B Kiens

Summary

Affiliation: University of Copenhagen
Country: Denmark

Publications

  1. ncbi request reprint Skeletal muscle lipid metabolism in exercise and insulin resistance
    Bente Kiens
    Copenhagen Muscle Research Centre, Dept of Human Physiology, Institute of Exercise and Sports Sciences, University of Copenhagen, 13 Universitetsparken, DK 2100 Copenhagen, Denmark
    Physiol Rev 86:205-43. 2006
  2. ncbi request reprint Lipid-binding proteins and lipoprotein lipase activity in human skeletal muscle: influence of physical activity and gender
    Bente Kiens
    Department of Human Physiology, The Copenhagen Muscle Research Centre, Institute of Exercise and Sport Sciences, University of Copenhagen, DK 2100 Copenhagen, Denmark
    J Appl Physiol (1985) 97:1209-18. 2004
  3. ncbi request reprint Endurance in high-fat-fed rats: effects of carbohydrate content and fatty acid profile
    J W Helge
    Copenhagen Muscle Research Centre, August Krogh Institute, DK 2100 Copenhagen O, Denmark
    J Appl Physiol (1985) 85:1342-8. 1998
  4. pmc Exercise metabolism in human skeletal muscle exposed to prior eccentric exercise
    S Asp
    Copenhagen Muscle Research Centre, August Krogh Institute, University of Copenhagen, 13 Universitetsparken, DK 2100 Copenhagen, Denmark
    J Physiol 509:305-13. 1998
  5. ncbi request reprint Insulin signaling in human skeletal muscle: time course and effect of exercise
    J F Wojtaszewski
    Copenhagen Muscle Research Centre, August Krogh Institute, University of Copenhagen, Denmark
    Diabetes 46:1775-81. 1997
  6. pmc Fat utilization during exercise: adaptation to a fat-rich diet increases utilization of plasma fatty acids and very low density lipoprotein-triacylglycerol in humans
    J W Helge
    Copenhagen Muscle Research Centre, Department of Human Physiology, University of Copenhagen, Denmark
    J Physiol 537:1009-20. 2001
  7. ncbi request reprint Impact of a fat-rich diet on endurance in man: role of the dietary period
    J W Helge
    Copenhagen Muscle Research Centre, August Krogh Institute, University of Copenhagen, Denmark
    Med Sci Sports Exerc 30:456-61. 1998
  8. ncbi request reprint Regulation of glycogen synthase kinase-3 in human skeletal muscle: effects of food intake and bicycle exercise
    J F Wojtaszewski
    Copenhagen Muscle Research Centre, Department of Human Physiology, University of Copenhagen, Denmark
    Diabetes 50:265-9. 2001
  9. pmc Eccentric exercise decreases maximal insulin action in humans: muscle and systemic effects
    S Asp
    Copenhagen Muscle Research Centre, August Krogh Institute, University of Copenhagen, Denmark
    J Physiol 494:891-8. 1996
  10. pmc Potential role of TBC1D4 in enhanced post-exercise insulin action in human skeletal muscle
    J T Treebak
    Copenhagen Muscle Research Centre, Department of Exercise and Sport Sciences, University of Copenhagen, Copenhagen, Denmark
    Diabetologia 52:891-900. 2009

Collaborators

Detail Information

Publications68

  1. ncbi request reprint Skeletal muscle lipid metabolism in exercise and insulin resistance
    Bente Kiens
    Copenhagen Muscle Research Centre, Dept of Human Physiology, Institute of Exercise and Sports Sciences, University of Copenhagen, 13 Universitetsparken, DK 2100 Copenhagen, Denmark
    Physiol Rev 86:205-43. 2006
    ..Finally, the role of lipids in development of insulin resistance in skeletal muscle, including possible molecular mechanisms involved, is discussed...
  2. ncbi request reprint Lipid-binding proteins and lipoprotein lipase activity in human skeletal muscle: influence of physical activity and gender
    Bente Kiens
    Department of Human Physiology, The Copenhagen Muscle Research Centre, Institute of Exercise and Sport Sciences, University of Copenhagen, DK 2100 Copenhagen, Denmark
    J Appl Physiol (1985) 97:1209-18. 2004
    ....
  3. ncbi request reprint Endurance in high-fat-fed rats: effects of carbohydrate content and fatty acid profile
    J W Helge
    Copenhagen Muscle Research Centre, August Krogh Institute, DK 2100 Copenhagen O, Denmark
    J Appl Physiol (1985) 85:1342-8. 1998
    ....
  4. pmc Exercise metabolism in human skeletal muscle exposed to prior eccentric exercise
    S Asp
    Copenhagen Muscle Research Centre, August Krogh Institute, University of Copenhagen, 13 Universitetsparken, DK 2100 Copenhagen, Denmark
    J Physiol 509:305-13. 1998
    ..This increases utilization of the decreased muscle glycogen stores, contributing to decreased endurance...
  5. ncbi request reprint Insulin signaling in human skeletal muscle: time course and effect of exercise
    J F Wojtaszewski
    Copenhagen Muscle Research Centre, August Krogh Institute, University of Copenhagen, Denmark
    Diabetes 46:1775-81. 1997
    ..Thus, the activity of IRS-1-associated PI 3-kinase and glucose uptake may not always be tightly coupled during insulin stimulation in human muscle...
  6. pmc Fat utilization during exercise: adaptation to a fat-rich diet increases utilization of plasma fatty acids and very low density lipoprotein-triacylglycerol in humans
    J W Helge
    Copenhagen Muscle Research Centre, Department of Human Physiology, University of Copenhagen, Denmark
    J Physiol 537:1009-20. 2001
    ..The decreased carbohydrate oxidation was apparently due to muscle glycogen sparing and not to diminished plasma glucose uptake...
  7. ncbi request reprint Impact of a fat-rich diet on endurance in man: role of the dietary period
    J W Helge
    Copenhagen Muscle Research Centre, August Krogh Institute, University of Copenhagen, Denmark
    Med Sci Sports Exerc 30:456-61. 1998
    ..The aim of the present study was to evaluate the effect of duration on the interaction between training and a fat-rich or a carbohydrate-rich diet on endurance performance...
  8. ncbi request reprint Regulation of glycogen synthase kinase-3 in human skeletal muscle: effects of food intake and bicycle exercise
    J F Wojtaszewski
    Copenhagen Muscle Research Centre, Department of Human Physiology, University of Copenhagen, Denmark
    Diabetes 50:265-9. 2001
    ..However, in contrast to findings in muscle from rats, exercise does not deactivate GSK3 in humans, suggesting a GSK3-independent mechanism in the regulation of GS activity in muscle during physical activity...
  9. pmc Eccentric exercise decreases maximal insulin action in humans: muscle and systemic effects
    S Asp
    Copenhagen Muscle Research Centre, August Krogh Institute, University of Copenhagen, Denmark
    J Physiol 494:891-8. 1996
    ..The local effect cannot account for the whole-body effect, suggesting the release of a factor which decreases insulin responsiveness systemically...
  10. pmc Potential role of TBC1D4 in enhanced post-exercise insulin action in human skeletal muscle
    J T Treebak
    Copenhagen Muscle Research Centre, Department of Exercise and Sport Sciences, University of Copenhagen, Copenhagen, Denmark
    Diabetologia 52:891-900. 2009
    ..We hypothesised that signalling through TBC1D4 is involved in this effect of exercise as it is a common signalling element for insulin and exercise...
  11. doi request reprint Impact of carbohydrate supplementation during endurance training on glycogen storage and performance
    L Nybo
    Institute of Exercise and Sport Sciences, University of Copenhagen, Copenhagen, Denmark
    Acta Physiol (Oxf) 197:117-27. 2009
    ..Therefore, we investigated how chronic training responses are affected by glucose ingestion...
  12. ncbi request reprint Regular exercise modulates muscle membrane phospholipid profile in rats
    J W Helge
    Copenhagen Muscle Research Centre, August Krogh Institute, University of Copenhagen, Denmark
    J Nutr 129:1636-42. 1999
    ..This change likely reflects an increased utilization of highly unsaturated fatty acids for energy, an effect which may have deleterious effects on insulin action...
  13. pmc Effect of muscle acidity on muscle metabolism and fatigue during intense exercise in man
    J Bangsbo
    Copenhagen Muscle Research Centre, August Krogh Institute, University of Copenhagen, Denmark
    J Physiol 495:587-96. 1996
    ..Instead, accumulation of potassium in muscle interstitium may be an important factor in the development of fatigue...
  14. pmc Isoform-specific and exercise intensity-dependent activation of 5'-AMP-activated protein kinase in human skeletal muscle
    J F Wojtaszewski
    Copenhagen Muscle Research Centre, Department of Human Physiology, University of Copenhagen, Denmark
    J Physiol 528:221-6. 2000
    ....
  15. ncbi request reprint Regulation of oxidative enzyme activity and eukaryotic elongation factor 2 in human skeletal muscle: influence of gender and exercise
    C Roepstorff
    The Copenhagen Muscle Research Centre, Department of Human Physiology, Institute of Exercise and Sport Sciences, University of Copenhagen, Copenhagen, Denmark
    Acta Physiol Scand 184:215-24. 2005
    ..To investigate gender-related differences in the responses of oxidative enzymes and eukaryotic elongation factor-2 (eEF2) to exercise...
  16. pmc Regulation of hormone-sensitive lipase activity and Ser563 and Ser565 phosphorylation in human skeletal muscle during exercise
    Carsten Roepstorff
    The Copenhagen Muscle Research Centre, Department of Human Physiology, Institute of Exercise and Sport Sciences, University of Copenhagen, DK 2100 Copenhagen, Denmark
    J Physiol 560:551-62. 2004
    ..Apparently, HSL Ser565 phosphorylation by AMPK during exercise had no effect on HSL activity. Alternatively, other factors including ERK may have counterbalanced any effect of AMPK on HSL activity...
  17. pmc Higher skeletal muscle alpha2AMPK activation and lower energy charge and fat oxidation in men than in women during submaximal exercise
    Carsten Roepstorff
    The Copenhagen Muscle Research Centre, Institute of Exercise and Sport Sciences, Department of Human Physiology, Universitetsparken 13, DK 2100 Copenhagen Ø, Denmark
    J Physiol 574:125-38. 2006
    ....
  18. ncbi request reprint Training affects muscle phospholipid fatty acid composition in humans
    J W Helge
    Copenhagen Muscle Research Centre, August Krogh Institute, University of Copenhagen, DK 2100 DK Copenhagen, Denmark
    J Appl Physiol (1985) 90:670-7. 2001
    ..Regular exercise training per se influences the phospholipid fatty acid composition of muscle membranes but has no effect on the composition of fatty acids stored in triacylglycerols within the muscle...
  19. ncbi request reprint Training and natural immunity: effects of diets rich in fat or carbohydrate
    B K Pedersen
    Copenhagen Muscle Research Centre, Department of Infectious Diseases M7721, Rigshospitalet, Denmark
    Eur J Appl Physiol 82:98-102. 2000
    ....
  20. ncbi request reprint Sex differences in hormone-sensitive lipase expression, activity, and phosphorylation in skeletal muscle at rest and during exercise
    Carsten Roepstorff
    The Copenhagen Muscle Research Centre, Department of Human Physiology, Institute of Exercise and Sport Sciences, University of Copenhagen, Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 291:E1106-14. 2006
    ..The higher basal IMTG content in women compared with men is therefore the best candidate to explain the higher IMTG net hydrolysis during exercise in women...
  21. ncbi request reprint Regulation of plasma long-chain fatty acid oxidation in relation to uptake in human skeletal muscle during exercise
    Carsten Roepstorff
    The Copenhagen Muscle Research Centre, Institute of Exercise and Sport Sciences, Department of Human Physiology, Universitetsparken 13, DK 2100 Ø, Denmark
    Am J Physiol Endocrinol Metab 287:E696-705. 2004
    ..Rather, the latter seems to be limited by intracellular regulatory mechanisms...
  22. doi request reprint Factors regulating fat oxidation in human skeletal muscle
    B Kiens
    Molecular Physiology Group, Department of Exercise and Sport Sciences, University of Copenhagen, Copenhagen, Denmark
    Obes Rev 12:852-8. 2011
    ..The regulation of both exercise and diet induced lipid oxidation will be discussed in this review...
  23. ncbi request reprint Membrane associated fatty acid binding protein (FABPpm) in human skeletal muscle is increased by endurance training
    B Kiens
    Copenhagen Muscle Research Center, August Krogh Institute, University of Copenhagen, Denmark
    Biochem Biophys Res Commun 231:463-5. 1997
    ..It is concluded that expression of FABPpm in human skeletal muscle is increased with endurance training consistent with a role of FABPpm as a sarcolemmal fatty acid transporter...
  24. ncbi request reprint Studies of plasma membrane fatty acid-binding protein and other lipid-binding proteins in human skeletal muscle
    C Roepstorff
    Copenhagen Muscle Research Centre, Department of Human Physiology, Institute of Exercise and Sport Sciences, University of Copenhagen, 13 Universitetsparken, 2100 Copenhagen Ø, Denmark
    Proc Nutr Soc 63:239-44. 2004
    ..The mechanisms involved in the regulation of the function and expression of FABPpm protein remain to be clarified...
  25. ncbi request reprint Regulation of muscle glucose transport during exercise
    E A Richter
    Copenhagen Muscle Research Centre, Department of Human Physiology, University of Copenhagen, Denmark
    Int J Sport Nutr Exerc Metab 11:S71-7. 2001
    ..It is indicated that at present no experiments definitively link activation of AMPK to activation of muscle glucose transport during exercise...
  26. doi request reprint Obesity augments the age-induced increase in mitochondrial capacity for H2O2 release in Zucker fatty rats
    M Hey-Mogensen
    Center for Healthy Aging, Department of Biomedical Sciences, University of Copenhagen, Denmark
    Acta Physiol (Oxf) 204:354-61. 2012
    ....
  27. ncbi request reprint Gender differences in substrate utilization during submaximal exercise in endurance-trained subjects
    Carsten Roepstorff
    Department of Human Physiology, Copenhagen Muscle Research Centre, University of Copenhagen, DK 2100 Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 282:E435-47. 2002
    ..However, an effect of gender appears to occur in the utilization of the different lipid sources...
  28. ncbi request reprint Interleukin-6 release from human skeletal muscle during exercise: relation to AMPK activity
    Christopher MacDonald
    Department of Human Physiology, Institute of Exercise and Sport Sciences, University of Copenhagen, Denmark
    J Appl Physiol (1985) 95:2273-7. 2003
    ..Alternatively, both AMPK and IL-6 are independent sensors of a low muscle glycogen concentration during exercise. In addition, leg release of IL-6 cannot alone explain the increase in plasma IL-6 during exercise...
  29. ncbi request reprint Malonyl-CoA and carnitine in regulation of fat oxidation in human skeletal muscle during exercise
    Carsten Roepstorff
    The Copenhagen Muscle Research Centre, Department of Human Physiology, Institute of Exercise and Sport Sciences, University of Copenhagen, Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 288:E133-42. 2005
    ..They also suggest that, with high muscle glycogen, the availability of free carnitine may limit fat oxidation during exercise, due to its increased use for acetylcarnitine formation...
  30. ncbi request reprint AS160 phosphorylation is associated with activation of alpha2beta2gamma1- but not alpha2beta2gamma3-AMPK trimeric complex in skeletal muscle during exercise in humans
    Jonas T Treebak
    Copenhagen Muscle Research Centre, Department of Human Physiology, Institute of Exercise and Sport Sciences, University of Copenhagen, DK 2100, Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 292:E715-22. 2007
    ..Furthermore, we show that AMPK complexes in skeletal muscle are activated differently depending on exercise intensity and duration...
  31. doi request reprint Higher intramuscular triacylglycerol in women does not impair insulin sensitivity and proximal insulin signaling
    Louise Høeg
    The Copenhagen Muscle Research Centre, Molecular Physiology Group, Section of Human Physiology, Department of Exercise and Sport Sciences, University of Copenhagen, DK 2100 Copenhagen Ø, Denmark
    J Appl Physiol (1985) 107:824-31. 2009
    ..This was not explained by sex differences in proximal insulin signaling in women. In women, it seems that a high capillary density and type 1 muscle fiber expression may be important for insulin action...
  32. pmc Contraction-induced skeletal muscle FAT/CD36 trafficking and FA uptake is AMPK independent
    J Jeppesen
    Copenhagen Muscle Research Center, Molecular Physiology Group, Section of Human Physiology, University of Copenhagen, Copenhagen, Denmark
    J Lipid Res 52:699-711. 2011
    ..However, AMPK could be important in regulation of FAT/CD36 distribution in other physiological situations...
  33. pmc AMP deamination and purine exchange in human skeletal muscle during and after intense exercise
    Y Hellsten
    Copenhagen Muscle Research Centre, Department of Human Physiology, Institute of Sport and Exercise Sciences, University of Copenhagen, Denmark
    J Physiol 520:909-20. 1999
    ..Furthermore, formation and release of purines occurs mainly after intense exercise and leads to a considerable loss of nucleotides...
  34. ncbi request reprint Utilization of long-chain fatty acids in human skeletal muscle during exercise
    B Kiens
    Department of Human Physiology, The Copenhagen Muscle Research Centre, Institute of Exercise and Sport Sciences, University of Copenhagen, Copenhagen, Denmark
    Acta Physiol Scand 178:391-6. 2003
    ..In contrast, it is suggested that the availability of free carnitine may play a major regulatory role in oxidation of LCFA during exercise...
  35. ncbi request reprint Insulin signaling and insulin sensitivity after exercise in human skeletal muscle
    J F Wojtaszewski
    Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Diabetes 49:325-31. 2000
    ..Diabetes 46:1775-1781, 1997]); and 3) prior exercise increases insulin stimulation of both glucose uptake and glycogen synthase activity in the absence of an upregulation of signaling events in human skeletal muscle...
  36. ncbi request reprint Regulation of 5'AMP-activated protein kinase activity and substrate utilization in exercising human skeletal muscle
    Jorgen F P Wojtaszewski
    Department of Human Physiology, Institute of Exercise and Sport Sciences, University of Copenhagen, 2100 Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 284:E813-22. 2003
    ..It is concluded that muscle AMPK activity and ACCbeta Ser(221) phosphorylation at rest and during exercise are sensitive to the fuel status of the muscle. During exercise, this dependence may in part be mediated by humoral factors...
  37. pmc Ca2+-calmodulin-dependent protein kinase expression and signalling in skeletal muscle during exercise
    Adam J Rose
    Copenhagen Muscle Research Centre, Department of Human Physiology, Institute of Exercise and Sport Sciences, University of Copenhagen, Universitetsparken 13, Copenhagen, Denmark, 2100
    J Physiol 574:889-903. 2006
    ..These data indicate that CaMKII is the major multifunctional CaMK in skeletal muscle and its activation occurs rapidly and is sustained during continuous exercise, with the activation being greater during intense exercise...
  38. ncbi request reprint [5'-adenosine monophosphate-activated protein kinase and lifestyle-mediated diseases]
    Erik A Richter
    Københavns Universitet, Institut for Idraet, Center for Muskelforskning, Afdelingen for Human Fysiologi, København
    Ugeskr Laeger 168:896-900. 2006
    ..It is likely that part of the effect of physical activity in preventing the development of diseases related to a sedentary lifestyle is due to activation of AMPK...
  39. ncbi request reprint Intramuscular triacylglycerol in energy metabolism during exercise in humans
    Carsten Roepstorff
    The Copenhagen Muscle Research Centre, Department of Human Physiology, Institute of Exercise and Sport Sciences, University of Copenhagen, Copenhagen, Denmark
    Exerc Sport Sci Rev 33:182-8. 2005
    ..It is important to consider how measurements of IMTG have been performed. Hormone-sensitive lipase is thought to regulate breakdown of IMTG during exercise...
  40. pmc Exercise rapidly increases eukaryotic elongation factor 2 phosphorylation in skeletal muscle of men
    Adam J Rose
    Copenhagen Muscle Research Centre, Institute of Exercise and Sport Sciences, Department of Human Physiology, Copenhagen University, Denmark
    J Physiol 569:223-8. 2005
    ..Given that eEF2 phosphorylation inhibits eEF2 activity and mRNA translation, these findings suggest that the inhibition of protein synthesis in contracting skeletal muscle is due to the Ca(2)(+)-induced stimulation of eEF2 kinase...
  41. pmc Differential effect of bicycling exercise intensity on activity and phosphorylation of atypical protein kinase C and extracellular signal-regulated protein kinase in skeletal muscle
    Erik A Richter
    Copenhagen Muscle Research Centre, Department of Human Physiology, Institute of Exercise and Sports Sciences, University of Copenhagen, 13 Universitetsparken, DK 2100 Copenhagen, Denmark
    J Physiol 560:909-18. 2004
    ..In addition, increase in muscle activity of aPKC or ERK1/2 during exercise is not closely related to energy demands of the muscle but may serve other regulatory or permissive functions in muscle...
  42. ncbi request reprint Interstitial glycerol concentrations in human skeletal muscle and adipose tissue during graded exercise
    B Stallknecht
    Copenhagen Muscle Research Centre, Department of Medical Physiology, The Panum Institute, University of Copenhagen, Copenhagen, Denmark
    Acta Physiol Scand 180:367-77. 2004
    ..It is not clear how lipolysis changes in skeletal muscle and adipose tissue during exercise of different intensities. We aimed at estimating this by microdialysis and muscle biopsy techniques...
  43. ncbi request reprint Partial restoration of dietary fat induced metabolic adaptations to training by 7 days of carbohydrate diet
    Jørn W Helge
    Copenhagen Muscle Research Centre, Department of Human Physiology, University of Copenhagen, DK 2100 Copenhagen Ø, Denmark
    J Appl Physiol (1985) 93:1797-805. 2002
    ....
  44. pmc Effect of endurance exercise training on Ca2+ calmodulin-dependent protein kinase II expression and signalling in skeletal muscle of humans
    Adam J Rose
    Copenhagen Muscle Research Centre, Department of Exercise and Sport Sciences, Section of Human Physiology, University of Copenhagen, Universitetsparken 13, Copenhagen, Denmark 2100
    J Physiol 583:785-95. 2007
    ..This may contribute to greater Ca(2+) mediated regulation during exercise and the altered muscle phenotype with training...
  45. ncbi request reprint Effects of endurance exercise training on insulin signaling in human skeletal muscle: interactions at the level of phosphatidylinositol 3-kinase, Akt, and AS160
    Christian Frøsig
    Copenhagen Muscle Research Centre, Section of Human Physiology, Department of Exercise and Sport Sciences, University of Copenhagen, Copenhagen, Denmark
    Diabetes 56:2093-102. 2007
    ....
  46. pmc Muscle metabolism during graded quadriceps exercise in man
    Jørn W Helge
    Copenhagen Muscle Research Centre, Department of Biomedical Sciences, Panum Institute, Blegdamsvej 3, DK 2200 N, Copenhagen, Denmark
    J Physiol 581:1247-58. 2007
    ..These findings are in contrast to whole body measurements performed during graded exercise involving a large muscle mass during which fat oxidation peaks at around 60% of ...
  47. pmc The effect of graded exercise on IL-6 release and glucose uptake in human skeletal muscle
    Jørn W Helge
    Copenhagen Muscle Research Centre, Rigshospitalet, Department of Medical Physiology, Panum Institute, University of Copenhagen, Denmark
    J Physiol 546:299-305. 2003
    ..The observation of a relationship between IL-6 release and muscle glycogen store both at rest and after exercise suggests that IL-6 may act as a carbohydrate sensor...
  48. doi request reprint Can exercise mimetics substitute for exercise?
    Erik A Richter
    Molecular Physiology Group, Copenhagen Muscle Research Centre, Department of Exercise and Sport Sciences, University of Copenhagen, Denmark
    Cell Metab 8:96-8. 2008
    ..A recent paper in Cell by Narkar et al. (2008) shows that many of the adaptations in muscle phenotype elicited by exercise can be mimicked by genetic manipulation and drug treatment in mice...
  49. pmc Exercise improves phosphatidylinositol-3,4,5-trisphosphate responsiveness of atypical protein kinase C and interacts with insulin signalling to peptide elongation in human skeletal muscle
    Christian Frøsig
    Copenhagen Muscle Research Centre, Section of Human Physiology, Department of Exercise and Sport Sciences, University of Copenhagen, 13, Universitetsparken, DK 2100, Copenhagen, Denmark
    J Physiol 582:1289-301. 2007
    ..Furthermore, endurance exercise increased the responsiveness of aPKC to PIP3 providing a possible link to improved insulin-stimulated glucose uptake after exercise...
  50. doi request reprint Adipose triglyceride lipase in human skeletal muscle is upregulated by exercise training
    Thomas J Alsted
    University of Copenhagen, The August Krogh Bldg 13, Universitetsparken, DK, 2100 Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 296:E445-53. 2009
    ..These results suggest that ATGL in addition to HSL may be important for human skeletal muscle lipolysis...
  51. ncbi request reprint Myocellular triacylglycerol breakdown in females but not in males during exercise
    Charlotte H Steffensen
    Department of Human Physiology, Copenhagen Muscle Research Centre, University of Copenhagen, DK 2100 Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 282:E634-42. 2002
    ..MCTG use was correlated to the resting concentration of MCTG (P < 0.001). We conclude that resting content and use of MCTG during exercise are related to gender and furthermore are independent of training status...
  52. doi request reprint Contractions but not AICAR increase FABPpm content in rat muscle sarcolemma
    Jacob Jeppesen
    Molecular Physiology Group, Section of Human Physiology, Copenhagen Muscle Research Centre, Department of Exercise and Sports Sciences, The August Krogh Building, University of Copenhagen, Universitetsparken 13, 2100, Copenhagen, Denmark
    Mol Cell Biochem 326:45-53. 2009
    ..Furthermore, the effect of AICAR stimulation on FAT/CD36 and FABPpm protein content in sarcolemma of rat skeletal muscle was evaluated...
  53. ncbi request reprint Diet and training in the week before competition
    B Kiens
    Copenhagen Muscle Research Centre, Department of Human Physiology, University of Copenhagen, Denmark
    Can J Appl Physiol 26:S56-63. 2001
    ..Data suggest that this dietary regimen impairs the ability to utilise carbohydrates...
  54. doi request reprint Skeletal muscle eEF2 and 4EBP1 phosphorylation during endurance exercise is dependent on intensity and muscle fiber type
    Adam J Rose
    Molecular Physiology Group, Copenhagen Muscle Research Centre, Dept of Exercise and Sport Sciences, Section of Human Physiology, University of Copenhagen, Universitetsparken 13, Copenhagen, Denmark, 2100
    Am J Physiol Regul Integr Comp Physiol 296:R326-33. 2009
    ..e., 4EBP1) and elongation (i.e., eEF2) steps, with eEF2 phosphorylation contributing at all exercise intensities but 4EBP1 dephosphorylation contributing to a greater extent at high vs. low exercise intensities...
  55. doi request reprint Near-normalization of glycaemic control with glucagon-like peptide-1 receptor agonist treatment combined with exercise in patients with type 2 diabetes
    P Mensberg
    Center for Diabetes Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark
    Diabetes Obes Metab . 2016
    ..To investigate the effects of exercise in combination with a glucagon-like peptide-1 receptor agonist (GLP-1RA), liraglutide, or placebo for the treatment of type 2 diabetes...
  56. ncbi request reprint A possible role for AMP-activated protein kinase in exercise-induced glucose utilization: insights from humans and transgenic animals
    J N Nielsen
    Copenhagen Muscle Research Centre, Institute of Exercise and Sports Sciences, Department of Human Physiology, University of Copenhagen, Denmark
    Biochem Soc Trans 31:186-90. 2003
    ..Taken together, these results question an essential role of AMPK in exercise-induced glucose uptake and imply that one or more additional pathways are involved in mediating glucose transport in skeletal muscle during exercise...
  57. pmc FAT/CD36 is localized in sarcolemma and in vesicle-like structures in subsarcolemma regions but not in mitochondria
    Jacob Jeppesen
    Copenhagen Muscle Research Center, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark
    J Lipid Res 51:1504-12. 2010
    ..However, FAT/CD36 is not present in mitochondria in rat or human skeletal muscle. Thus, the functional role of FAT/CD36 in lipid transport seems primarily to be allocated to the plasma membrane in skeletal muscle...
  58. ncbi request reprint Sarcolemmal FAT/CD36 in human skeletal muscle colocalizes with caveolin-3 and is more abundant in type 1 than in type 2 fibers
    Bodil Vistisen
    Copenhagen Muscle Research Centre, Department of Medical Anatomy, University of Copenhagen, Copenhagen, Denmark
    J Lipid Res 45:603-9. 2004
    ..Furthermore, we provide evidence that FAT/CD36 expression is significantly higher in type 1 compared with type 2 fibers, whereas caveolin-3 expression is significantly higher in type 2 fibers than in type 1 fibers...
  59. doi request reprint Reduced malonyl-CoA content in recovery from exercise correlates with improved insulin-stimulated glucose uptake in human skeletal muscle
    Christian Frøsig
    Copenhagen Muscle Research Centre, Molecular Physiology Group, Section of Human Physiology, Department of Exercise and Sport Sciences, University of Copenhagen, DK 2100 Copenhagen Ø, Denmark
    Am J Physiol Endocrinol Metab 296:E787-95. 2009
    ..Collectively, this study indicates that reduced muscle MCoA content in recovery from exercise may be part of the adaptive response leading to improved insulin action on glucose uptake after exercise in human muscle...
  60. ncbi request reprint Caffeine-induced impairment of insulin action but not insulin signaling in human skeletal muscle is reduced by exercise
    Farah S L Thong
    Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Canada
    Diabetes 51:583-90. 2002
    ....
  61. ncbi request reprint Effect of sex differences on human MEF2 regulation during endurance exercise
    Kristian Vissing
    Department of Sports Science, University of Aarhus, Dalgas Avenue 4, Aarhus C, Denmark
    Am J Physiol Endocrinol Metab 294:E408-15. 2008
    ..This signaling response was independent of sex...
  62. ncbi request reprint Postexercise muscle triacylglycerol and glycogen metabolism in obese insulin-resistant zucker rats
    Clinton R Bruce
    Exercise Metabolism Group School of Medical Sciences, RMIT University, PO Box 71, Bundoora 3083, Australia
    Obes Res 12:1158-65. 2004
    ..To determine the impact of insulin resistance and obesity on muscle triacylglycerol (IMTG) and glycogen metabolism during and after prolonged exercise...
  63. ncbi request reprint Prior exercise increases basal and insulin-induced p38 mitogen-activated protein kinase phosphorylation in human skeletal muscle
    Farah S L Thong
    Programme in Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada M5G 1X8
    J Appl Physiol (1985) 94:2337-41. 2003
    ..Because p38 MAPK has been suggested to play a necessary role in activation of GLUT-4 at the cell surface, the present data may suggest a putative role of p38 MAPK in the increased insulin sensitivity of skeletal muscle after exercise...
  64. ncbi request reprint Minor amounts of plasma medium-chain fatty acids and no improved time trial performance after consuming lipids
    Bodil Vistisen
    BioCentrum DTU, The Technical University of Denmark, Lyngby, Denmark
    J Appl Physiol (1985) 95:2434-43. 2003
    ..A higher level of plasma phospholipid fatty acids in the CHO+MLM compared with the CHO group was probably due to endogenous phospholipid release into chylomicrons...
  65. pmc Hormone-sensitive lipase serine phosphorylation and glycerol exchange across skeletal muscle in lean and obese subjects: effect of beta-adrenergic stimulation
    Johan W E Jocken
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    Diabetes 57:1834-41. 2008
    ..We aimed to investigate whether a blunted fasting or beta-adrenergically mediated lipolysis contributes to this increased IMTG storage in obesity...
  66. ncbi request reprint "Fat adaptation" for athletic performance: the nail in the coffin?
    Louise M Burke
    J Appl Physiol 100:7-8. 2006
  67. ncbi request reprint Carbohydrates and fat for training and recovery
    Louise M Burke
    Department of Sports Nutrition, Australian Institute of Sport, PO Box 176, Belconnen, ACT 2616, Australia
    J Sports Sci 22:15-30. 2004
    ..Although there is new interest in the recovery of intramuscular triglyceride stores between training sessions, there is no evidence that diets which are high in fat and restricted in carbohydrate enhance training...
  68. ncbi request reprint [Physical inactivity--consequences and correlations]
    Bente Kiens
    Motions og Ernaeringsrådet, Søborg
    Ugeskr Laeger 169:2442-5. 2007
    ..Furthermore, physical inactivity increases the risk of disability among the elderly...