Stine Knudsen

Summary

Affiliation: University of Copenhagen
Country: Denmark

Publications

  1. doi request reprint Normal levels of cerebrospinal fluid hypocretin-1 and daytime sleepiness during attacks of relapsing-remitting multiple sclerosis and monosymptomatic optic neuritis
    S Knudsen
    Danish Center of Sleep Medicine, University of Copenhagen, Glostrup Hospital, Glostrup, Denmark
    Mult Scler 14:734-8. 2008
  2. doi request reprint Rapid eye movement sleep behaviour disorder in patients with narcolepsy is associated with hypocretin-1 deficiency
    Stine Knudsen
    Danish Center for Sleep Medicine, University of Copenhagen, Glostrup Hospital, Nordre Ringvej 57, DK 2600 Glostrup, Denmark
    Brain 133:568-79. 2010
  3. pmc Validation of the ICSD-2 criteria for CSF hypocretin-1 measurements in the diagnosis of narcolepsy in the Danish population
    Stine Knudsen
    Danish Center for Sleep Medicine, University of Copenhagen, Glostrup Hospital, Glostrup, Denmark
    Sleep 33:169-76. 2010
  4. pmc Sleep transitions in hypocretin-deficient narcolepsy
    Gertrud Laura Sorensen
    Danish Center for Sleep Medicine, Department of Clinical Neurophysiology, Center for Healthy Aging, Faculty of Health Sciences, University of Copenhagen, Glostrup Hospital, Copenhagen, Denmark
    Sleep 36:1173-7. 2013
  5. pmc Attenuated heart rate response is associated with hypocretin deficiency in patients with narcolepsy
    Gertrud Laura Sorensen
    Danish Center for Sleep Medicine, Glostrup University Hospital, Glostrup Hospital, Denmark
    Sleep 36:91-8. 2013
  6. pmc Comorbidity and mortality of narcolepsy: a controlled retro- and prospective national study
    Poul Jennum
    Danish Center for Sleep Medicine, Department of Clinical Neurophysiology, Center for Healthy Aging, Faculty of Health Sciences, University of Copenhagen, Glostrup Hospital, Copenhagen, Denmark
    Sleep 36:835-40. 2013
  7. doi request reprint Health, social, and economic consequences of narcolepsy: a controlled national study evaluating the societal effect on patients and their partners
    Poul Jennum
    Danish Center for Sleep Medicine, Department of Clinical Neurophysiology, Center for Healthy Aging, University of Copenhagen, Glostrup Hospital, Copenhagen, Denmark
    Sleep Med 13:1086-93. 2012
  8. doi request reprint Reduced CSF hypocretin-1 levels are associated with cluster headache
    Mads Barloese
    Danish Headache Center, Dept of Neurology, Glostrup Hospital, University of Copenhagen, Denmark
    Cephalalgia 35:869-76. 2015
  9. pmc The economic consequences of narcolepsy
    Poul Jennum
    Danish Center for Sleep Medicine, Department of Clinical Neurophysiology, Faculty of Health Sciences, University of Copenhagen, Glostrup Hospital, Copenhagen, Denmark
    J Clin Sleep Med 5:240-5. 2009
  10. pmc Cerebrospinal fluid cytokine levels in type 1 narcolepsy patients very close to onset
    Birgitte Rahbek Kornum
    Center for Sleep Sciences and Medicine, Department of Psychiatry, Stanford University School of Medicine, Palo Alto, CA, USA Molecular Sleep Laboratory, Department of Diagnostics, Rigshospitalet, Glostrup, Denmark Danish Center for Sleep Medicine, Department of Neurophysiology, University of Copenhagen, Rigshospitalet, Glostrup, Denmark Electronic address
    Brain Behav Immun 49:54-8. 2015

Collaborators

  • Giuseppe Plazzi
  • Fabio Pizza
  • Jens D Mikkelsen
  • Poul Jennum
  • Jacob Kempfner
  • Gertrud Laura Sorensen
  • Birgitte Rahbek Kornum
  • Steen Gammeltoft
  • Mads Barloese
  • Julie B Jensen
  • Anja Holm
  • H Willenbrock
  • Nunu Lund
  • Emmanuel Mignot
  • Rigmor Jensen
  • Claus Heiner Bang-Berthelsen
  • Helge B D Sorensen
  • Signe Modvig
  • Gertrud L Sørensen
  • Helge Bjarup Dissing Sorensen
  • Eva Rosa Petersen
  • K Schmiegelow
  • L P Ryder
  • A S Juncker

Detail Information

Publications14

  1. doi request reprint Normal levels of cerebrospinal fluid hypocretin-1 and daytime sleepiness during attacks of relapsing-remitting multiple sclerosis and monosymptomatic optic neuritis
    S Knudsen
    Danish Center of Sleep Medicine, University of Copenhagen, Glostrup Hospital, Glostrup, Denmark
    Mult Scler 14:734-8. 2008
    ..MRI scans revealed no hypothalamic lesions. The results show that the hypocretin system is intact and sleepiness is not typical in RRMS and MON without hypothalamic lesions on MRI...
  2. doi request reprint Rapid eye movement sleep behaviour disorder in patients with narcolepsy is associated with hypocretin-1 deficiency
    Stine Knudsen
    Danish Center for Sleep Medicine, University of Copenhagen, Glostrup Hospital, Nordre Ringvej 57, DK 2600 Glostrup, Denmark
    Brain 133:568-79. 2010
    ..The study supports the hypothesis that an impaired hypocretin system causes a general instability of motor regulation during wakefulness, rapid eye movement and non-rapid eye movement sleep in human narcolepsy...
  3. pmc Validation of the ICSD-2 criteria for CSF hypocretin-1 measurements in the diagnosis of narcolepsy in the Danish population
    Stine Knudsen
    Danish Center for Sleep Medicine, University of Copenhagen, Glostrup Hospital, Glostrup, Denmark
    Sleep 33:169-76. 2010
    ....
  4. pmc Sleep transitions in hypocretin-deficient narcolepsy
    Gertrud Laura Sorensen
    Danish Center for Sleep Medicine, Department of Clinical Neurophysiology, Center for Healthy Aging, Faculty of Health Sciences, University of Copenhagen, Glostrup Hospital, Copenhagen, Denmark
    Sleep 36:1173-7. 2013
    ....
  5. pmc Attenuated heart rate response is associated with hypocretin deficiency in patients with narcolepsy
    Gertrud Laura Sorensen
    Danish Center for Sleep Medicine, Glostrup University Hospital, Glostrup Hospital, Denmark
    Sleep 36:91-8. 2013
    ..Several studies have suggested that hypocretin-1 may influence the cerebral control of the cardiovascular system. We analyzed whether hypocretin-1 deficiency in narcolepsy patients may result in a reduced heart rate response...
  6. pmc Comorbidity and mortality of narcolepsy: a controlled retro- and prospective national study
    Poul Jennum
    Danish Center for Sleep Medicine, Department of Clinical Neurophysiology, Center for Healthy Aging, Faculty of Health Sciences, University of Copenhagen, Glostrup Hospital, Copenhagen, Denmark
    Sleep 36:835-40. 2013
    ..To identify the factual morbidity and mortality of narcolepsy in a controlled design...
  7. doi request reprint Health, social, and economic consequences of narcolepsy: a controlled national study evaluating the societal effect on patients and their partners
    Poul Jennum
    Danish Center for Sleep Medicine, Department of Clinical Neurophysiology, Center for Healthy Aging, University of Copenhagen, Glostrup Hospital, Copenhagen, Denmark
    Sleep Med 13:1086-93. 2012
    ..We aimed to estimate the factual direct and indirect costs of narcolepsy patients and their families in a national sample using a controlled study design...
  8. doi request reprint Reduced CSF hypocretin-1 levels are associated with cluster headache
    Mads Barloese
    Danish Headache Center, Dept of Neurology, Glostrup Hospital, University of Copenhagen, Denmark
    Cephalalgia 35:869-76. 2015
    ..As it exhibits strong chronobiological traits and genetic studies have suggested a link with the hypocretin (HCRT) system, the objective of this study was to investigate HCRT-1 in CH patients...
  9. pmc The economic consequences of narcolepsy
    Poul Jennum
    Danish Center for Sleep Medicine, Department of Clinical Neurophysiology, Faculty of Health Sciences, University of Copenhagen, Glostrup Hospital, Copenhagen, Denmark
    J Clin Sleep Med 5:240-5. 2009
    ..The disease may, thus, present a significant socioeconomic burden, but no studies to date have addressed the indirect and direct costs of narcolepsy...
  10. pmc Cerebrospinal fluid cytokine levels in type 1 narcolepsy patients very close to onset
    Birgitte Rahbek Kornum
    Center for Sleep Sciences and Medicine, Department of Psychiatry, Stanford University School of Medicine, Palo Alto, CA, USA Molecular Sleep Laboratory, Department of Diagnostics, Rigshospitalet, Glostrup, Denmark Danish Center for Sleep Medicine, Department of Neurophysiology, University of Copenhagen, Rigshospitalet, Glostrup, Denmark Electronic address
    Brain Behav Immun 49:54-8. 2015
    ..Cytokine levels did not differ significantly between controls and patients, even in 5 patients with disease onset less than a month prior to CSF sampling. ..
  11. doi request reprint Sleep-wake transition in narcolepsy and healthy controls using a support vector machine
    Julie B Jensen
    Department of Electrical Engineering, Technical University of Denmark, Kongens Lyngby, Denmark and Danish Center for Sleep Medicine, Glostrup University Hospital, Glostrup, Denmark
    J Clin Neurophysiol 31:397-401. 2014
    ..Narcolepsy with cataplexy patients have more sleep-wake transitions during night, suggesting instability in the sleep-wake regulatory system. ..
  12. doi request reprint MiRNA profiles in cerebrospinal fluid from patients with central hypersomnias
    Anja Holm
    Molecular Sleep Laboratory, Department of Diagnostics, Glostrup Hospital, Nordre Ringvej 69, 2600 Glostrup, Denmark Danish Center for Sleep Medicine, University of Copenhagen, Glostrup Hospital, Glostrup, Denmark
    J Neurol Sci 347:199-204. 2014
    ..In conclusion, we were not able to demonstrate distinct levels or patterns of miRNAs in CSF from central hypersomnia patients. ..
  13. ncbi request reprint Antibodies in narcolepsy-cataplexy patient serum bind to rat hypocretin neurons
    Stine Knudsen
    Department of Clinical Neurophysiology, Danish Center for Sleep Medicine, University Hospital of Glostrup, Denmark
    Neuroreport 18:77-9. 2007
    ..These results show that antibodies bind to specific hypocretin- and nonhypocretin-containing neurons in the hypothalamus and indicate the presence of autoantibodies in narcolepsy patients...
  14. ncbi request reprint Prediction of immunophenotype, treatment response, and relapse in childhood acute lymphoblastic leukemia using DNA microarrays
    H Willenbrock
    Center for Biological Sequence Analysis, Technical University of Denmark, Lyngby, Denmark
    Leukemia 18:1270-7. 2004
    ..Further studies should focus on prediction of MRD, as this prediction would relate strongly to long-term outcome and could thus determine the intensity of induction therapy...