Ilker Y Eyupoglu

Summary

Publications

  1. ncbi request reprint Suberoylanilide hydroxamic acid (SAHA) has potent anti-glioma properties in vitro, ex vivo and in vivo
    Ilker Y Eyupoglu
    Department of Neurosurgery, University of Erlangen, Germany
    J Neurochem 93:992-9. 2005
  2. ncbi request reprint Malignant glioma-induced neuronal cell death in an organotypic glioma invasion model. Technical note
    Ilker Y Eyupoglu
    Department of Neurosurgery, University of Erlangen Nuremberg Department of Neuropathology, University of Erlangen Nuremberg, Erlangen, Germany
    J Neurosurg 102:738-44. 2005
  3. ncbi request reprint Experimental therapy of malignant gliomas using the inhibitor of histone deacetylase MS-275
    Ilker Y Eyupoglu
    Department of Neurosurgery, University of Erlangen Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany
    Mol Cancer Ther 5:1248-55. 2006
  4. ncbi request reprint Ex vivo therapy of malignant melanomas transplanted into organotypic brain slice cultures using inhibitors of histone deacetylases
    Annett Hölsken
    Department of Neuropathology, University of Erlangen Nuremberg, Krankenhausstr 8 10, 91054, Erlangen, Germany
    Acta Neuropathol 112:205-15. 2006
  5. doi request reprint Dynamic contrast enhancement of experimental glioma an intra-individual comparative study to assess the optimal time delay
    Tobias Engelhorn
    Department of Neuroradiology, University of Erlangen Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany
    Acad Radiol 17:188-93. 2010
  6. ncbi request reprint The peroxisome proliferator-activated receptor-gamma agonist troglitazone inhibits transforming growth factor-beta-mediated glioma cell migration and brain invasion
    Roland Coras
    Department of NeuropathologyI, University of Erlangen, Erlangen, Germany, Germany
    Mol Cancer Ther 6:1745-54. 2007
  7. ncbi request reprint Abundant hypermethylation of SOCS-1 in clinically silent pituitary adenomas
    Rolf Buslei
    Department of Neuropathology, Friedrich Alexander University of Erlangen Nuremberg, Krankenhausstrasse 8 10, 91054, Erlangen, Germany
    Acta Neuropathol 111:264-71. 2006
  8. ncbi request reprint Histone deacetylase inhibitors increase neuronal differentiation in adult forebrain precursor cells
    Florian A Siebzehnrubl
    Department of Neuropathology, University of Erlangen Nuremberg, Krankenhausstr 8 10, 91054, Erlangen, Germany
    Exp Brain Res 176:672-8. 2007
  9. pmc Sulfasalazine impacts on ferroptotic cell death and alleviates the tumor microenvironment and glioma-induced brain edema
    Tina Sehm
    Translational Cell Biology and Neurooncology Laboratory, Department of Neurosurgery Schwabachanlage 6 Kopfklinik, Universitätsklinikum Erlangen UKER, Medical School of The Friedrich Alexander University of Erlangen Nürnberg FAU, 91054 Erlangen, Germany
    Oncotarget 7:36021-36033. 2016
  10. pmc PRG3 induces Ras-dependent oncogenic cooperation in gliomas
    Zheng Fan
    Translational Neurooncology Laboratory, Department of Neurosurgery, University Hospital Erlangen, Friedrich Alexander University of Erlangen Nürnberg FAU, Erlangen, Germany
    Oncotarget 7:26692-708. 2016

Collaborators

Detail Information

Publications35

  1. ncbi request reprint Suberoylanilide hydroxamic acid (SAHA) has potent anti-glioma properties in vitro, ex vivo and in vivo
    Ilker Y Eyupoglu
    Department of Neurosurgery, University of Erlangen, Germany
    J Neurochem 93:992-9. 2005
    ..These observations identify chromatin-modifying enzymes as possible and promising targets for the pharmacotherapy of malignant gliomas...
  2. ncbi request reprint Malignant glioma-induced neuronal cell death in an organotypic glioma invasion model. Technical note
    Ilker Y Eyupoglu
    Department of Neurosurgery, University of Erlangen Nuremberg Department of Neuropathology, University of Erlangen Nuremberg, Erlangen, Germany
    J Neurosurg 102:738-44. 2005
    ..This new model allows researchers to address in a systematic manner the molecular pathways of brain invasion as well as specific tumor-host interactions such as necrosis...
  3. ncbi request reprint Experimental therapy of malignant gliomas using the inhibitor of histone deacetylase MS-275
    Ilker Y Eyupoglu
    Department of Neurosurgery, University of Erlangen Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany
    Mol Cancer Ther 5:1248-55. 2006
    ..Furthermore, its propensity to pass the blood-brain barrier and to increase the protein level of acetylated histone H3 in brain tissue identifies MS-275 as a promising candidate drug in the treatment of malignant gliomas...
  4. ncbi request reprint Ex vivo therapy of malignant melanomas transplanted into organotypic brain slice cultures using inhibitors of histone deacetylases
    Annett Hölsken
    Department of Neuropathology, University of Erlangen Nuremberg, Krankenhausstr 8 10, 91054, Erlangen, Germany
    Acta Neuropathol 112:205-15. 2006
    ....
  5. doi request reprint Dynamic contrast enhancement of experimental glioma an intra-individual comparative study to assess the optimal time delay
    Tobias Engelhorn
    Department of Neuroradiology, University of Erlangen Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany
    Acad Radiol 17:188-93. 2010
    ....
  6. ncbi request reprint The peroxisome proliferator-activated receptor-gamma agonist troglitazone inhibits transforming growth factor-beta-mediated glioma cell migration and brain invasion
    Roland Coras
    Department of NeuropathologyI, University of Erlangen, Erlangen, Germany, Germany
    Mol Cancer Ther 6:1745-54. 2007
    ....
  7. ncbi request reprint Abundant hypermethylation of SOCS-1 in clinically silent pituitary adenomas
    Rolf Buslei
    Department of Neuropathology, Friedrich Alexander University of Erlangen Nuremberg, Krankenhausstrasse 8 10, 91054, Erlangen, Germany
    Acta Neuropathol 111:264-71. 2006
    ..The data is compatible with epigenetic silencing of the SOCS-1 gene and constitutive activation of the JAK-STAT pathway in PA. This appears to contribute particularly to those tumours characterized by a hormone-inactive status...
  8. ncbi request reprint Histone deacetylase inhibitors increase neuronal differentiation in adult forebrain precursor cells
    Florian A Siebzehnrubl
    Department of Neuropathology, University of Erlangen Nuremberg, Krankenhausstr 8 10, 91054, Erlangen, Germany
    Exp Brain Res 176:672-8. 2007
    ..Increased expression levels of NeuroD, Cyclin D2 and B-lymphocyte translocation gene 3 (Btg3) point to a shift towards neuronal fate determination targeted by HDAC inhibitors...
  9. pmc Sulfasalazine impacts on ferroptotic cell death and alleviates the tumor microenvironment and glioma-induced brain edema
    Tina Sehm
    Translational Cell Biology and Neurooncology Laboratory, Department of Neurosurgery Schwabachanlage 6 Kopfklinik, Universitätsklinikum Erlangen UKER, Medical School of The Friedrich Alexander University of Erlangen Nürnberg FAU, 91054 Erlangen, Germany
    Oncotarget 7:36021-36033. 2016
    ..Altogether, we show that SAS can be utilized for targeting the glutamate antiporter xCT activity as a tumor microenvironment-normalizing drug, while crucial cytotoxic effects in brain tumors are minor...
  10. pmc PRG3 induces Ras-dependent oncogenic cooperation in gliomas
    Zheng Fan
    Translational Neurooncology Laboratory, Department of Neurosurgery, University Hospital Erlangen, Friedrich Alexander University of Erlangen Nürnberg FAU, Erlangen, Germany
    Oncotarget 7:26692-708. 2016
    ..Thus, our data show that the interference with PRG3 homeostasis amplifies oncogenic properties and foster the malignancy potential in gliomas. ..
  11. pmc A versatile ex vivo technique for assaying tumor angiogenesis and microglia in the brain
    Ali Ghoochani
    Laboratory for Translational Neurooncology, Department of Neurosurgery, Universitatsklinikum Erlangen, Friedrich Alexander University of Erlangen Nürnberg FAU, 91054 Erlangen, Germany
    Oncotarget 7:1838-53. 2016
    ....
  12. doi request reprint Cellular characterization of the peritumoral edema zone in malignant brain tumors
    Tobias Engelhorn
    Department of Neuroradiology, University of Erlangen Nuremberg, Erlangen, Germany
    Cancer Sci 100:1856-62. 2009
    ..These data corroborate that perifocal edema identified in T2-weighted MR scans are characterized with alterations in glial cell distribution and marker expression forming an inflammatory tumor microenvironment...
  13. pmc Hidden association of Cowden syndrome, PTEN mutation and meningioma frequency
    Eduard Yakubov
    Translational Neurooncology Laboratory, Department of Neurosurgery, Universitatsklinikum Erlangen, Friedrich Alexander University FAU Erlangen Nürnberg, Erlangen, Germany Department of Neurosurgery, Klinikum Nürnberg, Paracelsus Medical University, Nurnberg, Germany
    Oncoscience 3:149-55. 2016
    ..We propose to include meningiomas and brain tumors in the major criteria spectrum of CS-related disorders. This could warrant early diagnosis of brain lesions and close therapy, as well as better monitoring of patients with CS. ..
  14. pmc Plasticity Related Gene 3 (PRG3) overcomes myelin-associated growth inhibition and promotes functional recovery after spinal cord injury
    Thomas Broggini
    Department of Neurosurgery, Charite Universitatsmedizin Berlin, D 10115 Berlin, Germany
    Aging (Albany NY) 8:2463-2487. 2016
    ..Here, we provide evidence that PRG3 operates as an essential neuronal growth promoter in the nervous system. Maintaining PRG3 expression in aging brain may turn back the developmental clock for neuronal regeneration and plasticity...
  15. pmc Supra-complete surgery via dual intraoperative visualization approach (DiVA) prolongs patient survival in glioblastoma
    Ilker Y Eyupoglu
    Department of Neurosurgery, Translational Neurooncology Division, Medical Faculty of the Friedrich Alexander University of Erlangen Nürnberg FAU, Erlangen, Germany
    Oncotarget 7:25755-68. 2016
    ..This extension of overall survival did not come at the cost of neurological deterioration. We show for the first time that supra-complete glioma surgery leads to significant prolongation of overall survival time in GBM patients. ..
  16. doi request reprint Is Hypothermia Helpful in Severe Subarachnoid Hemorrhage? An Exploratory Study on Macro Vascular Spasm, Delayed Cerebral Infarction and Functional Outcome after Prolonged Hypothermia
    Joji B Kuramatsu
    Department of Neurology, University of Erlangen Nuremberg, Erlangen, Germany
    Cerebrovasc Dis 40:228-35. 2015
    ..A novel approach of early and prolonged TH and its influence on key complications in poor-grade SAH, vasospasm and delayed cerebral ischemia (DCI) was evaluated...
  17. pmc Improving the extent of malignant glioma resection by dual intraoperative visualization approach
    Ilker Y Eyupoglu
    Department of Neurosurgery, University of Erlangen Nuremberg, Germany
    PLoS ONE 7:e44885. 2012
    ..The extent of resection could be increased from 57.1% to 71.2% without incurring postoperative neurological deficits...
  18. doi request reprint Clinical evaluation of flat-panel detector compared with multislice computed tomography in 65 patients with acute intracranial hemorrhage: initial results. Clinical article
    Tobias Struffert
    Department of Neuroradiology, University of Erlangen Nuremberg, Erlangen, Germany
    J Neurosurg 113:901-7. 2010
    ....
  19. pmc Sunitinib impedes brain tumor progression and reduces tumor-induced neurodegeneration in the microenvironment
    Gökçe Hatipoglu
    Department of Neurosurgery, Universitatsklinikum Erlangen, Friedrich Alexander University Erlangen Nürnberg FAU, Erlangen, Germany
    Cancer Sci 106:160-70. 2015
    ..Thus, this report uncovered sunitinib's actions on the brain tumor microenvironment, revealing novel aspects for adjuvant approaches and new clinical assessment criteria when applied to brain tumor patients. ..
  20. doi request reprint Surgical resection of malignant gliomas-role in optimizing patient outcome
    Ilker Y Eyupoglu
    Department of Neurosurgery, University of Erlangen Nuremberg, Schwabachanlage 6, D 91054 Erlangen, Germany
    Nat Rev Neurol 9:141-51. 2013
    ..We highlight key surgical factors that enable optimization of adjuvant treatment to enhance patient quality of life and improve life expectancy...
  21. doi request reprint xCT modulation in gliomas: relevance to energy metabolism and tumor microenvironment normalization
    Nic E Savaskan
    Institute of Cell Biology and Neurobiology, Center for Anatomy, CCM2, Charite Medical School Berlin, D 10117 Berlin, Germany
    Ann Anat 192:309-13. 2010
    ....
  22. doi request reprint High resolution neurochemical gold staining method for myelin in peripheral and central nervous system at the light- and electron-microscopic level
    Nic E Savaskan
    Brain Research Institute, Swiss Federal Institute of Technology and University Zurich, Switzerland
    Cell Tissue Res 337:213-21. 2009
    ....
  23. pmc Cabazitaxel operates anti-metastatic and cytotoxic via apoptosis induction and stalls brain tumor angiogenesis
    Ali Ghoochani
    Translational Cell Biology and Neurooncology Laboratory, Department of Neurosurgery, Universitatsklinikum Erlangen, Medical School of The Friedrich Alexander University FAU of Erlangen Nürnberg, Erlangen, Germany
    Oncotarget 7:38306-38318. 2016
    ..Thus, our report uncovered cabazitaxel actions on gliomas and on the brain tumor microenvironment. These data reveal novel aspects for adjuvant approaches when applied to brain tumor patients...
  24. pmc Neurodegeneration and the Brain Tumor Microenvironment. [corrected]
    Nicolai E Savaskan
    Department of Neurosurgery, Universitatsklinikum Erlangen, Friedrich Alexander University of Erlangen Nürnberg FAU, Schwabachanlage 6, D 91054 Erlangen, Germany
    Curr Neuropharmacol 13:258-65. 2015
    ..Deciphering the impact of xCT and glutamate and its relation to TRP channels in brain tumors pave the way for developing important cancer microenvironmental modulators and drugable lead targets. ..
  25. doi request reprint Intraventricular fibrinolysis has no effects on shunt dependency and functional outcome in endovascular-treated aneurysmal SAH
    Stefan T Gerner
    Department of Neurology, University of Erlangen Nuremberg, Schwabachanlage 6, 91054, Erlangen, Germany
    Neurocrit Care 21:435-43. 2014
    ..Because of clinical heterogeneity of investigated patient effects of IVF on permanent shunt incidence and functional outcome are widely debated. The present study is the first to investigate solely endovascular-treated SAH patients...
  26. doi request reprint In vivo micro-CT imaging of rat brain glioma: a comparison with 3T MRI and histology
    Tobias Engelhorn
    Department of Neuroradiology, University of Erlangen Nuremberg, Schwabachanlage 6, D 91054 Erlangen, Germany
    Neurosci Lett 458:28-31. 2009
    ..14). In conclusion, micro-CT allows in vivo imaging of the contrast-enhancing part of experimental gliomas with an accuracy comparable to high-field MRI...
  27. ncbi request reprint Combined Laser-Doppler Flowmetry and Spectrophotometry: Feasibility Study of a Novel Device for Monitoring Local Cortical Microcirculation during Aneurysm Surgery
    Björn Sommer
    Department of Neurosurgery, University Hospital Erlangen, Erlangen, Germany
    J Neurol Surg A Cent Eur Neurosurg . 2016
    ..Our data indicate that this device is able to detect changes during routine neurosurgical maneuvers. Thus it may be useful for early detection of cerebral microcirculatory disturbances...
  28. pmc Identification of two novel Chlorotoxin derivatives CA4 and CTX-23 with chemotherapeutic and anti-angiogenic potential
    Tengfei Xu
    Translational Neurooncology Lab, Department of Neurosurgery, Universitatsklinikum Erlangen, Friedrich Alexander University FAU of Erlangen Nurnberg, D 91054 Erlangen, Germany
    Sci Rep 6:19799. 2016
    ..These data report on the identification of two novel CTX derivatives with multiple anti-glioma properties including anti-angiogenesis. ..
  29. doi request reprint Selenium action in neuro-oncology
    Eduard Yakubov
    Department of Neurosurgery, Universitatsklinikum Erlangen, FAU Friedrich Alexander Universität Erlangen Nürnberg, Schwabachanlage 6, 91054, Erlangen, Germany
    Biol Trace Elem Res 161:246-54. 2014
    ..Current selenium trials and selenium supplementation with focus on neuro-oncology will be discussed with regard to low-adequate-to-high/toxic selenium status. ..
  30. pmc Dexamethasone alleviates tumor-associated brain damage and angiogenesis
    Zheng Fan
    Department of Neurosurgery, University Hospital of Erlangen, Friedrich Alexander University of Erlangen Nuremberg, Erlangen, Bavaria, Germany
    PLoS ONE 9:e93264. 2014
    ..Thus, our investigations reveal that DEXA acts pleiotropically and impacts tumor growth, tumor vasculature and tumor-associated brain damage. ..
  31. pmc Brain miffed by macrophage migration inhibitory factor
    Nic E Savaskan
    Department of Neurosurgery, University of Erlangen Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany
    Int J Cell Biol 2012:139573. 2012
    ..We consider the possibility of MIF targeting in neurodegenerative processes and brain tumors by novel MIF-neutralizing approaches...
  32. ncbi request reprint Common mutations of beta-catenin in adamantinomatous craniopharyngiomas but not in other tumours originating from the sellar region
    Rolf Buslei
    Department of Neuropathology, Friedrich Alexander University Erlangen Nuremberg, Krankenhausstrasse 8 10, 91054, Erlangen, Germany
    Acta Neuropathol 109:589-97. 2005
    ..We conclude that beta-catenin mutations and/or nuclear accumulation serve as diagnostic hallmarks of the adamantinomatous variant, setting it apart from the papillary variant of craniopharyngioma...
  33. doi request reprint Early postoperative tumor progression predicts clinical outcome in glioblastoma-implication for clinical trials
    Andreas Merkel
    Department of Neurosurgery, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
    J Neurooncol . 2017
    ..Early tumor progression at the start of radiotherapy is associated with a worse prognosis for glioblastoma patients. A standardized baseline MRI might allow for better patient stratification...
  34. doi request reprint Comparison of the Ramirez technique for the closure of large open myelomeningocele defects with alternative methods
    Ulrich Kneser
    Department of Hand, Plastic and Reconstructive Surgery, Burn Center, BG Trauma Center Ludwigshafen, Ludwig Guttmann Strasse 13, 67071 Ludwigshafen, Germany Department of Hand and Plastic Surgery, University of Heidelberg, Heidelberg, Germany Department of Plastic and Hand Surgery, Friedrich Alexander University Erlangen Nuremberg, Krankenhausstrasse 12, 91054 Erlangen, Germany
    J Plast Reconstr Aesthet Surg 68:1675-82. 2015
    ..We hypothesized that the immediate surgical treatment with the Ramirez technique is superior to prior used operative techniques...
  35. pmc Epigenetics in Brain Tumors: HDACs Take Center Stage
    Ilker Y Eyupoglu
    Department of Neurosurgery, Universitatsklinikum Erlangen, University of Erlangen Nurnberg, Schwabachanlage 6, 91054 Erlangen, Germany
    Curr Neuropharmacol 14:48-54. 2016
    ..Here, the possibility of pharmacological intervention on tumor-associated genes by epigenetic priming opens a novel path in combating primary brain tumors. ..