Naglaa El-Lakkany

Summary

Publications

  1. doi request reprint Haemin enhances the in vivo efficacy of artemether against juvenile and adult Schistosoma mansoni in mice
    Naglaa Mohamed El-Lakkany
    Department of Pharmacology, Theodor Bilharz Research Institute, Warrak el Hadar, Imbaba, PO Box 30, Giza, 12411, Egypt
    Parasitol Res 112:2005-15. 2013
  2. doi request reprint Bioavailability and in vivo efficacy of a praziquantel-polyvinylpyrrolidone solid dispersion in Schistosoma mansoni-infected mice
    Naglaa El-Lakkany
    Pharmacology Department, Theodor Bilharz Research Institute, Warrak el Hadar, Imbaba, P O Box 30, Giza 12411, Egypt
    Eur J Drug Metab Pharmacokinet 37:289-99. 2012
  3. pmc Anti-inflammatory/anti-fibrotic effects of the hepatoprotective silymarin and the schistosomicide praziquantel against Schistosoma mansoni-induced liver fibrosis
    Naglaa M El-Lakkany
    Department of Pharmacology, Theodor Bilharz Research Institute, Warrak el Hadar, Imbaba, P, O Box 30, Giza 12411, Egypt
    Parasit Vectors 5:9. 2012
  4. doi request reprint The use of pentoxifylline as adjuvant therapy with praziquantel downregulates profibrogenic cytokines, collagen deposition and oxidative stress in experimental schistosomiasis mansoni
    Naglaa El-Lakkany
    Pharmacology Department, Theodor Bilharz Research Institute, Warrak el Hadar, Imbaba, P O Box 30, Giza 12411, Egypt
    Exp Parasitol 129:152-7. 2011
  5. doi request reprint Potential antifibrotic effects of AT1 receptor antagonist, losartan, and/or praziquantel on acute and chronic experimental liver fibrosis induced by Schistosoma mansoni
    Naglaa M El-Lakkany
    Department of Pharmacology, Theodor Bilharz Research Institute, Warrak el Hadar, Imbaba, Giza, Egypt
    Clin Exp Pharmacol Physiol 38:695-704. 2011
  6. ncbi request reprint Pharmacodynamics of pentoxifylline and/or praziquantel in murine schistosomiasis mansoni
    Naglaa El-Lakkany
    Department of Pharmacology, Theodor Bilharz Research Institute, Guiza, Egypt
    APMIS 115:184-94. 2007
  7. ncbi request reprint Effect of artemether alone and in combination with grapefruit juice on hepatic drug-metabolising enzymes and biochemical aspects in experimental Schistosoma mansoni
    N M El-Lakkany
    Department of Pharmacology, Theodor Bilharz Research Institute, P O Box 30, Imbaba, Giza 12411, Egypt
    Int J Parasitol 34:1405-12. 2004
  8. ncbi request reprint Pharmacodynamics of mefloquine and praziquantel combination therapy in mice harbouring juvenile and adult Schistosoma mansoni
    Naglaa Mohamed El-Lakkany
    Department of Pharmacology, Theodor Bilharz Research Institute, Warak El Hadar, Imbaba PO Box 30, Giza 12411, Egypt
    Mem Inst Oswaldo Cruz 106:814-22. 2011
  9. doi request reprint Comparative efficacy and bioavailability of different praziquantel brands
    Sanaa Botros
    Pharmacology Department, Theodor Bilharz Research Institute, Warak El Hadar, Imbaba, PO Box 30, Giza 12411, Egypt
    Exp Parasitol 127:515-21. 2011
  10. ncbi request reprint Altered immunoglobulin isotype profile and anti-immature worm surface immunoglobulins in mice harboring a praziquantel-resistant Schistosoma mansoni isolate
    Soad Hanallah
    Department of Immunology, Theodor Bilharz Research Institute, Guiza, Egypt
    APMIS 111:1125-32. 2003

Collaborators

Detail Information

Publications10

  1. doi request reprint Haemin enhances the in vivo efficacy of artemether against juvenile and adult Schistosoma mansoni in mice
    Naglaa Mohamed El-Lakkany
    Department of Pharmacology, Theodor Bilharz Research Institute, Warrak el Hadar, Imbaba, PO Box 30, Giza, 12411, Egypt
    Parasitol Res 112:2005-15. 2013
    ..This gives new insights into the importance of haemin in the antischistosomal properties of artemether...
  2. doi request reprint Bioavailability and in vivo efficacy of a praziquantel-polyvinylpyrrolidone solid dispersion in Schistosoma mansoni-infected mice
    Naglaa El-Lakkany
    Pharmacology Department, Theodor Bilharz Research Institute, Warrak el Hadar, Imbaba, P O Box 30, Giza 12411, Egypt
    Eur J Drug Metab Pharmacokinet 37:289-99. 2012
    ..Solid dispersion of PZQ with PVP could lead to a further improvement in the effectiveness of PZQ therapy especially with the appearance of some PZQ-tolerant S. mansoni isolates...
  3. pmc Anti-inflammatory/anti-fibrotic effects of the hepatoprotective silymarin and the schistosomicide praziquantel against Schistosoma mansoni-induced liver fibrosis
    Naglaa M El-Lakkany
    Department of Pharmacology, Theodor Bilharz Research Institute, Warrak el Hadar, Imbaba, P, O Box 30, Giza 12411, Egypt
    Parasit Vectors 5:9. 2012
    ..This study investigates the anti-inflammatory/anti-fibrotic effects of silymarin and/or PZQ on schistosomal hepatic fibrosis...
  4. doi request reprint The use of pentoxifylline as adjuvant therapy with praziquantel downregulates profibrogenic cytokines, collagen deposition and oxidative stress in experimental schistosomiasis mansoni
    Naglaa El-Lakkany
    Pharmacology Department, Theodor Bilharz Research Institute, Warrak el Hadar, Imbaba, P O Box 30, Giza 12411, Egypt
    Exp Parasitol 129:152-7. 2011
    ..Conclusion: PTX could attenuate liver fibrosis in early stages of S. mansoni infection through downregulation of profibrogenic cytokines, oxidative stress and collagen deposition...
  5. doi request reprint Potential antifibrotic effects of AT1 receptor antagonist, losartan, and/or praziquantel on acute and chronic experimental liver fibrosis induced by Schistosoma mansoni
    Naglaa M El-Lakkany
    Department of Pharmacology, Theodor Bilharz Research Institute, Warrak el Hadar, Imbaba, Giza, Egypt
    Clin Exp Pharmacol Physiol 38:695-704. 2011
    ..4. In conclusion, losartan has a promising antifibrotic action and could be introduced as a therapeutic tool with PZQ especially in acute schistosomal hepatic fibrosis...
  6. ncbi request reprint Pharmacodynamics of pentoxifylline and/or praziquantel in murine schistosomiasis mansoni
    Naglaa El-Lakkany
    Department of Pharmacology, Theodor Bilharz Research Institute, Guiza, Egypt
    APMIS 115:184-94. 2007
    ..Thus, PTX can be used as an adjuvant therapeutic tool with anti-helminthic drugs in the treatment of human schistosomiasis...
  7. ncbi request reprint Effect of artemether alone and in combination with grapefruit juice on hepatic drug-metabolising enzymes and biochemical aspects in experimental Schistosoma mansoni
    N M El-Lakkany
    Department of Pharmacology, Theodor Bilharz Research Institute, P O Box 30, Imbaba, Giza 12411, Egypt
    Int J Parasitol 34:1405-12. 2004
    ..Coadministration of grapefruit juice with artemether achieved complete protection of the host from damage induced by schistosomal infection...
  8. ncbi request reprint Pharmacodynamics of mefloquine and praziquantel combination therapy in mice harbouring juvenile and adult Schistosoma mansoni
    Naglaa Mohamed El-Lakkany
    Department of Pharmacology, Theodor Bilharz Research Institute, Warak El Hadar, Imbaba PO Box 30, Giza 12411, Egypt
    Mem Inst Oswaldo Cruz 106:814-22. 2011
    ..Therefore, the use of Mef with PZQ is more effective than PZQ alone and should be considered for clinical trials in humans as a potential treatment regimen to prevent treatment failures in areas with high rates of schistosomiasis...
  9. doi request reprint Comparative efficacy and bioavailability of different praziquantel brands
    Sanaa Botros
    Pharmacology Department, Theodor Bilharz Research Institute, Warak El Hadar, Imbaba, PO Box 30, Giza 12411, Egypt
    Exp Parasitol 127:515-21. 2011
    ..Quality of generic PZQ should include, in addition to examining the physicochemical characteristics of the brands, biological testing including efficacy and bioavailability studies...
  10. ncbi request reprint Altered immunoglobulin isotype profile and anti-immature worm surface immunoglobulins in mice harboring a praziquantel-resistant Schistosoma mansoni isolate
    Soad Hanallah
    Department of Immunology, Theodor Bilharz Research Institute, Guiza, Egypt
    APMIS 111:1125-32. 2003
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