Helsinki University Central Hospital, Department of Obstetrics and Gynaecology, PO Box 140, 00029 HUCH, Helsinki, Finland
    Thromb Res 118:705-8. 2006
  49. ncbi request reprint Major malformations in offspring of women with epilepsy
    Erja Kaaja
    Department of Obstetrics and Gynecology, Helsinki University Central Hospital, HUCH, Finland
    Neurology 60:575-9. 2003
    ..The offspring of women with epilepsy are at an increased risk of major congenital malformations, but the impact of the various contributing factors remains unresolved...
  50. pmc Susceptibility loci for preeclampsia on chromosomes 2p25 and 9p13 in Finnish families
    Hannele Laivuori
    Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, Finland
    Am J Hum Genet 72:168-77. 2003
    ..The locus at 9p13 has been shown to be a candidate region for type 2 diabetes in two recently published genomewide scans from Finland and China. The regions on chromosomes 2p25 and 9p13 may harbor susceptibility genes for preeclampsia...
  51. ncbi request reprint Plasma levels of annexins IV and V in relation to antiphospholipid antibody status in women with a history of recurrent miscarriage
    Veli Matti Ulander
    Department of Obstetrics and Gynaecology, Helsinki University Hospital, Haartmaninkatu 2, 00290 Helsinki, Finland
    Thromb Res 120:865-70. 2007
    ..The aim of our study was to define plasma concentrations of circulating annexins IV and V at the beginning of pregnancy among women with a history of RM, and in connection to their aPL antibody status...
  52. ncbi request reprint Pulse wave reflection in currently and previously preeclamptic women
    Mats Rönnback
    Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, Finland
    Hypertens Pregnancy 24:171-80. 2005
    ..This study tested the hypothesis that preeclampsia and a history of preeclampsia are associated with increased pulse wave reflection...
  53. ncbi request reprint Regional differences in the prevalence of pre-eclampsia in relation to the risk factors for coronary artery disease in women in Finland
    Risto Kaaja
    Department of Obstetrics and Gynecology, Helsinki University Hospital, Haartmaninkatu 2, 00290 Helsinki, Finland
    Eur Heart J 26:44-50. 2005
    ..The aim of this study was to examine the prevalence of pre-eclampsia in Southern, Eastern, and Northern Finland, and the relationship between history of pre-eclampsia and maternal coronary artery disease (CAD) risk factors...
  54. ncbi request reprint Long-term outcome of deep venous thrombosis during pregnancy treated with unfractionated heparin or low molecular weight heparin
    Veli Matti Ulander
    Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Haartmaninkatu 2, P O Box 140, 00029 Helsinki, Finland
    Thromb Res 111:239-42. 2003
  55. doi request reprint Thromboprophylaxis for recurrent miscarriage in women with or without thrombophilia. HABENOX: a randomised multicentre trial
    Jantien Visser
    Department of Obstetrics, Gynaecology and Reproductive Medicine, Leiden University Medical Center, Leiden, The Netherlands
    Thromb Haemost 105:295-301. 2011
    ..No significant difference in live birth rate was found with enoxaparin treatment versus aspirin or a combination of both versus aspirin in women with recurrent miscarriage...
  56. doi request reprint Pregnancy and childbirth in carriers of the lamin A/C-gene mutation
    Eeva Palojoki
    Department of Cardiology, Helsinki University Central Hospital, Helsinki, Finland
    Eur J Heart Fail 12:630-3. 2010
    ..All babies were healthy except for one with a small ventricular septal defect, one diagnosed with tracheobronchomalasia, and one with a patent ductus arteriosus. None of these defects have been associated with lamin A/C mutations...
  57. ncbi request reprint Treatment of deep venous thrombosis with low-molecular-weight heparin during pregnancy
    Veli Matti Ulander
    Department of Obstetrics and Gynaecology, Helsinki University Hospital, Haartmaninkatu 2, 00290, Helsinki, Finland
    Thromb Res 106:13-7. 2002
    ..Our results indicate that LMW heparin is as effective and safe as UF heparin for the first week of treatment, but LMW heparin has the advantage of being easily administered and few laboratory controls are required...
  58. ncbi request reprint Enzyme-inducing antiepileptic drugs in pregnancy and the risk of bleeding in the neonate
    Erja Kaaja
    Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Finland
    Neurology 58:549-53. 2002
    ..Antenatal administration of vitamin K(1) to mothers using these drugs therefore is widely recommended. There are, however, no studies on the incidence of this complication...
  59. doi request reprint Factor V Leiden as risk factor for unexplained stillbirth--a population-based nested case-control study
    Leena M Hiltunen
    Department of Hemostasis, Finnish Red Cross Blood Service, Helsinki, Finland
    Thromb Res 125:505-10. 2010
    ..Thrombophilia has been associated with stillbirth but population-based studies are few. We assessed selected genetic and acquired parameters for the risk of unexplained stillbirth, including FV Leiden...
  60. ncbi request reprint The procoagulant effects of factor V Leiden may be balanced against decreased levels of factor V and do not reflect in vivo thrombin formation in newborns
    Satu Hyytiäinen
    Hospital for Children and Adolescents, Helsinki, Finland
    Thromb Haemost 95:434-40. 2006
    ..Lack of elevated F1+2 levels in FVL-positive infants, however, suggested the existence of balancing mechanisms; one could be the observed lower level of factor V in FVL heterozygous newborns...
  61. doi request reprint Sex chromosome characteristics and recurrent miscarriage
    Milja Kaare
    Folkhalsan Institute of Genetics, University of Helsinki, Helsinki, Finland
    Fertil Steril 90:2328-33. 2008
    ..To investigate whether skewed X chromosome inactivation (XCI) and Y chromosome microdeletions are associated with recurrent miscarrige (RM)...
  62. ncbi request reprint Impaired vascular dilatation in women with a history of pre-eclampsia
    Katja H Lampinen
    Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, Finland
    J Hypertens 24:751-6. 2006
    ..We studied endothelial function and arterial compliance in non-pregnant, previously pre-eclamptic women...
  63. ncbi request reprint 50gram oral glucose challenge test combined with risk factor-based screening for gestational diabetes
    Maritta K Pöyhönen-Alho
    Department of Gynecology and Obstetrics, Helsinki University Central Hospital, Finland
    Eur J Obstet Gynecol Reprod Biol 121:34-7. 2005
    ..Our aim was to study whether universal screening of all pregnant women by Oral Glucose Challenge Test (OGCT) would identify a higher number of women with Gestational Diabetes (GDM) than risk factor based screening...
  64. ncbi request reprint Topographic change in the central macula coupled with contrast sensitivity loss in diabetic pregnancy
    Sirpa Loukovaara
    Department of Ophthalmology, Helsinki University Central Hospital, Haartmaninkatu 4 C, PO Box 220, 00029 HUCH, Helsinki, Finland
    Graefes Arch Clin Exp Ophthalmol 241:607-14. 2003
    ..To study macular topography and contrast sensitivity (CS) in diabetic and nondiabetic women during pregnancy and post partum...
  65. ncbi request reprint Insulin resistance and sympathetic overactivity in women
    Risto J Kaaja
    Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Haartmaninkatu, Helsinki, Finland
    J Hypertens 24:131-41. 2006
    ..g. metformin) to decrease insulin resistance, central sympatholytics (e.g. moxonidine), and AT-receptor blockers or angiotensin-converting enzyme (ACE) inhibitors to overcome sympathetic overactivity, hypertension and inflammation...
  66. ncbi request reprint Vasoactive mediators and retinopathy during type 1 diabetic pregnancy
    Sirpa Loukovaara
    Department of Ophthalmology, Helsinki University Central Hospital, Haartmaninkatu 4C, FIN 00290 Helsinki, Finland
    Acta Ophthalmol Scand 83:57-62. 2005
    ..To evaluate the role of various vasoactive hormones in the evolution of diabetic retinopathy during pregnancy and postpartum...
  67. doi request reprint A relationship between insulin sensitivity and vasodilation in women with a history of preeclamptic pregnancy
    Katja H Lampinen
    Department of Obstetrics and Gynecology, Helsinki University Hospital, Department of Obstetrics and Gynecology, Haartmaninkatu 2, 00290 Helsinki, Finland
    Hypertension 52:394-401. 2008
    ..The present study indicates a relation between insulin sensitivity with vascular dilatory function in women with previous preeclampsia. Furthermore, early onset preeclampsia correlates with impaired insulin sensitivity later in life...
  68. ncbi request reprint Glycodelin: a novel serum anti-inflammatory marker in type 1 diabetic retinopathy during pregnancy
    Sirpa Loukovaara
    Department of Ophthalmology, Helsinki University Central Hospital, Helsinki, Finland
    Acta Ophthalmol Scand 85:46-9. 2007
    ..Glycodelin has immunosuppressive properties thought to play a role in the protection of the fetoplacental unit. We studied the role of glycodelin in the development and progression of retinopathy in type 1 diabetes during pregnancy...
  69. ncbi request reprint The insulin-like growth factor system and Type 1 diabetic retinopathy during pregnancy
    Sirpa Loukovaara
    Department of Ophthalmology, Helsinki University Central Hospital, Haartmaninkatu 4 C, FIN 00290 Helsinki, Finland
    J Diabetes Complications 19:297-304. 2005
    ....
  70. ncbi request reprint [Hypertension in postmenopausal women]
    Risto J Kaaja
    HYKS n naistentautien klinikka PL 140, 00029 HUS
    Duodecim 118:25-30. 2002
  71. ncbi request reprint N-terminal pro-C-type natriuretic peptide, but not C-type natriuretic peptide, is greatly elevated in the fetal circulation
    Timothy C R Prickett
    Department of Medicine, Christchurch School of Medicine and Health Sciences, Christchurch, New Zealand
    Clin Sci (Lond) 106:535-40. 2004
    ..In conclusion, the greatly elevated ratio of NT-proCNP/CNP in fetal compared with maternal plasma suggests that synthesis, as well as clearance, of CNP (but not NT-proCNP clearance) are markedly increased in fetal tissues...
  72. doi request reprint Metabolic syndrome and the menopause
    Risto J Kaaja
    Department of Obstetrics and Gynaecology, Helsinki University Central Hospital, Helsinki, Finland
    Menopause Int 14:21-5. 2008
    ..If blood pressure, lipid and glycaemic control are not achieved through these interventions then pharmacological therapy will be required...