Benedikt Engels

Summary

Publications

  1. ncbi request reprint Helical tomotherapy with simultaneous integrated boost for high-risk and lymph node-positive prostate cancer: early report on acute and late toxicity
    Benedikt Engels
    Department of Radiation Oncology Oncologisch Centrum UZ Brussel Laarbeeklaan 101, B 1090 Brussels Belgium
    Technol Cancer Res Treat 8:353-59. 2009
  2. pmc A randomized hypofractionation dose escalation trial for high risk prostate cancer patients: interim analysis of acute toxicity and quality of life in 124 patients
    Darius Norkus
    Department of Radiotherapy, Institute of Oncology, Vilnius University, Vilnius, Lithuania
    Radiat Oncol 8:206. 2013
  3. doi request reprint Impact of planning target volume margins and rectal distention on biochemical failure in image-guided radiotherapy of prostate cancer
    Benedikt Engels
    Department of Radiotherapy, UZ Brussel, Vrije Universiteit Brussel, Belgium Electronic address
    Radiother Oncol 111:106-9. 2014
  4. doi request reprint Preoperative intensity-modulated and image-guided radiotherapy with a simultaneous integrated boost in locally advanced rectal cancer: report on late toxicity and outcome
    Benedikt Engels
    Department of Radiotherapy, UZ Brussel, Vrije Universiteit Brussel, Belgium Electronic address
    Radiother Oncol 110:155-9. 2014
  5. pmc Phase II study of helical tomotherapy in the multidisciplinary treatment of oligometastatic colorectal cancer
    Benedikt Engels
    Department of Radiation Oncology, UZ Brussel, Vrije Universiteit Brussel, Laarbeeklaan 101, B 1090 Brussels, Belgium
    Radiat Oncol 7:34. 2012
  6. doi request reprint Phase II study of preoperative helical tomotherapy with a simultaneous integrated boost for rectal cancer
    Benedikt Engels
    Department of Radiotherapy, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium
    Int J Radiat Oncol Biol Phys 83:142-8. 2012
  7. doi request reprint Prospective, risk-adapted strategy of stereotactic body radiotherapy for early-stage non-small-cell lung cancer: results of a Phase II trial
    Samuel Bral
    Department of Radiotherapy, University Hospital Brussels, Brussels, Belgium
    Int J Radiat Oncol Biol Phys 80:1343-9. 2011
  8. doi request reprint Toxicity and outcome results of a class solution with moderately hypofractionated radiotherapy in inoperable Stage III non-small cell lung cancer using helical tomotherapy
    Samuel Bral
    Department of Radiation Oncology, Oncology Center, Universitair Ziekenhuis Brussel UZB, Brussels, Belgium
    Int J Radiat Oncol Biol Phys 77:1352-9. 2010
  9. pmc Evaluation of a dedicated brain metastases treatment planning optimization for radiosurgery: a new treatment paradigm?
    Thierry Gevaert
    Department of Radiotherapy, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium
    Radiat Oncol 11:13. 2016
  10. doi request reprint Daily megavoltage computed tomography in lung cancer radiotherapy: correlation between volumetric changes and local outcome
    Samuel Bral
    Department of Radiation Oncology, Oncology Center, Universitair Ziekenhuis Brussel, Brussels, Belgium
    Int J Radiat Oncol Biol Phys 80:1338-42. 2011

Collaborators

Detail Information

Publications39

  1. ncbi request reprint Helical tomotherapy with simultaneous integrated boost for high-risk and lymph node-positive prostate cancer: early report on acute and late toxicity
    Benedikt Engels
    Department of Radiation Oncology Oncologisch Centrum UZ Brussel Laarbeeklaan 101, B 1090 Brussels Belgium
    Technol Cancer Res Treat 8:353-59. 2009
    ..In conclusion, WPRT with a SIB to the prostate and seminal vesicles by helical tomotherapy resulted in a favourable toxicity profile. Pelvic nodal dose escalation in node-positive patients is feasible without increasing toxicity...
  2. pmc A randomized hypofractionation dose escalation trial for high risk prostate cancer patients: interim analysis of acute toxicity and quality of life in 124 patients
    Darius Norkus
    Department of Radiotherapy, Institute of Oncology, Vilnius University, Vilnius, Lithuania
    Radiat Oncol 8:206. 2013
    ..Here, we report on acute toxicity and quality of life (QOL) for the first 124 randomized patients...
  3. doi request reprint Impact of planning target volume margins and rectal distention on biochemical failure in image-guided radiotherapy of prostate cancer
    Benedikt Engels
    Department of Radiotherapy, UZ Brussel, Vrije Universiteit Brussel, Belgium Electronic address
    Radiother Oncol 111:106-9. 2014
    ..Here, we investigated the impact of appropriate PTV margins and rectal distention on FFBF...
  4. doi request reprint Preoperative intensity-modulated and image-guided radiotherapy with a simultaneous integrated boost in locally advanced rectal cancer: report on late toxicity and outcome
    Benedikt Engels
    Department of Radiotherapy, UZ Brussel, Vrije Universiteit Brussel, Belgium Electronic address
    Radiother Oncol 110:155-9. 2014
    ..Here, we report outcome and late toxicity after a median follow-up of 54 months...
  5. pmc Phase II study of helical tomotherapy in the multidisciplinary treatment of oligometastatic colorectal cancer
    Benedikt Engels
    Department of Radiation Oncology, UZ Brussel, Vrije Universiteit Brussel, Laarbeeklaan 101, B 1090 Brussels, Belgium
    Radiat Oncol 7:34. 2012
    ..For inoperable patients, we evaluated in this study intensity-modulated and image-guided radiotherapy (IMRT-IGRT) by helical tomotherapy...
  6. doi request reprint Phase II study of preoperative helical tomotherapy with a simultaneous integrated boost for rectal cancer
    Benedikt Engels
    Department of Radiotherapy, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium
    Int J Radiat Oncol Biol Phys 83:142-8. 2012
    ..In addition, it is associated with considerable toxicity. As an alternative strategy, we explored prospectively, preoperative helical tomotherapy with a simultaneous integrated boost (SIB)...
  7. doi request reprint Prospective, risk-adapted strategy of stereotactic body radiotherapy for early-stage non-small-cell lung cancer: results of a Phase II trial
    Samuel Bral
    Department of Radiotherapy, University Hospital Brussels, Brussels, Belgium
    Int J Radiat Oncol Biol Phys 80:1343-9. 2011
    ..Validation of a prospective, risk-adapted strategy for early-stage non-small-cell lung cancer (NSCLC) patients treated with stereotactic body radiotherapy (SBRT)...
  8. doi request reprint Toxicity and outcome results of a class solution with moderately hypofractionated radiotherapy in inoperable Stage III non-small cell lung cancer using helical tomotherapy
    Samuel Bral
    Department of Radiation Oncology, Oncology Center, Universitair Ziekenhuis Brussel UZB, Brussels, Belgium
    Int J Radiat Oncol Biol Phys 77:1352-9. 2010
    ..To prospectively assess the feasibility, toxicity, and local control of a class solution protocol of moderately hypofractionated tomotherapy in Stage III, inoperable, locally advanced non-small-cell lung cancer patients...
  9. pmc Evaluation of a dedicated brain metastases treatment planning optimization for radiosurgery: a new treatment paradigm?
    Thierry Gevaert
    Department of Radiotherapy, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium
    Radiat Oncol 11:13. 2016
    ....
  10. doi request reprint Daily megavoltage computed tomography in lung cancer radiotherapy: correlation between volumetric changes and local outcome
    Samuel Bral
    Department of Radiation Oncology, Oncology Center, Universitair Ziekenhuis Brussel, Brussels, Belgium
    Int J Radiat Oncol Biol Phys 80:1338-42. 2011
    ..To assess the predictive or comparative value of volumetric changes, measured on daily megavoltage computed tomography during radiotherapy for lung cancer...
  11. doi request reprint Volumetric imaging by megavoltage computed tomography for assessment of internal organ motion during radiotherapy for cervical cancer
    Christine Collen
    Department of Radiotherapy, Oncology Centre University Hospital Brussels UZ Brussel, Brussels, Belgium
    Int J Radiat Oncol Biol Phys 77:1590-5. 2010
    ..To assess the internal organ motion of the cervix and uterus by megavoltage computed tomography (MVCT) during intensity-modulated radiotherapy (IMRT)...
  12. doi request reprint Clinical evaluation of a robotic 6-degree of freedom treatment couch for frameless radiosurgery
    Thierry Gevaert
    Department of Radiotherapy, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium
    Int J Radiat Oncol Biol Phys 83:467-74. 2012
    ....
  13. doi request reprint Quality Assurance of a 50-kV Radiotherapy Unit Using EBT3 GafChromic Film: A Feasibility Study
    Femke Steenbeke
    Department of Radiotherapy, UZ Brussel, Vrije Universiteit Brussel, Brussels, Belgium
    Technol Cancer Res Treat 15:163-70. 2016
    ..The aim of this study was to validate EBT3 film as a dosimeter for machine and treatment quality assurance (QA) of a 50-kV radiotherapy unit...
  14. doi request reprint Motion management during SBRT for oligometastatic cancer: Results of a prospective phase II trial
    Robbe Van den Begin
    Department of Radiotherapy, UZ Brussel, Vrije Universiteit Brussel, Belgium
    Radiother Oncol 119:519-24. 2016
    ..To optimize the local control of stereotactic body radiotherapy (SBRT) using the Vero-SBRT system and respiratory motion management in patients with oligometastatic cancer...
  15. doi request reprint Feasibility of markerless tumor tracking by sequential dual-energy fluoroscopy on a clinical tumor tracking system
    Jennifer Dhont
    Department of Radiotherapy, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Belgium Electronic address
    Radiother Oncol 117:487-90. 2015
    ..The implementation of this approach on a clinical tumor tracking system and its efficacy is shown feasible through optimization of the imaging parameters. ..
  16. doi request reprint Setup accuracy of the Novalis ExacTrac 6DOF system for frameless radiosurgery
    Thierry Gevaert
    Department of Radiotherapy, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium
    Int J Radiat Oncol Biol Phys 82:1627-35. 2012
    ..This study was designed to measure the detection and positioning accuracy of the ExacTrac/Novalis Body (ET/NB) for rotations and to compare the accuracy of the frameless with the frame-based radiosurgery technique...
  17. doi request reprint Prediction of response to neoadjuvant radiotherapy in patients with locally advanced rectal cancer by means of sequential 18FDG-PET
    Hendrik Everaert
    Department of Nuclear Medicine, UZ Brussel, Vrije Universiteit Brussel, Brussels, Belgium
    Int J Radiat Oncol Biol Phys 80:91-6. 2011
    ....
  18. pmc Implementation of HybridArc treatment technique in preoperative radiotherapy of rectal cancer: dose patterns in target lesions and organs at risk as compared to helical Tomotherapy and RapidArc
    Thierry Gevaert
    Department of Radiotherapy, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium
    Radiat Oncol 7:120. 2012
    ..This study compared this new technique to helical Tomotherapy, and RapidArc, in preoperative radiotherapy of rectal cancer...
  19. doi request reprint Preoperative helical tomotherapy and megavoltage computed tomography for rectal cancer: impact on the irradiated volume of small bowel
    Benedikt Engels
    Department of Radiation Oncology, Oncologisch Centrum UZ Brussel, Brussels, Belgium
    Int J Radiat Oncol Biol Phys 74:1476-80. 2009
    ..The aim of this study was to explore to what extent helical tomotherapy and daily megavolt (MV) CT imaging may reduce the irradiated volume of small bowel...
  20. doi request reprint Treating patients with real-time tumor tracking using the Vero gimbaled linac system: implementation and first review
    Tom Depuydt
    Radiotherapy Department, UZ Brussel, Vrije Universiteit Brussel, Brussels Vrije Universiteit Brussel, Medical Imaging and Physical Sciences Group, Faculty of Medicine and Pharmacy Department of Radiation Oncology, University Hospitals Leuven, Leuven, Belgium Electronic address
    Radiother Oncol 112:343-51. 2014
    ..To report on the first clinical application of a real-time tumor tracking (RTTT) solution based on the Vero SBRT gimbaled linac system for treatment of moving tumors...
  21. doi request reprint Dosimetric comparison of different treatment modalities for stereotactic radiosurgery of arteriovenous malformations and acoustic neuromas
    Thierry Gevaert
    Department of Radiotherapy, Universitair Ziekenhuis Brussel, Brussel, Belgium
    Radiother Oncol 106:192-7. 2013
    ....
  22. doi request reprint Toxicity report of a phase 1/2 dose-escalation study in patients with inoperable, locally advanced nonsmall cell lung cancer with helical tomotherapy and concurrent chemotherapy
    Samuel Bral
    Department of Radiation Oncology, Oncology Center, Brussels University Hospital, Brussels, Belgium
    Cancer 116:241-50. 2010
    ....
  23. doi request reprint Analysis of the targeting uncertainty of a stereotactic frameless radiosurgery technique for arteriovenous malformation
    Femke Steenbeke
    Department of Radiotherapy, UZ Brussel, Vrije Universiteit Brussel, Belgium
    Radiother Oncol 113:371-3. 2014
    ..This frameless approach assures accurate target localization and can be used in a clinical setting. ..
  24. doi request reprint Impact of inadequate respiratory motion management in SBRT for oligometastatic colorectal cancer
    Robbe Van den Begin
    Department of Radiotherapy, Universitair Ziekenhuis Brussel UZ Brussel, Vrije Universiteit Brussel VUB, Belgium
    Radiother Oncol 113:235-9. 2014
    ..Stereotactic body radiotherapy (SBRT) in oligometastatic colorectal cancer (CRC) resulted in a disappointing 1-year local control rate of 54% in our experience. We aimed to determine the root cause(s)...
  25. doi request reprint Assessment of rectal distention in radiotherapy of prostate cancer using daily megavoltage CT image guidance
    Benedikt Engels
    Department of Radiotherapy, Oncology Centre University Hospital Brussels, Belgium
    Radiother Oncol 90:377-81. 2009
    ..Assessment of rectal distention in a group of patients who are not receiving daily rectum emptying procedures during a course of prostate cancer radiotherapy to investigate which patients could benefit from daily rectum emptying...
  26. doi request reprint A complementary dual-modality verification for tumor tracking on a gimbaled linac system
    Kenneth Poels
    Department of Radiotherapy, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Belgium Electronic address
    Radiother Oncol 109:469-74. 2013
    ..A dual-modality verification system, consisting of an on-board orthogonal kV and planar MV imaging device, was validated and applied retrospectively to patient data...
  27. doi request reprint Initial assessment of tumor tracking with a gimbaled linac system in clinical circumstances: a patient simulation study
    Tom Depuydt
    Radiotherapy Department, Vrije Universiteit Brussel, Brussel, Belgium
    Radiother Oncol 106:236-40. 2013
    ..To have an initial assessment of the Vero Dynamic Tracking workflow in clinical circumstances and quantify the performance of the tracking system, a simulation study was set up on 5 lung and liver patients...
  28. ncbi request reprint Phase II study of helical tomotherapy in the multidisciplinary treatment of oligometastatic colorectal cancer
    Benedikt Engels
    UZ Brussel, Vrije Universiteit Brussel, Brussels, Belgium
    J Clin Oncol 30:653. 2012
    ..Aiming at higher response rates, we evaluated in this study helical tomotherapy delivering 50 Gy in daily fractions of 5 Gy...
  29. doi request reprint Improving the intra-fraction update efficiency of a correlation model used for internal motion estimation during real-time tumor tracking for SBRT patients: fast update or no update?
    Kenneth Poels
    Department Radiotherapy, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Belgium Electronic address
    Radiother Oncol 112:352-9. 2014
    ..In this study, the accuracy of the internal tumor position estimation for both the clinical available update at discrete points in time (rebuild) and an in-house developed non-clinical online update approach was investigated...
  30. doi request reprint Conformal arc radiotherapy for prostate cancer: increased biochemical failure in patients with distended rectum on the planning computed tomogram despite image guidance by implanted markers
    Benedikt Engels
    Department of Radiotherapy, University Hospital Brussels, Belgium
    Int J Radiat Oncol Biol Phys 74:388-91. 2009
    ..To evaluate the effect of rectal distention on the planning computed tomogram on freedom from biochemical failure (FFBF) of prostate cancer patients treated with image-guided conformal arc radiotherapy...
  31. doi request reprint Evaluation of the clinical usefulness for using verification images during frameless radiosurgery
    Thierry Gevaert
    Department of Radiotherapy, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Belgium
    Radiother Oncol 108:114-7. 2013
    ..With proper immobilization and verification images on a regular basis during treatment, mechanical (table-) inaccuracies and intrafraction motion can be corrected for and the absence of PTV-margins warranted...
  32. doi request reprint Assessment of intrafractional movement and internal motion in radiotherapy of rectal cancer using megavoltage computed tomography
    Koen Tournel
    UZ Brussel, Oncologisch Centrum, Department of Radiotherapy, Brussels, Belgium
    Int J Radiat Oncol Biol Phys 71:934-9. 2008
    ..In clinical protocols, however, margins originating from traditional setup procedures are still being applied. This work investigates whether this modality can aid in redefining treatment margins...
  33. doi request reprint Myeloid-derived suppressor cells reveal radioprotective properties through arginase-induced l-arginine depletion
    Wim Leonard
    Department of Radiotherapy, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium
    Radiother Oncol 119:291-9. 2016
    ..This study therefore examines whether Arg(+) overexpressing MDSC may confer radioresistance through depleting the substrate for NO synthesis...
  34. doi request reprint A multi-centre analysis of treatment procedures and error components in dynamic tumour tracking radiotherapy
    Yukinori Matsuo
    Radiotherapy Department, UZ Brussel, Vrije Universiteit Brussel, Belgium Department of Radiation Oncology and Image applied Therapy, Kyoto University, Japan Electronic address
    Radiother Oncol 115:412-8. 2015
    ....
  35. pmc Advances in radiotherapy and targeted therapies for rectal cancer
    Alexandra Sermeus
    Alexandra Sermeus, UZ Brussel, Vrije Universiteit Brussel, Department of Gastroenterology, B 1090 Brussels, Belgium
    World J Gastroenterol 20:1-5. 2014
    ..Therefore, integration of genetic and immune biomarkers is the next logical step towards effective targeted therapies in the context of personalized cancer treatment. ..
  36. doi request reprint Advances in radiotherapy delivery for rectal cancer: a European perspective
    Alexandra Sermeus
    Department of Gastroenterology, UZ Brussel, Vrije Universiteit Brussel, Laarbeeklaan 101, B 1090 Brussel, Belgium
    Expert Rev Gastroenterol Hepatol 9:393-7. 2015
    ..Tumor hypoxia limits the success of radiotherapy for locally advanced cancers. Modulation of the L-arginine/iNOS pathway and implementation of hypoxia imaging in radiotherapy planning may overcome this hurdle. ..
  37. pmc Current status of intensified neo-adjuvant systemic therapy in locally advanced rectal cancer
    Benedikt Engels
    Department of Radiotherapy, UZ Brussel, Vrije Universiteit Brussel Brussels, Belgium
    Front Oncol 2:47. 2012
    ....
  38. ncbi request reprint Phase II study of preoperative helical tomotherapy for rectal cancer
    Mark de Ridder
    Department of Radiation Oncology, Oncologisch Centrum UZ Brussel, Brussels, Belgium
    Int J Radiat Oncol Biol Phys 70:728-34. 2008
    ..To explore the efficacy and toxicity profile of helical tomotherapy in the preoperative treatment of patients with rectal cancer...
  39. doi request reprint Hypoxic tumor cell radiosensitization: role of the iNOS/NO pathway
    Mark de Ridder
    Oncologisch Centrum UZ Brussel, Department of Radiation Oncology, Laarbeeklaan 101, B 1090 Brussels, Belgium
    Bull Cancer 95:282-91. 2008
    ..Second, tumor associated macrophages can produce high levels of NO that may radiosensitize bystander tumor cells. Our ongoing research is focused on combining immunostimulatory and radiosensitizing strategies...