Arnaud Droit

Summary

Publications

  1. ncbi request reprint Experimental and bioinformatic approaches for interrogating protein-protein interactions to determine protein function
    Arnaud Droit
    Health and Environment Unit, Faculty of Medicine, Eastern Quebec Proteomics Centre, 2705 Laurier Blvd, Ste Foy, Quebec, Canada G1 V 4 G2
    J Mol Endocrinol 34:263-80. 2005
  2. pmc PARPs database: a LIMS systems for protein-protein interaction data mining or laboratory information management system
    Arnaud Droit
    Health and Environment Unit, Laval University Medical Research Center, CHUQ, Quebec, Canada
    BMC Bioinformatics 8:483. 2007
  3. doi request reprint Human Proteinpedia enables sharing of human protein data
    Suresh Mathivanan
    Nat Biotechnol 26:164-7. 2008
  4. doi request reprint Proteomic investigation of phosphorylation sites in poly(ADP-ribose) polymerase-1 and poly(ADP-ribose) glycohydrolase
    Jean Philippe Gagné
    Laval University Medical Research Center, Laval University, G1V4G2, Quebec, Canada
    J Proteome Res 8:1014-29. 2009
  5. pmc Comparative proteome analysis of human epithelial ovarian cancer
    Jean Philippe Gagné
    Health and Environment Unit, Laval University Medical Research Center, CHUQ, Faculty of Medicine, Laval University, 2705, boulevard Laurier, Ste Foy, Quebec, G1V 4G2, Canada
    Proteome Sci 5:16. 2007
  6. pmc Proteomic and genomic analyses of antimony resistant Leishmania infantum mutant
    Marie Christine Brotherton
    Centre de Recherche en Infectiologie du Centre de Recherche du CHU de Québec, Pavillon CHUL, and Département de Microbiologie Infectiologie et Immunologie, Faculte de Medecine, Universite Laval, Quebec, Canada
    PLoS ONE 8:e81899. 2013
  7. doi request reprint A metabolic labeling approach for glycoproteomic analysis reveals altered glycoprotein expression upon GALNT3 knockdown in ovarian cancer cells
    Razan Sheta
    Department of Molecular Medicine, Laval University, Quebec, PQ, Canada Centre de recherche du CHU de Québec, L Hôtel Dieu de Québec, Quebec, PQ, Canada
    J Proteomics 145:91-102. 2016
  8. doi request reprint Quantitative site-specific ADP-ribosylation profiling of DNA-dependent PARPs
    Jean Philippe Gagné
    Centre de recherche du CHU de Québec Pavillon CHUL, Faculte de Medecine, Universite Laval, Quebec, Canada
    DNA Repair (Amst) 30:68-79. 2015
  9. doi request reprint Selective and sensitive quantification of the cytochrome P450 3A4 protein in human liver homogenates through multiple reaction monitoring mass spectrometry
    Anna Cieslak
    Laboratory of Molecular Pharmacology, CHU de Québec Research Centre and the Faculty of Pharmacy, Laval University, Quebec, Canada
    Proteomics 16:2827-2837. 2016
  10. doi request reprint Divergent Expression and Metabolic Functions of Human Glucuronosyltransferases through Alternative Splicing
    Michele Rouleau
    Pharmacogenomics Laboratory, Centre Hospitalier Universitaire de Quebec Research Center, Quebec, QC G1V 4G2, Canada Faculty of Pharmacy, Laval University, Quebec, QC G1V 0A6, Canada
    Cell Rep 17:114-24. 2016

Collaborators

Detail Information

Publications14

  1. ncbi request reprint Experimental and bioinformatic approaches for interrogating protein-protein interactions to determine protein function
    Arnaud Droit
    Health and Environment Unit, Faculty of Medicine, Eastern Quebec Proteomics Centre, 2705 Laurier Blvd, Ste Foy, Quebec, Canada G1 V 4 G2
    J Mol Endocrinol 34:263-80. 2005
    ..Here, we present an overview of different experimental and bioinformatic methods to elucidate protein-protein interactions...
  2. pmc PARPs database: a LIMS systems for protein-protein interaction data mining or laboratory information management system
    Arnaud Droit
    Health and Environment Unit, Laval University Medical Research Center, CHUQ, Quebec, Canada
    BMC Bioinformatics 8:483. 2007
    ..This data must be archived and analysed using specialized bioinformatics tools...
  3. doi request reprint Human Proteinpedia enables sharing of human protein data
    Suresh Mathivanan
    Nat Biotechnol 26:164-7. 2008
  4. doi request reprint Proteomic investigation of phosphorylation sites in poly(ADP-ribose) polymerase-1 and poly(ADP-ribose) glycohydrolase
    Jean Philippe Gagné
    Laval University Medical Research Center, Laval University, G1V4G2, Quebec, Canada
    J Proteome Res 8:1014-29. 2009
    ..By documenting and annotating a collection of known and newly identified phosphorylation sites, this targeted proteomics study significantly advances our understanding of the roles of phosphorylation in the regulation of PARP-1 and PARG...
  5. pmc Comparative proteome analysis of human epithelial ovarian cancer
    Jean Philippe Gagné
    Health and Environment Unit, Laval University Medical Research Center, CHUQ, Faculty of Medicine, Laval University, 2705, boulevard Laurier, Ste Foy, Quebec, G1V 4G2, Canada
    Proteome Sci 5:16. 2007
    ..This investigation was aimed at a better understanding of the molecular mechanisms underlying differentiation, proliferation and neoplastic progression of ovarian cancer...
  6. pmc Proteomic and genomic analyses of antimony resistant Leishmania infantum mutant
    Marie Christine Brotherton
    Centre de Recherche en Infectiologie du Centre de Recherche du CHU de Québec, Pavillon CHUL, and Département de Microbiologie Infectiologie et Immunologie, Faculte de Medecine, Universite Laval, Quebec, Canada
    PLoS ONE 8:e81899. 2013
    ..Antimonials remain the primary antileishmanial drugs in most developing countries. However, drug resistance to these compounds is increasing and our understanding of resistance mechanisms is partial...
  7. doi request reprint A metabolic labeling approach for glycoproteomic analysis reveals altered glycoprotein expression upon GALNT3 knockdown in ovarian cancer cells
    Razan Sheta
    Department of Molecular Medicine, Laval University, Quebec, PQ, Canada Centre de recherche du CHU de Québec, L Hôtel Dieu de Québec, Quebec, PQ, Canada
    J Proteomics 145:91-102. 2016
    ..The GALNT3-dependent glycoproteins identified by this metabolic labeling approach support the oncogenic role of GALNT3 in EOC dissemination and may be pursued as novel EOC biomarkers and/or therapeutic targets...
  8. doi request reprint Quantitative site-specific ADP-ribosylation profiling of DNA-dependent PARPs
    Jean Philippe Gagné
    Centre de recherche du CHU de Québec Pavillon CHUL, Faculte de Medecine, Universite Laval, Quebec, Canada
    DNA Repair (Amst) 30:68-79. 2015
    ..Together our results suggest that poly(ADP-ribosyl)ation hot spots make a dominant contribution to the overall automodification process. ..
  9. doi request reprint Selective and sensitive quantification of the cytochrome P450 3A4 protein in human liver homogenates through multiple reaction monitoring mass spectrometry
    Anna Cieslak
    Laboratory of Molecular Pharmacology, CHU de Québec Research Centre and the Faculty of Pharmacy, Laval University, Quebec, Canada
    Proteomics 16:2827-2837. 2016
    ..The established method provides a sensitive tool to evaluate the CYP3A4 protein in human liver homogenates from patients with normal or chronic/severe hepatic injury...
  10. doi request reprint Divergent Expression and Metabolic Functions of Human Glucuronosyltransferases through Alternative Splicing
    Michele Rouleau
    Pharmacogenomics Laboratory, Centre Hospitalier Universitaire de Quebec Research Center, Quebec, QC G1V 4G2, Canada Faculty of Pharmacy, Laval University, Quebec, QC G1V 0A6, Canada
    Cell Rep 17:114-24. 2016
    ..This work highlights the biological relevance of alternative UGT expression, which we propose increases protein diversity through the evolution of metabolic regulators from specific enzymes. ..
  11. doi request reprint Effects of Long-term Serial Passaging on the Characteristics and Properties of Cell Lines Derived From Uveal Melanoma Primary Tumors
    Frederic Mouriaux
    Centre universitaire d ophtalmologie Recherche CUO Recherche, Axe Médecine Régénératrice, Hôpital du Saint Sacrement, Centre de Recherche FRQS du CHU de Québec Université Laval, Quebec, Canada 2Département d ophtalmologie, Faculte de Medecine, Universite Laval, Quebec, Canada 3CNRS, UMR 6301 ISTCT, CERVOxy GIP CYCERON, Caen, France 4CHU de Rennes, Service d Ophtalmologie, France
    Invest Ophthalmol Vis Sci 57:5288-5301. 2016
    ..In this study, we examined whether the properties of UM cell lines at various passages were similar to their corresponding primary tumors...
  12. pmc Evaluation of iTRAQ and SWATH-MS for the Quantification of Proteins Associated with Insulin Resistance in Human Duodenal Biopsy Samples
    Sylvie Bourassa
    Proteomics Center, CHU de Québec Research Center and Department of Molecular Medicine, Laval University, Quebec, Canada
    PLoS ONE 10:e0125934. 2015
    ..Furthermore, both methods quantified proteins of relevance to IR. These data also showed that SWATH-MS is a promising and compelling alternative to iTRAQ for protein quantitation of complex mixtures. ..
  13. ncbi request reprint The expanding role of poly(ADP-ribose) metabolism: current challenges and new perspectives
    Jean Philippe Gagné
    Health and Environment Unit, Laval University Medical Research Center, CHUQ, Faculty of Medicine, Laval University, 2705 Boulevard Laurier, Ste Foy, Quebec G1V 4G2, Canada
    Curr Opin Cell Biol 18:145-51. 2006
    ..Observations and suppositions towards functionally important regulatory elements in the N-terminal portion of PARG are also discussed...
  14. ncbi request reprint RT-PSM, a real-time program for peptide-spectrum matching with statistical significance
    Fang Xiang Wu
    Health and Environment Unit, Laval University Medical Research Center CHUL, Faculty of Medicine, 2705 Boul Laurier, Quebec City, QC Canada, G1V 4G2
    Rapid Commun Mass Spectrom 20:1199-208. 2006
    ..RT-PSM is clearly shown to be fast enough for real-time PSM assignment of MS/MS spectra generated every 3 s or so by a 3D ion trap or by a QqTOF instrument...