James Dooley

Summary

Publications

  1. pmc The microRNA-29 Family Dictates the Balance Between Homeostatic and Pathological Glucose Handling in Diabetes and Obesity
    James Dooley
    VIB, Leuven, Belgium Department of Microbiology and Immunology, KUL University of Leuven, Leuven, Belgium
    Diabetes 65:53-61. 2016
  2. pmc Models of aire-dependent gene regulation for thymic negative selection
    Dina Danso-Abeam
    VIB Autoimmune Genetics Laboratory Leuven, Belgium
    Front Immunol 2:14. 2011
  3. doi request reprint Molecular control over thymic involution: from cytokines and microRNA to aging and adipose tissue
    James Dooley
    Autoimmune Genetics Laboratory, VIB and University of Leuven, Belgium
    Eur J Immunol 42:1073-9. 2012
  4. doi request reprint Loss of T cell microRNA provides systemic protection against autoimmune pathology in mice
    Lei Tian
    Autoimmune Genetics Laboratory, VIB and University of Leuven, Leuven, Belgium
    J Autoimmun 38:39-48. 2012
  5. doi request reprint Aire mediates thymic expression and tolerance of pancreatic antigens via an unconventional transcriptional mechanism
    Dina Danso-Abeam
    Autoimmune Genetics Laboratory, VIB, Leuven, Belgium
    Eur J Immunol 43:75-84. 2013
  6. pmc Antiapoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3⁺ regulatory T cells
    Wim Pierson
    Autoimmune Genetics Laboratory, VIB, Leuven, Belgium
    Nat Immunol 14:959-65. 2013
  7. doi request reprint MicroRNA regulation of T-cell development
    James Dooley
    Autoimmune Genetics Laboratory, VIB, Leuven, Belgium
    Immunol Rev 253:53-64. 2013
  8. doi request reprint IL-2 consumption by highly activated CD8 T cells induces regulatory T-cell dysfunction in patients with hemophagocytic lymphohistiocytosis
    Stephanie Humblet-Baron
    Translational Immunology Laboratory, VIB, Leuven, Belgium Department of Microbiology and Immunology, KUL University of Leuven, Leuven, Belgium
    J Allergy Clin Immunol 138:200-209.e8. 2016
  9. pmc Promiscuous Foxp3-cre activity reveals a differential requirement for CD28 in Foxp3⁺ and Foxp3⁻ T cells
    Dean Franckaert
    1 Autoimmune Genetics Laboratory, VIB, Leuven, Belgium 2 Department of Microbiology and Immunology, University of Leuven, Leuven, Belgium
    Immunol Cell Biol 93:417-23. 2015
  10. doi request reprint MicroRNA-29 in the adaptive immune system: setting the threshold
    Adrian Liston
    Autoimmune Genetics Laboratory, VIB and University of Leuven, Leuven, Belgium
    Cell Mol Life Sci 69:3533-41. 2012

Collaborators

Detail Information

Publications24

  1. pmc The microRNA-29 Family Dictates the Balance Between Homeostatic and Pathological Glucose Handling in Diabetes and Obesity
    James Dooley
    VIB, Leuven, Belgium Department of Microbiology and Immunology, KUL University of Leuven, Leuven, Belgium
    Diabetes 65:53-61. 2016
    ..These results demonstrate strong regulatory functions for the miR-29 family in obesity and diabetes, culminating in a hierarchical and dose-dependent effect on premature lethality...
  2. pmc Models of aire-dependent gene regulation for thymic negative selection
    Dina Danso-Abeam
    VIB Autoimmune Genetics Laboratory Leuven, Belgium
    Front Immunol 2:14. 2011
    ..In this review, we evaluate each of these models and discuss their relative strengths and weaknesses...
  3. doi request reprint Molecular control over thymic involution: from cytokines and microRNA to aging and adipose tissue
    James Dooley
    Autoimmune Genetics Laboratory, VIB and University of Leuven, Belgium
    Eur J Immunol 42:1073-9. 2012
    ..This review outlines the disparate pathways through which involution can be mediated, from the transient infection-mediated pathway, tightly controlled by microRNA, to the chronic changes that occur through aging...
  4. doi request reprint Loss of T cell microRNA provides systemic protection against autoimmune pathology in mice
    Lei Tian
    Autoimmune Genetics Laboratory, VIB and University of Leuven, Leuven, Belgium
    J Autoimmun 38:39-48. 2012
    ..These results reverse the original conclusions of microRNA function in T cells by revealing a systemic pro-autoimmune function...
  5. doi request reprint Aire mediates thymic expression and tolerance of pancreatic antigens via an unconventional transcriptional mechanism
    Dina Danso-Abeam
    Autoimmune Genetics Laboratory, VIB, Leuven, Belgium
    Eur J Immunol 43:75-84. 2013
    ..These findings suggest that the capacity of Aire to regulate expression of a huge array of TRAs relies solely on an unconventional transcriptional mechanism, without intermediary transcription factors...
  6. pmc Antiapoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3⁺ regulatory T cells
    Wim Pierson
    Autoimmune Genetics Laboratory, VIB, Leuven, Belgium
    Nat Immunol 14:959-65. 2013
    ..Together, these data define the active processes by which Treg cells maintain homeostasis via critical survival pathways...
  7. doi request reprint MicroRNA regulation of T-cell development
    James Dooley
    Autoimmune Genetics Laboratory, VIB, Leuven, Belgium
    Immunol Rev 253:53-64. 2013
    ..In this review, we focus on integrating the research on individual microRNA into a more global understanding of the function of the microRNA regulatory network in T cells...
  8. doi request reprint IL-2 consumption by highly activated CD8 T cells induces regulatory T-cell dysfunction in patients with hemophagocytic lymphohistiocytosis
    Stephanie Humblet-Baron
    Translational Immunology Laboratory, VIB, Leuven, Belgium Department of Microbiology and Immunology, KUL University of Leuven, Leuven, Belgium
    J Allergy Clin Immunol 138:200-209.e8. 2016
    ..Recent studies have attributed the key distal event to excessive IFN-γ production; however, the proximal events driving immune dysregulation have remained undefined...
  9. pmc Promiscuous Foxp3-cre activity reveals a differential requirement for CD28 in Foxp3⁺ and Foxp3⁻ T cells
    Dean Franckaert
    1 Autoimmune Genetics Laboratory, VIB, Leuven, Belgium 2 Department of Microbiology and Immunology, University of Leuven, Leuven, Belgium
    Immunol Cell Biol 93:417-23. 2015
    ..This hypomorphism and 'leaky' expression of the Foxp3-CreYFP allele should be considered when analysing the conditionally mutated Treg. ..
  10. doi request reprint MicroRNA-29 in the adaptive immune system: setting the threshold
    Adrian Liston
    Autoimmune Genetics Laboratory, VIB and University of Leuven, Leuven, Belgium
    Cell Mol Life Sci 69:3533-41. 2012
    ..These results identify the miR-29 family as potent immune modulators which have already been exploited through the evolution of a viral mimic and could potentially be exploited further for therapeutic intervention...
  11. pmc Rapamycin increases survival in ALS mice lacking mature lymphocytes
    Kim A Staats
    Laboratory of Neurobiology, Vesalius Research Center, VIB, Leuven, Belgium
    Mol Neurodegener 8:31. 2013
    ..Rapamycin is frequently used to increase autophagy, but is also a potent immune suppressor. To properly assess the role of rapamycin-induced autophagy, the immune suppressive role of rapamycin should be negated...
  12. doi request reprint Defective germinal center B-cell response and reduced arthritic pathology in microRNA-29a-deficient mice
    Annemarie van Nieuwenhuijze
    VIB Center for Brain and Disease Research, VIB, KU Leuven Campus Gasthuisberg, Herestraat 49, bus 1026, 3000, Leuven, Belgium
    Cell Mol Life Sci . 2017
    ..Our results identify the hierarchical structure of the miR-29 family in T-cell biology, and identify miR-29a in B cells as a potential therapeutic target in arthritis...
  13. doi request reprint Genetic predisposition for beta cell fragility underlies type 1 and type 2 diabetes
    James Dooley
    Center for the Biology of Disease, VIB, Leuven, Belgium
    Nat Genet 48:519-27. 2016
    ..The same transcriptional relationships were observed in human islets, demonstrating the role of beta cell fragility in genetic predisposition to diabetes. ..
  14. pmc The thymic epithelial microRNA network elevates the threshold for infection-associated thymic involution via miR-29a mediated suppression of the IFN-α receptor
    Aikaterini S Papadopoulou
    VIB, Leuven, Belgium
    Nat Immunol 13:181-7. 2011
    ..In the absence of Dicer or the miR-29a cluster in the thymic epithelium, expression of the IFN-α receptor by the thymic epithelium was higher, which allowed suboptimal signals to trigger rapid loss of thymic cellularity...
  15. pmc Gain-of-function mutations in signal transducer and activator of transcription 1 (STAT1): chronic mucocutaneous candidiasis accompanied by enamel defects and delayed dental shedding
    Glynis Frans
    Department of Microbiology and Immunology, Experimental Laboratory Immunology, Katholieke Universiteit Leuven, Leuven, Belgium
    J Allergy Clin Immunol 134:1209-13.e6. 2014
  16. pmc Premature thymic involution is independent of structural plasticity of the thymic stroma
    Dean Franckaert
    Autoimmune Genetics Laboratory, VIB, Leuven, Belgium
    Eur J Immunol 45:1535-47. 2015
    ..These results identify pro-T-cell loss as the main driver of premature thymic involution, and highlight the plasticity of the thymic stroma, capable of maintaining function across diverse interstrain architectures...
  17. pmc Immunologic profiles of multiple sclerosis treatments reveal shared early B cell alterations
    James Dooley
    Department of Immunology and Microbiology J D, D F, J E G P, D D A, A T L N, A L, Laboratory for Neuroimmunology, Department of Neurosciences I P, I S, K H, B Dubois, A G, Laboratory for Neurobiology, Department of Neurosciences L D M, Laboratory for Clinical and Experimental Endocrinology, Department of Clinical and Experimental Medicine B Decallonne, and Department of Neurology, University Hospitals Leuven I S, J T, B Dubois, KU Leuven University of Leuven and Center for the Biology of Disease J D, D F, J E G P, D D A, A T L N, A L, VIB L D M, Leuven, Belgium
    Neurol Neuroimmunol Neuroinflamm 3:e240. 2016
    ....
  18. pmc The thymoprotective function of leptin is indirectly mediated via suppression of obesity
    Jayasree Sreenivasan
    VIB, Leuven, Belgium
    Immunology 146:122-9. 2015
    ....
  19. doi request reprint Transcriptional upregulation of myelin components in spontaneous myelin basic protein-deficient mice
    Kim A Staats
    Autoimmune Genetics Laboratory, VIB, Leuven, Belgium Department of Microbiology and Immunology, University of Leuven, Leuven, Belgium
    Brain Res 1606:125-32. 2015
    ..Further research will clarify the role and specifications of this myelin feedback loop, as well as determine its potential role in therapeutic strategies for demyelinating disorders. ..
  20. pmc Hematopoietic stem cell transplantation rescues the immunologic phenotype and prevents vasculopathy in patients with adenosine deaminase 2 deficiency
    Lien Van Eyck
    Department of Immunology and Microbiology, Autoimmune Genetics Laboratory, VIB and University of Leuven, Leuven, Belgium
    J Allergy Clin Immunol 135:283-287.e5. 2015
  21. pmc Olmsted syndrome: exploration of the immunological phenotype
    Dina Danso-Abeam
    Autoimmune Genetics Laboratory, VIB, Leuven, Belgium
    Orphanet J Rare Dis 8:79. 2013
    ..A recent study identified de novo mutations causing constitutive activation of TRPV3 as a cause of the keratotic manifestations of Olmsted syndrome...
  22. doi request reprint Psychological comorbidity increases the risk for postinfectious IBS partly by enhanced susceptibility to develop infectious gastroenteritis
    Mira M Wouters
    Department of Clinical and Experimental Medicine, Translational Research Center for Gastrointestinal Disorders, University Hospital Leuven, KU Leuven, Leuven, Belgium
    Gut 65:1279-88. 2016
    ....
  23. doi request reprint PD-1 expression correlates with disease severity and IL-5 in Chronic Rhinosinusitis with Nasal Polyps
    Inge Kortekaas Krohn
    Laboratory of Clinical Immunology, Dpt Microbiology and Immunology, KU Leuven, Leuven, Belgium
    Allergy . 2017
    ..Programmed cell Death 1 (PD-1) is a negative regulator of T cell responses. Expression of PD-1 and its ligands PD-L1 and PD-L2 in chronic rhinosinusitis with nasal polyps (CRSwNP) is poorly studied...
  24. pmc Foxp3⁺ regulatory T cells exert asymmetric control over murine helper responses by inducing Th2 cell apoptosis
    Lei Tian
    VIB, Leuven, Belgium
    Blood 118:1845-53. 2011
    ..These results indicate that the Th2 arm of the immune system is under tighter control by regulatory T cells than the Th1 arm, suggesting that Th2-driven diseases may be more responsive to regulatory T-cell manipulation...