Michael Kjaer

Summary

Affiliation: University of Copenhagen
Country: Denmark

Publications

  1. ncbi request reprint Role of extracellular matrix in adaptation of tendon and skeletal muscle to mechanical loading
    Michael Kjaer
    Sports Medicine Research Unit, Department of Rheumatology, Copenhagen University Hospital at Bispebjerg, 23 Bispebjerg Bakke, DK 2400 Copenhagen NV, Denmark
    Physiol Rev 84:649-98. 2004
  2. ncbi request reprint [Elective surgery reconvalescence after pre-operative physical training]
    Michael Kjaer
    Institut for Idraetsmedicin, Bispebjerg Hospital, DK 2400 København NV, Denmark
    Ugeskr Laeger 171:2920-2. 2009
  3. pmc Exercise increases interleukin-10 levels both intraarticularly and peri-synovially in patients with knee osteoarthritis: a randomized controlled trial
    Ida C Helmark
    Department of Orthopaedic Surgery, University of Copenhagen, Bispebjerg Bakke 23, Copenhagen NV, Denmark
    Arthritis Res Ther 12:R126. 2010
  4. ncbi request reprint Cardiovascular and neuroendocrine responses to exercise in hypoxia during impaired neural feedback from muscle
    M Kjaer
    Sports Medicine Research Unit, Department of Rheumatology H, Bispebjerg Hospital, University of Copenhagen, DK 2400 Copenhagen, Denmark
    Am J Physiol 277:R76-85. 1999
  5. pmc Redundancy reflects versatility of blood flow regulation mechanisms
    Robert Boushel
    Department of Exercise Science, Concordia University, Montreal, Canada
    J Physiol 557:346. 2004
  6. doi request reprint From mechanical loading to collagen synthesis, structural changes and function in human tendon
    M Kjaer
    Department of Orthopaedics, Institute of Sports Medicine, Bispebjerg Hospital, Copenhagen, Denmark
    Scand J Med Sci Sports 19:500-10. 2009
  7. doi request reprint Novel methods for tendon investigations
    M Kjaer
    Institute of Sports Medicine, Department of Rheumatology, Bispebjerg Hospital, Copenhagen University Hospital, Copenhagen, Denmark
    Disabil Rehabil 30:1514-22. 2008
  8. ncbi request reprint [Physical activity--what minimal level is sufficient seen from health perspective?]
    M Kjaer
    H S Bispebjerg Hospital, Idraetsmedicinsk Forsknings og Udviklingsenhed, Københavns Universitet
    Ugeskr Laeger 162:2164-9. 2000
  9. ncbi request reprint [From exercise physiology to sports medicine]
    M Kjaer
    reumatologisk klinik, Medicinsk Center, H S Bispebjerg Hospital, Idraetsmedicinsk Forsknings og Udviklingsenhed
    Ugeskr Laeger 161:6329-33. 1999
  10. pmc Adrenaline and glycogenolysis in skeletal muscle during exercise: a study in adrenalectomised humans
    M Kjaer
    Sports Medicine Research Unit, Departments of Rheumatology and Clinical Physiology, Copenhagen Muscle Research Centre, Bispebjerg Hospital, DK 2400
    J Physiol 528:371-8. 2000

Collaborators

Detail Information

Publications113 found, 100 shown here

  1. ncbi request reprint Role of extracellular matrix in adaptation of tendon and skeletal muscle to mechanical loading
    Michael Kjaer
    Sports Medicine Research Unit, Department of Rheumatology, Copenhagen University Hospital at Bispebjerg, 23 Bispebjerg Bakke, DK 2400 Copenhagen NV, Denmark
    Physiol Rev 84:649-98. 2004
    ..Full understanding of these physiological processes will provide the physiological basis for understanding of tissue overloading and injury seen in both tendons and muscle with repetitive work and leisure time physical activity...
  2. ncbi request reprint [Elective surgery reconvalescence after pre-operative physical training]
    Michael Kjaer
    Institut for Idraetsmedicin, Bispebjerg Hospital, DK 2400 København NV, Denmark
    Ugeskr Laeger 171:2920-2. 2009
    ....
  3. pmc Exercise increases interleukin-10 levels both intraarticularly and peri-synovially in patients with knee osteoarthritis: a randomized controlled trial
    Ida C Helmark
    Department of Orthopaedic Surgery, University of Copenhagen, Bispebjerg Bakke 23, Copenhagen NV, Denmark
    Arthritis Res Ther 12:R126. 2010
    ....
  4. ncbi request reprint Cardiovascular and neuroendocrine responses to exercise in hypoxia during impaired neural feedback from muscle
    M Kjaer
    Sports Medicine Research Unit, Department of Rheumatology H, Bispebjerg Hospital, University of Copenhagen, DK 2400 Copenhagen, Denmark
    Am J Physiol 277:R76-85. 1999
    ..In conclusion, in essence the hypoxia-induced enhancement of systemic adaptation to exercise is not mediated by neural feedback from working muscle in humans...
  5. pmc Redundancy reflects versatility of blood flow regulation mechanisms
    Robert Boushel
    Department of Exercise Science, Concordia University, Montreal, Canada
    J Physiol 557:346. 2004
  6. doi request reprint From mechanical loading to collagen synthesis, structural changes and function in human tendon
    M Kjaer
    Department of Orthopaedics, Institute of Sports Medicine, Bispebjerg Hospital, Copenhagen, Denmark
    Scand J Med Sci Sports 19:500-10. 2009
    ..An intimate interplay between mechanical signalling and biochemical changes in the matrix is needed in tendon, such that chemical changes can be converted into adaptations in the morphology, structure and material properties...
  7. doi request reprint Novel methods for tendon investigations
    M Kjaer
    Institute of Sports Medicine, Department of Rheumatology, Bispebjerg Hospital, Copenhagen University Hospital, Copenhagen, Denmark
    Disabil Rehabil 30:1514-22. 2008
    ....
  8. ncbi request reprint [Physical activity--what minimal level is sufficient seen from health perspective?]
    M Kjaer
    H S Bispebjerg Hospital, Idraetsmedicinsk Forsknings og Udviklingsenhed, Københavns Universitet
    Ugeskr Laeger 162:2164-9. 2000
    ....
  9. ncbi request reprint [From exercise physiology to sports medicine]
    M Kjaer
    reumatologisk klinik, Medicinsk Center, H S Bispebjerg Hospital, Idraetsmedicinsk Forsknings og Udviklingsenhed
    Ugeskr Laeger 161:6329-33. 1999
    ....
  10. pmc Adrenaline and glycogenolysis in skeletal muscle during exercise: a study in adrenalectomised humans
    M Kjaer
    Sports Medicine Research Unit, Departments of Rheumatology and Clinical Physiology, Copenhagen Muscle Research Centre, Bispebjerg Hospital, DK 2400
    J Physiol 528:371-8. 2000
    ..Finally, a novel finding is that the activity of HSL in human muscle is increased in exercising man and this is due, at least partly, to stimulation by adrenaline...
  11. ncbi request reprint Muscle enzyme adaptation to training and tapering-off in spinal-cord-injured humans
    M Kjaer
    Sports Medicine Research Unit, Department of Rheumatology, Bispebjerg Hospital, Bakke 23, 2400 Copenhagen NV, Denmark
    Eur J Appl Physiol 84:482-6. 2001
    ....
  12. ncbi request reprint Fatty acid kinetics and carbohydrate metabolism during electrical exercise in spinal cord-injured humans
    M Kjaer
    The Copenhagen Muscle Research Centre, Copenhagen University Hospital, DK 2400 Copenhagen NV, Denmark
    Am J Physiol Regul Integr Comp Physiol 281:R1492-8. 2001
    ..Furthermore, in exercising muscle, FFA delivery enhances FFA uptake and inhibits carbohydrate metabolism, while carbohydrate metabolism inhibits FFA uptake...
  13. doi request reprint Protein-containing nutrient supplementation following strength training enhances the effect on muscle mass, strength, and bone formation in postmenopausal women
    Lars Holm
    Institute of Sports Medicine, Bispebjerg Hospital, Copenhagen, Bispebjerg Bakke 23, DK 2400 Copenhagen NV, Denmark
    J Appl Physiol (1985) 105:274-81. 2008
    ..The observed differences following such a short intervention emphasize the significance of postexercise nutrient supply on musculoskeletal maintenance...
  14. pmc Growth hormone stimulates the collagen synthesis in human tendon and skeletal muscle without affecting myofibrillar protein synthesis
    Simon Doessing
    Institute of Sports Medicine, Bispebjerg Hospital, Center of Healthy Aging, Faculty of Health Sciences, University of Copenhagen, Copenhagen NV, Denmark
    J Physiol 588:341-51. 2010
    ..The results suggest that GH is more important in strengthening the matrix tissue than for muscle cell hypertrophy in adult human musculotendinous tissue...
  15. ncbi request reprint Exercise-dependent IGF-I, IGFBPs, and type I collagen changes in human peritendinous connective tissue determined by microdialysis
    Jens L Olesen
    Institute of Sports Medicine, Bispebjerg Hospital, DK 2400 Copenhagen, Denmark
    J Appl Physiol (1985) 102:214-20. 2007
    ..The local increased collagen synthesis was preceded by an elevation of local concentration of IGFBP-4, suggesting that IGFBP-4 may have a key role in the IGF-axis effect on the human collagen synthesis in vivo...
  16. doi request reprint Effect of estrogen on tendon collagen synthesis, tendon structural characteristics, and biomechanical properties in postmenopausal women
    Mette Hansen
    Institute of Sports Medicine, Bispebjerg Hospital, and Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    J Appl Physiol (1985) 106:1385-93. 2009
    ..These results indicate a pivotal role for estradiol in maintaining homeostasis of female connective tissue...
  17. doi request reprint The effects of neuromuscular training on knee joint motor control during sidecutting in female elite soccer and handball players
    Mette K Zebis
    Institute of Sports Medicine, Bispebjerg Hospital, Copenhagen, Denmark
    Clin J Sport Med 18:329-37. 2008
    ....
  18. pmc Extracellular matrix adaptation of tendon and skeletal muscle to exercise
    Michael Kjaer
    Institute of Sports Medicine, Bispebjerg Hospital, Copenhagen, Denmark
    J Anat 208:445-50. 2006
    ..These findings may provide the basis for understanding tissue overloading and injury in both tendons and skeletal muscle...
  19. pmc Sequenced response of extracellular matrix deadhesion and fibrotic regulators after muscle damage is involved in protection against future injury in human skeletal muscle
    Abigail L Mackey
    Institute of Sports Medicine, Department of Orthopaedic Surgery M, Bispebjerg Hospital, Bispebjerg Bakke 23, DK 2400 Copenhagen NV, Denmark
    FASEB J 25:1943-59. 2011
    ..001). The findings indicate that the sequenced events of load-induced early deadhesion and later strengthening of skeletal muscle ECM play a role in protecting human muscle against future injury...
  20. pmc No effect of growth hormone administration on substrate oxidation during exercise in young, lean men
    Mette Hansen
    Institute of Sports Medicine, Copenhagen, Denmark
    J Physiol 567:1035-45. 2005
    ..In conclusion, GH administration combined with aerobic exercise increased lipolytic parameters substantially more than exercise alone, but did not further augment whole body fat oxidation...
  21. doi request reprint Impact of oral contraceptive use and menstrual phases on patellar tendon morphology, biochemical composition, and biomechanical properties in female athletes
    Mette Hansen
    Institute of Sports Medicine, Department of Orthopedic Surgery M, Bispebjerg Hospital, and Center for Healthy Aging, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    J Appl Physiol (1985) 114:998-1008. 2013
    ..The results indicate that long-term OC use or menstrual phases does not influence structure or mechanical properties of the patellar tendon in female team handball athletes...
  22. ncbi request reprint No effect of menstrual cycle on myofibrillar and connective tissue protein synthesis in contracting skeletal muscle
    Benjamin F Miller
    Institute of Sports Medicine, Copenhagen
    Am J Physiol Endocrinol Metab 290:E163-E168. 2006
    ..Therefore, there is no effect of menstrual cycle phase, at rest or in response to an acute bout of exercise, on myofibrillar protein synthesis and muscle collagen synthesis in women...
  23. ncbi request reprint [Physical activity and chronic disease III. Musculoskeletal diseases and lung diseases]
    Peter Magnusson
    H S Bispebjerg Hospital, Medicinsk Center
    Ugeskr Laeger 166:1552-7. 2004
  24. ncbi request reprint [Physical activity and chronic disease II. Type 2 diabetes, obesity and cancer]
    Peter Magnusson
    H S Bispebjerg Hospital, Medicinsk Center
    Ugeskr Laeger 166:1547-51. 2004
  25. ncbi request reprint Tendon collagen synthesis at rest and after exercise in women
    Benjamin F Miller
    Institute of Sports Medicine, Bispebjerg Hospital, Copenhagen, Denmark
    J Appl Physiol (1985) 102:541-6. 2007
    ..It is concluded that both in the resting state and after exercise, tendon collagen FSR is lower in women than in men, which may contribute to a lower rate of tissue repair after exercise...
  26. ncbi request reprint Acute growth hormone administration causes exaggerated increases in plasma lactate and glycerol during moderate to high intensity bicycling in trained young men
    Kai Henrik Wiborg Lange
    Sports Medicine Research Unit, Building 8, Bispebjerg Hospital, Bispebjerg Bakke 23, DK 2400 Copenhagen NV, Denmark
    J Clin Endocrinol Metab 87:4966-75. 2002
    ..The exaggerated increase in plasma lactate may be associated with substantially decreased exercise performance...
  27. ncbi request reprint Muscle and blood metabolites during a soccer game: implications for sprint performance
    Peter Krustrup
    Institute of Exercise and Sport Sciences, Department of Human Physiology, University of Copenhagen, Copenhagen, Denmark
    Med Sci Sports Exerc 38:1165-74. 2006
    ..To examine muscle and blood metabolites during soccer match play and relate it to possible changes in sprint performance...
  28. doi request reprint GH and IGF1 levels are positively associated with musculotendinous collagen expression: experiments in acromegalic and GH deficiency patients
    Simon Doessing
    Department of Orthopaedic Surgery M, Faculty of Health Sciences, Institute of Sports Medicine, Bispebjerg Hospital and Centre for Healthy Aging, University of Copenhagen, Bispebjerg Bakke 23, Copenhagen DK 2400, Denmark
    Eur J Endocrinol 163:853-62. 2010
    ..GH/IGF1 is likely to play an important role in the regulation of tendon and muscle collagen. We hypothesized that the local production of collagen is associated with the level of GH/IGF1...
  29. ncbi request reprint The influence of anti-inflammatory medication on exercise-induced myogenic precursor cell responses in humans
    Abigail L Mackey
    Institute of Sports Medicine Copenhagen, Bispebjerg Hospital, Bldg 8, Bispebjerg Bakke 23, 2400 Copenhagen NV, Denmark
    J Appl Physiol (1985) 103:425-31. 2007
    ..05). These results suggest that ingestion of anti-inflammatory drugs attenuates the exercise-induced increase in satellite cell number, supporting the role of the cyclooxygenase pathway in satellite cell activity...
  30. ncbi request reprint Effects of 2 wk of GH administration on 24-h indirect calorimetry in young, healthy, lean men
    Mette Hansen
    Institute of Sports Medicine, Copenhagen, Building 8, Bispebjerg Hospital, Bispebjerg Bakke 23, DK 2400 Copenhagen NV, Denmark
    Am J Physiol Endocrinol Metab 289:E1030-8. 2005
    ..5 kg (baseline) vs. 64.7 +/- 2.4 kg (after), P < 0.001]. In conclusion, GH-adm. increases 24-h EE, which may be partly explained by increased LBM. Furthermore, GH-adm. stimulates fat combustion, especially in the postabsorptive state...
  31. ncbi request reprint Expression of insulin-like growth factor I, insulin-like growth factor binding proteins, and collagen mRNA in mechanically loaded plantaris tendon
    Jens L Olesen
    Institute of Sports Medicine, Bispebjerg Hospital, DK 2400 Copenhagen, Denmark
    J Appl Physiol (1985) 101:183-8. 2006
    ..Also, MGF is expressed with an early upregulation in loaded tendon tissue. We suggest that the IGF-I system could be involved in collagen synthesis in tendon in response to mechanical loading...
  32. ncbi request reprint Subcutaneous abdominal adipose tissue lipolysis during exercise determined by arteriovenous measurements in older women
    Kai Henrik Wiborg Lange
    Sports Medicine Research Unit, Bispebjerg Hospital, Copenhagen, Denmark
    J Am Geriatr Soc 50:275-81. 2002
    ..To characterize the lipolytic response in the subcutaneous abdominal adipose tissue in older women to endurance exercise...
  33. pmc The adaptability of tendon to loading differs in men and women
    S Peter Magnusson
    Institute of Sports Medicine Copenhagen, Bispebjerg Hospital, Copenhagen, Denmark
    Int J Exp Pathol 88:237-40. 2007
    ..These data indicate that tendons in women have a lower rate of new connective tissue formation, respond less to mechanical loading, and have a lower mechanical strength, which may leave the tissue more susceptible to injury...
  34. doi request reprint Effects of aging on muscle mechanical function and muscle fiber morphology during short-term immobilization and subsequent retraining
    Lars Hvid
    Institute of Sports Medicine, Bispebjerg Hospital and Center of Healthy Aging, Faculty of Health Science, University of Copenhagen, Copenhagen, Denmark
    J Appl Physiol (1985) 109:1628-34. 2010
    ..Furthermore, OM seems to require longer time to recover and regain rapid muscle force capacity, which may lead to a larger risk of falling in aged individuals after periods of short-term disuse...
  35. doi request reprint The single-biopsy approach in determining protein synthesis in human slow-turning-over tissue: use of flood-primed, continuous infusion of amino acid tracers
    Lars Holm
    Institute of Sports Medicine Copenhagen, Department of Orthopedic Surgery, Bispebjerg Hospital and Center for Healthy Aging, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark and Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 306:E1330-9. 2014
    ....
  36. doi request reprint Myogenic, matrix, and growth factor mRNA expression in human skeletal muscle: effect of contraction intensity and feeding
    Jakob Agergaard
    Institute of Sports Medicine, Department of Orthopedic Surgery M, Bispebjerg Hospital, Denmark
    Muscle Nerve 47:748-59. 2013
    ..We examined short-term (3-hour) and long-term (12-week) training effects after heavy load [HL; 70% 1RM] and light load (LL; 16% 1RM) exercise...
  37. pmc Effects of 2 weeks lower limb immobilization and two separate rehabilitation regimens on gastrocnemius muscle protein turnover signaling and normalization genes
    Anders Nedergaard
    Institute of Sports Medicine, Department of Orthopedic Surgery M, Bispebjerg Hospital, Copenhagen, Denmark
    BMC Res Notes 5:166. 2012
    ..To investigate the phosphorylation and expression of candidate key molecular muscle mass regulators after immobilization and subsequent rehabilitation we performed two separate studies...
  38. ncbi request reprint Nitric oxide and prostaglandins influence local skeletal muscle blood flow during exercise in humans: coupling between local substrate uptake and blood flow
    Kari K Kalliokoski
    Copenhagen Muscle Research Centre, Bispebjerg Hospital, Denmark
    Am J Physiol Regul Integr Comp Physiol 291:R803-9. 2006
    ..The findings suggest that local substrate uptake in skeletal muscle can be regulated independently of regional changes in blood flow...
  39. doi request reprint Evidence of skeletal muscle damage following electrically stimulated isometric muscle contractions in humans
    Abigail L Mackey
    Institute of Sports Medicine Copenhagen, Bispebjerg Hospital, Bldg 8, Bispebjerg Bakke 23, 2400 Copenhagen NV, Denmark
    J Appl Physiol (1985) 105:1620-7. 2008
    ..These data support the hypothesis that muscle damage at the level of the sarcomere can be induced without lengthening muscle contractions...
  40. doi request reprint Effects of long-term immobilization and recovery on human triceps surae and collagen turnover in the Achilles tendon in patients with healing ankle fracture
    Britt Christensen
    Institute of Sports Medicine, Bispebjerg Hospital, University of Copenhagen, Bispebjerg Bakke 23, 2400 Copenhagen NV, Denmark
    J Appl Physiol (1985) 105:420-6. 2008
    ..Remobilization increased muscle size and strength and tendon synthesis and degradation decreased to baseline levels. These dynamic changes in tendon connective tissue turnover were not associated with macroscopic changes in tendon size...
  41. ncbi request reprint Lateral force transmission between human tendon fascicles
    Bjarki T Haraldsson
    Institute of Sports Medicine Copenhagen, Bispebjerg Hospital, Copenhagen, Denmark
    Matrix Biol 27:86-95. 2008
    ....
  42. doi request reprint Assessment of satellite cell number and activity status in human skeletal muscle biopsies
    Abigail L Mackey
    Institute of Sports Medicine, Bispebjerg Hospital and Centre for Healthy Ageing, Faculty of Health Sciences, University of Copenhagen, Bispebjerg Bakke 23, 2400 Copenhagen, Denmark
    Muscle Nerve 40:455-65. 2009
    ..This study provides valuable tools to assess the behavior of satellite cells, both in pathological conditions and in response to physiological stimuli...
  43. doi request reprint The anabolic potential of dietary protein intake on skeletal muscle is prolonged by prior light-load exercise
    Rasmus Bechshoeft
    Institute of Sports Medicine, Dept of Orthopedic Surgery M81, Bispebjerg Hospital and Center for Healthy Aging, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Clin Nutr 32:236-44. 2013
    ..Hyperaminoacidemia stimulates myofibrillar fractional synthesis rate (myoFSR) transiently in resting skeletal muscle. We investigated whether light-load resistance exercise can extent this responsiveness...
  44. ncbi request reprint Contraction-induced [18F]-fluoro-deoxy-glucose uptake can be measured in human calf muscle using high-resolution PET
    Kari K Kalliokoski
    Turku PET Centre, University of Turku, Turku, Finland, and Physiotherapy Department, Bispebjerg Hospital, Copenhagen, Denmark
    Clin Physiol Funct Imaging 27:239-41. 2007
    ....
  45. doi request reprint Mechanical properties of human patellar tendon at the hierarchical levels of tendon and fibril
    René B Svensson
    Faculty of Health Sciences, Institute of Sports Medicine Copenhagen, Bispebjerg Hospital and Center for Healthy Aging, University of Copenhagen, Copenhagen, Denmark
    J Appl Physiol (1985) 112:419-26. 2012
    ..In addition to the primary work comparing the two hierarchical levels, we also verified the existence of viscoelastic behavior in isolated human collagen fibrils...
  46. pmc Use of cis-[18F]fluoro-proline for assessment of exercise-related collagen synthesis in musculoskeletal connective tissue
    Dorthe Skovgaard
    Institute of Sports Medicine Copenhagen, Bispebjerg Hospital and Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 6:e16678. 2011
    ..Further studies including kinetic compartment modeling must be performed to establish whether cis-Fpro can be used for non-invasive in-vivo assessment of exercise-induced changes in musculoskeletal collagen synthesis...
  47. doi request reprint Short-term immobilization and recovery affect skeletal muscle but not collagen tissue turnover in humans
    Britt Christensen
    Institute of Sports Medicine Copenhagen, Bispebjerg Hospital, Bispebjerg Bakke 23, 2400 Copenhagen NV, Denmark
    J Appl Physiol (1985) 105:1845-51. 2008
    ..Thus 2 wk of immobilization are sufficient to induce significant changes in muscle tissue, whereas tendon tissue seems to be more resistant to short-term immobilization...
  48. pmc Ethinyl oestradiol administration in women suppresses synthesis of collagen in tendon in response to exercise
    Mette Hansen
    Institute of Sports Medicine, Copenhagen, Build 8, Bispebjerg Hospital, Bispebjerg Bakke 23, DK 2400 Copenhagen NV, Denmark
    J Physiol 586:3005-16. 2008
    ..The mechanism behind this is either a direct effect of oestradiol, or an indirect effect via a reduction in levels of free IGF-I. However, the data did not indicate any long-term effect on tendon size associated with chronic OC use...
  49. doi request reprint GH receptor blocker administration and muscle-tendon collagen synthesis in humans
    Rie Harboe Nielsen
    Institute of Sports Medicine, Dept of Orthopaedic Surgery M, Bispebjerg Hospital and Center for Healthy Aging, Faculty of Health Sciences, University of Copenhagen, Denmark
    Growth Horm IGF Res 21:140-5. 2011
    ..The growth hormone (GH)/insulin-like growth factor-I (IGF-I) axis stimulates collagen synthesis in tendon and skeletal muscle, but no studies have investigated the effect of reducing IGF-I on collagen synthesis in healthy humans...
  50. doi request reprint Coordinated increase in skeletal muscle fiber area and expression of IGF-I with resistance exercise in elderly post-operative patients
    Charlotte Suetta
    Institute of Sports Medicine, Bispebjerg Hospital, University of Copenhagen, Denmark
    Growth Horm IGF Res 20:134-40. 2010
    ....
  51. ncbi request reprint Enhanced procollagen processing in skeletal muscle after a single bout of eccentric loading in humans
    Regina M Crameri
    Sports Medicine Research Unit, Bispebjerg Hospital, DK 2400, Copenhagen NV, Denmark
    Matrix Biol 23:259-64. 2004
    ..This study shows that following a single bout of high intensity eccentric exercise there is an increase in procollagen processing within skeletal muscle in humans...
  52. doi request reprint Resistance training induces qualitative changes in muscle morphology, muscle architecture, and muscle function in elderly postoperative patients
    Charlotte Suetta
    Institute of Sports Medicine, Bispebjerg Hospital, University of Copenhagen, Bispebjerg Bakke 23, 2400 NV, Copenhagen, Denmark
    J Appl Physiol (1985) 105:180-6. 2008
    ..The present data emphasize the importance of resistance training in future rehabilitation programs for elderly individuals...
  53. ncbi request reprint Gene expression of myogenic factors and phenotype-specific markers in electrically stimulated muscle of paraplegics
    Kristian Vissing
    Dept of Molecular Muscle Biology, Copenhagen Muscle Research Centre, Righospitalet, Univ of Copenhagen, Denmark
    J Appl Physiol 99:164-72. 2005
    ..The results indicate that myogenin is indeed involved in the regulation of the slow oxidative phenotype in human skeletal muscle fibers, whereas MyoD appears to have a more complex regulatory function...
  54. doi request reprint Growth hormone receptor antagonist treatment reduces exercise performance in young males
    Kazushige Goto
    Institute of Sports Medicine, Bispebjerg Hospital, DK 2400 Copenhagen, Denmark
    J Clin Endocrinol Metab 94:3265-72. 2009
    ..The effects of GH on exercise performance remain unclear...
  55. pmc Coordinated collagen and muscle protein synthesis in human patella tendon and quadriceps muscle after exercise
    Benjamin F Miller
    Institute of Sports Medicine, Copenhagen, Bispebjerg Hospital, Denmark
    J Physiol 567:1021-33. 2005
    ..The similar time course of changes of protein synthetic rates in different cell types supports the idea of coordinated musculotendinous adaptation...
  56. doi request reprint No inflammatory gene-expression response to acute exercise in human Achilles tendinopathy
    Jessica Pingel
    Department of Orthopaedic Surgery M Bispebjerg Hospital and Center for Healthy Aging, Faculty of Health Sciences, Institute of Sports Medicine Copenhagen, University of Copenhagen, Bispebjerg Bakke 23, Copenhagen NV, Denmark
    Eur J Appl Physiol 113:2101-9. 2013
    ..The signalling for collagen and TGF-beta was upregulated after acute loading in tendinopathic tendon. In contrast to the hypothesis, inflammatory signalling was not exaggerated in tendinopathic tendon 2 h after acute mechanical loading...
  57. ncbi request reprint Muscle performance during maximal isometric and dynamic contractions is influenced by the stiffness of the tendinous structures
    Jens Bojsen-Møller
    Institute of Sports Medicine Copenhagen Team Danmark Test Center, Bispebjerg Bakke, 23, bygn 8, Bispebjerg Hospital, 2400 Copenhagen NV, Denmark
    J Appl Physiol (1985) 99:986-94. 2005
    ....
  58. doi request reprint Micromechanical properties and collagen composition of ruptured human achilles tendon
    Philip Hansen
    Institute of Sports Medicine Copenhagen, Bispebjerg Bakke 23, Building 8, 1st Floor, DK 2400 Copenhagen, Denmark
    Am J Sports Med 41:437-43. 2013
    ..The Achilles tendon is one of the strongest tendons in the human body, and yet it frequently ruptures, which is a substantial clinical problem. However, the cause of ruptures remains elusive...
  59. doi request reprint No donor age effect of human serum on collagen synthesis signaling and cell proliferation of human tendon fibroblasts
    Monika L Bayer
    Institute of Sports Medicine, Department of Orthopedic Surgery M, Bispebjerg Hospital and Center for Healthy Aging, Faculty of Health Sciences, University of Copenhagen, Denmark
    Mech Ageing Dev 133:246-54. 2012
    ..These findings suggest that factors such as the cell intrinsic capacity or the tissue-specific environment rather than systemic circulating factors are important for functional capacity throughout life in human tendon cells...
  60. doi request reprint Lower strength of the human posterior patellar tendon seems unrelated to mature collagen cross-linking and fibril morphology
    Philip Hansen
    Institute of Sports Medicine Copenhagen, Bispebjerg Hospital and Center for Healthy Aging, University of Copenhagen, DK 2400 Copenhagen NV, Denmark
    J Appl Physiol (1985) 108:47-52. 2010
    ..10). Material properties did not appear closely related to cross-linking or fibril morphology. These findings suggest region-specific differences in mechanical, structural, and biochemical properties of the human patellar tendon...
  61. doi request reprint Fibril morphology and tendon mechanical properties in patellar tendinopathy: effects of heavy slow resistance training
    Mads Kongsgaard
    Department of Orthopedic Surgery M, Bispebjerg Hospital and Center for Healthy Aging, University of Copenhagen, Denmark
    Am J Sports Med 38:749-56. 2010
    ..Patellar tendinopathy is characterized by pathologic abnormalities. Heavy slow resistance training (HSR) is effective in the management of patellar tendinopathy, but the underlying functional mechanisms remain elusive...
  62. ncbi request reprint Incidence of injury and physical performance adaptations during military training
    Lars Rosendal
    Sports Medicine Research Unit, Bispebjerg Hospital, Copenhagen, Denmark
    Clin J Sport Med 13:157-63. 2003
    ....
  63. ncbi request reprint Lipolysis in human adipose tissue during exercise: comparison of microdialysis and a-v measurements
    Kai Henrik Wiborg Lange
    Sports Medicine Research Unit, Bispejerg Hospital, Copenhagen, Denmark
    J Appl Physiol (1985) 92:1310-6. 2002
    ..Caution should, therefore, be taken when lipolysis is evaluated, based on results obtained by the two techniques under non-steady-state conditions...
  64. ncbi request reprint Resistance training in the early postoperative phase reduces hospitalization and leads to muscle hypertrophy in elderly hip surgery patients--a controlled, randomized study
    Charlotte Suetta
    Sports Medicine Research Unit, University of Copenhagen, Copenhagen, Denmark
    J Am Geriatr Soc 52:2016-22. 2004
    ..To better understand how immobilization and surgery affect muscle size and function in the elderly and to identify effective training regimes...
  65. doi request reprint Contraction intensity and feeding affect collagen and myofibrillar protein synthesis rates differently in human skeletal muscle
    Lars Holm
    Institute of Sports Medicine, Bispebjerg Hospital and Center of Healthy Aging, University of Copenhagen, Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 298:E257-69. 2010
    ..Furthermore, although functionally linked, the contractile and the supportive matrix structures upregulate their protein synthesis rate quite differently in response to feeding and contractile activity and intensity...
  66. ncbi request reprint Prostaglandin synthesis can be inhibited locally by infusion of NSAIDS through microdialysis catheters in human skeletal muscle
    Ulla Ramer Mikkelsen
    Institute of Sports Medicine, Bispebjerg Hospital, DK 2400 Copenhagen NV, Copenhagen, Denmark
    J Appl Physiol (1985) 104:534-7. 2008
    ..In conclusion, the present study shows that infusion of NSAIDs into human muscle via microdialysis catheters results in a graded blockade of prostaglandin synthesis...
  67. doi request reprint Effect of anti-inflammatory medication on the running-induced rise in patella tendon collagen synthesis in humans
    Britt Christensen
    Institute of Sports Medicine Copenhagen, Bispebjerg Hospital, and Center of Healthy Aging, University of Copenhagen, Copenhagen, Denmark
    J Appl Physiol (1985) 110:137-41. 2011
    ..05). The present study demonstrates that intake of NSAID decreased interstitial PGE₂ and abolished the exercise-induced adaptive increase in collagen synthesis in human tendons...
  68. doi request reprint 18F-fluorodeoxyglucose and PET/CT for noninvasive study of exercise-induced glucose uptake in rat skeletal muscle and tendon
    Dorthe Skovgaard
    Cluster for Molecular Imaging, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Eur J Nucl Med Mol Imaging 36:859-68. 2009
    ..To investigate exercise-related glucose uptake in rat muscle and tendon using PET/CT and to study possible explanatory changes in gene expression for the glucose transporters (GLUT1 and GLUT4)...
  69. ncbi request reprint Experimental evidence against the mitochondrial theory of aging. A study of isolated human skeletal muscle mitochondria
    Ulla F Rasmussen
    Department of Biochemistry, August Krogh Institute, University of Copenhagen, Universitetsparken 13, Copenhagen, Denmark
    Exp Gerontol 38:877-86. 2003
    ..The obvious discord with reported age declines of human skeletal muscle mitochondrial function is discussed. It is concluded that the present results are incompatible with the mitochondrial theory of aging...
  70. ncbi request reprint Role of TGF-beta1 in relation to exercise-induced type I collagen synthesis in human tendinous tissue
    Katja Heinemeier
    Department of Rheumatology H, Bispebjerg Hospital, DK 2400 Copenhagen, Denmark
    J Appl Physiol (1985) 95:2390-7. 2003
    ..Although not conclusive, changes in circulating and local TGF-beta1, in response to exercise, suggest a role for TGF-beta1 in mechanical regulation of local collagen type I synthesis in tendon-related connective tissue in vivo...
  71. doi request reprint Nonsteroidal anti-inflammatory drug or glucosamine reduced pain and improved muscle strength with resistance training in a randomized controlled trial of knee osteoarthritis patients
    Susanne G Petersen
    Institute of Sports Medicine, Department of Orthopaedic Surgery M, Bispebjerg Hospital and Centre for Healthy Ageing, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Arch Phys Med Rehabil 92:1185-93. 2011
    ....
  72. doi request reprint Whey and casein labeled with L-[1-13C]leucine and muscle protein synthesis: effect of resistance exercise and protein ingestion
    Søren Reitelseder
    Institute of Sports Medicine Copenhagen, Department of Orthopedic Surgery M, Bispebjerg Hospital and Center for Healthy Aging, University of Copenhagen, Copenhagen NV, Denmark
    Am J Physiol Endocrinol Metab 300:E231-42. 2011
    ..05). In conclusion, whey and casein intake immediately after resistance exercise results in an overall equal MPS response despite temporal differences in insulin and amino acid concentrations and 4E-BP1...
  73. pmc Creatine supplementation augments the increase in satellite cell and myonuclei number in human skeletal muscle induced by strength training
    Steen Olsen
    Institute of Sports Medicine Copenhagen, Bispebjerg Hospital, Build 8, 1 Floor, DK 2400 Copenhagen NV, Denmark
    J Physiol 573:525-34. 2006
    ....
  74. ncbi request reprint The effect of resistance training combined with timed ingestion of protein on muscle fiber size and muscle strength
    Lars L Andersen
    Sports Medicine Research, Unit Team Denmark Test Center, Bispebjerg Hospital, DK 2400 Copenhagen, Denmark
    Metabolism 54:151-6. 2005
    ..However, the present results may have relevance for individuals who are particularly interested in gaining muscle size...
  75. doi request reprint Dynamic adaptation of tendon and muscle connective tissue to mechanical loading
    Abigail Louise Mackey
    Institute of Sports Medicine Copenhagen, Bispebjerg Hospital and Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Connect Tissue Res 49:165-8. 2008
    ..Taken together, the studies highlighted in this article provide strong evidence for the highly adaptable nature of connective tissue in muscle and tendon...
  76. ncbi request reprint Differential displacement of the human soleus and medial gastrocnemius aponeuroses during isometric plantar flexor contractions in vivo
    Jens Bojsen-Møller
    Sports Medicine Research Unit Team Danmark Test Center, Bispebjerg Bakke, 23, bygn 8, Bispebjerg Hospital, 2400 Copenhagen NV, Denmark
    J Appl Physiol (1985) 97:1908-14. 2004
    ....
  77. ncbi request reprint Resistance training, insulin sensitivity and muscle function in the elderly
    Flemming Dela
    Institute for Biomedical Sciences, University of Copenhagen, Denmark
    Essays Biochem 42:75-88. 2006
    ....
  78. ncbi request reprint [Physical activity and chronic disease I. Heart disease and hypertension]
    Peter Magnusson
    H S Bispebjerg Hospital, Medicinsk Center
    Ugeskr Laeger 166:1543-7. 2004
  79. ncbi request reprint Cardiovascular control during exercise: insights from spinal cord-injured humans
    Flemming Dela
    Department of Medical Physiology, The Panum Institute, Building 12 4 7, Blegdamsvej 3, DK 2200 Copenhagen N, Denmark
    Circulation 107:2127-33. 2003
    ..We studied the role of the central nervous system, neural feedback from contracting skeletal muscles, and sympathetic activity to the heart in the control of heart rate and blood pressure during 2 levels of dynamic exercise...
  80. pmc Human tendon behaviour and adaptation, in vivo
    S Peter Magnusson
    Institute of Sports Medicine, Copenhagen, Bispebjerg Hospital, Copenhagen, Denmark
    J Physiol 586:71-81. 2008
    ..Such adaptations seem advantageous for maintaining movement rapidity, reducing tendon stress and risk of injury, and possibly, for enabling muscles to operate closer to the optimum region of the length-tension relationship...
  81. ncbi request reprint Region-specific differences in Achilles tendon cross-sectional area in runners and non-runners
    S Peter Magnusson
    Sports Medicine Research Unit, Bispebjerg Hospital, Bispebjerg Bakke 23, 2400 NV, Copenhagen, Denmark
    Eur J Appl Physiol 90:549-53. 2003
    ....
  82. ncbi request reprint Increased cross-sectional area and reduced tensile stress of the Achilles tendon in elderly compared with young women
    S Peter Magnusson
    Team Danmark Test Center, Copenhagen, Denmark
    J Gerontol A Biol Sci Med Sci 58:123-7. 2003
    ..The greater tendon size combines to lower the stress on the tendon markedly, which may reduce the risk of injury to the tendon...
  83. pmc Substantial elevation of interleukin-6 concentration in peritendinous tissue, in contrast to muscle, following prolonged exercise in humans
    Henning Langberg
    Sports Medicine Research Unit, Department of Rheumatology H, Bispebjerg Hospital, Copenhagen, Denmark
    J Physiol 542:985-90. 2002
    ....
  84. ncbi request reprint Training by low-frequency stimulation of tibialis anterior in spinal cord-injured men
    Stephen D R Harridge
    Copenhagen Muscle Research Centre, Rigshospitalet, Copenhagen, Denmark
    Muscle Nerve 25:685-94. 2002
    ..This study provides evidence, at the level of gene transcription, that a fast-to-slow change in MHC isoform composition may be possible in human muscle when its usage is significantly increased...
  85. doi request reprint Muscle after spinal cord injury
    Bo Biering-Sørensen
    Clinic for Spinal Cord Injuries, Neuroscience Centre, Rigshospitalet, Copenhagen University Hospital, Havnevej 25, DK 3100 Hornbaek, Denmark
    Muscle Nerve 40:499-519. 2009
    ..Future studies should longitudinally examine changes in muscles from early SCI until steady state is reached in order to determine optimal training protocols for maintaining skeletal muscle after paralysis...
  86. pmc The initiation of embryonic-like collagen fibrillogenesis by adult human tendon fibroblasts when cultured under tension
    Monika L Bayer
    Institute of Sports Medicine, Department of Orthopedic Surgery M, Bispebjerg Hospital, and Center for Healthy Aging, Faculty of Health Sciences, University of Copenhagen, 2400 Copenhagen, Denmark
    Biomaterials 31:4889-97. 2010
    ....
  87. doi request reprint The pathogenesis of tendinopathy: balancing the response to loading
    S Peter Magnusson
    Institute of Sports Medicine, Bispebjerg Hospital and Center for Healthy Aging, University of Copenhagen, Bispebjerg Bakke, Copenhagen NV, Denmark
    Nat Rev Rheumatol 6:262-8. 2010
    ..Understanding how tendon tissue adapts to mechanical loading will help to unravel the pathogenesis of tendinopathy...
  88. ncbi request reprint [The physically-inactive surgical patient]
    Michael Kjaer
    Bispebjerg Hospital, Medicinsk Center, Institut for Idraetsmedicin
    Ugeskr Laeger 168:4322-4. 2006
    ..Knowledge regarding the potential effect of preoperative physical activity is sparse...
  89. ncbi request reprint Training-induced changes in muscle CSA, muscle strength, EMG, and rate of force development in elderly subjects after long-term unilateral disuse
    Charlotte Suetta
    Institute of Sports Medicine, Bispebjerg Hospital, University of Copenhagen, 2400 NV Copenhagen, Denmark
    J Appl Physiol (1985) 97:1954-61. 2004
    ..The improvement in both muscle mass and neural function is likely to have important functional implications for elderly individuals...
  90. ncbi request reprint GH administration changes myosin heavy chain isoforms in skeletal muscle but does not augment muscle strength or hypertrophy, either alone or combined with resistance exercise training in healthy elderly men
    Kai Henrik Wiborg Lange
    Sports Medicine Research Unit, Bispebjerg Hospital, DK 2400 Copenhagen NV, Denmark
    J Clin Endocrinol Metab 87:513-23. 2002
    ..Our results do not support a role for GH as a means of increasing muscle strength or mass, either alone or combined with RT, in healthy elderly men; although GH administration alone may induce changes in MHC composition...
  91. pmc Changes in satellite cells in human skeletal muscle after a single bout of high intensity exercise
    Regina M Crameri
    Sports Medicine Research Unit, Bispebjerg Hospital, Copenhagen, Denmark
    J Physiol 558:333-40. 2004
    ..However, a single bout of exercise is not sufficient for the satellite cell to undergo terminal differentiation...
  92. ncbi request reprint Postexercise nutrient intake enhances leg protein balance in early postmenopausal women
    Lars Holm
    Institute of Sports Medicine, Copenhagen, Bispebjerg Hospital, Bld 8 1st Bispebjerg Bakke 23, 2400 Copenhagen NV, Denmark
    J Gerontol A Biol Sci Med Sci 60:1212-8. 2005
    ....
  93. doi request reprint Glutaraldehyde cross-linking of tendon--mechanical effects at the level of the tendon fascicle and fibril
    Philip Hansen
    Institute of Sports Medicine Copenhagen, Bispebjerg Hospital and Centre for Healthy Aging, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Connect Tissue Res 50:211-22. 2009
    ....
  94. doi request reprint Noninvasive 64Cu-ATSM and PET/CT assessment of hypoxia in rat skeletal muscles and tendons during muscle contractions
    Dorthe Skovgaard
    Institute of Sports Medicine, Bispebjerg Hospital and Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    J Nucl Med 50:950-8. 2009
    ....
  95. ncbi request reprint Human skeletal muscle mitochondrial metabolism in youth and senescence: no signs of functional changes in ATP formation and mitochondrial oxidative capacity
    Ulla F Rasmussen
    Department of Biochemistry, August Krogh Institute, University of Copenhagen, Universitetsparken 13, 2100, Copenhagen, Denmark URasmussen aki ku dk
    Pflugers Arch 446:270-8. 2003
    ..They were related to physical activity, but not to age. The mitochondrial theory of ageing, which attributes the age-related decline of muscle performance to decreased mitochondrial function, is incompatible with these results...
  96. ncbi request reprint The effect of dynamic knee-extension exercise on patellar tendon and quadriceps femoris muscle glucose uptake in humans studied by positron emission tomography
    Kari K Kalliokoski
    Copenhagen Muscle Research Centre, Institute of Sports Medicine, Bispebjerg Hospital, Denmark
    J Appl Physiol (1985) 99:1189-92. 2005
    ..Thus tendon glucose uptake is likely to be regulated by mechanisms independently of those regulating skeletal muscle glucose uptake...
  97. doi request reprint Effect of two contrasting types of physical exercise on chronic neck muscle pain
    Lars L Andersen
    National Research Centre for the Working Environment, Copenhagen, Denmark
    Arthritis Rheum 59:84-91. 2008
    ..Our objective was to determine the effectiveness of specific strength training of the painful muscle versus general fitness training without direct involvement of the painful muscle (leg bicycling) on work-related neck muscle pain...
  98. ncbi request reprint Corticosteroids reduce the tensile strength of isolated collagen fascicles
    Bjarki Thor Haraldsson
    Institute of Sports Medicine Copenhagen, Bispebjerg Hospital, Bispebjerg Bakke 23, 2400 Copenhagen NV, Denmark
    Am J Sports Med 34:1992-7. 2006
    ..Overuse tendon injuries are frequent. Corticosteroid injections are commonly used as treatment, although their direct effects on the material properties of the tendon are poorly understood...
  99. ncbi request reprint The effects of regular strength training on telomere length in human skeletal muscle
    Fawzi Kadi
    Department of Health Sciences, Orebro University, Orebro, Sweden
    Med Sci Sports Exerc 40:82-7. 2008
    ..Therefore, we aimed to compare telomere length of a group of power lifters (PL; N = 7) who trained for 8 +/- 3 yr against that of a group of healthy, active subjects (C; N = 7) with no history of strength training...
  100. ncbi request reprint Effect of training on contractile and metabolic properties of wrist extensors in spinal cord-injured individuals
    Andreas Hartkopp
    Clinic for Para and Tetraplegia, The Neuroscience Centre, Rigshospitalet, Copenhagen University Hospitals, Copehagen, Denmark
    Muscle Nerve 27:72-80. 2003
    ..However, only the Hr protocol increased muscle strength and was shown to improve muscle aerobic metabolism after training. Muscle Nerve 27: 72-80, 2003..
  101. ncbi request reprint Role of adenosine in regulating the heterogeneity of skeletal muscle blood flow during exercise in humans
    Ilkka Heinonen
    Turku PET Centre, FIN 20521, Turku, Finland
    J Appl Physiol (1985) 103:2042-8. 2007
    ..Adenosine seems to play a role in muscle BF heterogeneity even in the absence of changes in bulk BF at low and moderate one-leg intermittent isometric exercise intensities...