Affiliation: Finnish Institute of Occupational Health
- Molecular and genetic changes in asbestos-related lung cancerPenny Nymark
Finnish Institute of Occupational Health, 00250 Helsinki, Finland
Cancer Lett 265:1-15. 2008..Specific asbestos-associated molecular signatures can assist the development of early biomarkers, molecular diagnosis, and molecular targeted treatments for asbestos-exposed lung cancer patients...
- Accumulation of genomic alterations in 2p16, 9q33.1 and 19p13 in lung tumours of asbestos-exposed patientsPenny Nymark
Health and Work Ability, Finnish Institute of Occupational Health, Topeliuksenkatu 41 aA, 00250 Helsinki, Finland
Mol Oncol 7:29-40. 2013..These alterations form the basis for the development of a combinatorial molecular assay that could be used to identify asbestos-related LC...
- Molecular alterations at 9q33.1 and polyploidy in asbestos-related lung cancerPenny Nymark
Health and Work Ability, Good Practices and Competence, and Work Environment Development, Finnish Institute of Occupational Health, Topeliuksenkatu 41 aA, 00250 Helsinki, Finland
Clin Cancer Res 15:468-75. 2009..In addition, the ploidy level of the tumors was studied...
- Gene expression profiles in asbestos-exposed epithelial and mesothelial lung cell linesPenny Nymark
Health and Work Ability, Biological Mechanisms and Prevention of Work related Diseases, Finnish Institute of Occupational Health, Helsinki, Finland
BMC Genomics 8:62. 2007..A canonical correlation analysis was applied to identify correlations between the cell lines, and a Gene Ontology analysis method for the identification of enriched, differentially expressed biological processes...
- In vitro and in vivo genotoxic effects of straight versus tangled multi-walled carbon nanotubesJulia Catalán
a Nanosafety Research Centre, Finnish Institute of Occupational Health, Helsinki, Finland
Nanotoxicology 10:794-806. 2016..Neither of the MWCNTs was able to induce micronuclei in vitro. Our findings suggest that both primary and secondary mechanisms may be involved in the genotoxicity of straight MWCNTs. ..
- Genotoxicity of polyvinylpyrrolidone-coated silver nanoparticles in BEAS 2B cellsPenny Nymark
Nanosafety Research Center and Safe New Technologies, Work Environment Development, Finnish Institute of Occupational Health, Helsinki, Finland
Toxicology 313:38-48. 2013....
- CDK4 is a probable target gene in a novel amplicon at 12q13.3-q14.1 in lung cancerHarriet Wikman
Department of Occupational Medicine, Finnish Institute of Occupational Health, Helsinki, Finland
Genes Chromosomes Cancer 42:193-9. 2005..Although CDK4 amplification seems to be a relatively rare event (4.3%) in lung tumors, it indicates the significance of the RB1-CCND1 pathway in lung tumorigenesis...
- Identification of specific gene copy number changes in asbestos-related lung cancerPenny Nymark
Department of Pathology, Haartman Institute, University of Helsinki and Helsinki University Central Hospital Diagnostics Laboratory, Helsinki University Central Hospital, Finland
Cancer Res 66:5737-43. 2006..08), which may imply preferentially caused DNA damage at these sites. Our findings are the first evidence, indicating that asbestos exposure may produce a specific DNA damage profile...