Olivier Devuyst

Summary

Publications

  1. ncbi request reprint Urine Osmolality, Response to Tolvaptan, and Outcome in Autosomal Dominant Polycystic Kidney Disease: Results from the TEMPO 3:4 Trial
    Olivier Devuyst
    Institute of Physiology, University of Zurich, Zurich, Switzerland
    J Am Soc Nephrol . 2016
  2. pmc Rare inherited kidney diseases: challenges, opportunities, and perspectives
    Olivier Devuyst
    Division of Nephrology, Universite Catholique de Louvain, Brussels, Belgium Institute of Physiology, Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland Electronic address
    Lancet 383:1844-59. 2014
  3. doi request reprint Osmoregulation, vasopressin, and cAMP signaling in autosomal dominant polycystic kidney disease
    Olivier Devuyst
    Institute of Physiology, University of Zurich, Zurich, Switzerland
    Curr Opin Nephrol Hypertens 22:459-70. 2013
  4. doi request reprint Parvalbumin: calcium and magnesium buffering in the distal nephron
    Eric Olinger
    Division of Nephrology and Laboratory of Cell Physiology, UCL Medical School, Brussels, Belgium
    Nephrol Dial Transplant 27:3988-94. 2012
  5. doi request reprint Physiopathology and diagnosis of nephrogenic diabetes insipidus
    Olivier Devuyst
    Institute of Physiology, Zurich Center for Integrative Human Physiology, Switzerland
    Ann Endocrinol (Paris) 73:128-9. 2012
  6. doi request reprint High-dose steroid treatment increases free water transport in peritoneal dialysis patients
    Javier De Arteaga
    Servicio de Nefrologia, Hospital Privado de Cordoba, Universidad Catolica de Cordoba, Cordoba, Argentina
    Nephrol Dial Transplant 26:4142-5. 2011
  7. ncbi request reprint Water channels in peritoneal dialysis
    Olivier Devuyst
    Institute of Physiology, University of Zurich, Zurich, Switzerland
    J Nephrol 23:S170-4. 2010
  8. doi request reprint Single photon emission-computed tomography (SPECT) for functional investigation of the proximal tubule in conscious mice
    Francois Jouret
    Division of Nephrology, Université Catholique de Louvain Medical School, Brussels, Belgium
    Am J Physiol Renal Physiol 298:F454-60. 2010
  9. pmc Expression patterns of the aquaporin gene family during renal development: influence of genetic variability
    Kleber S Parreira
    Division of Nephrology, Université Catholique de Louvain Medical School, 10 Avenue Hippocrate, 1200, Brussels, Belgium
    Pflugers Arch 458:745-59. 2009
  10. ncbi request reprint Ubiquitous and kidney-specific subunits of vacuolar H+-ATPase are differentially expressed during nephrogenesis
    Francois Jouret
    Division of Nephrology, Universite Catholique de Louvain, 10 Avenue Hippocrate, Brussels, Belgium B 1200
    J Am Soc Nephrol 16:3235-46. 2005

Detail Information

Publications60

  1. ncbi request reprint Urine Osmolality, Response to Tolvaptan, and Outcome in Autosomal Dominant Polycystic Kidney Disease: Results from the TEMPO 3:4 Trial
    Olivier Devuyst
    Institute of Physiology, University of Zurich, Zurich, Switzerland
    J Am Soc Nephrol . 2016
    ..The greatest renal benefit occurred in subjects achieving greater suppression of Uosm, that is, those with better eGFR at baseline. These results support the link between vasopressin V2 receptor signaling and ADPKD progression...
  2. pmc Rare inherited kidney diseases: challenges, opportunities, and perspectives
    Olivier Devuyst
    Division of Nephrology, Universite Catholique de Louvain, Brussels, Belgium Institute of Physiology, Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland Electronic address
    Lancet 383:1844-59. 2014
    ..Mechanistic insights from rare disorders are relevant for common disorders such as hypertension, kidney stones, cardiovascular disease, and progression of chronic kidney disease. ..
  3. doi request reprint Osmoregulation, vasopressin, and cAMP signaling in autosomal dominant polycystic kidney disease
    Olivier Devuyst
    Institute of Physiology, University of Zurich, Zurich, Switzerland
    Curr Opin Nephrol Hypertens 22:459-70. 2013
    ..This review will focus on the vasopressin and 3'-5'-cyclic adenosine monophosphate (cAMP) signaling pathways in ADPKD and will discuss how these insights offer new possibilities for the follow-up and treatment of the disease...
  4. doi request reprint Parvalbumin: calcium and magnesium buffering in the distal nephron
    Eric Olinger
    Division of Nephrology and Laboratory of Cell Physiology, UCL Medical School, Brussels, Belgium
    Nephrol Dial Transplant 27:3988-94. 2012
    ..PV is also considered a reliable marker of chromophobe carcinoma and oncocytoma, two neoplasms deriving from the distal nephron. The putative role of PV in tumour genesis remains to be investigated...
  5. doi request reprint Physiopathology and diagnosis of nephrogenic diabetes insipidus
    Olivier Devuyst
    Institute of Physiology, Zurich Center for Integrative Human Physiology, Switzerland
    Ann Endocrinol (Paris) 73:128-9. 2012
    ..Mutations of the water channel aquaporin-2 (AQP2) can be detected in autosomal recessive or dominant forms of NDI. Management of NDI should focus on free access to drinking water and reduction of polyuria...
  6. doi request reprint High-dose steroid treatment increases free water transport in peritoneal dialysis patients
    Javier De Arteaga
    Servicio de Nefrologia, Hospital Privado de Cordoba, Universidad Catolica de Cordoba, Cordoba, Argentina
    Nephrol Dial Transplant 26:4142-5. 2011
    ..The direct involvement of AQP1 in these changes is suggested by the expression of glucocorticoid receptors in the human peritoneum and the presence of conserved glucocorticoid response elements in the promoter of the human AQP1 gene...
  7. ncbi request reprint Water channels in peritoneal dialysis
    Olivier Devuyst
    Institute of Physiology, University of Zurich, Zurich, Switzerland
    J Nephrol 23:S170-4. 2010
    ..These studies on the peritoneal membrane also provide an experimental framework to investigate the role of water channels in the endothelium and various cell types...
  8. doi request reprint Single photon emission-computed tomography (SPECT) for functional investigation of the proximal tubule in conscious mice
    Francois Jouret
    Division of Nephrology, Université Catholique de Louvain Medical School, Brussels, Belgium
    Am J Physiol Renal Physiol 298:F454-60. 2010
    ..These data show that SPECT imaging with well-validated radiotracers allows in vivo investigations of specific proximal tubule functions in conscious mice...
  9. pmc Expression patterns of the aquaporin gene family during renal development: influence of genetic variability
    Kleber S Parreira
    Division of Nephrology, Université Catholique de Louvain Medical School, 10 Avenue Hippocrate, 1200, Brussels, Belgium
    Pflugers Arch 458:745-59. 2009
    ....
  10. ncbi request reprint Ubiquitous and kidney-specific subunits of vacuolar H+-ATPase are differentially expressed during nephrogenesis
    Francois Jouret
    Division of Nephrology, Universite Catholique de Louvain, 10 Avenue Hippocrate, Brussels, Belgium B 1200
    J Am Soc Nephrol 16:3235-46. 2005
    ..They provide new insights into the complex regulation of V-ATPase subunits, the maturation of IC along the nephron, and the pathophysiology of hereditary dRTA...
  11. ncbi request reprint Aquaporin-1 in the peritoneal membrane: implications for peritoneal dialysis and endothelial cell function
    Olivier Devuyst
    Division of Nephrology, Université Catholique de Louvain Medical School, Brussels, Belgium
    Biol Cell 97:667-73. 2005
    ..The results also emphasize the critical role of AQP1 during PD and suggest that manipulation of AQP1 expression may be used to increase water permeability across the PM...
  12. doi request reprint Diagnosis of cyst infection in patients with autosomal dominant polycystic kidney disease: attributes and limitations of the current modalities
    Francois Jouret
    Cliniques Universitaires Saint Luc, Universite Catholique de Louvain, Brussels, Belgium
    Nephrol Dial Transplant 27:3746-51. 2012
    ..This review summarizes the attributes and limitations of these recent clinical, biological and imaging advances in the diagnosis of cyst infection in patients with ADPKD...
  13. doi request reprint Progression of coronary artery calcification and thoracic aorta calcification in kidney transplant recipients
    Céline Maréchal
    Division of Nephrology, Cliniques Universitaires Saint Luc, Université Catholique de Louvain Medical School, Brussels, Belgium
    Am J Kidney Dis 59:258-69. 2012
    ..Longitudinal studies of vascular calcification in KTRs are few and small and have short follow-up. We assessed the evolution of coronary artery (CAC) and thoracic aorta calcification and their determinants in a cohort of prevalent KTRs...
  14. doi request reprint Glomerular and proximal tubule cysts as early manifestations of Pkd1 deletion
    Ali K Ahrabi
    Division of Nephrology, Université Catholique de Louvain Medical School, Brussels, Belgium
    Nephrol Dial Transplant 25:1067-78. 2010
    ..The homozygous deletion of Pkd1 in the mouse results in embryonic lethality with renal cysts and hydrops fetalis, but there is no precise data on the segmental origin of cysts and potential changes associated with polyhydramnios...
  15. doi request reprint Tubular proteinuria in patients with HNF1α mutations: HNF1α drives endocytosis in the proximal tubule
    Sara Terryn
    Division of Nephrology, Université Catholique de Louvain Medical School, Brussels, Belgium
    Kidney Int 89:1075-89. 2016
    ..These findings provide new insight into the renal phenotype of individuals with mutations of HNF1A...
  16. pmc Haploinsufficiency of the ammonia transporter Rhcg predisposes to chronic acidosis: Rhcg is critical for apical and basolateral ammonia transport in the mouse collecting duct
    Soline Bourgeois
    Institute of Physiology and Zurich Center for Integrative Human Physiology, University of Zurich, CH 8057 Zurich, Switzerland
    J Biol Chem 288:5518-29. 2013
    ..Haploinsufficiency or reduced expression of RhCG may underlie human forms of (in)complete dRTA...
  17. doi request reprint PKD1 haploinsufficiency is associated with altered vascular reactivity and abnormal calcium signaling in the mouse aorta
    Nicole Morel
    Laboratoire de Physiologie Cellulaire, Universite Catholique de Louvain, Avenue Hippocrate 55, UCL 5540, Brussels, Belgium
    Pflugers Arch 457:845-56. 2009
    ....
  18. doi request reprint Decreased renal accumulation of aminoglycoside reflects defective receptor-mediated endocytosis in cystic fibrosis and Dent's disease
    Claudia Raggi
    Division of Nephrology, Université Catholique de Louvain Medical School, Brussels, Belgium
    Pflugers Arch 462:851-60. 2011
    ..They also demonstrate that the functional loss of these two chloride transporters is associated with impaired uptake of AG in PT cells, reflected by a decreased renal accumulation of the drug...
  19. ncbi request reprint PKD1 haploinsufficiency causes a syndrome of inappropriate antidiuresis in mice
    Ali K Ahrabi
    Division of Nephrology, UCL Medical School, Universite Catholique de Louvain, 10 Avenue Hippocrate, B 1200 Brussels, Belgium
    J Am Soc Nephrol 18:1740-53. 2007
    ..These data give new insights in the potential roles of polycystin-1 in the AVP and Ca(2+) signaling and the trafficking of AQP2 in the CD...
  20. doi request reprint The rhesus protein RhCG: a new perspective in ammonium transport and distal urinary acidification
    Carsten A Wagner
    Institute of Physiology, University of Zurich, Zurich, Switzerland
    Kidney Int 79:154-61. 2011
    ..Similarly, crystal structures of human RhCG and the homologous bacterial AmtB protein suggest that these proteins may form gas channels...
  21. doi request reprint Autosomal dominant polycystic kidney disease is associated with central and nephrogenic defects in osmoregulation
    Thien Anh Ho
    Division of Nephrology, Cliniques Universitaires Saint Luc, Université Catholique de Louvain Medical School, Brussels, Belgium
    Kidney Int 82:1121-9. 2012
    ..This reflects expression of polycystins in hypothalamic nuclei that synthesize vasopressin, and this should be considered when evaluating treatments targeting the vasopressin pathway in ADPKD...
  22. doi request reprint Targeting of sodium-glucose cotransporters with phlorizin inhibits polycystic kidney disease progression in Han:SPRD rats
    Xueqi Wang
    1 Division of Nephrology, University Hospital, Zurich, Switzerland 2 Institute of Physiology, University of Zurich, Zurich, Switzerland 3 Department of Nephrology, Kidney Institute of PLA, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, PRC
    Kidney Int 84:962-8. 2013
    ..Hence, induction of glycosuria and osmotic diuresis (glycuresis) by renal sodium-glucose cotransporters inhibition could have a therapeutic effect in polycystic kidney disease. ..
  23. ncbi request reprint Cystic fibrosis is associated with a defect in apical receptor-mediated endocytosis in mouse and human kidney
    Francois Jouret
    Division of Nephrology, Universite Catholique de Louvain, 10 Avenue Hippocrate, B 1200 Brussels, Belgium
    J Am Soc Nephrol 18:707-18. 2007
    ..The magnitude of the endocytosis defect that is caused by CFTR versus ClC-5 loss likely reflects functional heterogeneity along the PT...
  24. ncbi request reprint Inhibition of nitric oxide synthase reverses permeability changes in a mouse model of acute peritonitis
    Jie Ni
    Division of Nephrology, Université Catholique de Louvain Medical School, Brussels, Belgium
    Perit Dial Int 25:S11-4. 2005
    ..These results confirm that increased NO mediates permeability modifications during acute peritonitis, and illustrate the potential of mouse models to investigate the molecular mechanisms regulating peritoneal permeability...
  25. doi request reprint A homozygous mutation in INVS causing juvenile nephronophthisis with abnormal reactivity of the Wnt/beta-catenin pathway
    Salvatore Bellavia
    Division of Nephrology, Cliniques Universitaires St Luc, Universite Catholique de Louvain, Bruxelles, Belgium
    Nephrol Dial Transplant 25:4097-102. 2010
    ..This case shows that INVS mutation can cause juvenile nephronophthisis with abnormal reactivity of the Wnt/β-catenin pathway...
  26. ncbi request reprint Transgenic mouse models
    Tomoya Nishino
    Division of Nephrology, Université Catholique de Louvain Medical School, 10 Avenue Hippocrate, Brussels, Belgium
    Perit Dial Int 27:625-33. 2007
    ....
  27. doi request reprint Positron-emission computed tomography in cyst infection diagnosis in patients with autosomal dominant polycystic kidney disease
    Francois Jouret
    Division of Nephrology, Cliniques Universitaires Saint Luc, Universite Catholique de Louvain, Brussels, Belgium
    Clin J Am Soc Nephrol 6:1644-50. 2011
    ..In most patients, conventional imaging techniques are inconclusive. Isolated observations suggest that (18)fluorodeoxyglucose (¹⁸FDG) positron-emission computed tomography (PET/CT) might help detect cyst infection in ADPKD patients...
  28. pmc Ultrafiltration Failure and Impaired Sodium Sieving During Long-Term Peritoneal Dialysis: More Than Aquaporin Dysfunction?
    Johann Morelle
    Division of Nephrology, Cliniques Universitaires Saint Luc, Brussels, Belgium Laboratory of Nephrology, Institute of Experimental and Clinical Research, Universite Catholique de Louvain, Brussels, Belgium
    Perit Dial Int 36:227-31. 2016
    ....
  29. ncbi request reprint Peritoneal membrane transport: driving under the influence
    Olivier Devuyst
    Division of Nephrology, Université Catholique de Louvain Medical School, Brussels, Belgium
    Perit Dial Int 26:35-7. 2006
  30. doi request reprint Regulated acid-base transport in the collecting duct
    Carsten A Wagner
    Zurich Center for Human Integrative Physiology, University of Zurich, Switzerland
    Pflugers Arch 458:137-56. 2009
    ..Dysregulation of intercalated cell function or abundance causes various syndromes of distal renal tubular acidosis underlining the importance of these processes for acid-base homeostasis...
  31. ncbi request reprint Genetic and clinical factors influence the baseline permeability of the peritoneal membrane
    Gaëlle Gillerot
    Division of Nephrology, and Division of Epidemiology and Statistics, Université Catholique de Louvain Medical School, Brussels, Belgium
    Kidney Int 67:2477-87. 2005
    ..The latter parameter determines dialysis prescription and survival. Clinical factors probably influence solute transport across the PM, but the putative role of genetic variants is unknown...
  32. doi request reprint Segmental and subcellular distribution of CFTR in the kidney
    Francois Jouret
    Division of Nephrology, Université Catholique de Louvain Medical School, B 1200, Brussels, Belgium
    Methods Mol Biol 741:285-99. 2011
    ..The segmental and subcellular distribution of CFTR in mouse kidney supports a role for CFTR in PT receptor-mediated endocytosis of ultrafiltered LMW proteins...
  33. doi request reprint Fluid transport and cystogenesis in autosomal dominant polycystic kidney disease
    Sara Terryn
    Division of Nephrology, Université Catholique de Louvain Medical School, B 1200, Brussels, Belgium
    Biochim Biophys Acta 1812:1314-21. 2011
    ..This article is part of a Special Issue entitled: Polycystic Kidney Disease...
  34. doi request reprint Evaluating PVALB as a candidate gene for SLC12A3-negative cases of Gitelman's syndrome
    Eva Riveira-Munoz
    Division of Nephrology, Universite Catholique de Louvain, 10 Avenue Hippocrate, Brussels B 1200, Belgium
    Nephrol Dial Transplant 23:3120-5. 2008
    ..Locus heterogeneity could explain the lack of detection of mutant SLC12A3 alleles in GS patients. The renal phenotype of the parvalbumin knockout mice pointed to PVALB as a candidate gene for GS for SLC12A3-negative cases...
  35. pmc Soluble klotho and autosomal dominant polycystic kidney disease
    Ivana Pavik
    Institute of Physiology and Zurich Center for Integrative Human Physiology, Zurich, Switzerland
    Clin J Am Soc Nephrol 7:248-57. 2012
    ..This study explored potential mechanisms underlying resistance to FGF23 in ADPKD...
  36. doi request reprint Human proximal tubule cells form functional microtissues
    Jenny A Prange
    Institute of Physiology, Zurich Center for Integrative Human Physiology ZIHP, University of Zurich, Zurich, Switzerland
    Pflugers Arch 468:739-50. 2016
    ..These microtissues could be used for high-throughput drug and toxicology screenings, with endocytosis as a functional readout...
  37. doi request reprint Building a network of ADPKD reference centres across Europe: the EuroCYST initiative
    Katja Petzold
    Institute of Physiology and Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland
    Nephrol Dial Transplant 29:iv26-32. 2014
    ..Similarly, assessing disease severity and prognosis in an individual with ADPKD remains difficult. Epidemiological studies are limited due to the fragmentation of ADPKD research in Europe...
  38. pmc The role of the renal ammonia transporter Rhcg in metabolic responses to dietary protein
    Lisa Bounoure
    Institute of Physiology and Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland and
    J Am Soc Nephrol 25:2040-52. 2014
    ..Furthermore, bone metabolism is altered by a high-protein acidogenic diet, presumably to buffer the acid load. ..
  39. pmc Dent's disease
    Olivier Devuyst
    Division of Nephrology, Université Catholique de Louvain Medical School, Brussels, Belgium
    Orphanet J Rare Dis 5:28. 2010
    ..The vital prognosis is good in the majority of patients. Progression to end-stage renal failure occurs between the 3rd and 5th decades of life in 30-80% of affected males...
  40. ncbi request reprint Transcriptional and functional analyses of SLC12A3 mutations: new clues for the pathogenesis of Gitelman syndrome
    Eva Riveira-Munoz
    Division of Nephrology, Université Catholique de Louvain Medical School, Brussels, Belgium
    J Am Soc Nephrol 18:1271-83. 2007
    ..These data suggest that the nature/position of SLC12A3 mutation, combined with male gender, is a determinant factor in the severity of GS and provide new insights in the underlying pathogenic mechanisms of the disease...
  41. doi request reprint Bone marrow transplantation improves proximal tubule dysfunction in a mouse model of Dent disease
    Sarah S Gabriel
    Institute of Physiology, University of Zurich, Zurich, Switzerland Division of Nephrology, University Hospital Zurich, Zurich, Switzerland
    Kidney Int . 2017
    ..Thus, bone marrow transplantation may rescue the epithelial phenotype due to an inherited endosomal defect. Direct contacts between bone marrow-derived cells and diseased tubular cells play a key role in the rescue mechanism...
  42. pmc Regulation of macrophage motility by the water channel aquaporin-1: crucial role of M0/M2 phenotype switch
    Donatienne Tyteca
    CELL Unit, de Duve Institute DDUV, Universite Catholique de Louvain, Brussels, Belgium
    PLoS ONE 10:e0117398. 2015
    ..Taken together, these data indicate that AQP1 oppositely regulates macrophage migration, depending on stimulation or not by LPS, and that macrophage phenotypic and migratory changes may be regulated independently of external cues. ..
  43. doi request reprint Gitelman syndrome and glomerular proteinuria: a link between loss of sodium-chloride cotransporter and podocyte dysfunction?
    Nathalie Demoulin
    Division of Nephrology, Cliniques Universitaires Saint Luc, Universite Catholique de Louvain, Brussels, Belgium
    Nephrol Dial Transplant 29:iv117-20. 2014
    ..Possible mechanisms include angiotensin II- or renin-induced podocyte lesions, as well as chronic hypokalaemia...
  44. doi request reprint Paradoxical response to furosemide in uromodulin-associated kidney disease
    Laura Labriola
    Cliniques Universitaires Saint Luc, Universite Catholique de Louvain, Brussels, Belgium
    Nephrol Dial Transplant 30:330-5. 2015
    ..These data reveal that mutations of uromodulin cause specific transport alterations, including exaggerated response to furosemide and a failure to maximally concentrate urine, in the early phase of the disease. ..
  45. ncbi request reprint Functional and molecular characterization of a peritoneal dialysis model in the C57BL/6J mouse
    Jie Ni
    Division of Nephrology, Université Catholique de Louvain Medical School, Brussels, Belgium
    Kidney Int 67:2021-31. 2005
    ..Genetically modified mice could provide an attractive alternative to the above models. In this study, we have characterized PD parameters and tested the effect of gender and dialysate volume and/or osmolality in the C57BL/6J mouse...
  46. ncbi request reprint Identification and subcellular localization of the Na+/H+ exchanger and a novel related protein in the endocrine pancreas and adrenal medulla
    Pierre Moulin
    Unit of Pathology, Faculty of Medicine, Universite Catholique de Louvain, Brussels, Belgium
    J Mol Endocrinol 38:409-22. 2007
    ..The complete protein is addressed to the plasma membrane and the shorter one to the membrane of secretory granules where its function remains to be established...
  47. doi request reprint Coronary artery calcification: a strong predictor of cardiovascular events in renal transplant recipients
    Pauline T H Nguyen
    Nephrology, Cliniques Universitaires St Luc, Universite Catholique de Louvain, Brussels, Belgium
    Nephrol Dial Transplant 25:3773-8. 2010
    ..Whether this applies to renal transplant recipients (RTR) is unknown. This prospective study assessed the prognostic impact of CAC on CVE in RTR...
  48. doi request reprint Renal transplantation in autosomal dominant polycystic kidney disease
    Nada Kanaan
    Division of Nephrology, Cliniques Universitaires Saint Luc, Universite Catholique de Louvain, 10 Avenue Hippocrate, B 1200 Brussels, Belgium
    Nat Rev Nephrol 10:455-65. 2014
    ..Finally, no data currently support the preferential use of mammalian target of rapamycin inhibitors as immunosuppressive agents in transplant recipients with ADPKD. ..
  49. ncbi request reprint Chloride channels and endocytosis: new insights from Dent's disease and ClC-5 knockout mice
    Olivier Devuyst
    Division of Nephrology, CELL Unit, Christian de Duve Institute of Cellular Pathology, Université Catholique de Louvain Medical School, Brussels, Belgium
    Nephron Physiol 99:p69-73. 2005
    ..These studies also provided insights into important functions such as apical endocytosis, handling of proteins by renal tubular cells, calcium metabolism, and urinary acidification...
  50. pmc A classification of ductal plate malformations based on distinct pathogenic mechanisms of biliary dysmorphogenesis
    Peggy Raynaud
    de Duve Institute, Universite Catholique de Louvain, Brussels, Belgium
    Hepatology 53:1959-66. 2011
    ..In HNF1β-deficient liver, maturation of the primitive ductal structures was impaired. Normal differentiation and maturation but abnormal duct expansion was apparent in cpk mouse livers and in human fetal ARPKD...
  51. doi request reprint Carbohydrate antigen 19-9 as a diagnostic marker for hepatic cyst infection in autosomal dominant polycystic kidney disease
    Nada Kanaan
    Division of Nephrology, Cliniques Universitaires Saint Luc, Universite Catholique de Louvain, Brussels, Belgium
    Am J Kidney Dis 55:916-22. 2010
    ..Although further study is necessary, these data suggest that serum CA 19-9 level is markedly increased during liver cyst infection in kidney transplant recipients with ADPKD and has potential utility as a diagnostic marker...
  52. doi request reprint Dedifferentiation and aberrations of the endolysosomal compartment characterize the early stage of nephropathic cystinosis
    Claudia Raggi
    Division of Nephrology, Universite Catholique de Louvain, Brussels, Belgium
    Hum Mol Genet 23:2266-78. 2014
    ..Insights into the early manifestations of cystinosis may offer new targets for intervention, before irreversible renal damage. ..
  53. pmc Impaired Lysosomal Function Underlies Monoclonal Light Chain-Associated Renal Fanconi Syndrome
    Alessandro Luciani
    Institute of Physiology, Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland
    J Am Soc Nephrol 27:2049-61. 2016
    ..The characterization of these early events, which are similar to those encountered in congenital lysosomal disorders, provides a basis for the reported differential LC toxicity and new perspectives on LC-induced RFS. ..
  54. pmc Chloride transporters and receptor-mediated endocytosis in the renal proximal tubule
    Olivier Devuyst
    Institute of Physiology, Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland
    J Physiol 593:4151-64. 2015
    ..Vesicular chloride transport appears to be important for the integrity of the endolysosomal pathway in epithelial cells...
  55. doi request reprint Rab-GAP TBC1D4 (AS160) is dispensable for the renal control of sodium and water homeostasis but regulates GLUT4 in mouse kidney
    Marianna Di Chiara
    Institute of Anatomy, University of Zurich, Zurich, Switzerland Zurich Center of Integrative Human Physiology, University of Zurich, Zurich, Switzerland
    Am J Physiol Renal Physiol 309:F779-90. 2015
    ..The latter may contribute to the known anaerobic glycolytic capacity of distal tubules during renal ischemia...
  56. pmc Somatic uniparental isodisomy explains multifocality of glomuvenous malformations
    Mustapha Amyere
    Laboratory of Human Molecular Genetics, de Duve Institute, Universite Catholique de Louvain, Brussels, Belgium
    Am J Hum Genet 92:188-96. 2013
    ..Furthermore, these data suggest that pairwise analysis of blood and tissue, even on heterogeneous tissue, can be used for localizing double-hit mutations in disease-causing genes...
  57. ncbi request reprint Comparative ontogeny, processing, and segmental distribution of the renal chloride channel, ClC-5
    Francois Jouret
    Division of Nephrology and Laboratory of Developmental Genetics, Universite Catholique de Louvain, Brussels, Belgium
    Kidney Int 65:198-208. 2004
    ..However, the ontogeny of ClC-5, and its processing and segmental distribution with respect to related proteins during nephrogenesis remain unknown...
  58. doi request reprint Role of caveolin-1 in thyroid phenotype, cell homeostasis, and hormone synthesis: in vivo study of caveolin-1 knockout mice
    Maximin Senou
    Unité de Morphologie Expérimentale, Universite Catholique de Louvain, Brussels, Belgium
    Am J Physiol Endocrinol Metab 297:E438-51. 2009
    ..Because the expression and subcellular localization of caveolin-1 were similar between normal human and murine thyroids, our findings in caveolin-1 knockout mice may have direct relevance to the human counterpart...
  59. ncbi request reprint Genotyping: a new application for the spent dialysate in peritoneal dialysis
    Gaëlle Gillerot
    Division of Nephrology, Université Catholique de Louvain Medical School, Brussels, Belgium
    Nephrol Dial Transplant 19:1298-301. 2004
    ..We hypothesized that the cells contained in spent dialysate samples obtained at the time of the peritoneal equilibration test (PET) and subsequently stored may represent a source of DNA from a given PD patient...
  60. doi request reprint Aquaporin-1: new developments and perspectives for peritoneal dialysis
    Olivier Devuyst
    Division of Nephrology, Université Catholique de Louvain Medical School, Brussels, Belgium
    Perit Dial Int 30:135-41. 2010
    ..By modulating water transport, these pharmacological agents could have clinically relevant effects in targeting specific tissues or disease states...