J A L Ives
Affiliation: F. Hoffmann-La Roche Ltd
- The H274Y mutation in the influenza A/H1N1 neuraminidase active site following oseltamivir phosphate treatment leave virus severely compromised both in vitro and in vivoJ A L Ives
Roche Products Ltd, 40 Broadwater Road, Welwyn Garden City, AL7 3AY, Hertfordshire, UK
Antiviral Res 55:307-17. 2002..Additionally, pathogenicity of the mutant virus is significantly compromised in ferret, compared to the corresponding wild type virus. Virus carrying a H274Y mutation is unlikely to be of clinical consequence in man...