Affiliation: University of Copenhagen
- Epithelial-stromal interaction 1 (EPSTI1) substitutes for peritumoral fibroblasts in the tumor microenvironmentMichala de Neergaard
Department of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen, and Department of Pathology, State University Hospital, Rigshospitalet, Copenhagen, Denmark
Am J Pathol 176:1229-40. 2010..These observations implicate EPSTI1 as a hitherto unappreciated regulator of tumor cell properties...
- Breast cancer by proxy: can the microenvironment be both the cause and consequence?Lone Rønnov-Jessen
Department of Biology, University of Copenhagen, Universitetsparken 13, DK 2100 Copenhagen, Denmark
Trends Mol Med 15:5-13. 2009..As such, the tumor microenvironment and its constituents, alone or in combination, might serve as promising targets for therapy...
- Tumor initiating but differentiated luminal-like breast cancer cells are highly invasive in the absence of basal-like activityJiyoung Kim
Department of Cellular and Molecular Medicine, Centre for Biological Disease Analysis and Danish Stem Cell Centre, Faculty of Health Sciences, University of Copenhagen, DK 2200 Copenhagen N, Denmark
Proc Natl Acad Sci U S A 109:6124-9. 2012....
- Propagation of oestrogen receptor-positive and oestrogen-responsive normal human breast cells in cultureAgla J Fridriksdottir
Department of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen, DK 2200 Copenhagen N, Denmark
Nat Commun 6:8786. 2015..These findings open a new avenue of experimentation with normal ER(pos) HBECs and provide a basis for understanding the evolution of human breast cancer. ..
- Mammary gland stem cells: current status and future challengesAgla J R Fridriksdottir
Department of Cellular and Molecular Medicine, Centre for Cell Biological Disease Analysis, and The Danish Stem Cell Centre, Faculty of Health Sciences, University of Copenhagen, Denmark
Int J Dev Biol 55:719-29. 2011....
- Identification of EPSTI1, a novel gene induced by epithelial-stromal interaction in human breast cancerHelga Lind Nielsen
Structural Cell Biology Unit, Department of Medical Anatomy A, The Panum Institute, University of Copenhagen, Blegdamsvej 3, DK 2200 Copenhagen N, Denmark
Genomics 79:703-10. 2002..Thus, EPSTI1 is a novel human gene expressed in tissues characterized by extensive epithelial-stromal interaction, and expression of this gene may be a crucial event in invasion and metastasis of cancer...
- The Na+/H+ exchanger NHE1, but not the Na+, HCO3(-) cotransporter NBCn1, regulates motility of MCF7 breast cancer cells expressing constitutively active ErbB2Gitte Lauritzen
Section for Cell and Developmental Biology, Department of Biology, University of Copenhagen, DK 2100 Copenhagen, Denmark
Cancer Lett 317:172-83. 2012..These findings demonstrate that NHE1 inhibition can enhance cancer cell motility, adding an important facet to the understanding of NHE1 in cancer...