Affiliation: F. Hoffmann-La Roche Ltd
- Comparison of different cytotoxicity measures for the in vitro micronucleus test (MNVit) in L5178Y tk(+/-) cells: Summary of 4 compounds (Mitomycin C, Cyclophosphamide, Colchicine and Diethylstilboestrol) with clastogenic and aneugenic mode of actionStephan Kirchner
Non Clinical Safety, F Hoffmann La Roche Ltd, Basel, Switzerland
Mutat Res 702:193-8. 2010..Therefore, all measures of cytotoxicity in the absence of cytochalasin B proved to be equally acceptable to select the top-dose without missing micronucleation activity for any of the four compounds...
- Computational toxicology in drug developmentWolfgang Muster
F Hoffmann La Roche Ltd, Non Clinical Drug Safety, Basel CH 4070, Switzerland
Drug Discov Today 13:303-10. 2008....
- Identification of a kinase profile that predicts chromosome damage induced by small molecule kinase inhibitorsAndrew J Olaharski
Non Clinical Safety, Roche Palo Alto LLC, Palo Alto, California, United States of America
PLoS Comput Biol 5:e1000446. 2009..Equally important, by identifying a panel of kinases predictive of genotoxicity, we provide medicinal chemists a set of kinases to avoid when designing compounds, thereby providing a basis for rational drug design away from genotoxicity...