Flemming Tofteng

Summary

Affiliation: University of Copenhagen
Country: Denmark

Publications

  1. ncbi request reprint The effect of indomethacin on intracranial pressure, cerebral perfusion and extracellular lactate and glutamate concentrations in patients with fulminant hepatic failure
    Flemming Tofteng
    Department of Hepatology, Rigshospitalet, Copenhagen University Hospital, Denmark
    J Cereb Blood Flow Metab 24:798-804. 2004
  2. doi request reprint Brain hypoxanthine concentration correlates to lactate/pyruvate ratio but not intracranial pressure in patients with acute liver failure
    Peter Nissen Bjerring
    Department of Hepatology, Rigshospitalet, University Hospital of Copenhagen, Denmark
    J Hepatol 53:1054-8. 2010
  3. doi request reprint Cerebral glutamine concentration and lactate-pyruvate ratio in patients with acute liver failure
    Peter Nissen Bjerring
    Department of Hepatology, section A 2121, Rigshospitalet, University Hospital of Copenhagen, Blegdamsvej 9, 2100, Copenhagen O, Denmark
    Neurocrit Care 9:3-7. 2008
  4. pmc Effect of Prometheus liver assist system on systemic hemodynamics in patients with cirrhosis: a randomized controlled study
    Thomas Dethloff
    Department of Hepatology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    World J Gastroenterol 14:2065-71. 2008
  5. ncbi request reprint Monitoring extracellular concentrations of lactate, glutamate, and glycerol by in vivo microdialysis in the brain during liver transplantation in acute liver failure
    Flemming Tofteng
    Department of Hepatology, Rigshospitalet, University Hospital of Copenhagen, Denmark
    Liver Transpl 8:302-5. 2002
  6. ncbi request reprint Cerebral microdialysis in patients with fulminant hepatic failure
    Flemming Tofteng
    Department of Hepatology and Neurosurgery, Rigshospitalet, University Hospital of Copenhagen, Denmark
    Hepatology 36:1333-40. 2002
  7. ncbi request reprint Cerebral oxygenation determined by near-infrared spectrophotometry in patients with fulminant hepatic failure
    Henning Bay Nielsen
    Department of Hepatology, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, 2100, København Ø, Denmark
    J Hepatol 38:188-92. 2003
  8. ncbi request reprint Cerebral blood flow and metabolism during infusion of norepinephrine and propofol in patients with bacterial meningitis
    Kirsten Møller
    Department of Infectious Diseases, M5132, University Hospital Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen Ø, Denmark
    Stroke 35:1333-9. 2004
  9. doi request reprint Circulating levels of vasoactive peptides in patients with acute bacterial meningitis
    Ronan M G Berg
    Department of Infectious Diseases, Centre of Inflammation and Metabolism, University Hospital Rigshospitalet, 2100 Copenhagen, Denmark
    Intensive Care Med 35:1604-8. 2009
  10. ncbi request reprint Cerebral output of cytokines in patients with pneumococcal meningitis
    Kirsten Møller
    Departments of Infectious Diseases, University Hospital Rigshospitalet, Copenhagen, Denmark
    Crit Care Med 33:979-83. 2005

Collaborators

Detail Information

Publications11

  1. ncbi request reprint The effect of indomethacin on intracranial pressure, cerebral perfusion and extracellular lactate and glutamate concentrations in patients with fulminant hepatic failure
    Flemming Tofteng
    Department of Hepatology, Rigshospitalet, Copenhagen University Hospital, Denmark
    J Cereb Blood Flow Metab 24:798-804. 2004
    ..This finding indicates that indomethacin may be valuable as rescue treatment of uncontrolled intracranial hypertension in fulminant hepatic failure...
  2. doi request reprint Brain hypoxanthine concentration correlates to lactate/pyruvate ratio but not intracranial pressure in patients with acute liver failure
    Peter Nissen Bjerring
    Department of Hepatology, Rigshospitalet, University Hospital of Copenhagen, Denmark
    J Hepatol 53:1054-8. 2010
    ..Furthermore, we expect the purines and L/P ratio to correlate with intracranial pressure (ICP) (positively), and cerebral perfusion pressure (CPP) (negatively)...
  3. doi request reprint Cerebral glutamine concentration and lactate-pyruvate ratio in patients with acute liver failure
    Peter Nissen Bjerring
    Department of Hepatology, section A 2121, Rigshospitalet, University Hospital of Copenhagen, Blegdamsvej 9, 2100, Copenhagen O, Denmark
    Neurocrit Care 9:3-7. 2008
    ..Since a high-level glutamine may compromise mitochondrial function, the aim of this study was to determine if the lactate-pyruvate ratio is associated with a rise in the glutamine concentration and ICP...
  4. pmc Effect of Prometheus liver assist system on systemic hemodynamics in patients with cirrhosis: a randomized controlled study
    Thomas Dethloff
    Department of Hepatology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    World J Gastroenterol 14:2065-71. 2008
    ..To evaluate treatment safety and hemodynamic changes during a single 6-h treatment with the Prometheus liver assist system in a randomized, controlled study...
  5. ncbi request reprint Monitoring extracellular concentrations of lactate, glutamate, and glycerol by in vivo microdialysis in the brain during liver transplantation in acute liver failure
    Flemming Tofteng
    Department of Hepatology, Rigshospitalet, University Hospital of Copenhagen, Denmark
    Liver Transpl 8:302-5. 2002
    ..These findings indicate disturbances in glutamate neurotransmission, arachidonic acid metabolism, and lactate flux across the blood-brain barrier in patients with ALF...
  6. ncbi request reprint Cerebral microdialysis in patients with fulminant hepatic failure
    Flemming Tofteng
    Department of Hepatology and Neurosurgery, Rigshospitalet, University Hospital of Copenhagen, Denmark
    Hepatology 36:1333-40. 2002
    ..The data suggest that bedside cerebral microdialysis is a valuable tool in monitoring patients with FHF and severe hyperammonemia...
  7. ncbi request reprint Cerebral oxygenation determined by near-infrared spectrophotometry in patients with fulminant hepatic failure
    Henning Bay Nielsen
    Department of Hepatology, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, 2100, København Ø, Denmark
    J Hepatol 38:188-92. 2003
    ..The aim of this study was to determine if near-infrared spectrophotometry (NIRS) could detect a raise in cerebral blood flow and oxygenation induced by noradrenaline (NA) infusion...
  8. ncbi request reprint Cerebral blood flow and metabolism during infusion of norepinephrine and propofol in patients with bacterial meningitis
    Kirsten Møller
    Department of Infectious Diseases, M5132, University Hospital Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen Ø, Denmark
    Stroke 35:1333-9. 2004
    ..The latter possibility implies a CBF-metabolism coupling. This has not been studied during meningitis. We studied the effect of norepinephrine and propofol on CBF and oxidative metabolism in patients with severe bacterial meningitis...
  9. doi request reprint Circulating levels of vasoactive peptides in patients with acute bacterial meningitis
    Ronan M G Berg
    Department of Infectious Diseases, Centre of Inflammation and Metabolism, University Hospital Rigshospitalet, 2100 Copenhagen, Denmark
    Intensive Care Med 35:1604-8. 2009
    ..We measured arterial levels as well as the net cerebral flux of these peptides in patients with ABM, and in healthy volunteers undergoing interventions relevant to intensive care...
  10. ncbi request reprint Cerebral output of cytokines in patients with pneumococcal meningitis
    Kirsten Møller
    Departments of Infectious Diseases, University Hospital Rigshospitalet, Copenhagen, Denmark
    Crit Care Med 33:979-83. 2005
    ..However, it is unknown whether the brain contributes to the intravascular accumulation of cytokines in meningitis. We measured the cerebral output of cytokines to the blood during severe pneumococcal meningitis accompanied by sepsis...
  11. ncbi request reprint Persistent arterial hyperammonemia increases the concentration of glutamine and alanine in the brain and correlates with intracranial pressure in patients with fulminant hepatic failure
    Flemming Tofteng
    Department of Hepatology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    J Cereb Blood Flow Metab 26:21-7. 2006
    ..The elevation of brain glutamine concentration correlated to ICP in patients with FHF...