Henriette Pilegaard

Summary

Affiliation: University of Copenhagen
Country: Denmark

Publications

  1. ncbi request reprint PDH-E1alpha dephosphorylation and activation in human skeletal muscle during exercise: effect of intralipid infusion
    Henriette Pilegaard
    August Krogh Building, Universitetsparken 13, 2100 Copenhagen Ø, Denmark
    Diabetes 55:3020-7. 2006
  2. ncbi request reprint Transcriptional regulation of pyruvate dehydrogenase kinase 4 in skeletal muscle during and after exercise
    Henriette Pilegaard
    Copenhagen Muscle Research Centre, August Krogh Institute, University of Copenhagen, Universitetsparken 13, 2100 Copenhagen Ø, Denmark
    Proc Nutr Soc 63:221-6. 2004
  3. doi request reprint PGC-1alpha increases PDH content but does not change acute PDH regulation in mouse skeletal muscle
    Kristian Kiilerich
    Centre of Inflammation and Metabolism, August Krogh Bldg, Dept of Biology, Universitetsparken 13, 2100 Copenhagen, Denmark
    Am J Physiol Regul Integr Comp Physiol 299:R1350-9. 2010
  4. doi request reprint Exercise-induced pyruvate dehydrogenase activation is not affected by 7 days of bed rest
    Kristian Kiilerich
    August Krogh Bldg, Dept of Biology, Universitetsparken 13, 2100 Copenhagen, Denmark
    J Appl Physiol (1985) 111:751-7. 2011
  5. ncbi request reprint Effects of alpha-AMPK knockout on exercise-induced gene activation in mouse skeletal muscle
    Sebastian B Jørgensen
    Copenhagen Muscle Research Centre, Department of Human Physiology, Institute of Exercise and Sport Sciences, University of Copenhagen, Copenhagen, Denmark
    FASEB J 19:1146-8. 2005
  6. ncbi request reprint PGC-1alpha is not mandatory for exercise- and training-induced adaptive gene responses in mouse skeletal muscle
    Lotte Leick
    Centre of Inflammation and Metabolism, and Copenhagen Muscle Research Centre, Department of Molecular Biology, Institute of Exercise and Sport Sciences, University of Copenhagen, Universitetsparken 13, Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 294:E463-74. 2008
  7. pmc Low muscle glycogen and elevated plasma free fatty acid modify but do not prevent exercise-induced PDH activation in human skeletal muscle
    Kristian Kiilerich
    Copenhagen Muscle Research Centre, University of Copenhagen, Copenhagen, Denmark
    Diabetes 59:26-32. 2010
  8. pmc GLUT4 and glycogen synthase are key players in bed rest-induced insulin resistance
    Rasmus S Biensø
    Copenhagen Muscle Research Centre, University of Copenhagen, Copenhagen, Denmark
    Diabetes 61:1090-9. 2012
  9. doi request reprint PGC-1alpha mediates exercise-induced skeletal muscle VEGF expression in mice
    Lotte Leick
    Department of Biology, University of Copenhagen, Universitetsparken 13, 2100 Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 297:E92-103. 2009
  10. ncbi request reprint Substrate availability and transcriptional regulation of metabolic genes in human skeletal muscle during recovery from exercise
    Henriette Pilegaard
    Copenhagen Muscle Research Centre, University of Copenhagen, Copenhagen, Denmark
    Metabolism 54:1048-55. 2005

Detail Information

Publications79

  1. ncbi request reprint PDH-E1alpha dephosphorylation and activation in human skeletal muscle during exercise: effect of intralipid infusion
    Henriette Pilegaard
    August Krogh Building, Universitetsparken 13, 2100 Copenhagen Ø, Denmark
    Diabetes 55:3020-7. 2006
    ....
  2. ncbi request reprint Transcriptional regulation of pyruvate dehydrogenase kinase 4 in skeletal muscle during and after exercise
    Henriette Pilegaard
    Copenhagen Muscle Research Centre, August Krogh Institute, University of Copenhagen, Universitetsparken 13, 2100 Copenhagen Ø, Denmark
    Proc Nutr Soc 63:221-6. 2004
    ..The impact of substrate availability on PDK4 expression during recovery from exercise also underlines the high metabolic priority given to replenishing muscle glycogen stores and re-establishing intracellular homeostasis after exercise...
  3. doi request reprint PGC-1alpha increases PDH content but does not change acute PDH regulation in mouse skeletal muscle
    Kristian Kiilerich
    Centre of Inflammation and Metabolism, August Krogh Bldg, Dept of Biology, Universitetsparken 13, 2100 Copenhagen, Denmark
    Am J Physiol Regul Integr Comp Physiol 299:R1350-9. 2010
    ..In conclusion, PGC-1α regulates PDH-E1α protein content in parallel with mitochondrial oxidative proteins, but does not seem to influence PDH regulation in mouse skeletal muscle in response to fasting and in recovery from exercise...
  4. doi request reprint Exercise-induced pyruvate dehydrogenase activation is not affected by 7 days of bed rest
    Kristian Kiilerich
    August Krogh Bldg, Dept of Biology, Universitetsparken 13, 2100 Copenhagen, Denmark
    J Appl Physiol (1985) 111:751-7. 2011
    ..This suggests that exercise-induced PDH regulation in skeletal muscle is maintained in glucose-intolerant (e.g., insulin resistant) individuals...
  5. ncbi request reprint Effects of alpha-AMPK knockout on exercise-induced gene activation in mouse skeletal muscle
    Sebastian B Jørgensen
    Copenhagen Muscle Research Centre, Department of Human Physiology, Institute of Exercise and Sport Sciences, University of Copenhagen, Copenhagen, Denmark
    FASEB J 19:1146-8. 2005
    ....
  6. ncbi request reprint PGC-1alpha is not mandatory for exercise- and training-induced adaptive gene responses in mouse skeletal muscle
    Lotte Leick
    Centre of Inflammation and Metabolism, and Copenhagen Muscle Research Centre, Department of Molecular Biology, Institute of Exercise and Sport Sciences, University of Copenhagen, Universitetsparken 13, Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 294:E463-74. 2008
    ..However, PGC-1alpha is not mandatory for training-induced increases in ALAS1, COXI, and cyt c expression, showing that factors other than PGC-1alpha can exert these adaptations...
  7. pmc Low muscle glycogen and elevated plasma free fatty acid modify but do not prevent exercise-induced PDH activation in human skeletal muscle
    Kristian Kiilerich
    Copenhagen Muscle Research Centre, University of Copenhagen, Copenhagen, Denmark
    Diabetes 59:26-32. 2010
    ..To test the hypothesis that free fatty acid (FFA) and muscle glycogen modify exercise-induced regulation of PDH (pyruvate dehydrogenase) in human skeletal muscle through regulation of PDK4 expression...
  8. pmc GLUT4 and glycogen synthase are key players in bed rest-induced insulin resistance
    Rasmus S Biensø
    Copenhagen Muscle Research Centre, University of Copenhagen, Copenhagen, Denmark
    Diabetes 61:1090-9. 2012
    ..The present findings demonstrate that physical inactivity-induced insulin resistance in muscle is associated with lower content/activity of key proteins in glucose transport/phosphorylation and storage...
  9. doi request reprint PGC-1alpha mediates exercise-induced skeletal muscle VEGF expression in mice
    Lotte Leick
    Department of Biology, University of Copenhagen, Universitetsparken 13, 2100 Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 297:E92-103. 2009
    ..Furthermore, the findings suggest an AMPK-mediated regulation of VEGF expression through PGC-1alpha...
  10. ncbi request reprint Substrate availability and transcriptional regulation of metabolic genes in human skeletal muscle during recovery from exercise
    Henriette Pilegaard
    Copenhagen Muscle Research Centre, University of Copenhagen, Copenhagen, Denmark
    Metabolism 54:1048-55. 2005
    ....
  11. ncbi request reprint Regulation of PDH in human arm and leg muscles at rest and during intense exercise
    Kristian Kiilerich
    Copenhagen Muscle Research Center, August Krogh Bldg, University of Copenhagen, 2100 Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 294:E36-42. 2008
    ....
  12. doi request reprint Role of PGC-1α in exercise and fasting-induced adaptations in mouse liver
    Tobias Nørresø Haase
    Centre of Inflammation and Metabolism and Copenhagen Muscle Research Centre, Section of Molecular and Integrative Physiology, Dept of Biology, University of Copenhagen, Copenhagen, Denmark
    Am J Physiol Regul Integr Comp Physiol 301:R1501-9. 2011
    ....
  13. doi request reprint PGC-1alpha is required for training-induced prevention of age-associated decline in mitochondrial enzymes in mouse skeletal muscle
    Lotte Leick
    Centre of Inflammation and Metabolism and Copenhagen Muscle Research Centre, Department of Biology, Section of Molecular, Integrative Physiology, University of Copenhagen, Copenhagen, Denmark
    Exp Gerontol 45:336-42. 2010
    ..In conclusion, the present findings indicate that PGC-1alpha is required for training-induced prevention of an age-associated decline in CS activity and SOD2 protein expression in skeletal muscle...
  14. ncbi request reprint Lack of AMPKalpha2 enhances pyruvate dehydrogenase activity during exercise
    Ditte K Klein
    Copenhagen Muscle Research Centre, Section of Human Physiology, Department of Exercise and Sport Sciences, University of Copenhagen, 13, Universitetsparken, 2100, Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 293:E1242-9. 2007
    ..During exercise, alpha(2)KO muscles display deranged energy homeostasis despite enhanced glycolytic flux and PDH(a) activity. This may be linked to decreased mitochondrial oxidative capacity...
  15. doi request reprint Bed rest reduces metabolic protein content and abolishes exercise-induced mRNA responses in human skeletal muscle
    Stine Ringholm
    Copenhagen Muscle Research Centre, University of Copenhagen, Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 301:E649-58. 2011
    ....
  16. pmc Lipid-induced insulin resistance affects women less than men and is not accompanied by inflammation or impaired proximal insulin signaling
    Louise D Høeg
    Copenhagen Muscle Research Centre, Department of Exercise and Sport Sciences, University of Copenhagen, Denmark
    Diabetes 60:64-73. 2011
    ..Women also express higher muscle mRNA levels of proteins related to lipid metabolism than men. We therefore hypothesized that women would be less prone to lipid-induced insulin resistance...
  17. doi request reprint Relative workload determines exercise-induced increases in PGC-1alpha mRNA
    Nikolai Baastrup Nordsborg
    Copenhagen Muscle Research Centre, University of Copenhagen, Denmark
    Med Sci Sports Exerc 42:1477-84. 2010
    ..The hypothesis that brief intermittent exercise-induced increases in human skeletal muscle metabolic mRNA is dependent on relative workload was investigated...
  18. ncbi request reprint Dissociation of AMPK activity and ACCbeta phosphorylation in human muscle during prolonged exercise
    Jørgen F P Wojtaszewski
    Copenhagen Muscle Research Centre, Institute of Exercise and Sport Sciences, University of Copenhagen, Copenhagen, Denmark
    Biochem Biophys Res Commun 298:309-16. 2002
    ....
  19. pmc Higher skeletal muscle alpha2AMPK activation and lower energy charge and fat oxidation in men than in women during submaximal exercise
    Carsten Roepstorff
    The Copenhagen Muscle Research Centre, Institute of Exercise and Sport Sciences, Department of Human Physiology, Universitetsparken 13, DK 2100 Copenhagen Ø, Denmark
    J Physiol 574:125-38. 2006
    ....
  20. doi request reprint PGC-1alpha-mediated adaptations in skeletal muscle
    Jesper Olesen
    Department of Biology, Centre of Inflammation and Metabolism, Copenhagen Muscle Research Centre, University of Copenhagen, August Krogh Building, Universitetsparken 13, 2100, Copenhagen Ø, Denmark
    Pflugers Arch 460:153-62. 2010
    ..The absence of exercise-induced PGC-1alpha-mediated gene regulation during a physical inactive lifestyle is suggested to lead to reduced oxidative capacity of skeletal muscle and concomitant impaired metabolism...
  21. doi request reprint Effect of lifelong resveratrol supplementation and exercise training on skeletal muscle oxidative capacity in aging mice; impact of PGC-1α
    Stine Ringholm
    Centre of Inflammation and Metabolism, August Krogh Centre, Department of Biology, August Krogh Building, University of Copenhagen, Denmark
    Exp Gerontol 48:1311-8. 2013
    ....
  22. doi request reprint Erythropoietin receptor in human skeletal muscle and the effects of acute and long-term injections with recombinant human erythropoietin on the skeletal muscle
    Carsten Lundby
    Copenhagen Muscle Research Centre, Rigshospitalet, Section 7652, Blegdamsvej 3, 2100 Copenhagen Ø, Denmark
    J Appl Physiol (1985) 104:1154-60. 2008
    ..However, in contrast to our hypothesis, prolonged Epo administration had no apparent effect on capillarization or muscle fiber hypertrophy...
  23. ncbi request reprint Effect of short-term fasting and refeeding on transcriptional regulation of metabolic genes in human skeletal muscle
    Henriette Pilegaard
    Copenhagen Muscle Research Centre, Copenhagen, Denmark
    Diabetes 52:657-62. 2003
    ..Marked heterogeneity in the transcriptional response to the fasting/refeeding protocol suggests that individual differences in genetic profile may play an important role in adaptive molecular responses to metabolic challenges...
  24. doi request reprint Na,K-ATPase activity in mouse muscle is regulated by AMPK and PGC-1α
    Maria S Ingwersen
    Department of Biology, University of Copenhagen, Denmark
    J Membr Biol 242:1-10. 2011
    ..Phosphorylation of the Na,K-ATPase subunit PLM is an important regulatory mechanism...
  25. doi request reprint Role of vitamin C and E supplementation on IL-6 in response to training
    Christina Yfanti
    The Centre of Inflammation and Metabolism, Department of Infectious Diseases, and Copenhagen Muscle Research Centre, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    J Appl Physiol (1985) 112:990-1000. 2012
    ..In conclusion, our results indicate that, although vitamin C and E supplementation may attenuate exercise-induced increases in plasma IL-6 there is no clear additive effect when combined with endurance training...
  26. ncbi request reprint Contraction-induced increases in Na+-K+-ATPase mRNA levels in human skeletal muscle are not amplified by activation of additional muscle mass
    Nikolai Nordsborg
    Institute of Exercise and Sport Sciences, University of Copenhagen, Denmark
    Am J Physiol Regul Integr Comp Physiol 289:R84-91. 2005
    ..In conclusion, activation of additional muscle mass does not result in a higher exercise-induced increase in Na(+)-K(+)-ATPase subunit-specific mRNA...
  27. ncbi request reprint Antioxidant supplementation enhances the exercise-induced increase in mitochondrial uncoupling protein 3 and endothelial nitric oxide synthase mRNA content in human skeletal muscle
    Ylva Hellsten
    Department of Exercise and Sport Science, Copenhagen Muscle Research Center, University of Copenhagen, DK 2100 Copenhagen, Denmark
    Free Radic Biol Med 43:353-61. 2007
    ..The data show that ROS are formed within skeletal muscle during exercise and that oral intake of antioxidants can enhance the exercise-induced adaptive mRNA responses of eNOS and UCP3...
  28. doi request reprint Mitochondrial biogenesis and angiogenesis in skeletal muscle of the elderly
    Ninna Iversen
    Copenhagen Muscle Research Centre, University of Copenhagen, Copenhagen, Denmark
    Exp Gerontol 46:670-8. 2011
    ....
  29. doi request reprint Evidence for a release of brain-derived neurotrophic factor from the brain during exercise
    Peter Rasmussen
    Copenhagen Muscle Research Centre, Denmark
    Exp Physiol 94:1062-9. 2009
    ..These results suggest that the brain is a major but not the sole contributor to circulating BDNF. Moreover, the importance of the cortex and hippocampus as a source for plasma BDNF becomes even more prominent in response to exercise...
  30. pmc Attenuated purinergic receptor function in patients with type 2 diabetes
    Pia Thaning
    Copenhagen Muscle Research Centre, Rigshospitalet, Denmark
    Diabetes 59:182-9. 2010
    ..The present study investigated 1) the vasodilatatory effect of ATP, uridine-triphosphate (UTP), and adenosine (ADO) and 2) the expression and distribution of P2Y(2) and P2X(1) receptors in skeletal muscles of diabetic subjects...
  31. pmc Role of PGC-1α in exercise training- and resveratrol-induced prevention of age-associated inflammation
    Jesper Olesen
    Centre of Inflammation and Metabolism, August Krogh Centre, August Krogh Building, Department of Biology, University of Copenhagen, Copenhagen, Denmark Electronic address
    Exp Gerontol 48:1274-84. 2013
    ..To address this, a long-term voluntary exercise training and resveratrol supplementation study was conducted...
  32. pmc 5'AMP activated protein kinase expression in human skeletal muscle: effects of strength training and type 2 diabetes
    Jørgen F P Wojtaszewski
    The Institute of Exercise and Sport Sciences, The Copenhagen Muscle Research Centre, University of Copenhagen, 13 Universitetsparken, 2100 Copenhagen, Denmark
    J Physiol 564:563-73. 2005
    ....
  33. ncbi request reprint Acclimatization to 4100 m does not change capillary density or mRNA expression of potential angiogenesis regulatory factors in human skeletal muscle
    Carsten Lundby
    The Copenhagen Muscle Research Centre at Rigshospitalet section 7652, Blegdamsvej 9, 2100 Copenhagen Ø, Denmark
    J Exp Biol 207:3865-71. 2004
    ..05). In conclusion, human muscle VEGF mRNA expression and capillary density are not significantly increased by 8 weeks of exposure to high altitude and are not increased in Aymara high-altitude natives compared with sea level residents...
  34. ncbi request reprint Carbohydrate metabolism during prolonged exercise and recovery: interactions between pyruvate dehydrogenase, fatty acids, and amino acids
    Marina Mourtzakis
    The Copenhagen Muscle Research Centre, Human Biology and Nutritional Sciences, University of Guelph, Ontario, Canada, and Rigshospitalet, University of Copenhagen, Denmark
    J Appl Physiol (1985) 100:1822-30. 2006
    ..Thus reduced pyruvate production was primarily associated with reduced carbohydrate oxidation, whereas the greatest production of pyruvate was related to glutamate, glutamine, and alanine metabolism in early exercise...
  35. pmc Resveratrol blunts the positive effects of exercise training on cardiovascular health in aged men
    Lasse Gliemann
    L Gliemann, Universitetsparken 13, 2nd Floor, 2100 Copenhagen, Denmark
    J Physiol 591:5047-59. 2013
    ..These findings indicate that, whereas exercise training effectively improves several cardiovascular health parameters in aged men, concomitant resveratrol supplementation can blunt these effects...
  36. pmc PGC-1α is required for exercise- and exercise training-induced UCP1 up-regulation in mouse white adipose tissue
    Stine Ringholm
    Department of Biology, Centre of Inflammation and Metabolism and August Krogh Centre, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 8:e64123. 2013
    ....
  37. pmc Skeletal muscle PGC-1α is required for maintaining an acute LPS-induced TNFα response
    Jesper Olesen
    Centre of Inflammation and Metabolism and Copenhagen Muscle Research Centre, Department of Biology, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 7:e32222. 2012
    ..Lack of skeletal muscle PGC-1α seems however to impair the acute TNFα response, which may reflect a phenotype more susceptible to infections as also observed in type 2 diabetes patients...
  38. pmc Exercise-induced liver chemokine CXCL-1 expression is linked to muscle-derived interleukin-6 expression
    Line Pedersen
    Centre of Inflammation and Metabolism at Department of Infectious Diseases and Copenhagen Muscle Research Centre, Rigshospitalet and Faculty of Health Sciences, University of Copenhagen, Denmark
    J Physiol 589:1409-20. 2011
    ..Taken together, these data indicate that liver is the main source of serum CXCL-1 during exercise in mice, and that the CXCL-1 expression in the liver is regulated by muscle-derived IL-6...
  39. ncbi request reprint Calcium signalling in the regulation of PGC-1alpha, PDK4 and HKII mRNA expression
    Keiko Kusuhara
    Copenhagen Muscle Research Centre and Centre of Inflammation and Metabolism, The August Krogh Building, Department of Molecular Biology, University of Copenhagen, Copenhagen Ø, Denmark
    Biol Chem 388:481-8. 2007
    ..Both calcineurin and CaMK signalling seem to be involved in the calcium- and contraction-mediated PGC-1alpha up-regulation in skeletal muscle...
  40. ncbi request reprint Gene expression in human skeletal muscle: alternative normalization method and effect of repeated biopsies
    Carsten Lundby
    Copenhagen Muscle Research Centre, Rigshospitalet, Section 7652, Blegdamsvej 9, 2100, Copenhagen, Denmark
    Eur J Appl Physiol 95:351-60. 2005
    ..In addition, the present study shows that multiple muscle biopsies obtained from the same muscle do not influence the mRNA response induced by an acute exercise bout for any of the genes examined...
  41. pmc Exercise induces transient transcriptional activation of the PGC-1alpha gene in human skeletal muscle
    Henriette Pilegaard
    Copenhagen Muscle Research Centre and The August Krogh Institute, University of Copenhagen, Denmark
    J Physiol 546:851-8. 2003
    ..Consistent with its role as a transcriptional coactivator, these findings suggest that PGC-1alpha may coordinate the activation of metabolic genes in human muscle in response to exercise...
  42. pmc Skeletal muscle IL-6 and regulation of liver metabolism during high-fat diet and exercise training
    Jakob G Knudsen
    Centre for Inflammation and Metabolism, Department of Biology, University of Copenhagen, Copenhagen, Denmark
    Physiol Rep 4:. 2016
    ....
  43. pmc 5'-AMP activated protein kinase α2 controls substrate metabolism during post-exercise recovery via regulation of pyruvate dehydrogenase kinase 4
    Andreas Maechel Fritzen
    Section of Molecular Physiology, Department of Nutrition, Exercise and Sports, The August Krogh Centre, University of Copenhagen, Copenhagen, Denmark
    J Physiol 593:4765-80. 2015
    ..These findings indicate that AMPKα2 regulates muscle metabolism post-exercise through inhibition of the PDH complex and hence glucose oxidation, subsequently creating conditions for increased fatty acid oxidation...
  44. pmc Exercise-induced AMPK and pyruvate dehydrogenase regulation is maintained during short-term low-grade inflammation
    Rasmus Sjørup Biensø
    Centre of Inflammation and Metabolism, The Center for Physical Activity Research and August Krogh Centre, Department of Biology, University of Copenhagen, Universitesparken 13, 2100, Copenhagen Ø, Denmark
    Pflugers Arch 467:341-50. 2015
    ..This suggests that metabolic flexibility during exercise is maintained during short-term low-grade inflammation in humans...
  45. pmc Effects of IL-6 on pyruvate dehydrogenase regulation in mouse skeletal muscle
    Rasmus S Biensø
    Centre of Inflammation and Metabolism and The August Krogh Centre, University of Copenhagen, Copenhagen, Denmark
    Pflugers Arch 466:1647-57. 2014
    ..In addition, AMPK and p38 may contribute to the IL-6-mediated PDH regulation in the fasted state...
  46. ncbi request reprint Adipose tissue interleukin-18 mRNA and plasma interleukin-18: effect of obesity and exercise
    Lotte Leick
    Centre of Inflammation and Metabolism, Department of Molecular Biology, The August Krogh Building, University of Copenhagen, Copenhagen, Denmark
    Obesity (Silver Spring) 15:356-63. 2007
    ..Furthermore, we speculated that acute exercise and exercise training would regulate AT IL-18 mRNA expression...
  47. pmc Influence of pre-exercise muscle glycogen content on exercise-induced transcriptional regulation of metabolic genes
    Henriette Pilegaard
    Copenhagen Muscle Research Centre, The August Krogh Institute, University of Copenhagen, Denmark
    J Physiol 541:261-71. 2002
    ....
  48. ncbi request reprint Effect of high-intensity training on exercise-induced gene expression specific to ion homeostasis and metabolism
    Nikolai Nordsborg
    Institute of Exercise and Sports Sciences, August Krogh Institute, 2100 Copenhagen, Denmark
    J Appl Physiol 95:1201-6. 2003
    ..In conclusion, cellular adaptations to high-intensity exercise training may, in part, be induced by transcriptional regulation. After training, the transcriptional response to an exercise bout at a given workload is diminished...
  49. ncbi request reprint Regular endurance training reduces the exercise induced HIF-1alpha and HIF-2alpha mRNA expression in human skeletal muscle in normoxic conditions
    Carsten Lundby
    Copenhagen Muscle Research Centre, Copenhagen, Denmark
    Eur J Appl Physiol 96:363-9. 2006
    ..We propose that HIFs expression is upregulated with exercise and that it may be an important transcription factor that regulates adaptive gene responses to exercise...
  50. pmc Combined speed endurance and endurance exercise amplify the exercise-induced PGC-1α and PDK4 mRNA response in trained human muscle
    Casper Skovgaard
    Section of Integrated Physiology, Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark Team Danmark Danish elite sports institution, Copenhagen, Denmark
    Physiol Rep 4:. 2016
    ..These responses are reinforced when speed endurance exercise is followed by endurance exercise. ..
  51. pmc PGC-1α promotes exercise-induced autophagy in mouse skeletal muscle
    Jens F Halling
    Department of Biology, Centre of Inflammation and Metabolism, University of Copenhagen, Copenhagen, Denmark
    Physiol Rep 4:. 2016
    ..In conclusion, the present results suggest a role of skeletal muscle PGC-1α in coordinating several exercise-induced adaptive responses including autophagic removal of damaged cellular components. ..
  52. doi request reprint AMPKα is essential for acute exercise-induced gene responses but not for exercise training-induced adaptations in mouse skeletal muscle
    Joachim Fentz
    Section of Molecular Physiology, The August Krogh Centre, Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 309:E900-14. 2015
    ....
  53. pmc Lack of Skeletal Muscle IL-6 Affects Pyruvate Dehydrogenase Activity at Rest and during Prolonged Exercise
    Anders Gudiksen
    Section for Cell Biology and Physiology, Department of Biology, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 11:e0156460. 2016
    ....
  54. doi request reprint Endurance training enhances BDNF release from the human brain
    Thomas Seifert
    Department of Anesthesia, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen Ø, Denmark
    Am J Physiol Regul Integr Comp Physiol 298:R372-7. 2010
    ..4.6 + or - 1.4 mRNA/ssDNA) compared with untrained mice. The increased BDNF expression in the hippocampus and the enhanced release of BDNF from the human brain following training suggest that endurance training promotes brain health...
  55. ncbi request reprint 5'-AMP-activated protein kinase activity and subunit expression in exercise-trained human skeletal muscle
    Jakob N Nielsen
    Institute of Exercise and Sport Sciences, Copenhagen Muscle Research Centre, University of Copenhagen, Denmark
    J Appl Physiol (1985) 94:631-41. 2003
    ..01). In conclusion, trained human skeletal muscle has increased alpha(1)-AMPK protein levels and blunted AMPK activation during exercise...
  56. ncbi request reprint Effect of acute exercise and exercise training on VEGF splice variants in human skeletal muscle
    Lotte Jensen
    Institute for Exercise and Sport Science, Copenhagen Muscle Research Centre, Copenhagen University, 2100 Copenhagen, Denmark
    Am J Physiol Regul Integr Comp Physiol 287:R397-402. 2004
    ..Furthermore, 4 wk of training attenuated the exercise-induced response in skeletal muscle VEGF(165) mRNA...
  57. pmc Expression of interleukin-15 in human skeletal muscle effect of exercise and muscle fibre type composition
    Anders Rinnov Nielsen
    Department of Infectious Diseases Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    J Physiol 584:305-12. 2007
    ..IL-15 mRNA levels in skeletal muscle were not paralleled by similar changes in muscular IL-15 protein expression suggesting that muscle IL-15 may exist in a translationally inactive pool...
  58. pmc Impact of adrenaline and metabolic stress on exercise-induced intracellular signaling and PGC-1α mRNA response in human skeletal muscle
    Nina Brandt
    The August Krogh Centre, Section for Cell Biology and Physiology, Department of Biology, University of Copenhagen, Copenhagen, Denmark
    Physiol Rep 4:. 2016
    ..Furthermore, higher exercise-induced changes in AMPK, p38, and CREB phosphorylation are not associated with differences in the PGC-1α mRNA response. ..
  59. pmc Role of IL-6 in exercise training- and cold-induced UCP1 expression in subcutaneous white adipose tissue
    Jakob G Knudsen
    Centre of Inflammation and Metabolism, Department of Biology, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 9:e84910. 2014
    ..In addition IL-6 is required for a full induction of UCP1 protein expression in response to cold exposure and influences the UCP1 protein content iWAT of both untrained and exercise trained animals. ..
  60. doi request reprint Exercise-induced regulation of key factors in substrate choice and gluconeogenesis in mouse liver
    Jakob G Knudsen
    Centre of Inflammation and Metabolism, The August Krogh Centre, Department of Biology, University of Copenhagen, Universitetsparken 13 4th floor, 2100, Copenhagen, Denmark
    Mol Cell Biochem 403:209-17. 2015
    ....
  61. pmc Exercise training, but not resveratrol, improves metabolic and inflammatory status in skeletal muscle of aged men
    Jesper Olesen
    August Krogh Building, Universitetsparken 13, 4th Floor, 2100 Kbh Ø, Denmark
    J Physiol 592:1873-86. 2014
    ..Collectively, this highlights the metabolic efficacy of exercise training in aged subjects and does not support the contention that resveratrol is a potential exercise mimetic in healthy aged subjects...
  62. doi request reprint Subcellular localization and mechanism of secretion of vascular endothelial growth factor in human skeletal muscle
    Birgitte Hoier
    Department of Nutrition, Exercise, and Sport, University of Copenhagen, Universitetsparken 13, 2100 Copenhagen, Denmark
    FASEB J 27:3496-504. 2013
    ..This study provides the first evidence in humans for a mechanism by which skeletal muscle fibers can control capillary growth by releasing VEGF from intracellular vesicles during contraction...
  63. ncbi request reprint Resistance exercise alters MRF and IGF-I mRNA content in human skeletal muscle
    Niklas Psilander
    August Krogh Institute, Copenhagen Muscle Research Centre, DK 2100 Copenhagen, Denmark
    J Appl Physiol (1985) 95:1038-44. 2003
    ..The results also suggest that IGF-IEa expression may be downregulated at the mRNA level during the initial part of recovery from resistance exercise...
  64. doi request reprint Skeletal muscle interleukin-6 regulates metabolic factors in iWAT during HFD and exercise training
    Jakob G Knudsen
    Department of Biology, Centre for Inflammation and Metabolism, The August Krogh Centre, University of Copenhagen, Copenhagen, Denmark
    Obesity (Silver Spring) 23:1616-24. 2015
    ..To investigate the role of skeletal muscle (SkM) interleukin (IL)-6 in the regulation of adipose tissue metabolism...
  65. doi request reprint New Nordic Diet-Induced Weight Loss Is Accompanied by Changes in Metabolism and AMPK Signaling in Adipose Tissue
    Andreas Mæchel Fritzen
    Section of Molecular Physiology, The August Krogh Centre, Department of Nutrition, Exercise and Sports A M F, A M L, A B J, J F P W, E A R, B K, University of Copenhagen, 2100 Copenhagen Ø, Denmark Department of Nutrition, Exercise and Sports S K P, A A, T M L, University of Copenhagen, 1958 Frederiksberg, Denmark Department of Clinical Biochemistry S S, Copenhagen University Hospitals, Gentofte, 2900 Hellerup, Denmark Centre of Inflammation and Metabolism, Department of Biology H P, University of Copenhagen, 2100 Copenhagen Ø, Denmark and Danish Diabetes Academy A M L, 5000 Odense, Denmark
    J Clin Endocrinol Metab 100:3509-19. 2015
    ..The molecular mechanisms behind diet-induced metabolic improvements remain to be studied...
  66. doi request reprint Insulin sensitivity is independent of lipid binding protein trafficking at the plasma membrane in human skeletal muscle: effect of a 3-day, high-fat diet
    Andreas B Jordy
    Section of Molecular Physiology, Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark
    Am J Physiol Regul Integr Comp Physiol 307:R1136-45. 2014
    ..Finally, FATP1 and FATP4 protein was located intracellularly but not at the sarcolemma in humans. ..
  67. pmc Sucrose counteracts the anti-inflammatory effect of fish oil in adipose tissue and increases obesity development in mice
    Tao Ma
    Department of Biology, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 6:e21647. 2011
    ..Here we aimed to investigate if the amount of sucrose in the background diet influences the ability of n-3 PUFAs to protect against diet-induced obesity, adipose tissue inflammation and glucose intolerance...
  68. ncbi request reprint Adipose tissue expression of IL-18 and HIV-associated lipodystrophy
    Birgitte Lindegaard
    Department of Infectious Diseases, University of Copenhagen, Copenhagen, Denmark
    AIDS 18:1956-8. 2004
    ..Higher levels of IL-18 mRNA were found in femoral-gluteal AT compared with abdominal AT, and correlated with limb fat loss. These findings suggest that IL-18 is linked to HIV-associated lipodystrophy...
  69. ncbi request reprint PGC-1alpha: important for exercise performance?
    Henriette Pilegaard
    J Appl Physiol 104:1264-5. 2008
  70. ncbi request reprint PGC-1beta is downregulated by training in human skeletal muscle: no effect of training twice every second day vs. once daily on expression of the PGC-1 family
    Ole Hartvig Mortensen
    Centre of Inflammation and Metabolism, Department of Infectious Diseases, Rigshospitalet 7641, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    J Appl Physiol (1985) 103:1536-42. 2007
    ..In conclusion, there was no difference between training protocols on the acute exercise and training response of the PGC-1 family. However, training caused a decrease in PGC-1beta mRNA levels...
  71. ncbi request reprint [Metabolic fitness: physical activity and health]
    Bengt Saltin
    Rigshospitalet, afsnit 7652, Blegdamsvej 9, DK 2100 København Ø
    Ugeskr Laeger 164:2156-62. 2002
    ..Thus, metabolic fitness is directly related to how much the muscle is used, but even low levels of physical activity have a beneficial effect on metabolic fitness and the overall health of the individual...
  72. ncbi request reprint Differential transcriptional activation of select metabolic genes in response to variations in exercise intensity and duration
    Audrey L Hildebrandt
    John B Pierce Laboratory, 290 Congress Ave, New Haven, CT 06519, USA
    Am J Physiol Endocrinol Metab 285:E1021-7. 2003
    ....
  73. ncbi request reprint Nitric oxide production is a proximal signaling event controlling exercise-induced mRNA expression in human skeletal muscle
    Adam Steensberg
    Centre of Inflammation and Metabolism, Department of Infectious Diseases, National Hospital, Copenhagen O, Denmark
    FASEB J 21:2683-94. 2007
    ..Subsequently, we sought evidence for involvement of AMP-activated kinase or nuclear factor kappa B, but found none...
  74. ncbi request reprint Endurance training reduces the contraction-induced interleukin-6 mRNA expression in human skeletal muscle
    Christian P Fischer
    Dept of Infectious Diseases, Rigshospitalet, Blegdamsvej 9, Section M7641, DK 2100 Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 287:E1189-94. 2004
    ..In conclusion, the magnitude of the exercise-induced IL-6 mRNA expression in contracting human skeletal muscle was markedly reduced by 10 wk of training...
  75. ncbi request reprint The mRNA expression profile of metabolic genes relative to MHC isoform pattern in human skeletal muscles
    Peter Plomgaard
    Centre of Inflammation and Metabolism, Dept of Infectious Diseases, Rigshospitalet, DK 2100 Copenhagen, Denmark
    J Appl Physiol (1985) 101:817-25. 2006
    ....
  76. ncbi request reprint The contraction induced increase in gene expression of peroxisome proliferator-activated receptor (PPAR)-gamma coactivator 1alpha (PGC-1alpha), mitochondrial uncoupling protein 3 (UCP3) and hexokinase II (HKII) in primary rat skeletal muscle cells is depe
    Leonardo R Silveira
    Institute of Biomedical Sciences, Department of Physiology and Biophysics, University of Sao Paulo, Sao Paulo, SP, Brazil
    Biochim Biophys Acta 1763:969-76. 2006
    ....
  77. ncbi request reprint Control of gene expression and mitochondrial biogenesis in the muscular adaptation to endurance exercise
    Anna Maria Joseph
    Department of Biology, York University, Toronto, Ontario, Canada, M3J 1P3
    Essays Biochem 42:13-29. 2006
    ..An understanding of how exercise can produce this effect could help us decide whether exercise is beneficial for patients suffering from mitochondrial disorders, as well as a variety of metabolic diseases...
  78. ncbi request reprint Oxidative DNA damage and repair in skeletal muscle of humans exposed to high-altitude hypoxia
    Carsten Lundby
    The Copenhagen Muscle Research Centre, Rigshospitalet, DK 2200 Copenhagen N, Denmark
    Toxicology 192:229-36. 2003
    ....
  79. ncbi request reprint Strong iron demand during hypoxia-induced erythropoiesis is associated with down-regulation of iron-related proteins and myoglobin in human skeletal muscle
    Paul Robach
    Département médical, Ecole Nationale de Ski et d Alpinisme, Chamonix, France
    Blood 109:4724-31. 2007
    ..Thus, in HA, the elevated iron requirement associated with enhanced erythropoiesis presumably elicits iron mobilization and myoglobin down-modulation, suggesting an altered muscle oxygen homeostasis...