Malcolm J D'Souza

Summary

Publications

  1. pmc Influence of sulfur for oxygen substitution in the solvolytic reactions of chloroformate esters and related compounds
    Malcolm J D'Souza
    Department of Chemistry, Wesley College, 120 N State Street, Dover, DE 19901 3875, USA
    Int J Mol Sci 15:18310-32. 2014
  2. pmc Concerted solvent processes for common sulfonyl chloride precursors used in the synthesis of sulfonamide-based drugs
    Malcolm J D'Souza
    Department of Chemistry, Dover, Delaware 19901 3875, USA
    Int J Mol Sci 9:914-25. 2008
  3. pmc Analysis of the nucleophilic solvation effects in isopropyl chlorothioformate solvolysis
    Malcolm J D'Souza
    Department of Chemistry, Wesley College, 120 N State Street, Dover, DE 19901 3875, USA
    Int J Mol Sci 11:2597-611. 2010
  4. pmc Use of empirical correlations to determine solvent effects in the solvolysis of S-methyl chlorothioformate
    Malcolm J D'Souza
    Department of Chemistry, Wesley College, 120 N State Street, Dover, Delaware 19901 3875, USA
    Int J Mol Sci 11:2253-66. 2010
  5. pmc Correlation of the rates of solvolysis of two arenesulfonyl chlorides and of trans-beta-styrenesulfonyl chloride - precursors in the development of new pharmaceuticals
    Zoon H Ryu
    Department of Chemistry, Dong Eui University, Busan, Korea
    Int J Mol Sci 9:2639-57. 2008
  6. pmc Extended Grunwald-Winstein analysis - LFER used to gauge solvent effects in p-nitrophenyl chloroformate solvolysis
    Malcolm J D'Souza
    Department of Chemistry, Wesley College, Dover, Delaware 19901 3875, USA
    Int J Mol Sci 9:2231-42. 2008
  7. pmc Grunwald-Winstein analysis: isopropyl chloroformate solvolysis revisited
    Malcolm J D'Souza
    Department of Chemistry, Wesley College, Dover, Delaware 19901 3875, USA
    Int J Mol Sci 10:862-79. 2009
  8. pmc Kinetic studies that evaluate the solvolytic mechanisms of allyl and vinyl chloroformate esters
    Malcolm J D'Souza
    Department of Chemistry, Wesley College, 120 N State Street, Dover, DE 19901 3875, USA
    Int J Mol Sci 14:7286-301. 2013
  9. pmc Kinetic evaluation of the solvolysis of isobutyl chloro- and chlorothioformate esters
    Malcolm J D'Souza
    Department of Chemistry, Wesley College, 120 N State Street, Dover, DE 19901 3875, USA
    Beilstein J Org Chem 7:543-52. 2011
  10. pmc Mechanistic Studies of the Solvolyses of Carbamoyl Chlorides and Related Reactions
    Malcolm J D'Souza
    Department of Chemistry, Wesley College, Dover, DE 19901 3875, USA
    Int J Mol Sci 17:. 2016

Collaborators

  • Zoon H Ryu
  • Sang W Lee
  • Samantha E Feld
  • Lamia Yaakoubd
  • Dennis N Kevill

Detail Information

Publications13

  1. pmc Influence of sulfur for oxygen substitution in the solvolytic reactions of chloroformate esters and related compounds
    Malcolm J D'Souza
    Department of Chemistry, Wesley College, 120 N State Street, Dover, DE 19901 3875, USA
    Int J Mol Sci 15:18310-32. 2014
    ....
  2. pmc Concerted solvent processes for common sulfonyl chloride precursors used in the synthesis of sulfonamide-based drugs
    Malcolm J D'Souza
    Department of Chemistry, Dover, Delaware 19901 3875, USA
    Int J Mol Sci 9:914-25. 2008
    ..With a methyl, isopropyl, benzyl, aromatic or heteroaromatic group as the R group of RSO(2)Cl, a concerted S(N)2 mechanism is proposed for the solvolysis...
  3. pmc Analysis of the nucleophilic solvation effects in isopropyl chlorothioformate solvolysis
    Malcolm J D'Souza
    Department of Chemistry, Wesley College, 120 N State Street, Dover, DE 19901 3875, USA
    Int J Mol Sci 11:2597-611. 2010
    ....
  4. pmc Use of empirical correlations to determine solvent effects in the solvolysis of S-methyl chlorothioformate
    Malcolm J D'Souza
    Department of Chemistry, Wesley College, 120 N State Street, Dover, Delaware 19901 3875, USA
    Int J Mol Sci 11:2253-66. 2010
    ....
  5. pmc Correlation of the rates of solvolysis of two arenesulfonyl chlorides and of trans-beta-styrenesulfonyl chloride - precursors in the development of new pharmaceuticals
    Zoon H Ryu
    Department of Chemistry, Dong Eui University, Busan, Korea
    Int J Mol Sci 9:2639-57. 2008
    ..For 3, kinetic solvent isotope effects of 1.46 for k(H(2)O)/k(D(2)O) and 1.76 for k(MeOH)/k(MeOD) were determined. These are also compared to literature values for other sulfonyl chlorides...
  6. pmc Extended Grunwald-Winstein analysis - LFER used to gauge solvent effects in p-nitrophenyl chloroformate solvolysis
    Malcolm J D'Souza
    Department of Chemistry, Wesley College, Dover, Delaware 19901 3875, USA
    Int J Mol Sci 9:2231-42. 2008
    ..The l/m ratios obtained for 1, 2, and 3, are also compared to the previously published l/m ratios for benzyl chloroformate (4) and p-nitrobenzyl chloroformate (5)...
  7. pmc Grunwald-Winstein analysis: isopropyl chloroformate solvolysis revisited
    Malcolm J D'Souza
    Department of Chemistry, Wesley College, Dover, Delaware 19901 3875, USA
    Int J Mol Sci 10:862-79. 2009
    ..Deficiencies in the acid production indicate 2-33% isopropyl chloride formation, with the higher values in less nucleophilic solvents...
  8. pmc Kinetic studies that evaluate the solvolytic mechanisms of allyl and vinyl chloroformate esters
    Malcolm J D'Souza
    Department of Chemistry, Wesley College, 120 N State Street, Dover, DE 19901 3875, USA
    Int J Mol Sci 14:7286-301. 2013
    ..Both substrates were found to solvolyze by similar dual bimolecular carbonyl-addition and unimolecular ionization channels, each heavily dependent upon the solvents nucleophilicity and ionizing ability...
  9. pmc Kinetic evaluation of the solvolysis of isobutyl chloro- and chlorothioformate esters
    Malcolm J D'Souza
    Department of Chemistry, Wesley College, 120 N State Street, Dover, DE 19901 3875, USA
    Beilstein J Org Chem 7:543-52. 2011
    ....
  10. pmc Mechanistic Studies of the Solvolyses of Carbamoyl Chlorides and Related Reactions
    Malcolm J D'Souza
    Department of Chemistry, Wesley College, Dover, DE 19901 3875, USA
    Int J Mol Sci 17:. 2016
    ..Recommended synthetic procedures require it to survive reaction temperatures in the 300-400 °C range. There has been very little study of its reactions...
  11. pmc Correlation of the rates of solvolysis of neopentyl chloroformate-a recommended protecting agent
    Malcolm J D'Souza
    Department of Chemistry, Wesley College, 120 N State Street, Dover, DE 19901, USA
    Int J Mol Sci 12:1161-74. 2011
    ....
  12. pmc Use of Linear Free Energy Relationships (LFERs) to elucidate the mechanisms of reaction of a γ-methyl-β-alkynyl and an ortho-substituted aryl chloroformate ester
    Malcolm J D'Souza
    Department of Chemistry, Wesley College, 120 N State Street, Dover, DE 19901, USA E Mails J A K G A F B
    Int J Mol Sci 13:665-82. 2012
    ..For 2, the analyses indicate that the dominant mechanism is a bimolecular one where the formation of a tetrahedral intermediate is rate-determining...