Bente Kiens

Summary

Affiliation: University of Copenhagen
Country: Denmark

Publications

  1. pmc Contraction-induced lipolysis is not impaired by inhibition of hormone-sensitive lipase in skeletal muscle
    Thomas J Alsted
    B Kiens Section of Molecular Physiology, Department of Nutrition, Exercise and Sport, University of Copenhagen, Universitetsparken 13, DK, 2100 Copenhagen, Denmark
    J Physiol 591:5141-55. 2013
  2. doi request reprint Factors regulating fat oxidation in human skeletal muscle
    B Kiens
    Molecular Physiology Group, Department of Exercise and Sport Sciences, University of Copenhagen, Copenhagen, Denmark
    Obes Rev 12:852-8. 2011
  3. ncbi request reprint Sex differences in hormone-sensitive lipase expression, activity, and phosphorylation in skeletal muscle at rest and during exercise
    Carsten Roepstorff
    The Copenhagen Muscle Research Centre, Department of Human Physiology, Institute of Exercise and Sport Sciences, University of Copenhagen, Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 291:E1106-14. 2006
  4. pmc Regulation of hormone-sensitive lipase activity and Ser563 and Ser565 phosphorylation in human skeletal muscle during exercise
    Carsten Roepstorff
    The Copenhagen Muscle Research Centre, Department of Human Physiology, Institute of Exercise and Sport Sciences, University of Copenhagen, DK 2100 Copenhagen, Denmark
    J Physiol 560:551-62. 2004
  5. pmc Lipid-induced insulin resistance affects women less than men and is not accompanied by inflammation or impaired proximal insulin signaling
    Louise D Høeg
    Copenhagen Muscle Research Centre, Department of Exercise and Sport Sciences, University of Copenhagen, Denmark
    Diabetes 60:64-73. 2011
  6. doi request reprint Higher intramuscular triacylglycerol in women does not impair insulin sensitivity and proximal insulin signaling
    Louise Høeg
    The Copenhagen Muscle Research Centre, Molecular Physiology Group, Section of Human Physiology, Department of Exercise and Sport Sciences, University of Copenhagen, DK 2100 Copenhagen Ø, Denmark
    J Appl Physiol (1985) 107:824-31. 2009
  7. pmc Exercise alleviates lipid-induced insulin resistance in human skeletal muscle-signaling interaction at the level of TBC1 domain family member 4
    Christian Pehmøller
    Department of Exercise and Sport Sciences, Molecular Physiology Group, University of Copenhagen, Copenhagen, Denmark
    Diabetes 61:2743-52. 2012
  8. ncbi request reprint Regulation of plasma long-chain fatty acid oxidation in relation to uptake in human skeletal muscle during exercise
    Carsten Roepstorff
    The Copenhagen Muscle Research Centre, Institute of Exercise and Sport Sciences, Department of Human Physiology, Universitetsparken 13, DK 2100 Ø, Denmark
    Am J Physiol Endocrinol Metab 287:E696-705. 2004
  9. doi request reprint Reduced malonyl-CoA content in recovery from exercise correlates with improved insulin-stimulated glucose uptake in human skeletal muscle
    Christian Frøsig
    Copenhagen Muscle Research Centre, Molecular Physiology Group, Section of Human Physiology, Department of Exercise and Sport Sciences, University of Copenhagen, DK 2100 Copenhagen Ø, Denmark
    Am J Physiol Endocrinol Metab 296:E787-95. 2009
  10. pmc Higher skeletal muscle alpha2AMPK activation and lower energy charge and fat oxidation in men than in women during submaximal exercise
    Carsten Roepstorff
    The Copenhagen Muscle Research Centre, Institute of Exercise and Sport Sciences, Department of Human Physiology, Universitetsparken 13, DK 2100 Copenhagen Ø, Denmark
    J Physiol 574:125-38. 2006

Collaborators

Detail Information

Publications56

  1. pmc Contraction-induced lipolysis is not impaired by inhibition of hormone-sensitive lipase in skeletal muscle
    Thomas J Alsted
    B Kiens Section of Molecular Physiology, Department of Nutrition, Exercise and Sport, University of Copenhagen, Universitetsparken 13, DK, 2100 Copenhagen, Denmark
    J Physiol 591:5141-55. 2013
    ..Furthermore, the results suggest that ATGL is activated and plays a major role in lipolysis of IMTG during muscle contractions...
  2. doi request reprint Factors regulating fat oxidation in human skeletal muscle
    B Kiens
    Molecular Physiology Group, Department of Exercise and Sport Sciences, University of Copenhagen, Copenhagen, Denmark
    Obes Rev 12:852-8. 2011
    ..The regulation of both exercise and diet induced lipid oxidation will be discussed in this review...
  3. ncbi request reprint Sex differences in hormone-sensitive lipase expression, activity, and phosphorylation in skeletal muscle at rest and during exercise
    Carsten Roepstorff
    The Copenhagen Muscle Research Centre, Department of Human Physiology, Institute of Exercise and Sport Sciences, University of Copenhagen, Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 291:E1106-14. 2006
    ..The higher basal IMTG content in women compared with men is therefore the best candidate to explain the higher IMTG net hydrolysis during exercise in women...
  4. pmc Regulation of hormone-sensitive lipase activity and Ser563 and Ser565 phosphorylation in human skeletal muscle during exercise
    Carsten Roepstorff
    The Copenhagen Muscle Research Centre, Department of Human Physiology, Institute of Exercise and Sport Sciences, University of Copenhagen, DK 2100 Copenhagen, Denmark
    J Physiol 560:551-62. 2004
    ..Apparently, HSL Ser565 phosphorylation by AMPK during exercise had no effect on HSL activity. Alternatively, other factors including ERK may have counterbalanced any effect of AMPK on HSL activity...
  5. pmc Lipid-induced insulin resistance affects women less than men and is not accompanied by inflammation or impaired proximal insulin signaling
    Louise D Høeg
    Copenhagen Muscle Research Centre, Department of Exercise and Sport Sciences, University of Copenhagen, Denmark
    Diabetes 60:64-73. 2011
    ..Women also express higher muscle mRNA levels of proteins related to lipid metabolism than men. We therefore hypothesized that women would be less prone to lipid-induced insulin resistance...
  6. doi request reprint Higher intramuscular triacylglycerol in women does not impair insulin sensitivity and proximal insulin signaling
    Louise Høeg
    The Copenhagen Muscle Research Centre, Molecular Physiology Group, Section of Human Physiology, Department of Exercise and Sport Sciences, University of Copenhagen, DK 2100 Copenhagen Ø, Denmark
    J Appl Physiol (1985) 107:824-31. 2009
    ..This was not explained by sex differences in proximal insulin signaling in women. In women, it seems that a high capillary density and type 1 muscle fiber expression may be important for insulin action...
  7. pmc Exercise alleviates lipid-induced insulin resistance in human skeletal muscle-signaling interaction at the level of TBC1 domain family member 4
    Christian Pehmøller
    Department of Exercise and Sport Sciences, Molecular Physiology Group, University of Copenhagen, Copenhagen, Denmark
    Diabetes 61:2743-52. 2012
    ..The prophylactic effect of exercise on lipid-induced insulin resistance may involve augmented TBC1D4 signaling and glycogen synthase activation...
  8. ncbi request reprint Regulation of plasma long-chain fatty acid oxidation in relation to uptake in human skeletal muscle during exercise
    Carsten Roepstorff
    The Copenhagen Muscle Research Centre, Institute of Exercise and Sport Sciences, Department of Human Physiology, Universitetsparken 13, DK 2100 Ø, Denmark
    Am J Physiol Endocrinol Metab 287:E696-705. 2004
    ..Rather, the latter seems to be limited by intracellular regulatory mechanisms...
  9. doi request reprint Reduced malonyl-CoA content in recovery from exercise correlates with improved insulin-stimulated glucose uptake in human skeletal muscle
    Christian Frøsig
    Copenhagen Muscle Research Centre, Molecular Physiology Group, Section of Human Physiology, Department of Exercise and Sport Sciences, University of Copenhagen, DK 2100 Copenhagen Ø, Denmark
    Am J Physiol Endocrinol Metab 296:E787-95. 2009
    ..Collectively, this study indicates that reduced muscle MCoA content in recovery from exercise may be part of the adaptive response leading to improved insulin action on glucose uptake after exercise in human muscle...
  10. pmc Higher skeletal muscle alpha2AMPK activation and lower energy charge and fat oxidation in men than in women during submaximal exercise
    Carsten Roepstorff
    The Copenhagen Muscle Research Centre, Institute of Exercise and Sport Sciences, Department of Human Physiology, Universitetsparken 13, DK 2100 Copenhagen Ø, Denmark
    J Physiol 574:125-38. 2006
    ....
  11. pmc AMPK and insulin action--responses to ageing and high fat diet
    Christian Frøsig
    Section of Molecular Physiology, The August Krogh Centre, Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 8:e62338. 2013
    ....
  12. pmc Muscle metabolism during graded quadriceps exercise in man
    Jørn W Helge
    Copenhagen Muscle Research Centre, Department of Biomedical Sciences, Panum Institute, Blegdamsvej 3, DK 2200 N, Copenhagen, Denmark
    J Physiol 581:1247-58. 2007
    ..These findings are in contrast to whole body measurements performed during graded exercise involving a large muscle mass during which fat oxidation peaks at around 60% of ...
  13. ncbi request reprint Interleukin-6 release from human skeletal muscle during exercise: relation to AMPK activity
    Christopher MacDonald
    Department of Human Physiology, Institute of Exercise and Sport Sciences, University of Copenhagen, Denmark
    J Appl Physiol (1985) 95:2273-7. 2003
    ..Alternatively, both AMPK and IL-6 are independent sensors of a low muscle glycogen concentration during exercise. In addition, leg release of IL-6 cannot alone explain the increase in plasma IL-6 during exercise...
  14. pmc Exercise improves phosphatidylinositol-3,4,5-trisphosphate responsiveness of atypical protein kinase C and interacts with insulin signalling to peptide elongation in human skeletal muscle
    Christian Frøsig
    Copenhagen Muscle Research Centre, Section of Human Physiology, Department of Exercise and Sport Sciences, University of Copenhagen, 13, Universitetsparken, DK 2100, Copenhagen, Denmark
    J Physiol 582:1289-301. 2007
    ..Furthermore, endurance exercise increased the responsiveness of aPKC to PIP3 providing a possible link to improved insulin-stimulated glucose uptake after exercise...
  15. doi request reprint Adiponectin concentration is associated with muscle insulin sensitivity, AMPK phosphorylation, and ceramide content in skeletal muscles of men but not women
    Louise D Høeg
    The August Krogh Centre, Molecular Physiology Group, Section of Human Physiology, Department of Exercise and Sport Sciences, University of Copenhagen, DK 2100 Copenhagen, Denmark
    J Appl Physiol (1985) 114:592-601. 2013
    ..The lower skeletal muscle AdipoR1 protein expression and lower expression of adiponectin-sensitive type 2 muscle fibers in women than in men may explain the apparent lesser sensitivity to adiponectin in women...
  16. pmc The effect of graded exercise on IL-6 release and glucose uptake in human skeletal muscle
    Jørn W Helge
    Copenhagen Muscle Research Centre, Rigshospitalet, Department of Medical Physiology, Panum Institute, University of Copenhagen, Denmark
    J Physiol 546:299-305. 2003
    ..The observation of a relationship between IL-6 release and muscle glycogen store both at rest and after exercise suggests that IL-6 may act as a carbohydrate sensor...
  17. ncbi request reprint Malonyl-CoA and carnitine in regulation of fat oxidation in human skeletal muscle during exercise
    Carsten Roepstorff
    The Copenhagen Muscle Research Centre, Department of Human Physiology, Institute of Exercise and Sport Sciences, University of Copenhagen, Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 288:E133-42. 2005
    ..They also suggest that, with high muscle glycogen, the availability of free carnitine may limit fat oxidation during exercise, due to its increased use for acetylcarnitine formation...
  18. ncbi request reprint Effects of endurance exercise training on insulin signaling in human skeletal muscle: interactions at the level of phosphatidylinositol 3-kinase, Akt, and AS160
    Christian Frøsig
    Copenhagen Muscle Research Centre, Section of Human Physiology, Department of Exercise and Sport Sciences, University of Copenhagen, Copenhagen, Denmark
    Diabetes 56:2093-102. 2007
    ....
  19. doi request reprint Contractions but not AICAR increase FABPpm content in rat muscle sarcolemma
    Jacob Jeppesen
    Molecular Physiology Group, Section of Human Physiology, Copenhagen Muscle Research Centre, Department of Exercise and Sports Sciences, The August Krogh Building, University of Copenhagen, Universitetsparken 13, 2100, Copenhagen, Denmark
    Mol Cell Biochem 326:45-53. 2009
    ..Furthermore, the effect of AICAR stimulation on FAT/CD36 and FABPpm protein content in sarcolemma of rat skeletal muscle was evaluated...
  20. doi request reprint Adipose triglyceride lipase in human skeletal muscle is upregulated by exercise training
    Thomas J Alsted
    University of Copenhagen, The August Krogh Bldg 13, Universitetsparken, DK, 2100 Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 296:E445-53. 2009
    ..These results suggest that ATGL in addition to HSL may be important for human skeletal muscle lipolysis...
  21. doi request reprint A new method to study changes in microvascular blood volume in muscle and adipose tissue: real-time imaging in humans and rat
    Kim A Sjøberg
    Molecular Physiology Group, Department of Exercise and Sport Sciences, University of Copenhagen, Denmark
    Am J Physiol Heart Circ Physiol 301:H450-8. 2011
    ..Because of real-time imaging, the method has wide applications for determining MBV in different organs during various physiological or pathophysiological conditions...
  22. doi request reprint Skeletal muscle eEF2 and 4EBP1 phosphorylation during endurance exercise is dependent on intensity and muscle fiber type
    Adam J Rose
    Molecular Physiology Group, Copenhagen Muscle Research Centre, Dept of Exercise and Sport Sciences, Section of Human Physiology, University of Copenhagen, Universitetsparken 13, Copenhagen, Denmark, 2100
    Am J Physiol Regul Integr Comp Physiol 296:R326-33. 2009
    ..e., 4EBP1) and elongation (i.e., eEF2) steps, with eEF2 phosphorylation contributing at all exercise intensities but 4EBP1 dephosphorylation contributing to a greater extent at high vs. low exercise intensities...
  23. pmc Effect of endurance exercise training on Ca2+ calmodulin-dependent protein kinase II expression and signalling in skeletal muscle of humans
    Adam J Rose
    Copenhagen Muscle Research Centre, Department of Exercise and Sport Sciences, Section of Human Physiology, University of Copenhagen, Universitetsparken 13, Copenhagen, Denmark 2100
    J Physiol 583:785-95. 2007
    ..This may contribute to greater Ca(2+) mediated regulation during exercise and the altered muscle phenotype with training...
  24. ncbi request reprint AS160 phosphorylation is associated with activation of alpha2beta2gamma1- but not alpha2beta2gamma3-AMPK trimeric complex in skeletal muscle during exercise in humans
    Jonas T Treebak
    Copenhagen Muscle Research Centre, Department of Human Physiology, Institute of Exercise and Sport Sciences, University of Copenhagen, DK 2100, Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 292:E715-22. 2007
    ..Furthermore, we show that AMPK complexes in skeletal muscle are activated differently depending on exercise intensity and duration...
  25. ncbi request reprint Myocellular triacylglycerol breakdown in females but not in males during exercise
    Charlotte H Steffensen
    Department of Human Physiology, Copenhagen Muscle Research Centre, University of Copenhagen, DK 2100 Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 282:E634-42. 2002
    ..MCTG use was correlated to the resting concentration of MCTG (P < 0.001). We conclude that resting content and use of MCTG during exercise are related to gender and furthermore are independent of training status...
  26. doi request reprint Regulation of autophagy in human skeletal muscle: effects of exercise, exercise training and insulin stimulation
    Andreas M Fritzen
    Section of Molecular Physiology, Department of Nutrition, Exercise and Sports, The August Krogh Centre, Faculty of Science, University of Copenhagen, Copenhagen, Denmark
    J Physiol 594:745-61. 2016
    ..AMPK activation during exercise seems insufficient to regulate autophagosome content in muscle, while mTORC1 signalling via ULK1 probably mediates the autophagy-inhibiting effect of insulin...
  27. pmc Exercise rapidly increases eukaryotic elongation factor 2 phosphorylation in skeletal muscle of men
    Adam J Rose
    Copenhagen Muscle Research Centre, Institute of Exercise and Sport Sciences, Department of Human Physiology, Copenhagen University, Denmark
    J Physiol 569:223-8. 2005
    ..Given that eEF2 phosphorylation inhibits eEF2 activity and mRNA translation, these findings suggest that the inhibition of protein synthesis in contracting skeletal muscle is due to the Ca(2)(+)-induced stimulation of eEF2 kinase...
  28. ncbi request reprint Lipid-binding proteins and lipoprotein lipase activity in human skeletal muscle: influence of physical activity and gender
    Bente Kiens
    Department of Human Physiology, The Copenhagen Muscle Research Centre, Institute of Exercise and Sport Sciences, University of Copenhagen, DK 2100 Copenhagen, Denmark
    J Appl Physiol (1985) 97:1209-18. 2004
    ....
  29. pmc LKB1 regulates lipid oxidation during exercise independently of AMPK
    Jacob Jeppesen
    August Krogh Centre and Molecular Physiology Group, Department of Exercise and Sport Sciences, University of Copenhagen, Copenhagen, Denmark
    Diabetes 62:1490-9. 2013
    ..Our findings demonstrate that LKB1 is a novel molecular regulator of major importance for FA oxidation but not glucose uptake in muscle during exercise...
  30. pmc Enhanced fatty acid oxidation and FATP4 protein expression after endurance exercise training in human skeletal muscle
    Jacob Jeppesen
    Molecular Physiology Group, Department of Exercise and Sport Sciences, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 7:e29391. 2012
    ....
  31. doi request reprint Can exercise mimetics substitute for exercise?
    Erik A Richter
    Molecular Physiology Group, Copenhagen Muscle Research Centre, Department of Exercise and Sport Sciences, University of Copenhagen, Denmark
    Cell Metab 8:96-8. 2008
    ..A recent paper in Cell by Narkar et al. (2008) shows that many of the adaptations in muscle phenotype elicited by exercise can be mimicked by genetic manipulation and drug treatment in mice...
  32. ncbi request reprint Regulation of 5'AMP-activated protein kinase activity and substrate utilization in exercising human skeletal muscle
    Jorgen F P Wojtaszewski
    Department of Human Physiology, Institute of Exercise and Sport Sciences, University of Copenhagen, 2100 Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 284:E813-22. 2003
    ..It is concluded that muscle AMPK activity and ACCbeta Ser(221) phosphorylation at rest and during exercise are sensitive to the fuel status of the muscle. During exercise, this dependence may in part be mediated by humoral factors...
  33. ncbi request reprint Partial restoration of dietary fat induced metabolic adaptations to training by 7 days of carbohydrate diet
    Jørn W Helge
    Copenhagen Muscle Research Centre, Department of Human Physiology, University of Copenhagen, DK 2100 Copenhagen Ø, Denmark
    J Appl Physiol (1985) 93:1797-805. 2002
    ....
  34. ncbi request reprint Intramuscular triacylglycerol in energy metabolism during exercise in humans
    Carsten Roepstorff
    The Copenhagen Muscle Research Centre, Department of Human Physiology, Institute of Exercise and Sport Sciences, University of Copenhagen, Copenhagen, Denmark
    Exerc Sport Sci Rev 33:182-8. 2005
    ..It is important to consider how measurements of IMTG have been performed. Hormone-sensitive lipase is thought to regulate breakdown of IMTG during exercise...
  35. pmc FAT/CD36 is localized in sarcolemma and in vesicle-like structures in subsarcolemma regions but not in mitochondria
    Jacob Jeppesen
    Copenhagen Muscle Research Center, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark
    J Lipid Res 51:1504-12. 2010
    ..However, FAT/CD36 is not present in mitochondria in rat or human skeletal muscle. Thus, the functional role of FAT/CD36 in lipid transport seems primarily to be allocated to the plasma membrane in skeletal muscle...
  36. pmc Ca2+-calmodulin-dependent protein kinase expression and signalling in skeletal muscle during exercise
    Adam J Rose
    Copenhagen Muscle Research Centre, Department of Human Physiology, Institute of Exercise and Sport Sciences, University of Copenhagen, Universitetsparken 13, Copenhagen, Denmark, 2100
    J Physiol 574:889-903. 2006
    ..These data indicate that CaMKII is the major multifunctional CaMK in skeletal muscle and its activation occurs rapidly and is sustained during continuous exercise, with the activation being greater during intense exercise...
  37. pmc Rac1 signaling is required for insulin-stimulated glucose uptake and is dysregulated in insulin-resistant murine and human skeletal muscle
    Lykke Sylow
    Molecular Physiology Group, Department of Nutrition, Exercise, and Sports, August Krogh Centre, University of Copenhagen, Copenhagen, Denmark
    Diabetes 62:1865-75. 2013
    ..These findings show that Rac1 is a regulator of insulin-stimulated glucose uptake and a novel candidate involved in skeletal muscle insulin resistance...
  38. doi request reprint Effects of contraction on localization of GLUT4 and v-SNARE isoforms in rat skeletal muscle
    Adam J Rose
    Molecular Physiology Group, Department of Exercise and Sport Sciences, Copenhagen, Denmark
    Am J Physiol Regul Integr Comp Physiol 297:R1228-37. 2009
    ..These findings suggest that VAMP2, VAMP5, and VAMP7 may be involved in translocation of GLUT4 during muscle contractions...
  39. doi request reprint AMPKα is critical for enhancing skeletal muscle fatty acid utilization during in vivo exercise in mice
    Joachim Fentz
    Section of Molecular Physiology, August Krogh Centre, Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark Institute of Sports Medicine, Department of Orthopedic Surgery, Bispebjerg Hospital and Center for Healthy Aging, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark INSERM, U1016, Institute Cochin, Paris, France Centre National de la Recherche Scientifique, Unités Mixtes de Recherche 8104, Paris, France and Université Descartes, Sorbonne Paris Cité, Paris, France
    FASEB J 29:1725-38. 2015
    ..AMPKα is thus required for normal FA metabolism during exercise and muscle contraction...
  40. pmc GLP-1 increases microvascular recruitment but not glucose uptake in human and rat skeletal muscle
    Kim A Sjøberg
    Section of Molecular Physiology, The August Krogh Centre, Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 306:E355-62. 2014
    ..It is concluded that GLP-1 in physiological concentrations causes a rapid insulin-independent increase in muscle MVR but does not affect muscle glucose uptake. ..
  41. doi request reprint New Nordic Diet-Induced Weight Loss Is Accompanied by Changes in Metabolism and AMPK Signaling in Adipose Tissue
    Andreas Mæchel Fritzen
    Section of Molecular Physiology, The August Krogh Centre, Department of Nutrition, Exercise and Sports A M F, A M L, A B J, J F P W, E A R, B K, University of Copenhagen, 2100 Copenhagen Ø, Denmark Department of Nutrition, Exercise and Sports S K P, A A, T M L, University of Copenhagen, 1958 Frederiksberg, Denmark Department of Clinical Biochemistry S S, Copenhagen University Hospitals, Gentofte, 2900 Hellerup, Denmark Centre of Inflammation and Metabolism, Department of Biology H P, University of Copenhagen, 2100 Copenhagen Ø, Denmark and Danish Diabetes Academy A M L, 5000 Odense, Denmark
    J Clin Endocrinol Metab 100:3509-19. 2015
    ..The molecular mechanisms behind diet-induced metabolic improvements remain to be studied...
  42. ncbi request reprint Skeletal muscle lipid metabolism in exercise and insulin resistance
    Bente Kiens
    Copenhagen Muscle Research Centre, Dept of Human Physiology, Institute of Exercise and Sports Sciences, University of Copenhagen, 13 Universitetsparken, DK 2100 Copenhagen, Denmark
    Physiol Rev 86:205-43. 2006
    ..Finally, the role of lipids in development of insulin resistance in skeletal muscle, including possible molecular mechanisms involved, is discussed...
  43. pmc 5'-AMP activated protein kinase α2 controls substrate metabolism during post-exercise recovery via regulation of pyruvate dehydrogenase kinase 4
    Andreas Maechel Fritzen
    Section of Molecular Physiology, Department of Nutrition, Exercise and Sports, The August Krogh Centre, University of Copenhagen, Copenhagen, Denmark
    J Physiol 593:4765-80. 2015
    ..These findings indicate that AMPKα2 regulates muscle metabolism post-exercise through inhibition of the PDH complex and hence glucose oxidation, subsequently creating conditions for increased fatty acid oxidation...
  44. pmc Differential effects of glucagon-like peptide-1 on microvascular recruitment and glucose metabolism in short- and long-term insulin resistance
    Kim A Sjøberg
    Section of Molecular Physiology, The August Krogh Centre, Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Denmark
    J Physiol 593:2185-98. 2015
    ..Thus, like insulin, GLP-1 increased the microvascular recruitment but unlike insulin, GLP-1 had no direct effect on skeletal muscle glucose uptake...
  45. pmc Acute mTOR inhibition induces insulin resistance and alters substrate utilization in vivo
    Maximilian Kleinert
    Molecular Physiology Group, Department of Nutrition, Exercise and Sports, August Krogh Centre, University of Copenhagen, Copenhagen, Denmark
    Mol Metab 3:630-41. 2014
    ..Taken together, acute mTOR inhibition is detrimental to glucose homeostasis in part by blocking muscle mTORC2, indicating its importance in muscle metabolism in vivo...
  46. doi request reprint Insulin sensitivity is independent of lipid binding protein trafficking at the plasma membrane in human skeletal muscle: effect of a 3-day, high-fat diet
    Andreas B Jordy
    Section of Molecular Physiology, Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark
    Am J Physiol Regul Integr Comp Physiol 307:R1136-45. 2014
    ..Finally, FATP1 and FATP4 protein was located intracellularly but not at the sarcolemma in humans. ..
  47. doi request reprint Acute exercise improves motor memory: exploring potential biomarkers
    Kasper Skriver
    Department of Neuroscience and Pharmacology, University of Copenhagen, Copenhagen, Blegdamsvej 3, DK 2200 Copenhagen N, Denmark Department of Nutrition, Exercise and Sports, University of Copenhagen, Universitetsparken, DK 2300 Copenhagen N, Denmark Electronic address
    Neurobiol Learn Mem 116:46-58. 2014
    ..More mechanistic studies are required to elucidate the specific role of each biomarker in the formation of motor memory...
  48. doi request reprint Health effect of the New Nordic Diet in adults with increased waist circumference: a 6-mo randomized controlled trial
    Sanne K Poulsen
    Department of Nutrition, Exercise and Sports NEXS, Faculty of Science, University of Copenhagen, Frederiksberg C, Denmark SKP, AD, AA, and TML the NEXS, Faculty of Science, University of Copenhagen, København N, Denmark ABJ and BK the Department of Kinesiology, University of Waterloo, Waterloo, Canada KDS the Department of Clinical Biochemistry, Gentofte University Hospital, Hellerup, Denmark SS and the Institute of Preventive Medicine, Copenhagen University Hospitals, Frederiksberg Hospital, Frederiksberg, Denmark CH
    Am J Clin Nutr 99:35-45. 2014
    ..The regional Mediterranean Diet has been associated with lower risk of disease...
  49. pmc A single bout of exercise improves motor memory
    Marc Roig
    Department of Neuroscience and Pharmacology, University of Copenhagen, Copenhagen, Copenhagen, Denmark
    PLoS ONE 7:e44594. 2012
    ..Thus, the timing of exercise in relation to practice is possibly an important factor regulating the effects of acute exercise on long-term motor memory...
  50. pmc Regulation and limitations to fatty acid oxidation during exercise
    Jacob Jeppesen
    Molecular Physiology Group, Department of Exercise and Sport Sciences, University of Copenhagen, Denmark
    J Physiol 590:1059-68. 2012
    ..This review summarizes our present view on how FA metabolism is regulated during exercise with a special focus on the limitations in FA oxidation in the transition from moderate to high intensity exercise in humans...
  51. pmc Differential effect of bicycling exercise intensity on activity and phosphorylation of atypical protein kinase C and extracellular signal-regulated protein kinase in skeletal muscle
    Erik A Richter
    Copenhagen Muscle Research Centre, Department of Human Physiology, Institute of Exercise and Sports Sciences, University of Copenhagen, 13 Universitetsparken, DK 2100 Copenhagen, Denmark
    J Physiol 560:909-18. 2004
    ..In addition, increase in muscle activity of aPKC or ERK1/2 during exercise is not closely related to energy demands of the muscle but may serve other regulatory or permissive functions in muscle...
  52. ncbi request reprint Minor amounts of plasma medium-chain fatty acids and no improved time trial performance after consuming lipids
    Bodil Vistisen
    BioCentrum DTU, The Technical University of Denmark, Lyngby, Denmark
    J Appl Physiol (1985) 95:2434-43. 2003
    ..A higher level of plasma phospholipid fatty acids in the CHO+MLM compared with the CHO group was probably due to endogenous phospholipid release into chylomicrons...
  53. ncbi request reprint Sarcolemmal FAT/CD36 in human skeletal muscle colocalizes with caveolin-3 and is more abundant in type 1 than in type 2 fibers
    Bodil Vistisen
    Copenhagen Muscle Research Centre, Department of Medical Anatomy, University of Copenhagen, Copenhagen, Denmark
    J Lipid Res 45:603-9. 2004
    ..Furthermore, we provide evidence that FAT/CD36 expression is significantly higher in type 1 compared with type 2 fibers, whereas caveolin-3 expression is significantly higher in type 2 fibers than in type 1 fibers...
  54. doi request reprint Enhanced insulin signaling in human skeletal muscle and adipose tissue following gastric bypass surgery
    Peter H Albers
    Section of Molecular Physiology, Department of Nutrition, Exercise and Sports, The August Krogh Centre, University of Copenhagen, Copenhagen, Denmark Diabetes Research Unit, Novo Nordisk A S, Maaloev, Denmark
    Am J Physiol Regul Integr Comp Physiol 309:R510-24. 2015
    ..In conclusion, an improved molecular insulin-sensitive phenotype of skeletal muscle and adipose tissue appears to contribute to the improved whole body insulin action following a substantial weight loss after RYGB. ..
  55. doi request reprint Analysis of the liver lipidome reveals insights into the protective effect of exercise on high-fat diet-induced hepatosteatosis in mice
    Andreas B Jordy
    Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia and Department of Nutrition, Exercise, and Sports, University of Copenhagen, Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 308:E778-91. 2015
    ..Given the important role of the liver in the regulation of whole body glucose homeostasis, hepatic lipid regression may be a key component by which exercise can improve metabolism...
  56. ncbi request reprint Gender differences in substrate utilization during submaximal exercise in endurance-trained subjects
    Carsten Roepstorff
    Department of Human Physiology, Copenhagen Muscle Research Centre, University of Copenhagen, DK 2100 Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 282:E435-47. 2002
    ..However, an effect of gender appears to occur in the utilization of the different lipid sources...