Damiaan Denys

Summary

Publications

  1. pmc Deep brain stimulation for treatment-refractory obsessive compulsive disorder: a systematic review
    Sina Kohl
    Department of Psychiatry and Psychotherapy, University of Cologne, Kerpener Strasse 62, Cologne, 50937, Germany
    BMC Psychiatry 14:214. 2014
  2. pmc Efficacy of oxytocin administration early after psychotrauma in preventing the development of PTSD: study protocol of a randomized controlled trial
    Jessie L Frijling
    Department of Psychiatry, Academic Medical Center, University of Amsterdam, Meibergdreef 5, 1105 AZ Amsterdam, The Netherlands
    BMC Psychiatry 14:92. 2014
  3. pmc The effects of Psychotropic drugs On Developing brain (ePOD) study: methods and design
    Marco A Bottelier
    Brain Imaging Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    BMC Psychiatry 14:48. 2014
  4. pmc Body integrity identity disorder
    Rianne M Blom
    Department of Psychiatry, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    PLoS ONE 7:e34702. 2012
  5. pmc Is deep brain stimulation a treatment option for anorexia nervosa?
    Marloes S Oudijn
    Department of Psychiatry, Academic Medical Centre, University of Amsterdam, Meibergdreef 5, 1105, AZ Amsterdam, The Netherlands
    BMC Psychiatry 13:277. 2013
  6. doi request reprint Dopaminergic activity in Tourette syndrome and obsessive-compulsive disorder
    Damiaan Denys
    Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands the Netherlands Institute for Neuroscience, an institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, The Netherlands Electronic address
    Eur Neuropsychopharmacol 23:1423-31. 2013
  7. pmc Fluoxetine reduces murine graft-versus-host disease by induction of T cell immunosuppression
    Veerle Gobin
    Laboratory of Pharmaceutical Biotechnology, Faculty of Pharmaceutical Sciences, University of Ghent, Harelbekestraat 72, 9000 Ghent, Belgium
    J Neuroimmune Pharmacol 8:934-43. 2013
  8. doi request reprint Quetiapine augments the effect of citalopram in non-refractory obsessive-compulsive disorder: a randomized, double-blind, placebo-controlled study of 76 patients
    Nienke C C Vulink
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Centre Utrecht, Utrecht, The Netherlands
    J Clin Psychiatry 70:1001-8. 2009
  9. ncbi request reprint Effects of paroxetine and venlafaxine on immune parameters in patients with obsessive compulsive disorder
    Damiaan Denys
    Department of Psychiatry, UMC, Rudolf Magnus Institute of Neuroscience, B 01 206, P O Box 85500, 3508 GA Utrecht, The Netherlands
    Psychoneuroendocrinology 31:355-60. 2006
  10. ncbi request reprint A double-blind, randomized, placebo-controlled trial of quetiapine addition in patients with obsessive-compulsive disorder refractory to serotonin reuptake inhibitors
    Damiaan Denys
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    J Clin Psychiatry 65:1040-8. 2004

Collaborators

Detail Information

Publications76

  1. pmc Deep brain stimulation for treatment-refractory obsessive compulsive disorder: a systematic review
    Sina Kohl
    Department of Psychiatry and Psychotherapy, University of Cologne, Kerpener Strasse 62, Cologne, 50937, Germany
    BMC Psychiatry 14:214. 2014
    ..For some of these patients deep brain stimulation offers an appropriate treatment method. The scope of this article is to review the published data and to compare different target structures and their effectiveness...
  2. pmc Efficacy of oxytocin administration early after psychotrauma in preventing the development of PTSD: study protocol of a randomized controlled trial
    Jessie L Frijling
    Department of Psychiatry, Academic Medical Center, University of Amsterdam, Meibergdreef 5, 1105 AZ Amsterdam, The Netherlands
    BMC Psychiatry 14:92. 2014
    ..Therefore, we propose that oxytocin may be important in reducing adverse consequences of trauma. The 'BONDS' study is conducted in order to assess the efficacy of an early intervention with intranasal oxytocin for the prevention of PTSD...
  3. pmc The effects of Psychotropic drugs On Developing brain (ePOD) study: methods and design
    Marco A Bottelier
    Brain Imaging Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    BMC Psychiatry 14:48. 2014
    ..The effects of Psychotropic drugs On the Developing brain (ePOD) study is a combination of different approaches to determine whether there are related findings in humans...
  4. pmc Body integrity identity disorder
    Rianne M Blom
    Department of Psychiatry, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    PLoS ONE 7:e34702. 2012
    ..Aim of the study is to broaden the knowledge of BIID amongst medical professionals, by describing all who deal with BIID...
  5. pmc Is deep brain stimulation a treatment option for anorexia nervosa?
    Marloes S Oudijn
    Department of Psychiatry, Academic Medical Centre, University of Amsterdam, Meibergdreef 5, 1105, AZ Amsterdam, The Netherlands
    BMC Psychiatry 13:277. 2013
    ..Possible targets for DBS in AN are the ACC, the ventral anterior limb of the capsula interna (vALIC) and the VS. We suggest conducting larger efficacy studies that also explore the functional effects of DBS in AN. ..
  6. doi request reprint Dopaminergic activity in Tourette syndrome and obsessive-compulsive disorder
    Damiaan Denys
    Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands the Netherlands Institute for Neuroscience, an institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, The Netherlands Electronic address
    Eur Neuropsychopharmacol 23:1423-31. 2013
    ..In addition, it provides the first direct evidence that ventral striatal dopamine release is related to the pathophysiology of tics...
  7. pmc Fluoxetine reduces murine graft-versus-host disease by induction of T cell immunosuppression
    Veerle Gobin
    Laboratory of Pharmaceutical Biotechnology, Faculty of Pharmaceutical Sciences, University of Ghent, Harelbekestraat 72, 9000 Ghent, Belgium
    J Neuroimmune Pharmacol 8:934-43. 2013
    ..We discuss these results in the light of potential future exploration of SRIs as a novel class of T cell immunosuppressive drugs. ..
  8. doi request reprint Quetiapine augments the effect of citalopram in non-refractory obsessive-compulsive disorder: a randomized, double-blind, placebo-controlled study of 76 patients
    Nienke C C Vulink
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Centre Utrecht, Utrecht, The Netherlands
    J Clin Psychiatry 70:1001-8. 2009
    ..To assess the efficacy of quetiapine addition to citalopram in treatment-naive or medication-free obsessive-compulsive disorder (OCD) patients...
  9. ncbi request reprint Effects of paroxetine and venlafaxine on immune parameters in patients with obsessive compulsive disorder
    Damiaan Denys
    Department of Psychiatry, UMC, Rudolf Magnus Institute of Neuroscience, B 01 206, P O Box 85500, 3508 GA Utrecht, The Netherlands
    Psychoneuroendocrinology 31:355-60. 2006
    ..This study was carried out to investigate whether treatment with paroxetine and venlafaxine modifies the immune function in OCD and whether this modification is related to treatment outcome...
  10. ncbi request reprint A double-blind, randomized, placebo-controlled trial of quetiapine addition in patients with obsessive-compulsive disorder refractory to serotonin reuptake inhibitors
    Damiaan Denys
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    J Clin Psychiatry 65:1040-8. 2004
    ..This study was conducted to evaluate the efficacy and tolerability of quetiapine in addition to an SRI for treatment-refractory patients with OCD...
  11. doi request reprint Deep brain stimulation for obsessive-compulsive disorder affects language: a case report
    A Rosaura Polak
    Department of Psychiatry and Department of Neurosurgery, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands Arq Psychotrauma Expert Group, Diemen, The Netherlands Netherlands Institute for Neuroscience, an institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, The Netherlands
    Neurosurgery 73:E907-10; discussion E910. 2013
    ..Along with symptom improvement, DBS may have concurrent behavioral effects that help to unravel the role of specific brain circuitries in complex human behavior...
  12. ncbi request reprint Female hormones affect symptom severity in obsessive-compulsive disorder
    Nienke C C Vulink
    The Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    Int Clin Psychopharmacol 21:171-5. 2006
    ..Because reproductive cycle events influence the symptom severity of OCD, the menstrual cycle should be taken into account when assessing the severity of OCD symptoms during pharmacological studies...
  13. doi request reprint Top-down-directed synchrony from medial frontal cortex to nucleus accumbens during reward anticipation
    Michael X Cohen
    Department of Psychology, University of Amsterdam, Amsterdam, The Netherlands
    Hum Brain Mapp 33:246-52. 2012
    ....
  14. doi request reprint Deep brain stimulation restores frontostriatal network activity in obsessive-compulsive disorder
    Martijn Figee
    Department of Psychiatry, Academic Medical Center, Amsterdam, The Netherlands
    Nat Neurosci 16:386-7. 2013
    ..Our findings suggest that DBS is able to reduce maladaptive activity and connectivity of the stimulated region...
  15. doi request reprint Surgery for psychiatric disorders
    Judy Luigjes
    Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    World Neurosurg 80:S31.e17-28. 2013
    ..In addition, new indications for DBS and new target options should be explored in preclinical research. ..
  16. doi request reprint Catechol-O-methyltranferase gene expression is associated with response to citalopram in obsessive-compulsive disorder
    Nienke C C Vulink
    Department of Psychiatry, AMC, University of Amsterdam, Amsterdam, The Netherlands
    Int J Psychiatry Clin Pract 16:277-83. 2012
    ..To determine whether polymorphisms of the dopamine D(2) receptor (DRD2) and catechol-O-methyl-transferase (COMT) receptor genes affect the efficacy of quetiapine addition to citalopram in patients with OCD...
  17. doi request reprint Deep brain stimulation of the accumbens increases dopamine, serotonin, and noradrenaline in the prefrontal cortex
    Addy van Dijk
    Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Neurochem 123:897-903. 2012
    ..These results provide further evidence for the distal effects of DBS and corroborate previous clinical and pre-clinical findings of altered neuronal activity in prefrontal areas...
  18. doi request reprint Deep brain stimulation for obsessive-compulsive disorders: long-term analysis of quality of life
    Pieter Ooms
    Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Neurol Neurosurg Psychiatry 85:153-8. 2014
    ..To evaluate the long-term effects of deep brain stimulation (DBS) on quality of life (QOL) in therapy-refractory obsessive-compulsive disorder (OCD) patients...
  19. doi request reprint Deep brain stimulation of the nucleus accumbens for treatment-refractory obsessive-compulsive disorder
    Damiaan Denys
    Department of Psychiatry, Academic Medical Center, University of Amsterdam, The Netherlands
    Arch Gen Psychiatry 67:1061-8. 2010
    ..Even when the best available treatments are applied, approximately 10% of patients remain severely afflicted and run a long-term deteriorating course of OCD...
  20. doi request reprint Lipopolysaccharide-induced cytokine production in obsessive-compulsive disorder and generalized social anxiety disorder
    Sjoerd Fluitman
    The Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    Psychiatry Res 178:313-6. 2010
    ..This supports the idea of immunological involvement in the pathophysiology of OCD and suggests that GSAD and OCD might be different in immunological respect...
  21. ncbi request reprint Effects of quetiapine on cognitive functioning in obsessive-compulsive disorder
    Femke de Geus
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Int Clin Psychopharmacol 22:77-84. 2007
    ..It is proposed that this failure may be caused by attention difficulties owing to somnolence...
  22. ncbi request reprint A double-blind switch study of paroxetine and venlafaxine in obsessive-compulsive disorder
    Damiaan Denys
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    J Clin Psychiatry 65:37-43. 2004
    ..However, no controlled research has been published yet that prospectively examined the effects of changing SRIs. This article describes the first double-blind switch study of 2 SRIs in patients with OCD...
  23. ncbi request reprint Symptom dimensions in obsessive-compulsive disorder: factor analysis on a clinician-rated scale and a self-report measure
    Damiaan Denys
    Department of Psychiatry, University Medical Centre, Utrecht, The Netherlands
    Psychopathology 37:181-9. 2004
    ..This means that the use of both clinician-administered and self-report measures is recommended, so that the entire spectrum of symptoms is represented...
  24. ncbi request reprint Quetiapine addition in obsessive-compulsive disorder: is treatment outcome affected by type and dose of serotonin reuptake inhibitors?
    Damiaan Denys
    The Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    Biol Psychiatry 61:412-4. 2007
    ..The purpose of this study was to assess the effect of type and dose of serotonin reuptake inhibitors (SRIs) on treatment outcome in quetiapine addition trials for obsessive-compulsive disorder...
  25. ncbi request reprint A double blind comparison of venlafaxine and paroxetine in obsessive-compulsive disorder
    Damiaan Denys
    Department of Psychiatry, University Medical Center B 01 206, PO Box 85500, 3508 GA Utrecht, The Netherlands
    J Clin Psychopharmacol 23:568-75. 2003
    ..These results show that venlafaxine was equally effective to paroxetine in treating patients with OCD. Venlafaxine may be a useful therapy for obsessive-compulsive patients, but is not superior to SSRIs...
  26. doi request reprint Dysfunctional reward circuitry in obsessive-compulsive disorder
    Martijn Figee
    Department of Psychiatry, Academic Medical Center, Amsterdam, The Netherlands
    Biol Psychiatry 69:867-74. 2011
    ..This is the first functional imaging study to investigate explicitly reward circuitry in OCD...
  27. doi request reprint Deep brain stimulation for obsessive-compulsive disorder is associated with cortisol changes
    Pelle P de Koning
    Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Psychoneuroendocrinology 38:1455-9. 2013
    ..The increase in Y-BOCS (39%), and HAM-D (78%) scores correlated strongly with increased UFC levels in the OFF condition. Our findings indicate that symptom changes following DBS for OCD patients are associated with changes in UFC levels...
  28. ncbi request reprint Bupropion for patients with obsessive-compulsive disorder: an open-label, fixed-dose study
    Nienke C C Vulink
    Department of Psychiatry, University Medical Center Utrecht, The Rudolf Magnus Institute of Neuroscience, Utrecht, The Netherlands
    J Clin Psychiatry 66:228-30. 2005
    ..In the present study, we examined the efficacy of bupropion for patients with obsessive-compulsive disorder (OCD)...
  29. ncbi request reprint New pharmacotherapeutic approaches to obsessive-compulsive disorder
    Martijn Figee
    Department of Psychiatry, Academic Medical Centre, University of Amsterdam, The Netherlands
    CNS Spectr 14:13-23. 2009
    ..Lastly, successful treatment with an SSRI results in both serotonergic and dopaminergic changes, but more research is necessary in order to define the biological characteristics of responders and nonresponders...
  30. ncbi request reprint A score for predicting response to pharmacotherapy in obsessive-compulsive disorder
    Damiaan Denys
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, The Netherlands
    Int Clin Psychopharmacol 18:315-22. 2003
    ..63-0.8), demonstrating a reasonable discriminatory power. This study is the first to present a model that can estimate by the use of prediction rules the probability of treatment response to antidepressants in patients with OCD...
  31. doi request reprint Current status of deep brain stimulation for obsessive-compulsive disorder: a clinical review of different targets
    Pelle P de Koning
    Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Curr Psychiatry Rep 13:274-82. 2011
    ..We conclude that DBS may be a promising and safe therapy for treatment-resistant OCD...
  32. doi request reprint Review of atypical antipsychotics in anxiety
    Nienke C C Vulink
    Department of Psychiatry, Academic Medical Center, University of Amsterdam, The Netherlands
    Eur Neuropsychopharmacol 21:429-49. 2011
    ..In addition, higher dropout rates and side effects from treatment with atypical antipsychotics may limit the use of atypical antipsychotics in patients with anxiety disorders...
  33. ncbi request reprint The role of dopamine in obsessive-compulsive disorder: preclinical and clinical evidence
    Damiaan Denys
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    J Clin Psychiatry 65:11-7. 2004
    ..In this review, the preclinical and clinical evidence on the role of dopamine in OCD is summarized...
  34. pmc Compulsive carnival song whistling following cardiac arrest: a case study
    A Rosaura Polak
    Department of Anxiety Disorders, Academic Medical Center AMC, University of Amsterdam UvA, Meibergdreef 5, Amsterdam, 1105 AZ, The Netherlands
    BMC Psychiatry 12:75. 2012
    ..In this case report, we describe a patient who developed compulsivity following cardiac arrest. We review diagnostic options, underlying mechanisms and possible treatments...
  35. ncbi request reprint Prediction of response to paroxetine and venlafaxine by serotonin-related genes in obsessive-compulsive disorder in a randomized, double-blind trial
    Damiaan Denys
    Department of Psychiatry, The Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    J Clin Psychiatry 68:747-53. 2007
    ..The purpose of the present study was to determine whether polymorphisms of the serotonin transporter (5-HTT), 5-HT1B, and 5-HT2A receptor genes affect the efficacy of SRI treatment in OCD...
  36. doi request reprint Prazosin addition to fluvoxamine: A preclinical study and open clinical trial in OCD
    Matthijs G P Feenstra
    Department of Psychiatry, Academic Medical Center, University of Amsterdam, The Netherlands Netherlands Institute for Neuroscience, an institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, The Netherlands
    Eur Neuropsychopharmacol 26:310-9. 2016
    ..controlled-trials.com/ISRCTN61562706. ..
  37. doi request reprint Rebound of affective symptoms following acute cessation of deep brain stimulation in obsessive-compulsive disorder
    Pieter Ooms
    Department of Psychiatry, Academic Medical Center, University of Amsterdam, P O Box 75867, 1070 AW Amsterdam, The Netherlands Electronic address
    Brain Stimul 7:727-31. 2014
    ..Deep brain stimulation (DBS) is regarded as an effective way to treat refractory obsessive-compulsive disorder (OCD). Little is known about the effects of DBS cessation following a longer period of stimulation...
  38. ncbi request reprint Low level of dopaminergic D2 receptor binding in obsessive-compulsive disorder
    Damiaan Denys
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    Biol Psychiatry 55:1041-5. 2004
    ..Despite growing evidence for involvement of the dopaminergic system in obsessive-compulsive disorder (OCD), the functional anatomy of the dopaminergic system in the basal ganglia has been investigated sparsely...
  39. ncbi request reprint Use of factor analysis to detect potential phenotypes in obsessive-compulsive disorder
    Damiaan Denys
    Department of Psychiatry, University Medical Center, HP B 01 206, PO Box 85500, GA Utrecht 3508, The Netherlands
    Psychiatry Res 128:273-80. 2004
    ..We observed significant differences in sex distribution, age of onset, Y-BOCS scores and familial prevalence of OCD in relation to the symptom dimensions. These findings provide further evidence for distinct clinical phenotypes in OCD...
  40. doi request reprint Deep brain stimulation induces striatal dopamine release in obsessive-compulsive disorder
    Martijn Figee
    Department of Psychiatry, Academic Medical Center, Amsterdam Brain Imaging Center, Academic Medical Center, Amsterdam Electronic address
    Biol Psychiatry 75:647-52. 2014
    ..Deep brain stimulation (DBS) targeted at the nucleus accumbens (NAc) has recently become an effective treatment for therapy-refractory obsessive-compulsive disorder, but its effect on dopaminergic transmission is unknown...
  41. pmc Comparison of the effectiveness of trauma-focused cognitive behavioral therapy and paroxetine treatment in PTSD patients: design of a randomized controlled trial
    A Rosaura Polak
    Academic Medical Center, Department of Anxiety Disorders, University of Amsterdam, Meibergdreef 5, Amsterdam 1105 AZ, The Netherlands
    BMC Psychiatry 12:166. 2012
    ..International guidelines recommend trauma-focused psychological interventions for all PTSD patients as first-line treatment (NICE). However, no clear-cut evidence is available to support this recommendation...
  42. ncbi request reprint Sexual pleasure in women with obsessive-compulsive disorder?
    Nienke C C Vulink
    The Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht UMCU, B 01 206, P O Box 85500, 3508 GA Utrecht, The Netherlands
    J Affect Disord 91:19-25. 2006
    ..This study compared subjective appreciation of sexuality and sexual functioning between OCD patients and healthy subjects and controlled for the influence of medication or OCD subtypes on sexual functioning and satisfaction...
  43. ncbi request reprint Spatial working memory in obsessive-compulsive disorder improves with clinical response: A functional MRI study
    Nic J A van der Wee
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Heidelberglaan 100, 3584 X Utrecht, The Netherlands
    Eur Neuropsychopharmacol 17:16-23. 2007
    ..Our preliminary findings suggests that spatial working memory deficits in OCD and their functional anatomical correlates, as assessed with a spatial n-back task, are, at least to some extent, state dependent...
  44. doi request reprint Co-occurrence of obsessive-compulsive disorder and substance use disorder in the general population
    Rianne M Blom
    Department of Psychiatry, Academical Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Addiction 106:2178-85. 2011
    ..The aim of this study is to compare the co-occurrence of OCD with SUD to the co-occurrence of SUD with other psychiatric disorders in a representative community sample...
  45. pmc Cognitive effects of deep brain stimulation in patients with obsessive-compulsive disorder
    Mariska Mantione
    From the Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands Mantione, Nieman, Figee, Denys the Department of Neurosurgery, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands van den Munckhof, Schuurman and the Netherlands Institute for Neuroscience, an institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, The Netherlands Denys
    J Psychiatry Neurosci 40:378-86. 2015
    ..However, the effects of DBS on cognitive functioning remain unclear. Therefore, we aimed to assess cognitive safety of DBS for treatment-refractory OCD and the association between clinical changes and cognitive functioning...
  46. ncbi request reprint Synergistic dopamine increase in the rat prefrontal cortex with the combination of quetiapine and fluvoxamine
    Damiaan Denys
    Department of Psychiatry, The Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, P O Box 85500, 3508 GA Utrecht, The Netherlands
    Psychopharmacology (Berl) 176:195-203. 2004
    ....
  47. ncbi request reprint Predictors of pharmacotherapy response in anxiety disorders
    Damiaan Denys
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center, 3508 GA Utrecht, The Netherlands
    Curr Psychiatry Rep 7:252-7. 2005
    ..Prediction of treatment response may be founded on demographic and clinical variables, neurochemical and electrophysiologic parameters, imaging studies, and genetic markers...
  48. doi request reprint Cognitive functioning in psychiatric disorders following deep brain stimulation
    Isidoor O Bergfeld
    Department of Psychiatry, Academic Medical Center, University of Amsterdam, P O Box 22660, 1100 DD Amsterdam, The Netherlands
    Brain Stimul 6:532-7. 2013
    ..Although cognitive deterioration has repeatedly been shown in patients with Parkinson's disease following DBS, the impact of DBS on cognitive functioning in psychiatric patients has not yet been reviewed...
  49. ncbi request reprint A case of venlafaxine-induced inhibition of T-lymphocyte proliferation
    Damiaan Denys
    Department of Psychiatry, University Medical Center, Utrecht, The Netherlands
    Psychopharmacology (Berl) 164:432. 2002
  50. pmc Neural basis of limb ownership in individuals with body integrity identity disorder
    Milenna T van Dijk
    Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands Sackler Institute of Graduate Biomedical Sciences, New York University School of Medicine, New York, New York, United States of America
    PLoS ONE 8:e72212. 2013
    ..These results suggest that altered somatosensory processing in the premotor cortex is associated with the feeling of disownership in BIID, which may be related to altered integration of somatosensory and proprioceptive information. ..
  51. doi request reprint Deep brain stimulation increases impulsivity in two patients with obsessive-compulsive disorder
    Judy Luigjes
    Department of Psychiatry, Academic Medical Center, University of Amsterdam, The Netherlands
    Int Clin Psychopharmacol 26:338-40. 2011
    ..Location and amplitude of stimulation might be critical in inducing these behaviours. These two cases underline the importance of a careful clinical assessment of impulsive behaviours during DBS for OCD...
  52. doi request reprint Neurosurgical targets for compulsivity: what can we learn from acquired brain lesions?
    Martijn Figee
    Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Neurosci Biobehav Rev 37:328-39. 2013
    ..These case reports provide strong evidence supporting the rationale for DBS in the ventral striatum and internal capsule for treatment of compulsivity and reveal the putamen and fronto-parietal cortex as promising new targets...
  53. pmc What Cure Models Can Teach us About Genome-Wide Survival Analysis
    Sven Stringer
    Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research CNCR, Neuroscience Campus Amsterdam NCA, VU Amsterdam, Amsterdam, The Netherlands
    Behav Genet 46:269-80. 2016
    ..Since genome-wide cure survival analysis is not computationally feasible, we recommend this analysis for genetic variants that are significant in a traditional survival analysis. ..
  54. doi request reprint Executive function in posttraumatic stress disorder (PTSD) and the influence of comorbid depression
    Miranda Olff
    Department of Psychiatry, Academic Medical Center AMC, University of Amsterdam UvA, Amsterdam, The Netherlands Arq Psychotrauma Expert Group, Nienoord 5, 1112 XE Diemen, The Netherlands Electronic address
    Neurobiol Learn Mem 112:114-21. 2014
    ..Recently, studies have shown that verbal memory impairments may be associated with comorbid depressive symptoms, but their role in executive function impairments is still unclear...
  55. pmc Striatal dopamine D2/3 receptor availability in treatment resistant depression
    Bart P de Kwaasteniet
    Department of Psychiatry, Academic Medical Center, Amsterdam, the Netherlands Brain Imaging Center, Academic Medical Center, Amsterdam, The Netherlands
    PLoS ONE 9:e113612. 2014
    ..Atypical antipsychotics appear to have no clinical benefit in severe TRD patients who remain depressed, despite their strong occupancy of D2/3Rs...
  56. pmc Update on repetitive transcranial magnetic stimulation in obsessive-compulsive disorder: different targets
    Rianne M Blom
    Department of Psychiatry, Academic Medical Center, University of Amsterdam, PA 3 127, P O Box 75867, 1070 AW, Amsterdam, The Netherlands
    Curr Psychiatry Rep 13:289-94. 2011
    ..In general, rTMS appears to be effective in open-label studies; however, this has not yet been replicated in randomized, sham-controlled trials...
  57. pmc Misophonia: diagnostic criteria for a new psychiatric disorder
    Arjan Schröder
    Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    PLoS ONE 8:e54706. 2013
    ..This condition is relatively unknown and has hitherto never been described, although the phenomenon has anecdotally been named misophonia...
  58. doi request reprint Selective serotonin reuptake inhibitors as a novel class of immunosuppressants
    Veerle Gobin
    Laboratory of Pharmaceutical Biotechnology, University of Ghent, Belgium
    Int Immunopharmacol 20:148-56. 2014
    ..This review summarizes preclinical and clinical evidence supporting a role for SSRIs in autoimmune diseases and graft-versus-host disease, and discusses what is known about the mechanism underlying these effects. ..
  59. ncbi request reprint Decreased TNF-alpha and NK activity in obsessive-compulsive disorder
    Damiaan Denys
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    Psychoneuroendocrinology 29:945-52. 2004
    ..This study was carried out to investigate whether obsessive-compulsive disorder is associated with altered activity of the immune system, and whether these changes are related to particular clinical characteristics...
  60. doi request reprint Postoperative displacement of deep brain stimulation electrodes related to lead-anchoring technique
    M Fiorella Contarino
    Departments of Neurology Neurosurgery and Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands Department of Neurology, University Medical Centre Groningen, Groningen, The Netherlands
    Neurosurgery 73:681-8; discussion 188. 2013
    ..Displacement of deep brain stimulation (DBS) electrodes may occur after surgery, especially due to large subdural air collections, but other factors might contribute...
  61. doi request reprint Smoking cessation and weight loss after chronic deep brain stimulation of the nucleus accumbens: therapeutic and research implications: case report
    Mariska Mantione
    Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Neurosurgery 66:E218; discussion E218. 2010
    ..In this case report, we describe a patient who quit smoking and lost weight without any effort, and we review the underlying mechanisms of action...
  62. doi request reprint Unilateral deep brain stimulation in the nucleus accumbens core does not affect local monoamine release
    Addy van Dijk
    Department of Psychiatry, Academic Medical Center, University of Amsterdam, Postbus 22660, 1100 DD Amsterdam, The Netherlands
    J Neurosci Methods 202:113-8. 2011
    ..For future directions it is interesting to note that several microdialysis and electrophysiology studies have shown effects of DBS in areas distant from the stimulation target...
  63. ncbi request reprint Emerging skin-picking behaviour after serotonin reuptake inhibitor-treatment in patients with obsessive-compulsive disorder: possible mechanisms and implications for clinical care
    Damiaan Denys
    Department of Psychiatry, University Medical Centre, Utrecht, The Netherlands
    J Psychopharmacol 17:127-9. 2003
    ..Two case reports are presented demonstrating that SSRI-treatment may induce or aggravate pathological skin-picking behaviour. Possible mechanisms of SSRI-induced pathological skin-picking and implications for clinical care are discussed...
  64. doi request reprint Incidence and prevalence of "diagnosed OCD" in a primary care, treatment seeking, population
    Joris Veldhuis
    Department of Psychiatry, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Int J Psychiatry Clin Pract 16:85-92. 2012
    ..To obtain valid and accurate estimates of the incidence and prevalence of OCD in a treatment-seeking primary care population and to compare these estimates with estimates from epidemiological community studies...
  65. doi request reprint Relation between structural and functional connectivity in major depressive disorder
    Bart de Kwaasteniet
    Department of Psychiatry, Brain Imaging Center, Amsterdam, The Netherlands
    Biol Psychiatry 74:40-7. 2013
    ..Here, we used a multimodal neuroimaging approach to investigate the relation between structural connectivity and functional connectivity within the frontolimbic network...
  66. doi request reprint A guide on gene prioritization in studies of psychiatric disorders
    Sven Stringer
    Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Int J Methods Psychiatr Res 24:245-56. 2015
    ..Copyright © 2015 John Wiley & Sons, Ltd. ..
  67. pmc Breathing biofeedback as an adjunct to exposure in cognitive behavioral therapy hastens the reduction of PTSD symptoms: a pilot study
    A Rosaura Polak
    Department of Anxiety Disorders, Academic Medical Center AMC, University of Amsterdam UvA, Meibergdreef 5, 1105 AZ, Amsterdam, The Netherlands
    Appl Psychophysiol Biofeedback 40:25-31. 2015
    ..The mechanism of action of breathing biofeedback may relate to competing working memory resources decreasing vividness and emotionality, similar to eye movement desensitization and reprocessing. Future research is needed to examine this...
  68. doi request reprint On the nature of obsessions and compulsions
    Sanneke de Haan
    Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Mod Trends Pharmacopsychiatri 29:1-15. 2013
    ..Moreover, we suggest that the patients' attempts to attain certainty are counter-productive as their excessive conscious control in fact undermines the trust they need. ..
  69. ncbi request reprint Prevalence of psychotic disorders in patients with obsessive-compulsive disorder
    Lieuwe De Haan
    Department of Psychiatry, Academic Medical Centre, Amsterdam
    CNS Spectr 14:415-7. 2009
    ..However, the rate of psychosis comorbidity in OCD patients has yet to be systematically evaluated...
  70. doi request reprint Incidence rates and risk factors of bipolar disorder in the general population: a population-based cohort study
    Jojanneke S Kroon
    Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Bipolar Disord 15:306-13. 2013
    ..To estimate the incidence rates (IRs) of bipolar I and bipolar II disorders in the general population according to sociodemographic population characteristics...
  71. doi request reprint Obsessive-compulsive disorder and female reproductive cycle events: results from the OCD and reproduction collaborative study
    Valeria Guglielmi
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Depress Anxiety 31:979-87. 2014
    ....
  72. ncbi request reprint Quetiapine addition to serotonin reuptake inhibitor treatment in patients with treatment-refractory obsessive-compulsive disorder: an open-label study
    Damiaan Denys
    Department of Psychiatry, University Medical Center, Utrecht, The Netherlands
    J Clin Psychiatry 63:700-3. 2002
    ..The objective of this study was to examine whether addition of the atypical antipsychotic quetiapine to SRIs is useful for patients with OCD who do not respond to SRI monotherapy...
  73. doi request reprint Neuromodulation in obsessive-compulsive disorder
    Melisse Bais
    Department of Psychiatry, Academic Medical Center, Meibergdreef 5, Amsterdam 1105 AZ, The Netherlands
    Psychiatr Clin North Am 37:393-413. 2014
    ..DBS shows a response rate of 60% in open and sham-controlled studies. In OCD, it can be concluded that DBS, although more invasive, is the most efficacious technique. ..
  74. doi request reprint Deep brain stimulation in obsessive-compulsive disorder
    Damiaan Denys
    Department of Psychiatry, AMC, Netherlands Institute for Neuroscience, Amsterdam, The Netherlands
    Prog Brain Res 175:419-27. 2009
    ..The speed of the effect of deep brain stimulation causes fundamental assumptions on the pathophysiology of obsessive-compulsive disorder...
  75. doi request reprint Social affordances in context: what is it that we are bodily responsive to?
    Erik Rietveld
    Cognitive Science Center Amsterdam, University of Amsterdam, 1018 WS Amsterdam, The Netherlands
    Behav Brain Sci 36:436. 2013
    ....
  76. doi request reprint Region-specific modulations in oscillatory alpha activity serve to facilitate processing in the visual and auditory modalities
    Ali Mazaheri
    Department of Psychiatry, Academic Medical Center, University of Amsterdam, The Netherlands Electronic address
    Neuroimage 87:356-62. 2014
    ..Here, we find that this phenomenon is not restricted to the domain of spatial attention and can be generalized to other sensory modalities than vision...