Ole D Wolthers

Summary

Affiliation: University of Copenhagen
Country: Denmark

Publications

  1. ncbi Short-term growth after withdrawal of exogenous glucocorticoids
    Ole D Wolthers
    Children s Clinic Randers, Randers, Denmark
    Horm Res 64:116-8. 2005
  2. ncbi Impact of inhaled and intranasal corticosteroids on the growth of children
    O D Wolthers
    Department of Paediatrics, Randers Hospital, DK 8900 Randers, Denmark
    BioDrugs 13:347-57. 2000
  3. ncbi Measures of hypothalamic-pituitary-adrenal function in patients with asthma treated with inhaled glucocorticoids: clinical and research implications
    O D Wolthers
    Department of Paediatrics, Randers Hospital, Denmark
    J Asthma 36:477-86. 1999
  4. ncbi Eosinophil granule proteins in the assessment of airway inflammation in pediatric bronchial asthma
    O D Wolthers
    Children s Clinic Randers, Randers, Denmark
    Pediatr Allergy Immunol 14:248-54. 2003
  5. ncbi Circadian variations in serum eosinophil cationic protein, and serum and urine eosinophil protein X
    O D Wolthers
    Children s Clinic Randers, Randers, Department of Paediatrics, Denmark
    Pediatr Allergy Immunol 14:130-3. 2003
  6. ncbi Growth problems in children with asthma
    Ole D Wolthers
    Children s Clinic Randers, Randers, Denmark
    Horm Res 57:83-7. 2002
  7. ncbi Systemic activity versus systemic adverse effects of nasal glucocorticoids in the treatment of allergic rhinitis
    O D Wolthers
    Department of Paediatrics, Randers Hospital, Denmark
    Acta Paediatr 89:1158-61. 2000
  8. ncbi Inhaled corticosteroids and growth
    O D Wolthers
    Children s Clinic Randers, Denmark
    J Pediatr Endocrinol Metab 14:1487-90. 2001
  9. ncbi Does vitamin D administered to children with asthma treated with inhaled glucocorticoids affect short-term growth or bone turnover?
    Anders J Schou
    Children s Clinic Randers, Randers, Denmark
    Pediatr Pulmonol 36:399-404. 2003
  10. ncbi Short-term growth in children with eczema during treatment with topical mometasone furoate and tacrolimus
    Josefine Gradman
    Children s Clinic Randers, Randers, Denmark
    Acta Paediatr 96:1233-7. 2007

Detail Information

Publications30

  1. ncbi Short-term growth after withdrawal of exogenous glucocorticoids
    Ole D Wolthers
    Children s Clinic Randers, Randers, Denmark
    Horm Res 64:116-8. 2005
    ..The growth-suppressive effect of systemic glucocorticoids in children is well established, however, recovery of growth after withdrawal of short-term treatment in school-age children has not been evaluated...
  2. ncbi Impact of inhaled and intranasal corticosteroids on the growth of children
    O D Wolthers
    Department of Paediatrics, Randers Hospital, DK 8900 Randers, Denmark
    BioDrugs 13:347-57. 2000
    ..Topical corticosteroids should be given in doses that control disease symptoms; however, height measurements should be performed regularly in children receiving corticosteroids...
  3. ncbi Measures of hypothalamic-pituitary-adrenal function in patients with asthma treated with inhaled glucocorticoids: clinical and research implications
    O D Wolthers
    Department of Paediatrics, Randers Hospital, Denmark
    J Asthma 36:477-86. 1999
    ..Measures of basal adrenal activity are useful in clinical trials that assess and compare systemic activity of specific drugs, application devices, and administration regimens, but have no place in the management of asthma...
  4. ncbi Eosinophil granule proteins in the assessment of airway inflammation in pediatric bronchial asthma
    O D Wolthers
    Children s Clinic Randers, Randers, Denmark
    Pediatr Allergy Immunol 14:248-54. 2003
    ..In the future, perhaps, a combination of products of inflammatory cells may give more clinically relevant information with respect to prediction, diagnosis, monitoring and outcome of childhood asthma...
  5. ncbi Circadian variations in serum eosinophil cationic protein, and serum and urine eosinophil protein X
    O D Wolthers
    Children s Clinic Randers, Randers, Department of Paediatrics, Denmark
    Pediatr Allergy Immunol 14:130-3. 2003
    ..To avoid confounding influence from circadian variations in ECP and EPX in clinical studies blood or urine should be sampled at consistent times...
  6. ncbi Growth problems in children with asthma
    Ole D Wolthers
    Children s Clinic Randers, Randers, Denmark
    Horm Res 57:83-7. 2002
    ....
  7. ncbi Systemic activity versus systemic adverse effects of nasal glucocorticoids in the treatment of allergic rhinitis
    O D Wolthers
    Department of Paediatrics, Randers Hospital, Denmark
    Acta Paediatr 89:1158-61. 2000
    ..Children on long-term treatment with intranasal glucocorticoids should be followed with height measurements every 6 mo...
  8. ncbi Inhaled corticosteroids and growth
    O D Wolthers
    Children s Clinic Randers, Denmark
    J Pediatr Endocrinol Metab 14:1487-90. 2001
    ..In children with severe asthma, high doses of inhaled corticosteroids may be potentially lifesaving and thus outweigh the potential risk of mild growth suppression...
  9. ncbi Does vitamin D administered to children with asthma treated with inhaled glucocorticoids affect short-term growth or bone turnover?
    Anders J Schou
    Children s Clinic Randers, Randers, Denmark
    Pediatr Pulmonol 36:399-404. 2003
    ..In conclusion, administration of 25-OH-vitamin D does not affect short-term growth or markers of bone turnover in children with asthma treated with inhaled dry-powder budesonide 400 microg daily...
  10. ncbi Short-term growth in children with eczema during treatment with topical mometasone furoate and tacrolimus
    Josefine Gradman
    Children s Clinic Randers, Randers, Denmark
    Acta Paediatr 96:1233-7. 2007
    ..Treatment with topical glucocorticoids in children with atopic eczema may be associated with systemic adverse effects, such as suppression of growth...
  11. doi Suppressive effects of topical mometasone furoate and tacrolimus on skin prick testing in children
    Josefine Gradman
    Children s Clinic Randers, Randers, Denmark
    Pediatr Dermatol 25:269-70. 2008
    ..Mometasone furoate reduced the histamine wheal size as well. Skin prick testing in children treated with topical glucocorticoids or tacrolimus is associated with a risk of false-negative test results...
  12. doi Anti-inflammatory treatment of asthma: differentiation and trial-and-error
    Ole D Wolthers
    Asthma and Allergy Clinic, Children s Clinic Randers, 8900 Randers, Denmark
    Acta Paediatr 98:1237-41. 2009
    ..In toddlers with viral wheeze and in children with mild asthma oral leukotriene receptor antagonists or inhaled corticosteroids may be given on a trial-and-error basis...
  13. ncbi A 2-week, crossover study to investigate the effect of fluticasone furoate nasal spray on short-term growth in children with allergic rhinitis
    Josefine Gradman
    Asthma and Allergy Clinic, Children s Clinic Randers, Randers, Denmark
    Clin Ther 29:1738-47. 2007
    ..Fluticasone furoate is a recently approved, enhanced- affinity intranasal corticosteroid with low systemic bioavailability and proven efficacy in treating allergic rhinitis...
  14. doi A randomized trial of lower leg and height growth in children with asthma treated with inhaled budesonide from a new dry powder inhaler
    Josefine Gradman
    Children s Clinic Randers, Randers, Denmark
    Pediatr Allergy Immunol 21:e206-12. 2010
    ..Short-term knemometry should be performed as part of the safety assessments of new inhaled corticosteroids and inhalation devices in children with asthma before long-term height growth evaluations are initiated...
  15. ncbi Relevance of pharmacokinetics and bioavailability of intranasal corticosteroids in allergic rhinitis
    Ole D Wolthers
    Asthma and Allergy Clinic, Children s Clinic Randers, Randers, Germany
    Recent Pat Inflamm Allergy Drug Discov 4:118-23. 2010
    ..Evidence for intranasal corticosteroids in pre-school children has not been provided. In this paper, a brief review of recent patents for the treatment of allergic rhinitis has also been presented...
  16. ncbi Differential effects of short-term prednisolone treatment on peripheral and abdominal subcutaneous thickness in children assessed by ultrasound
    Anders J Schou
    Children s Clinic Randers, Dytmaersken 9, 3, Dk 8900, Randers, Denmark
    Steroids 68:525-31. 2003
    ..Short-term treatment with 5mg prednisolone daily may cause differential effects in peripheral and abdominal subcutaneous thickness in children...
  17. ncbi Anti-neutrophil cytoplasmic autoantibody (ANCA) profiles in propylthiouracil-induced lupus-like manifestations in monozygotic triplets with hyperthyroidism
    Troels Herlin
    Department of Pediatrics, Skejby Sygehus, Aarhus University Hospital, Denmark
    Scand J Rheumatol 31:46-9. 2002
    ..Triplet A and B, but not C, both developed a strongly positive elastase-ANCA. Our results confirm the importance of a genetic factor influencing the susceptibility to drug-induced LE...
  18. ncbi Age and gender related differences in children's evaluation of procedures experienced during participation in clinical research
    Ole D Wolthers
    Children s Clinic Randers, Dytmaersken 9, 8900 Randers, Denmark
    Eur J Pediatr 164:50-1. 2005
  19. ncbi New patents of fixed combinations of nasal antihistamines and corticosteroids in allergic rhinitis
    Ole D Wolthers
    Asthma and Allergy Clinic, Children s Clinic Randers, Dytmærsken 9, 8900 Randers, Denmark
    Recent Pat Inflamm Allergy Drug Discov 7:223-8. 2013
    ..Fixed combination treatment of azelastine and fluticasone propionate may offer additional benefit to selected populations of adolescents and adults with moderate-to-severe symptoms...
  20. doi Systemic activity of inhaled beclomethasone dipropionate: a double-blind comparison of volume spacers
    Ole D Wolthers
    Children s Clinic Randers, Denmark
    Acta Paediatr 101:159-63. 2012
    ..To which extent volume spacers may influence systemic activity of inhaled beclomethasone dipropionate (BDP) has not been evaluated...
  21. ncbi Growth suppression caused by corticosteroid eye drops
    Ole D Wolthers
    Children s Clinic Randers, Randers, Denmark
    J Pediatr Endocrinol Metab 24:393-4. 2011
    ..Two weeks treatment with fluorometholone eye drops in a case series of five children caused growth suppression detected by knemometry. The suppression had no impact on height growth during the following year...
  22. doi Short-term lower leg growth in 5- to 11-year-old asthmatic children using beclomethasone dipropionate inhalers with chlorofluorocarbon or hydrofluoroalkane propellants: a 9-week, open-label, randomized, crossover, noninferiority study
    Ole D Wolthers
    Children s Clinic Randers, Randers, Denmark
    Clin Ther 33:1069-76. 2011
    ..Beclomethasone dipropionate-hydrofluoroalkane (BDP-HFA) is a non-chlorofluorocarbon (CFC)-propelled metered dose inhaler. Data is needed to support the registration of BDP-HFA in pediatric populations for countries in the European Union...
  23. ncbi Diurnal leptin rhythms in children treated with prednisolone once daily in the morning or in the evening
    Ole D Wolthers
    Children s Clinic Randers, Denmark
    J Pediatr Endocrinol Metab 15:313-8. 2002
    ..44, p = 0.53). Therefore, the timing of administration of exogenous glucocorticoids does not affect diurnal leptin rhythms in children...
  24. ncbi The usefulness of the multiple allergen simultaneous test-chemiluminescent as compared to the Phadia Immunocap IgE test panel system in children and adolescents
    Ole D Wolthers
    Asthma and Allergy Clinic, Children s Clinic Randers, Dytmaersken 9, DK 8900 Randers, Denmark
    Recent Pat Inflamm Allergy Drug Discov 7:96-9. 2013
    ..The sensitizations gave clinically useful information in 7 patients (6.6%). As compared to the Phadia CAP the MAST CLA screening test panel adds little to the diagnostic work-up of IgE mediated disease in children and adolescents...
  25. ncbi Allergic conjunctivitis in children with asthma, rhinitis and eczema in a secondary outpatient clinic
    Josefine Gradman
    Children s Clinic Randers, Randers, Denmark
    Pediatr Allergy Immunol 17:524-6. 2006
    ..Allergic conjunctivitis need to be included as an important co-morbidity in future guidelines on asthma, rhinitis and eczema management...
  26. ncbi Placebo-controlled study of montelukast and budesonide on short-term growth in prepubertal asthmatic children
    Søren Pedersen
    University of Southern Denmark, Kolding Hospital, Kolding, Denmark
    Pediatr Pulmonol 42:838-43. 2007
    ..The aim of this study was to assess the influence of montelukast on short-term lower leg growth rate (LLGR) in prepubertal children with asthma...
  27. ncbi Inhaled corticosteroids, growth, and compliance
    Ole D Wolthers
    N Engl J Med 347:1210-1. 2002
  28. ncbi [Longitudinal growth in children with asthma treated with inhaled glucocorticoids]
    Josefine Gradman
    Randers, Speciallaegepraksis, BørneklinikkenRanders
    Ugeskr Laeger 168:885-9. 2006
    ..Children with asthma on continuous treatment with inhaled glucocorticoids should have their height measured at six-month intervals. In the case of growth deviation, they should be referred for evaluation...
  29. ncbi Gender differences of oligomers and total adiponectin during puberty: a cross-sectional study of 859 Danish school children
    Kristian Kjaer Andersen
    The Medical Research Laboratories, Clinical Institute, Medical Department M Diabetes and Endocrinology, Aarhus University Hospital, DK 8000 Aarhus C, Denmark
    J Clin Endocrinol Metab 92:1857-62. 2007
    ..Pubertal stages have been shown to influence total adiponectin (ADPN) levels. Furthermore, testosterone has been shown to alter the isomer distribution of ADPN...
  30. ncbi Normal growth spurt and final height despite low levels of all forms of circulating insulin-like growth factor-I in a patient with acid-labile subunit deficiency
    Horacio M Domene
    Endocrinology Research Center CEDIE, Division of Endocrinology, Ricardo Gutierrez Children s Hospital, Buenos Aires, Argentina
    Horm Res 67:243-9. 2007
    ..To further study the role of circulating versus locally produced IGF-I in skeletal growth in this patient, we now describe in detail growth changes and their relationship with several components of the circulating IGF system...