Mark A Espeland

Summary

Publications

  1. ncbi request reprint Effects of Physical Activity Intervention on Physical and Cognitive Function in Sedentary Adults With and Without Diabetes
    Mark A Espeland
    Wake Forest School of Medicine
    J Gerontol A Biol Sci Med Sci . 2016
  2. ncbi request reprint Long-term Effects on Cognitive Trajectories of Postmenopausal Hormone Therapy in Two Age Groups
    Mark A Espeland
    Department of Biostatistical Sciences
    J Gerontol A Biol Sci Med Sci . 2016
  3. pmc Brain and White Matter Hyperintensity Volumes After 10 Years of Random Assignment to Lifestyle Intervention
    Mark A Espeland
    Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston Salem, NC
    Diabetes Care 39:764-71. 2016
  4. pmc Associations Between Ankle-Brachial Index and Cognitive Function: Results From the Lifestyle Interventions and Independence for Elders Trial
    Mark A Espeland
    Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston Salem, NC Electronic address
    J Am Med Dir Assoc 16:682-9. 2015
  5. pmc Postmenopausal hormone therapy, type 2 diabetes mellitus, and brain volumes
    Mark A Espeland
    From the Departments of Biostatistical Sciences M A E, R C, Internal Medicine C H, S C, and Social Sciences and Health Policy L V, Wake Forest School of Medicine, Winston Salem, NC Departments of Pharmacology and Pharmaceutical Sciences, Biomedical Engineering, and Neurology R D B, University of Southern California, Los Angeles, CA Division of Preventive Medicine J E M, Brigham and Women s Hospital, Harvard Medical School, Boston, MA Departments of Epidemiology and Biostatistics, Psychiatry, and Neurology K Y, University of California, San Francisco Department of Internal Medicine B J E, The University of Texas MD Anderson Cancer Center, Houston, TX Department of Geriatric Medicine K M, University of Hawaii at Manoa, Honolulu, HI and Laboratory of Behavioral Neuroscience S M R, Intramural Research Program, National Institute on Aging, NIH, Baltimore, MD
    Neurology 85:1131-8. 2015
  6. pmc Impact of Type 2 Diabetes and Postmenopausal Hormone Therapy on Incidence of Cognitive Impairment in Older Women
    Mark A Espeland
    Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston Salem, NC
    Diabetes Care 38:2316-24. 2015
  7. pmc Systolic Blood Pressure Control Among Individuals With Type 2 Diabetes: A Comparative Effectiveness Analysis of Three Interventions
    Mark A Espeland
    Wake Forest School of Medicine, Winston Salem, North Carolina, USA
    Am J Hypertens 28:995-1009. 2015
  8. pmc Demographic and health factors associated with enrollment in posttrial studies: the Women's Health Initiative Hormone Therapy Trials
    Mark A Espeland
    Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston Salem, NC 27157, USA
    Clin Trials 10:463-72. 2013
  9. pmc Long-term impact of behavioral weight loss intervention on cognitive function
    Mark A Espeland
    Department of Biostatistical Sciences and
    J Gerontol A Biol Sci Med Sci 69:1101-8. 2014
  10. pmc Impact of an intensive lifestyle intervention on use and cost of medical services among overweight and obese adults with type 2 diabetes: the action for health in diabetes
    Mark A Espeland
    Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston Salem, NC
    Diabetes Care 37:2548-56. 2014

Detail Information

Publications81

  1. ncbi request reprint Effects of Physical Activity Intervention on Physical and Cognitive Function in Sedentary Adults With and Without Diabetes
    Mark A Espeland
    Wake Forest School of Medicine
    J Gerontol A Biol Sci Med Sci . 2016
    ..Type 2 diabetes mellitus may alter the effect of physical activity on physical and cognitive function...
  2. ncbi request reprint Long-term Effects on Cognitive Trajectories of Postmenopausal Hormone Therapy in Two Age Groups
    Mark A Espeland
    Department of Biostatistical Sciences
    J Gerontol A Biol Sci Med Sci . 2016
    ..Postmenopausal hormone therapy may have long-term effects on cognitive function depending on women's age...
  3. pmc Brain and White Matter Hyperintensity Volumes After 10 Years of Random Assignment to Lifestyle Intervention
    Mark A Espeland
    Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston Salem, NC
    Diabetes Care 39:764-71. 2016
    ..We assessed whether participation in a successful 10-year lifestyle intervention was associated with better profiles of brain structure...
  4. pmc Associations Between Ankle-Brachial Index and Cognitive Function: Results From the Lifestyle Interventions and Independence for Elders Trial
    Mark A Espeland
    Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston Salem, NC Electronic address
    J Am Med Dir Assoc 16:682-9. 2015
    ..The objective of this study was to evaluate cross-sectional and longitudinal associations between ankle-brachial index (ABI) and indicators of cognitive function...
  5. pmc Postmenopausal hormone therapy, type 2 diabetes mellitus, and brain volumes
    Mark A Espeland
    From the Departments of Biostatistical Sciences M A E, R C, Internal Medicine C H, S C, and Social Sciences and Health Policy L V, Wake Forest School of Medicine, Winston Salem, NC Departments of Pharmacology and Pharmaceutical Sciences, Biomedical Engineering, and Neurology R D B, University of Southern California, Los Angeles, CA Division of Preventive Medicine J E M, Brigham and Women s Hospital, Harvard Medical School, Boston, MA Departments of Epidemiology and Biostatistics, Psychiatry, and Neurology K Y, University of California, San Francisco Department of Internal Medicine B J E, The University of Texas MD Anderson Cancer Center, Houston, TX Department of Geriatric Medicine K M, University of Hawaii at Manoa, Honolulu, HI and Laboratory of Behavioral Neuroscience S M R, Intramural Research Program, National Institute on Aging, NIH, Baltimore, MD
    Neurology 85:1131-8. 2015
    ..To examine whether the effect of postmenopausal hormone therapy (HT) on brain volumes in women aged 65-79 years differs depending on type 2 diabetes status during postintervention follow-up of a randomized controlled clinical trial...
  6. pmc Impact of Type 2 Diabetes and Postmenopausal Hormone Therapy on Incidence of Cognitive Impairment in Older Women
    Mark A Espeland
    Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston Salem, NC
    Diabetes Care 38:2316-24. 2015
    ..We examined whether the effect of postmenopausal hormone therapy (HT) on cognitive impairment incidence differs depending on type 2 diabetes...
  7. pmc Systolic Blood Pressure Control Among Individuals With Type 2 Diabetes: A Comparative Effectiveness Analysis of Three Interventions
    Mark A Espeland
    Wake Forest School of Medicine, Winston Salem, North Carolina, USA
    Am J Hypertens 28:995-1009. 2015
    ....
  8. pmc Demographic and health factors associated with enrollment in posttrial studies: the Women's Health Initiative Hormone Therapy Trials
    Mark A Espeland
    Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston Salem, NC 27157, USA
    Clin Trials 10:463-72. 2013
    ..Factors influencing participants' decisions to consent to additional follow-up and how these shape posttrial cohorts have not been broadly studied...
  9. pmc Long-term impact of behavioral weight loss intervention on cognitive function
    Mark A Espeland
    Department of Biostatistical Sciences and
    J Gerontol A Biol Sci Med Sci 69:1101-8. 2014
    ..It is unknown whether intentional weight loss provides long-term benefits for cognitive function...
  10. pmc Impact of an intensive lifestyle intervention on use and cost of medical services among overweight and obese adults with type 2 diabetes: the action for health in diabetes
    Mark A Espeland
    Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston Salem, NC
    Diabetes Care 37:2548-56. 2014
    ..To assess the relative impact of an intensive lifestyle intervention (ILI) on use and costs of health care within the Look AHEAD trial...
  11. pmc Do weight loss and adherence cluster within behavioral treatment groups?
    Rena R Wing
    The Miriam Hospital Alpert Medical School, Providence, Rhode Island, 02903, USA
    Obesity (Silver Spring) 22:638-44. 2014
    ..g., size or homogeneity) affect outcomes. We examined these questions within Look AHEAD, a multicenter study of the effects of an intensive lifestyle intervention (ILI) in overweight/obese individuals with type 2 diabetes...
  12. pmc Influence of type 2 diabetes on brain volumes and changes in brain volumes: results from the Women's Health Initiative Magnetic Resonance Imaging studies
    Mark A Espeland
    Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston Salem, NC, USA
    Diabetes Care 36:90-7. 2013
    ..To study how type 2 diabetes adversely affects brain volumes, changes in volume, and cognitive function...
  13. pmc Muscle strength and BMI as predictors of major mobility disability in the Lifestyle Interventions and Independence for Elders pilot (LIFE-P)
    Anthony P Marsh
    Department of Health and Exercise Science, Wake Forest University, Winston Salem, NC 27109 7868, USA
    J Gerontol A Biol Sci Med Sci 66:1376-83. 2011
    ..To date, there are no studies that have examined the association of strength and body mass index (BMI) on event rates on a widely used performance measure of major mobility disability...
  14. pmc Long-term effects of conjugated equine estrogen therapies on domain-specific cognitive function: results from the Women's Health Initiative study of cognitive aging extension
    Mark A Espeland
    Division of Public Health Sciences, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
    J Am Geriatr Soc 58:1263-71. 2010
    ..To determine whether small decrements in global cognitive function that conjugated equine estrogen (CEE) therapies have been shown to produce in older women persist after cessation and extend to specific cognitive domains...
  15. pmc Patterns of weight change associated with long-term weight change and cardiovascular disease risk factors in the Look AHEAD Study
    Rebecca H Neiberg
    Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston Salem, North Carolina, USA
    Obesity (Silver Spring) 20:2048-56. 2012
    ..001). While relationships with year 4 weight loss were stronger, the pattern of larger monthly weight loss during year 1 was also independently predictive of year 4 levels of HbA1c, HDL-cholesterol, and systolic blood pressure...
  16. pmc Designing clinical trials for assessing the effects of cognitive training and physical activity interventions on cognitive outcomes: the Seniors Health and Activity Research Program Pilot (SHARP-P) study, a randomized controlled trial
    Claudine Legault
    Division of Public Health Sciences, Department of Biostatistical Sciences Wachovia 21st floor, Medical Center Boulevard, Winston Salem, North Carolina 27157, USA
    BMC Geriatr 11:27. 2011
    ..Before definitive trials are mounted, important design questions on participation/adherence, training and interventions effects must be answered to more fully inform a full-scale trial...
  17. pmc A uniform approach to modeling risk factor relationships for ischemic lesion prevalence and extent: the Women's Health Initiative Magnetic Resonance Imaging study
    Janet A Tooze
    Department of Biostatistical Sciences, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
    Neuroepidemiology 34:55-62. 2010
    ..Typically these associations have been explored separately, but an integrated modeling approach would allow the separate relationships to be consistently described and contrasted...
  18. pmc Brain volumes, cognitive impairment, and conjugated equine estrogens
    Mark A Espeland
    Department of Biostatistical Sciences, Wake Forest University Health Sciences, Medical Center Boulevard, Winston Salem, NC 27157, USA
    J Gerontol A Biol Sci Med Sci 64:1243-50. 2009
    ....
  19. pmc Application of machine learning methods to describe the effects of conjugated equine estrogens therapy on region-specific brain volumes
    Ramon Casanova
    Department of Biostatistical Sciences, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Magn Reson Imaging 29:546-53. 2011
    ..6 years is associated with lower regional brain volumes, but it does not induce a characteristic spatial pattern of changes in brain volumes of sufficient magnitude to discriminate users and nonusers...
  20. pmc Effects of conjugated equine estrogens on cognition and affect in postmenopausal women with prior hysterectomy
    Susan M Resnick
    Laboratory of Personality and Cognition, National Institute on Aging, Biomedical Research Center, Baltimore, Maryland 21224 6825, USA
    J Clin Endocrinol Metab 94:4152-61. 2009
    ..We previously reported that conjugated equine estrogens (CEE) with medroxyprogesterone acetate had a negative impact on verbal memory but tended to impact figural memory positively over time in older postmenopausal women...
  21. pmc Intensive lifestyle intervention improves physical function among obese adults with knee pain: findings from the Look AHEAD trial
    Capri G Foy
    Division of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Obesity (Silver Spring) 19:83-93. 2011
    ..The ILI condition also resulted in significant weight loss and improved fitness, which are possible mechanisms through which the ILI condition improved physical function...
  22. pmc Weight change and cognitive function: findings from the Women's Health Initiative Study of Cognitive Aging
    Ira Driscoll
    Laboratory of Personality and Cognition, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA
    Obesity (Silver Spring) 19:1595-600. 2011
    ..Relationships were largely independent of initial BMI, self-reported caloric intake or dieting. The lack of associations between weight gain and cognition in women is consistent with the existing literature...
  23. pmc Educational attainment, MRI changes, and cognitive function in older postmenopausal women from the Women's Health Initiative Memory Study
    Stephen R Rapp
    Department of Psychiatry and Behavioral Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Int J Psychiatry Med 46:121-43. 2013
    ..001). Thus, higher educational attainment was associated with a delay in diagnosis of dementia/MCI in the face of a growing neuropathological load...
  24. pmc Change in brain and lesion volumes after CEE therapies: the WHIMS-MRI studies
    Laura H Coker
    From the Division of Public Health Sciences L H C, M A E, P E H, S A S, and Departments of Internal Medicine and Geriatrics J D W and Neurology C D B, Wake Forest School of Medicine, Winston Salem, NC Intramural Research Program S M R, National Institute on Aging, NIH, Baltimore, MD Department of Radiology R N B, C D, University of Pennsylvania, Philadelphia Department of Internal Medicine and Epidemiology J G R, University of Iowa, Iowa City Department of Psychiatry and Behavioral Medicine J S G, Medical College of Wisconsin, Milwaukee and Department of Epidemiology L H K, University of Pittsburgh, PA
    Neurology 82:427-34. 2014
    ..1 to 7.7 years later in WHIMS-MRI2...
  25. ncbi request reprint Effects of combination estrogen plus progestin hormone treatment on cognition and affect
    Susan M Resnick
    National Institute on Aging, Baltimore, Maryland 21224 6825, USA
    J Clin Endocrinol Metab 91:1802-10. 2006
    ..Some studies of hormone treatment in postmenopausal women suggest benefits on specific cognitive functions, particularly memory...
  26. pmc Constructing common cohorts from trials with overlapping eligibility criteria: implications for comparing effect sizes between trials
    David L Mount
    Wake Forest University School of Medicine, Winston Salem, NC, USA
    Clin Trials 6:416-29. 2009
    ..Comparing findings from separate trials is necessary to choose among treatment options, however differences among study cohorts may impede these comparisons...
  27. pmc Global cognitive function before, surrounding, and after ischemic stroke: the role of risk and protective factors varies with time among ischemic stroke survivors
    Leslie Vaughan
    a Department of Social Sciences and Health Policy, Wake Forest School of Medicine, Winston Salem, NC, 27157, USA
    Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 23:117-31. 2016
    ..01). Baseline factors may play either a risk or a protective role in global cognitive function depending on the phase of ischemic stroke. ..
  28. pmc Postmenopausal hormone therapy and cognitive outcomes: the Women's Health Initiative Memory Study (WHIMS)
    Laura H Coker
    Department of Social Sciences and Health Policy, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    J Steroid Biochem Mol Biol 118:304-10. 2010
    ..05); frontal lobe (P=0.004); and total brain (P=0.07). HT-associated reductions in hippocampal volumes were greatest in women with baseline 3MS scores < or = 90...
  29. ncbi request reprint Association between alcohol intake and domain-specific cognitive function in older women
    Mark A Espeland
    Department of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Neuroepidemiology 27:1-12. 2006
    ..However, our observational study cannot rule out confounding associations with unmeasured factors...
  30. pmc Higher RBC EPA + DHA corresponds with larger total brain and hippocampal volumes: WHIMS-MRI study
    James V Pottala
    From the Department of Internal Medicine J V P, W S H, Sanford School of Medicine, University of South Dakota, Sioux Falls Health Diagnostic Laboratory Inc J V P, W S H, Richmond, VA Department of Psychiatry K Y, University of California Medical Center, San Francisco Departments of Epidemiology and Internal Medicine J R, R W, University of Iowa College of Public Health, Iowa City Department of Biostatistical Services M A E, Wake Forest School of Medicine, Winston Salem, NC and OmegaQuant Analytics W S H, Sioux Falls, SD
    Neurology 82:435-42. 2014
    ..To test whether red blood cell (RBC) levels of marine omega-3 fatty acids measured in the Women's Health Initiative Memory Study were related to MRI brain volumes measured 8 years later...
  31. pmc Validation of a cognitive assessment battery administered over the telephone
    Stephen R Rapp
    Department of Psychiatry and Behavioral Medicine, School of Medicine, Wake Forest University, Winston Salem, North Carolina 27157, USA
    J Am Geriatr Soc 60:1616-23. 2012
    ..To evaluate the validity and reliability of a cognitive test battery and questionnaires administered by telephone...
  32. pmc Telephone interview for cognitive status (TICS) screening for clinical trials of physical activity and cognitive training: the seniors health and activity research program pilot (SHARP-P) study
    Mark A Espeland
    Division of Public Health Sciences, Wake Forest University Health Sciences, Winston Salem, NC, USA
    Int J Geriatr Psychiatry 26:135-43. 2011
    ..To examine the performance of the Telephone Interview for Cognitive Status (TICS) for identifying participants appropriate for trials of physical activity and cognitive training interventions...
  33. pmc Performance of a computer-based assessment of cognitive function measures in two cohorts of seniors
    Mark A Espeland
    Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston Salem, NC, USA
    Int J Geriatr Psychiatry 28:1239-50. 2013
    ..Computer-administered assessment of cognitive function is being increasingly incorporated in clinical trials; however, its performance in these settings has not been systematically evaluated...
  34. pmc Enrollment in a brain magnetic resonance study: results from the Women's Health Initiative Memory Study Magnetic Resonance Imaging Study (WHIMS-MRI)
    Sarah A Jaramillo
    Division of Public Health Sciences, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Acad Radiol 14:603-12. 2007
    ..We use data from a large MRI study to identify factors associated with differential enrollment and to examine potential biases this may produce in study results...
  35. pmc The rationale, design, and baseline characteristics of the Women's Health Initiative Memory Study of Younger Women (WHIMS-Y)
    Leslie Vaughan
    Division of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Brain Res 1514:3-11. 2013
    ..Integrated into the WHI, WHIMS-Y optimized the experience of WHI investigators to ensure high retention and excellent quality assurance across sites. This article is part of a Special Issue entitled Hormone Therapy...
  36. pmc The Lifestyle Interventions and Independence for Elders Study: design and methods
    Roger A Fielding
    Nutrition, Exercise Physiology, and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    J Gerontol A Biol Sci Med Sci 66:1226-37. 2011
    ..A Phase 3 randomized controlled trial is needed to fill this evidence gap...
  37. ncbi request reprint Association between reported alcohol intake and cognition: results from the Women's Health Initiative Memory Study
    Mark A Espeland
    Department of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Am J Epidemiol 161:228-38. 2005
    ..Moderate levels of alcohol intake may be associated with better cognition and reduced risk of significant cognitive decline; however, confounding associations with unmeasured factors cannot be ruled out...
  38. pmc Cognitive function and fine motor speed in older women with diabetes mellitus: results from the women's health initiative study of cognitive aging
    Mark A Espeland
    Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston Salem, North Carolina 27157, USA
    J Womens Health (Larchmt) 20:1435-43. 2011
    ..We sought to determine if type 2 diabetes mellitus (T2DM) was associated with accelerated decline in domain-specific measures of cognitive function and fine motor speed...
  39. pmc Relative effects of tamoxifen, raloxifene, and conjugated equine estrogens on cognition
    Mark A Espeland
    Division of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Womens Health (Larchmt) 19:371-9. 2010
    ..To compare the relative effects of conjugated equine estrogens (CEE), raloxifene, and tamoxifen therapies on cognition among women aged > or =65 years...
  40. pmc Measurement characteristics of the ankle-brachial index: results from the Action for Health in Diabetes study
    Mark A Espeland
    Department of Biostatistical Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Vasc Med 13:225-33. 2008
    ..Replicating SBP measurements reduces the error and bias of ABI. Averaging leg-specific values may increase power for characterizing cardiovascular disease risk...
  41. ncbi request reprint Racial disparity in pregnancy-related mortality following a live birth outcome
    Margaret A Harper
    Department of Obstetrics and Gynecology M A H, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Ann Epidemiol 14:274-9. 2004
    ..We conducted this study to determine if differences in a combination of socioeconomic and medical risk factors may explain this racial disparity in pregnancy-related death...
  42. pmc Intensive weight loss intervention in older individuals: results from the Action for Health in Diabetes Type 2 diabetes mellitus trial
    Mark A Espeland
    Department of Biostatistical Sciences, School of Medicine, Wake Forest University, Winston Salem, North Carolina 27157, USA
    J Am Geriatr Soc 61:912-22. 2013
    ..To compare the effects of 4 years of intensive lifestyle intervention on weight, fitness, and cardiovascular disease risk factors in older and younger individuals...
  43. ncbi request reprint Conjugated equine estrogens and global cognitive function in postmenopausal women: Women's Health Initiative Memory Study
    Mark A Espeland
    Department of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    JAMA 291:2959-68. 2004
    ..The effect of estrogen-alone therapy, also evaluated in WHIMS, on cognition has not been established for this population...
  44. pmc Healthy Living Partnerships to Prevent Diabetes (HELP PD): design and methods
    Jeffrey A Katula
    Department of Health and Exercise Science, Wake Forest University, PO Box 7868, Winston Salem, NC 27109, USA
    Contemp Clin Trials 31:71-81. 2010
    ....
  45. pmc Ascertaining dementia-related outcomes for deceased or proxy-dependent participants: an overview of the Women's Health Initiative Memory Study supplemental case ascertainment protocol
    Sarah A Gaussoin
    Division of Public Health Science, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Int J Geriatr Psychiatry 27:205-14. 2012
    ..The aim of the study was to compare a two-staged clinic-based standardized protocol with a supplemental proxy-based protocol...
  46. pmc Action for Health in Diabetes (Look AHEAD) trial: baseline evaluation of selected nutrients and food group intake
    Mara Z Vitolins
    Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27104, USA
    J Am Diet Assoc 109:1367-75. 2009
    ..Little has been reported regarding food and nutrient intake in individuals diagnosed with type 2 diabetes, and most reports have been based on findings in select groups or individuals who self-reported having diabetes...
  47. ncbi request reprint Coronary artery calcium outperforms carotid artery intima-media thickness as a noninvasive index of prevalent coronary artery stenosis
    James G Terry
    Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Arterioscler Thromb Vasc Biol 25:1723-8. 2005
    ..We compared CAC to IMT for noninvasive detection of prevalent CAD in participants whose coronary status was identified by coronary angiography...
  48. pmc The effect of intentional weight loss on all-cause mortality in older adults: results of a randomized controlled weight-loss trial
    M Kyla Shea
    Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Am J Clin Nutr 94:839-46. 2011
    ....
  49. pmc Sleep duration, cognitive decline, and dementia risk in older women
    Jiu Chiuan Chen
    Department of Preventive Medicine, University of Southern California, Keck School of Medicine, Los Angeles, CA, USA Electronic address
    Alzheimers Dement 12:21-33. 2016
    ..Consistent evidence linking habitual sleep duration with risks of mild cognitive impairment (MCI) and dementia is lacking...
  50. pmc Four-year analysis of cardiovascular disease risk factors, depression symptoms, and antidepressant medicine use in the Look AHEAD (Action for Health in Diabetes) clinical trial of weight loss in diabetes
    Richard R Rubin
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Diabetes Care 36:1088-94. 2013
    ..To study the association of depressive symptoms or antidepressant medicine (ADM) use with subsequent cardiovascular disease (CVD) risk factor status in the Look AHEAD (Action for Health in Diabetes) trial of weight loss in type 2 diabetes...
  51. ncbi request reprint The Women's Health Initiative Study of Cognitive Aging (WHISCA): a randomized clinical trial of the effects of hormone therapy on age-associated cognitive decline
    Susan M Resnick
    Laboratory of Personality and Cognition, National Institute on Aging, Baltimore, Maryland 21224 6825, USA
    Clin Trials 1:440-50. 2004
    ....
  52. ncbi request reprint Site-specific progression of carotid artery intimal-medial thickness
    Mark A Espeland
    Department of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Atherosclerosis 171:137-43. 2003
    ..To characterize the intercorrelation of changes in intimal-medial thickness (IMT) among carotid artery sites and examine the influence of diabetes and sex on these correlations...
  53. pmc Designing clinical trials of interventions for mobility disability: results from the lifestyle interventions and independence for elders pilot (LIFE-P) trial
    Mark A Espeland
    Department of Biostatistical Sciences, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    J Gerontol A Biol Sci Med Sci 62:1237-43. 2007
    ..Clinical trials to assess interventions for mobility disability are critically needed; however, data for efficiently designing such trials are lacking...
  54. pmc Classification of structural MRI images in Alzheimer's disease from the perspective of ill-posed problems
    Ramon Casanova
    Department of Biostatistical Sciences, Wake Forest School of Medicine, North Carolina, United States of America
    PLoS ONE 7:e44877. 2012
    ..In addition, to avoid the effects of the "curse of dimensionality" very often dimension reduction is applied to the data...
  55. pmc Impact of the look AHEAD intervention on NT-pro brain natriuretic peptide in overweight and obese adults with diabetes
    Alain G Bertoni
    Department of Epidemiology and Prevention, Wake Forest School of Medicine, Winston Salem, NC, USA
    Obesity (Silver Spring) 20:1511-8. 2012
    ..In conclusion, among overweight and obese persons with diabetes, an ILI that reduced weight was associated with an increased NT-proBNP...
  56. pmc The relationship between cognitive function and physical performance in older women: results from the women's health initiative memory study
    Hal H Atkinson
    Wake Forest University School of Medicine, Sticht Center on Aging, Roena Kulynych Center for Memory and Cognition Research, and Department of Internal Medicine Gerontology and Geriatric Medicine, Winston Salem, North Carolina 27157, USA
    J Gerontol A Biol Sci Med Sci 65:300-6. 2010
    ..Cognitive function and physical performance are associated, but the common sequence of cognitive and physical decline remains unclear...
  57. pmc A Voxel-Based Morphometry Study Reveals Local Brain Structural Alterations Associated with Ambient Fine Particles in Older Women
    Ramon Casanova
    Department of Biostatistical Sciences, Wake Forest School of Medicine Winston Salem, NC, USA
    Front Hum Neurosci 10:495. 2016
    ..5, this is the first neuroimaging study reporting associations between air pollution exposure and smaller volumes of cortical GM. Our data support the hypothesized synaptic neurotoxicity of airborne particles...
  58. pmc Abnormalities in Diffusional Kurtosis Metrics Related to Head Impact Exposure in a Season of High School Varsity Football
    Elizabeth M Davenport
    1 Advanced Neuroscience Imaging Research ANSIR Laboratory, Wake Forest School of Medicine, Winston Salem, North Carolina
    J Neurotrauma 33:2133-2146. 2016
    ..In summary, we demonstrate a single season of high school football can produce DKI measurable changes in the absence of clinically diagnosed concussion...
  59. pmc Impact of weight loss on ankle-brachial index and interartery blood pressures
    Mark A Espeland
    Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston Salem, North Carolina, USA
    Obesity (Silver Spring) 22:1032-41. 2014
    ..To assess whether weight loss improves markers of peripheral artery disease and vascular stenosis...
  60. pmc ω-3 fatty acids and domain-specific cognitive aging: secondary analyses of data from WHISCA
    Eric M Ammann
    From the Department of Epidemiology E M A, R W, R M C, J G R, College of Public Health, and Departments of Internal Medicine R W, J G R and Neurology N L D, College of Medicine, University of Iowa, Iowa City OmegaQuant Analytics J V P, W S H, Sioux Falls Department of Medicine W S H, Sanford School of Medicine, University of South Dakota, Vermillion and Department of Biostatistical Sciences M A E, Wake Forest School of Medicine, Winston Salem, NC
    Neurology 81:1484-91. 2013
    ..To test the hypothesis that higher levels of red blood cell (RBC) docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) have a protective association with domain-specific cognitive function in women aged 65 years and older...
  61. pmc Liver fat and SHBG affect insulin resistance in midlife women: the Study of Women's Health Across the Nation (SWAN)
    Kylie Kavanagh
    Department of Pathology, Wake Forest School of Medicine, North Carolina, Winston Salem, USA
    Obesity (Silver Spring) 21:1031-8. 2013
    ..Our objective was to explore whether lower SHBG was associated with ectopic liver fat and mediated its effect on insulin resistance in The Study of Women's Health Across the Nation (SWAN)...
  62. pmc Alzheimer's disease risk assessment using large-scale machine learning methods
    Ramon Casanova
    Wake Forest School of Medicine, Winston Salem, North Carolina, United States of America
    PLoS ONE 8:e77949. 2013
    ....
  63. pmc The LIFE Cognition Study: design and baseline characteristics
    Kaycee M Sink
    Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Sticht Center on Aging, Wake Forest School of Medicine, Winston Salem, NC, USA
    Clin Interv Aging 9:1425-36. 2014
    ..In addition to its importance in the area of prevention of cognitive decline, the LIFE Study will also likely serve as a model for exercise and other behavioral intervention trials in older adults...
  64. doi request reprint The Evolution of the WHI 80+ Cohort
    Daniel P Beavers
    Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston Salem, North Carolina
    J Gerontol A Biol Sci Med Sci 71:S13-22. 2016
    ..However, there has not been any previous effort to characterize the 80+ cohort and to identify associated retention factors...
  65. ncbi request reprint Effect of estrogen plus progestin on global cognitive function in postmenopausal women: the Women's Health Initiative Memory Study: a randomized controlled trial
    Stephen R Rapp
    Department of Psychiatry and Behavioral Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    JAMA 289:2663-72. 2003
    ..On July 8, 2002, the estrogen plus progestin therapy in the WHI trial was discontinued because of certain increased health risks for women...
  66. ncbi request reprint Serial audiometry in a clinical trial of AIED treatment
    John K Niparko
    Department of Otolaryngology, Head and Neck Surgery, The Johns Hopkins University, Baltimore, MD, USA
    Otol Neurotol 26:908-17. 2005
    ..We sought to characterize the pattern and size of the treatment effect as reflected in clinical audiometry and to identify audiometric predictors of response to steroid treatment of AIED...
  67. pmc Relationships between selected gene polymorphisms and blood pressure sensitivity to weight loss in elderly persons with hypertension
    William J Kostis
    Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Hypertension 61:857-63. 2013
    ..Polymorphisms related to hypertension, obesity, and diabetes mellitus are associated with weight sensitivity of BP...
  68. pmc Factors influencing enrollment of African Americans in the Look AHEAD trial
    David L Mount
    Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Clin Trials 9:80-9. 2012
    ..We used the experience from the Look AHEAD (Action for Health in Diabetes) trial screening process to examine the differential impact eligibility criteria had on the enrollment of African Americans compared to other volunteers...
  69. pmc Differential effects of estradiol on carotid artery inflammation when administered early versus late after surgical menopause
    Areepan Sophonsritsuk
    Section on Comparative Medicine, Department of Pathology, Wake Forest School of Medicine, Winston Salem, NC 27157 1040, USA
    Menopause 20:540-7. 2013
    ..The aim of this study was to determine the effects of estrogen therapy (ET) on carotid artery inflammation when initiated early and late relative to surgical menopause...
  70. ncbi request reprint Racial differences in endothelial function in postmenopausal women
    Laura R Loehr
    Department of Internal Medicine, Sections on Section on Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Am Heart J 148:606-11. 2004
    ..To further study differences in endothelial function between African American and Caucasian women, we analyzed measures of brachial artery flow-mediated dilation (FMD) in women enrolled in the Cardiovascular Health Study (CHS)...
  71. pmc Describing patterns of weight changes using principal components analysis: results from the Action for Health in Diabetes (Look AHEAD) research group
    Mark A Espeland
    Department of Biostatistical Sciences, Wake Forest University School of Medicine and Winston Salem, NC 27157, USA
    Ann Epidemiol 19:701-10. 2009
    ..To demonstrate how principal components analysis can be used to describe patterns of weight changes in response to an intensive lifestyle intervention...
  72. pmc High dimensional classification of structural MRI Alzheimer's disease data based on large scale regularization
    Ramon Casanova
    Department of Biostatistical Sciences, Wake Forest School of Medicine Winston Salem, NC, USA
    Front Neuroinform 5:22. 2011
    ..Although we have demonstrated the efficacy of this voxel-wise classification method in discriminating cognitive normal subjects from AD patients, in principle it could be applied to any clinical population...
  73. pmc Concurrent and longitudinal relationships between cognitive activity, cognitive performance, and brain volume in older adult women
    Leslie Vaughan
    Department of Social Sciences and Health Policy, Wake Forest School of Medicine, Winston Salem, North Carolina
    J Gerontol B Psychol Sci Soc Sci 69:826-36. 2014
    ....
  74. pmc Timing of estrogen replacement influences atherosclerosis progression and plaque leukocyte populations in ApoE-/- mice
    Jennifer A Cann
    Department of Pathology, Comparative Medicine Clinical Research Center, Wake Forest University Health Sciences, Winston Salem, NC 27157, United States
    Atherosclerosis 201:43-52. 2008
    ..These results suggest that a period of estrogen deficiency followed by reintroduction alters the immunologic environment of atherosclerotic lesions as well as plaque progression...
  75. pmc Cognitive factors associated with adherence to oral antiestrogen therapy: results from the cognition in the study of tamoxifen and raloxifene (Co-STAR) study
    Heidi D Klepin
    Section on Hematology and Oncology, Wake Forest Baptist Health, Medical Center Blvd, Winston Salem, NC 27157
    Cancer Prev Res (Phila) 7:161-8. 2014
    ..08-1.51)]. Among nondemented older women, subtle differences in memory performance were associated with medication adherence. Differential performance across cognitive domains may help identify persons at greater risk for poor adherence...
  76. pmc Abnormal white matter integrity related to head impact exposure in a season of high school varsity football
    Elizabeth M Davenport
    1 Advanced Neuroscience Imaging Research ANSIR Laboratory, Wake Forest School of Medicine, Winston Salem, North Carolina
    J Neurotrauma 31:1617-24. 2014
    ..We demonstrate that a single season of football can produce brain MRI changes in the absence of clinical concussion. Similar brain MRI changes have been previously associated with mild traumatic brain injury...
  77. pmc The association of pericardial fat with incident coronary heart disease: the Multi-Ethnic Study of Atherosclerosis (MESA)
    Jingzhong Ding
    Sticht Center on Aging, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Am J Clin Nutr 90:499-504. 2009
    ..Cross-sectional studies suggest that pericardial fat is positively associated with coronary artery disease independent of total body fat...
  78. ncbi request reprint Benchmarks for designing two-stage studies using modified mini-mental state examinations: experience from the Women's Health Initiative Memory Study
    Mark A Espeland
    Department of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Clin Trials 3:99-106. 2006
    ..The modified mini-mental state examination (3MS) is commonly used as this initial screen in such two-stage designs, however its properties for this role require further study...
  79. pmc Recruitment of young adults into a randomized controlled trial of weight gain prevention: message development, methods, and cost
    Deborah F Tate
    The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Trials 15:326. 2014
    ..Few studies have recruited for prevention of weight gain, particularly in young adults. This paper describes the recruitment protocol used in the Study of Novel Approaches to Prevention (SNAP)...
  80. pmc Using network science to evaluate exercise-associated brain changes in older adults
    Jonathan H Burdette
    Department of Radiology, Laboratory for Complex Brain Networks, Wake Forest University Health Sciences Winston Salem, NC, USA
    Front Aging Neurosci 2:23. 2010
    ..We show a link between neurological network features and CBF, and it is possible that this alteration of functional brain networks may lead to the known improvement in cognitive function among older adults following exercise...
  81. ncbi request reprint Pregnancy-related death and health care services
    Margaret A Harper
    Department of Obstetrics and Gynecology, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Obstet Gynecol 102:273-8. 2003
    ..To examine the association between health care services variables and pregnancy-related death using a contemporary geographically defined population and enhanced methods for case identification...