Sebastian B Jørgensen

Summary

Affiliation: University of Copenhagen
Country: Denmark

Publications

  1. ncbi request reprint Knockout of the alpha2 but not alpha1 5'-AMP-activated protein kinase isoform abolishes 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranosidebut not contraction-induced glucose uptake in skeletal muscle
    Sebastian B Jørgensen
    Copenhagen Muscle Research Centre, Department of Human Physiology, 13 Universitetsparken, University of Copenhagen, DK 2100 Copenhagen, Denmark
    J Biol Chem 279:1070-9. 2004
  2. doi request reprint Genetic impairment of AMPKalpha2 signaling does not reduce muscle glucose uptake during treadmill exercise in mice
    Stine J Maarbjerg
    Department of Exercise and Sport Sciences, Copenhagen Muscle Research Centre, University of Copenhagen, Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 297:E924-34. 2009
  3. ncbi request reprint Effects of alpha-AMPK knockout on exercise-induced gene activation in mouse skeletal muscle
    Sebastian B Jørgensen
    Copenhagen Muscle Research Centre, Department of Human Physiology, Institute of Exercise and Sport Sciences, University of Copenhagen, Copenhagen, Denmark
    FASEB J 19:1146-8. 2005
  4. ncbi request reprint The alpha2-5'AMP-activated protein kinase is a site 2 glycogen synthase kinase in skeletal muscle and is responsive to glucose loading
    Sebastian B Jørgensen
    Copenhagen Muscle Research Centre, Department of Human Physiology, Institute of Exercise and Sport Sciences, University of Copenhagen, Copenhagen, Denmark
    Diabetes 53:3074-81. 2004
  5. ncbi request reprint Role of AMPKalpha2 in basal, training-, and AICAR-induced GLUT4, hexokinase II, and mitochondrial protein expression in mouse muscle
    Sebastian B Jørgensen
    Dept of Human Physiology, Copenhagen Muscle Research Centre, Inst of Exercise and Sport Sciences, 13 Universitetsparken, Univ of Copenhagen, DK 2100 Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 292:E331-9. 2007
  6. ncbi request reprint Possible CaMKK-dependent regulation of AMPK phosphorylation and glucose uptake at the onset of mild tetanic skeletal muscle contraction
    Thomas E Jensen
    Department of Human Physiology, Copenhagen Muscle Research Centre, Institute of Exercise and Sport Sciences, University of Copenhagen, Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 292:E1308-17. 2007
  7. pmc Role of AMPK in skeletal muscle metabolic regulation and adaptation in relation to exercise
    Sebastian B Jørgensen
    Department of Human Physiology, Copenhagen Muscle Research Centre, Inst of Exercise and Sport Sciences, 13 Universitetsparken, University of Copenhagen, DK 2100 Copenhagen, Denmark
    J Physiol 574:17-31. 2006
  8. ncbi request reprint Glycogen-dependent effects of 5-aminoimidazole-4-carboxamide (AICA)-riboside on AMP-activated protein kinase and glycogen synthase activities in rat skeletal muscle
    Jørgen F P Wojtaszewski
    Copenhagen Muscle Research Centre, Institute of Exercise and Sports Sciences, University of Copenhagen, Copenhagen, Denmark
    Diabetes 51:284-92. 2002
  9. ncbi request reprint Exercise signalling to glucose transport in skeletal muscle
    Erik A Richter
    Copenhagen Muscle Research Centre, Department of Human Physiology, Institute of Exercise and Sport Sciences, University of Copenhagen, Universitetsparken 13, 2100 Copenhagen Ø, Denmark
    Proc Nutr Soc 63:211-6. 2004
  10. ncbi request reprint 5'-AMP-activated protein kinase activity and protein expression are regulated by endurance training in human skeletal muscle
    Christian Frøsig
    Copenhagen Muscle Research Centre, Department of Human Physiology, Institute of Exercise and Sport Sciences, University of Copenhagen, DK 2100 Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 286:E411-7. 2004

Detail Information

Publications12

  1. ncbi request reprint Knockout of the alpha2 but not alpha1 5'-AMP-activated protein kinase isoform abolishes 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranosidebut not contraction-induced glucose uptake in skeletal muscle
    Sebastian B Jørgensen
    Copenhagen Muscle Research Centre, Department of Human Physiology, 13 Universitetsparken, University of Copenhagen, DK 2100 Copenhagen, Denmark
    J Biol Chem 279:1070-9. 2004
    ..Alternatively, neither alpha-isoform of AMPK is involved in contraction-induced muscle glucose uptake...
  2. doi request reprint Genetic impairment of AMPKalpha2 signaling does not reduce muscle glucose uptake during treadmill exercise in mice
    Stine J Maarbjerg
    Department of Exercise and Sport Sciences, Copenhagen Muscle Research Centre, University of Copenhagen, Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 297:E924-34. 2009
    ..Collectively, these findings suggest that AMPKalpha2 signaling is not essential in regulating glucose uptake in mouse skeletal muscle during treadmill exercise and that other mechanisms play a central role...
  3. ncbi request reprint Effects of alpha-AMPK knockout on exercise-induced gene activation in mouse skeletal muscle
    Sebastian B Jørgensen
    Copenhagen Muscle Research Centre, Department of Human Physiology, Institute of Exercise and Sport Sciences, University of Copenhagen, Copenhagen, Denmark
    FASEB J 19:1146-8. 2005
    ....
  4. ncbi request reprint The alpha2-5'AMP-activated protein kinase is a site 2 glycogen synthase kinase in skeletal muscle and is responsive to glucose loading
    Sebastian B Jørgensen
    Copenhagen Muscle Research Centre, Department of Human Physiology, Institute of Exercise and Sport Sciences, University of Copenhagen, Copenhagen, Denmark
    Diabetes 53:3074-81. 2004
    ..The fact that alpha2-AMPK is a GS kinase that inactivates GS while simultaneously activating glucose transport suggests that a balanced view on the suitability for AMPK as an antidiabetic drug target should be taken...
  5. ncbi request reprint Role of AMPKalpha2 in basal, training-, and AICAR-induced GLUT4, hexokinase II, and mitochondrial protein expression in mouse muscle
    Sebastian B Jørgensen
    Dept of Human Physiology, Copenhagen Muscle Research Centre, Inst of Exercise and Sport Sciences, 13 Universitetsparken, Univ of Copenhagen, DK 2100 Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 292:E331-9. 2007
    ..However, the alpha2-KO did not reduce training-induced increases in HKII, GLUT4, COX-1, HAD, or CS protein in WG, suggesting that AMPKalpha2 may not be essential for metabolic adaptations of skeletal muscles to exercise training...
  6. ncbi request reprint Possible CaMKK-dependent regulation of AMPK phosphorylation and glucose uptake at the onset of mild tetanic skeletal muscle contraction
    Thomas E Jensen
    Department of Human Physiology, Copenhagen Muscle Research Centre, Institute of Exercise and Sport Sciences, University of Copenhagen, Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 292:E1308-17. 2007
    ....
  7. pmc Role of AMPK in skeletal muscle metabolic regulation and adaptation in relation to exercise
    Sebastian B Jørgensen
    Department of Human Physiology, Copenhagen Muscle Research Centre, Inst of Exercise and Sport Sciences, 13 Universitetsparken, University of Copenhagen, DK 2100 Copenhagen, Denmark
    J Physiol 574:17-31. 2006
    ..Finally, AMPK has a well established role in regulating expression of genes encoding various enzymes in muscle, and this issue is discussed in relation to adaptation of skeletal muscle to exercise training...
  8. ncbi request reprint Glycogen-dependent effects of 5-aminoimidazole-4-carboxamide (AICA)-riboside on AMP-activated protein kinase and glycogen synthase activities in rat skeletal muscle
    Jørgen F P Wojtaszewski
    Copenhagen Muscle Research Centre, Institute of Exercise and Sports Sciences, University of Copenhagen, Copenhagen, Denmark
    Diabetes 51:284-92. 2002
    ..Because the glycogen level did not affect adenine nucleotide concentrations, our data suggest that glycogen may directly affect the activation state of AMPK in skeletal muscle...
  9. ncbi request reprint Exercise signalling to glucose transport in skeletal muscle
    Erik A Richter
    Copenhagen Muscle Research Centre, Department of Human Physiology, Institute of Exercise and Sport Sciences, University of Copenhagen, Universitetsparken 13, 2100 Copenhagen Ø, Denmark
    Proc Nutr Soc 63:211-6. 2004
    ..Furthermore, the p38 mitogen-activated protein kinase may be involved in activating the GLUT4 translocated to the surface membrane. Nevertheless, the picture is incomplete, and fibre type differences also seem to be involved...
  10. ncbi request reprint 5'-AMP-activated protein kinase activity and protein expression are regulated by endurance training in human skeletal muscle
    Christian Frøsig
    Copenhagen Muscle Research Centre, Department of Human Physiology, Institute of Exercise and Sport Sciences, University of Copenhagen, DK 2100 Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 286:E411-7. 2004
    ..Except for the increase in gamma1 protein, all observed adaptations to training could be ascribed to local contraction-induced mechanisms, since they did not occur in the contralateral untrained muscle...
  11. ncbi request reprint Role of AMPK in skeletal muscle gene adaptation in relation to exercise
    Sebastian B Jørgensen
    Department of Human Physiology, Copenhagen Muscle Research Centre, Institute of Exercise and Sport Sciences, 13 Universitetsparken, University of Copenhagen, DK 2100 Copenhagen, Denmark
    Appl Physiol Nutr Metab 32:904-11. 2007
    ..Although decreased AMPK activity in muscle causes reduced protein expression of mitochondrial enzymes in the basal state, AMPK does not appear to be indispensable for exercise-training induced increase in mitochondrial enzyme expression...
  12. doi request reprint Leukemia inhibitory factor increases glucose uptake in mouse skeletal muscle
    Nina Brandt
    Molecular Physiology Group, Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 309:E142-53. 2015
    ..In conclusion, LIF acutely increased muscle glucose uptake by a mechanism potentially involving the PI 3-kinase/mTORC2/Akt pathway and is not impaired in EDL muscle from obese insulin-resistant mice. ..