Jørn Wulff Helge

Summary

Affiliation: University of Copenhagen
Country: Denmark

Publications

  1. pmc The effect of graded exercise on IL-6 release and glucose uptake in human skeletal muscle
    Jørn W Helge
    Copenhagen Muscle Research Centre, Rigshospitalet, Department of Medical Physiology, Panum Institute, University of Copenhagen, Denmark
    J Physiol 546:299-305. 2003
  2. ncbi request reprint Four weeks one-leg training and high fat diet does not alter PPARalpha protein or mRNA expression in human skeletal muscle
    J W Helge
    Copenhagen Muscle Research Centre, Department Medical Physiology, Panum Institute building 12, University of Copenhagen, Blegdamsvej 3, 2200 N, Copenhagen, Denmark
    Eur J Appl Physiol 101:105-14. 2007
  3. ncbi request reprint Increased fat oxidation and regulation of metabolic genes with ultraendurance exercise
    J W Helge
    Department of Biomedical Sciences, Copenhagen Muscle Research Centre, University of Copenhagen, Copenhagen, Denmark
    Acta Physiol (Oxf) 191:77-86. 2007
  4. pmc Muscle metabolism during graded quadriceps exercise in man
    Jørn W Helge
    Copenhagen Muscle Research Centre, Department of Biomedical Sciences, Panum Institute, Blegdamsvej 3, DK 2200 N, Copenhagen, Denmark
    J Physiol 581:1247-58. 2007
  5. ncbi request reprint Low-intensity training dissociates metabolic from aerobic fitness
    J W Helge
    Copenhagen Muscle Research Centre, Department of Medical Physiology, Panum Institute, University of Copenhagen, Copenhagen, Denmark
    Scand J Med Sci Sports 18:86-94. 2008
  6. ncbi request reprint Muscle triacylglycerol and hormone-sensitive lipase activity in untrained and trained human muscles
    Jørn Wulff Helge
    Department of Medical Physiology, The Panum Institute, Copenhagen Muscle Research Centre, Building 12 4, Blegdamsvej 3, 2102 Copenhagen N, Denmark
    Eur J Appl Physiol 97:566-72. 2006
  7. ncbi request reprint Repeated prolonged whole-body low-intensity exercise: effects on insulin sensitivity and limb muscle adaptations
    Joern W Helge
    Copenhagen Muscle Research Centre, State Hospital, 2200 Copenhagen, Denmark
    Metabolism 55:217-23. 2006
  8. ncbi request reprint Exercise and training effects on ceramide metabolism in human skeletal muscle
    Jørn Wulff Helge
    Copenhagen Muscle Research Centre, Department of Medical Physiology, The Panum Institute, University of Copenhagen, Blegdamsvej 3, DK 2102 Copenhagen N, Denmark
    Exp Physiol 89:119-27. 2004
  9. ncbi request reprint Effect of training on muscle triacylglycerol and structural lipids: a relation to insulin sensitivity?
    Jørn W Helge
    Department of Medical Physiology, Copenhagen Muscle Research Centre, The Panum Institute, University of Copenhagen, Copenhagen, Denmark
    Diabetes 52:1881-7. 2003
  10. doi request reprint Interleukin-6 release is higher across arm than leg muscles during whole-body exercise
    Jørn W Helge
    Centre of Healthy Ageing, Department of Biomedical Sciences, University of Copenhagen, Denmark
    Exp Physiol 96:590-8. 2011

Collaborators

Detail Information

Publications57

  1. pmc The effect of graded exercise on IL-6 release and glucose uptake in human skeletal muscle
    Jørn W Helge
    Copenhagen Muscle Research Centre, Rigshospitalet, Department of Medical Physiology, Panum Institute, University of Copenhagen, Denmark
    J Physiol 546:299-305. 2003
    ..The observation of a relationship between IL-6 release and muscle glycogen store both at rest and after exercise suggests that IL-6 may act as a carbohydrate sensor...
  2. ncbi request reprint Four weeks one-leg training and high fat diet does not alter PPARalpha protein or mRNA expression in human skeletal muscle
    J W Helge
    Copenhagen Muscle Research Centre, Department Medical Physiology, Panum Institute building 12, University of Copenhagen, Blegdamsvej 3, 2200 N, Copenhagen, Denmark
    Eur J Appl Physiol 101:105-14. 2007
    ..After the training and diet CS, HAD, PPARalpha, UCP2, UCP3 and mFABP mRNA content remained unchanged, whereas GLUT4 mRNA was lower in both groups and LDHA mRNA was lower (P < 0.05) only in FAT...
  3. ncbi request reprint Increased fat oxidation and regulation of metabolic genes with ultraendurance exercise
    J W Helge
    Department of Biomedical Sciences, Copenhagen Muscle Research Centre, University of Copenhagen, Copenhagen, Denmark
    Acta Physiol (Oxf) 191:77-86. 2007
    ..This study examined muscle substrate availability and utilization during prolonged endurance exercise, and associated metabolic genes...
  4. pmc Muscle metabolism during graded quadriceps exercise in man
    Jørn W Helge
    Copenhagen Muscle Research Centre, Department of Biomedical Sciences, Panum Institute, Blegdamsvej 3, DK 2200 N, Copenhagen, Denmark
    J Physiol 581:1247-58. 2007
    ..These findings are in contrast to whole body measurements performed during graded exercise involving a large muscle mass during which fat oxidation peaks at around 60% of ...
  5. ncbi request reprint Low-intensity training dissociates metabolic from aerobic fitness
    J W Helge
    Copenhagen Muscle Research Centre, Department of Medical Physiology, Panum Institute, University of Copenhagen, Copenhagen, Denmark
    Scand J Med Sci Sports 18:86-94. 2008
    ....
  6. ncbi request reprint Muscle triacylglycerol and hormone-sensitive lipase activity in untrained and trained human muscles
    Jørn Wulff Helge
    Department of Medical Physiology, The Panum Institute, Copenhagen Muscle Research Centre, Building 12 4, Blegdamsvej 3, 2102 Copenhagen N, Denmark
    Eur J Appl Physiol 97:566-72. 2006
    ..However, the tendency to higher muscle TG recruitment during exercise in the trained subjects suggests a difference in the regulation of HSL or other lipases during exercise in trained compared with untrained subjects...
  7. ncbi request reprint Repeated prolonged whole-body low-intensity exercise: effects on insulin sensitivity and limb muscle adaptations
    Joern W Helge
    Copenhagen Muscle Research Centre, State Hospital, 2200 Copenhagen, Denmark
    Metabolism 55:217-23. 2006
    ....
  8. ncbi request reprint Exercise and training effects on ceramide metabolism in human skeletal muscle
    Jørn Wulff Helge
    Copenhagen Muscle Research Centre, Department of Medical Physiology, The Panum Institute, University of Copenhagen, Blegdamsvej 3, DK 2102 Copenhagen N, Denmark
    Exp Physiol 89:119-27. 2004
    ..The results indicate that acute prolonged exercise affects ceramide metabolism in human skeletal muscle both in untrained and in trained subjects and this may influence muscle cell adaptation and metabolism...
  9. ncbi request reprint Effect of training on muscle triacylglycerol and structural lipids: a relation to insulin sensitivity?
    Jørn W Helge
    Department of Medical Physiology, Copenhagen Muscle Research Centre, The Panum Institute, University of Copenhagen, Copenhagen, Denmark
    Diabetes 52:1881-7. 2003
    ..In contrast, training induced a minor increase in the content of phospholipid fatty acid membrane polyunsaturates, which may indicate that membrane lipids may have a role in the training-induced increase in insulin sensitivity...
  10. doi request reprint Interleukin-6 release is higher across arm than leg muscles during whole-body exercise
    Jørn W Helge
    Centre of Healthy Ageing, Department of Biomedical Sciences, University of Copenhagen, Denmark
    Exp Physiol 96:590-8. 2011
    ..The novel finding of a markedly higher IL-6 release from the exercising arm compared with the leg during whole-body exercise was not directly correlated to release or uptake of exogenous substrate, nor to muscle glycogen utilization...
  11. doi request reprint Arm and leg substrate utilization and muscle adaptation after prolonged low-intensity training
    J W Helge
    Center for Healthy Aging, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark
    Acta Physiol (Oxf) 199:519-28. 2010
    ..Finally, the influence and capacity of low-intensity training to influence metabolic fitness in the face of a limited effect on aerobic fitness will be challenged...
  12. doi request reprint Effect of gender on lipid-induced insulin resistance in obese subjects
    Bodil Vistisen
    Department of Biomedical Sciences, The Panum Institute, The Copenhagen Muscle Research Centre, University of Copenhagen, Blegdamsvej 3, DK 2200 Copenhagen N, Denmark
    Eur J Endocrinol 158:61-8. 2008
    ..However, neither the lipid-induced reduction of glucose disposal nor the intramyocellular lipid deposition has been compared directly in obese females and males...
  13. pmc Sex hormone-binding globulin levels predict insulin sensitivity, disposition index, and cardiovascular risk during puberty
    Kaspar Sørensen
    Department of Growth and Reproduction, Copenhagen University Hospital, Copenhagen, Denmark
    Diabetes Care 32:909-14. 2009
    ..The aim of the present study was to evaluate SHBG as a predictor of glucose metabolism and metabolic risk during puberty...
  14. doi request reprint High-fat feeding inhibits exercise-induced increase in mitochondrial respiratory flux in skeletal muscle
    Mette Skovbro
    Xlab, Center for Healthy Aging, Dept of Biomedical Sciences, Faculty of Health Sciences, Bldg 12 4 7, Univ of Copenhagen, Blegdamsvej 3b, 2200 Copenhagen N, Denmark
    J Appl Physiol (1985) 110:1607-14. 2011
    ..The effect of HFD is present even without effects on insulin sensitivity and intramyocellular lipid accumulation. An isocaloric high-fat diet does not cause insulin resistance...
  15. doi request reprint Effects of immobilization and aerobic training on proteins related to intramuscular substrate storage and metabolism in young and older men
    Andreas Vigelsø
    Xlab, Center for Healthy Aging, Department of Biomedical Sciences, Faculty of Health Sciences, University of Copenhagen, 2200, Copenhagen, Denmark
    Eur J Appl Physiol 116:481-94. 2016
    ..Therefore, we investigated how muscle lipid and glycogen stores and major regulatory proteins were affected by short-term immobilization followed by aerobic training in young and older men...
  16. pmc Influence of pre-exercise muscle glycogen content on exercise-induced transcriptional regulation of metabolic genes
    Henriette Pilegaard
    Copenhagen Muscle Research Centre, The August Krogh Institute, University of Copenhagen, Denmark
    J Physiol 541:261-71. 2002
    ....
  17. ncbi request reprint Contraction-mediated glucose uptake is increased in men with impaired glucose tolerance
    Camilla Skov-Jensen
    Copenhagen Muscle Research Centre, Department of Biomedical Sciences, University of Copenhagen, Blegdamsvej 3, 2200 Kbh N, Denmark
    Appl Physiol Nutr Metab 32:115-24. 2007
    ..Humans with IGT are resistant to insulin-stimulated but not to exercise-induced glucose uptake...
  18. doi request reprint The effects of diet- and RYGB-induced weight loss on insulin sensitivity in obese patients with and without type 2 diabetes
    Merethe Hansen
    Xlab, Center for Healthy Aging, Department of Biomedical Sciences, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3b, 2200, Copenhagen, Denmark
    Acta Diabetol 53:423-32. 2016
    ..The impact of diet-induced weight loss and weight loss due to RYGB in patients with (T2DM, N = 16) and without (OB, N = 27) type 2 diabetes was studied...
  19. ncbi request reprint Are blood flow and lipolysis in subcutaneous adipose tissue influenced by contractions in adjacent muscles in humans?
    Bente Stallknecht
    Department of Medical Physiology, The Panum Institute, Blegdamsvej 3, DK 2200 Copenhagen N, Denmark
    Am J Physiol Endocrinol Metab 292:E394-9. 2007
    ..05). In conclusion, blood flow and lipolysis are generally higher in SCAT adjacent to contracting than adjacent to resting muscle irrespective of exercise intensity. Thus specific exercises can induce "spot lipolysis" in adipose tissue...
  20. ncbi request reprint Impact of a fat-rich diet on endurance in man: role of the dietary period
    J W Helge
    Copenhagen Muscle Research Centre, August Krogh Institute, University of Copenhagen, Denmark
    Med Sci Sports Exerc 30:456-61. 1998
    ..The aim of the present study was to evaluate the effect of duration on the interaction between training and a fat-rich or a carbohydrate-rich diet on endurance performance...
  21. ncbi request reprint Whole-body fat oxidation determined by graded exercise and indirect calorimetry: a role for muscle oxidative capacity?
    P Nordby
    Copenhagen Muscle Research Centre, Department of Medical Physiology, The Panum Institute, University of Copenhagen, Copenhagen, Denmark
    Scand J Med Sci Sports 16:209-14. 2006
    ..This may suggest that leg muscle oxidative activity is not the main determinant of whole-body peak fat oxidation...
  22. ncbi request reprint Prolonged adaptation to fat-rich diet and training; effects on body fat stores and insulin resistance in man
    J W Helge
    Copenhagen Muscle Research Centre, Copenhagen, Denmark
    Int J Obes Relat Metab Disord 26:1118-24. 2002
    ..To investigate the effect of prolonged adaptation to training and fat- or carbohydrate-rich diet on body composition and insulin resistance...
  23. pmc Fat utilization during exercise: adaptation to a fat-rich diet increases utilization of plasma fatty acids and very low density lipoprotein-triacylglycerol in humans
    J W Helge
    Copenhagen Muscle Research Centre, Department of Human Physiology, University of Copenhagen, Denmark
    J Physiol 537:1009-20. 2001
    ..The decreased carbohydrate oxidation was apparently due to muscle glycogen sparing and not to diminished plasma glucose uptake...
  24. pmc Hepatic mitochondrial oxidative phosphorylation is normal in obese patients with and without type 2 diabetes
    Michael Taulo Lund
    Xlab, Centre for Healthy Aging, Department of Biomedical Sciences, University of Copenhagen, Blegdamsvej 3, 2200, Copenhagen N, Denmark
    J Physiol 594:4351-8. 2016
    ..Together the present findings indicate that hepatic mitochondrial oxidative phosphorylation capacity is not impaired in patients with obesity or type 2 diabetes...
  25. doi request reprint Validation of an Internet-based long version of the International Physical Activity Questionnaire in Danish adults using combined accelerometry and heart rate monitoring
    Andreas Wolff Hansen
    National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark
    J Phys Act Health 11:654-64. 2014
    ..The International Physical Activity Questionnaire (IPAQ) is commonly used in surveys, but reliability and validity has not been established in the Danish population...
  26. doi request reprint Immobilization increases interleukin-6, but not tumour necrosis factor-α, release from the leg during exercise in humans
    Dace Reihmane
    Department of Biomedical Sciences, University of Copenhagen, Blegdamsvej 3b, DK 2200 Copenhagen N, Denmark
    Exp Physiol 98:778-83. 2013
    ..Neither immobilization nor exercise had an effect on TNF-α release in the working legs...
  27. ncbi request reprint Long-term fat diet adaptation effects on performance, training capacity, and fat utilization
    Jørn Wulff Helge
    Copenhagen Muscle Research Centre, H S State Hospital, Blegdamsvej 9, DK 2100 Copenhagen Ø, Denmark
    Med Sci Sports Exerc 34:1499-504. 2002
    ....
  28. doi request reprint Are substrate use during exercise and mitochondrial respiratory capacity decreased in arm and leg muscle in type 2 diabetes?
    S Larsen
    Department of Biomedical Sciences, Center for Healthy Ageing, Faculty of Health Sciences, Blegdamsvej 3, Denmark
    Diabetologia 52:1400-8. 2009
    ..The aim of the study was to investigate mitochondrial function, fibre type distribution and substrate oxidation in arm and leg muscle during exercise in patients with type 2 diabetes and in obese and lean controls...
  29. ncbi request reprint Adaptation to a fat-rich diet: effects on endurance performance in humans
    J W Helge
    Copenhagen Muscle Research Centre, August Krogh Institute, University of Copenhagen, Denmark
    Sports Med 30:347-57. 2000
    ....
  30. doi request reprint The Effect of Reduced Physical Activity and Retraining on Blood Lipids and Body Composition in Young and Older Adult Men
    Jesper Nørregaard
    Xlab, Center for Healthy Aging, Department of Biomedical Sciences, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    J Aging Phys Act 23:489-95. 2015
    ..05). A minor reduction in daily physical activity for two weeks increased blood lipids in both young and older men. Six weeks of training improved blood lipids along with loss of visceral fat. ..
  31. pmc Skeletal muscle mitochondrial H2 O2 emission increases with immobilization and decreases after aerobic training in young and older men
    Martin Gram
    Xlab, Center for Healthy Aging, Department of Biomedical Sciences, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    J Physiol 593:4011-27. 2015
    ..Age, on the other hand, was not associated with impairments in anti-oxidant protein levels, mitochondrial respiration or H2 O2 emission using either protocol...
  32. ncbi request reprint Effects of physical training on endothelial function and limb blood flow in type 2 diabetes
    Mette Paulli Sonne
    Copenhagen Muscle Research Centre, Department of Biomedical Sciences, Section of Systems Biology, University of Copenhagen, Blegdamsvej 3, 2200 Kbh N, Denmark
    Appl Physiol Nutr Metab 32:936-41. 2007
    ..In general, physical training can improve endothelial function when this is impaired. However, physical training does not seem to have any effect on endothelial function when this is normal...
  33. ncbi request reprint Endurance in high-fat-fed rats: effects of carbohydrate content and fatty acid profile
    J W Helge
    Copenhagen Muscle Research Centre, August Krogh Institute, DK 2100 Copenhagen O, Denmark
    J Appl Physiol (1985) 85:1342-8. 1998
    ....
  34. doi request reprint Childhood hypo-adiponectinaemia but not hyper-leptinaemia is associated with insulin insensitivity 6 years later
    Iben Kynde
    Department of Biomedical Sciences, Centre for Healthy Ageing, University of Copenhagen, DK 2200, Copenhagen N, Denmark
    Pediatr Diabetes 11:195-202. 2010
    ..Biomarkers of metabolism and inflammation may predict children with increased diabetes risk...
  35. ncbi request reprint Interstitial glycerol concentrations in human skeletal muscle and adipose tissue during graded exercise
    B Stallknecht
    Copenhagen Muscle Research Centre, Department of Medical Physiology, The Panum Institute, University of Copenhagen, Copenhagen, Denmark
    Acta Physiol Scand 180:367-77. 2004
    ..It is not clear how lipolysis changes in skeletal muscle and adipose tissue during exercise of different intensities. We aimed at estimating this by microdialysis and muscle biopsy techniques...
  36. doi request reprint Muscle ceramide content in man is higher in type I than type II fibers and not influenced by glycogen content
    P Nordby
    Department of Biomedical Sciences 12 4, Center of Healthy Ageing, University of Copenhagen, Blegdamsvej 3, 2200 N, Copenhagen, Denmark
    Eur J Appl Physiol 109:935-43. 2010
    ..Despite rather large changes in muscle glycogen induced by prior depletion, exercise to exhaustion and repletion, total muscle ceramide concentration remained unchanged...
  37. ncbi request reprint [Skeletal muscles, physical activity and health]
    B Saltin
    Copenhagen Muscle Research Centre, Rigshospitalet, Copenhagen, Denmark
    Orthopade 29:941-7. 2000
    ..Moreover, the article points at the role of these fatty acids in activating genes via the PPAR-receptor system essential for enzyme and transport proteins in the lipid metabolism...
  38. doi request reprint Two weeks of one-leg immobilization decreases skeletal muscle respiratory capacity equally in young and elderly men
    Martin Gram
    Xlab, Center for Healthy Aging, Department of Biomedical Sciences, Faculty of Health Sciences, University of Copenhagen, DK 2200 Copenhagen, Denmark Electronic address
    Exp Gerontol 58:269-78. 2014
    ..This suggests that inactivity and training alter mitochondrial biogenesis equally in young and elderly men. ..
  39. doi request reprint Changes in physical activity in leisure time and the risk of myocardial infarction, ischemic heart disease, and all-cause mortality
    Christina Bjørk Petersen
    National Institute of Public Health, University of Southern Denmark, Øster Farimagsgade 5A, 1399 Copenhagen, Denmark
    Eur J Epidemiol 27:91-9. 2012
    ..Findings from this prospective study suggest that changes in physical activity affect the risk of MI, IHD and all-cause mortality. A decrease in physical activity was associated to a higher risk of coronary heart disease...
  40. doi request reprint Impact of the growth hormone receptor exon 3 deletion gene polymorphism on glucose metabolism, lipids, and insulin-like growth factor-I levels during puberty
    Kaspar Sørensen
    Department of Growth and Reproduction, Copenhagen University Hospital, Blegdamsvej 9, Copenhagen, Denmark
    J Clin Endocrinol Metab 94:2966-9. 2009
    ..The GH/IGF-I axis has major impact on insulin sensitivity and insulin secretion. Recently a polymorphism in the GH receptor gene (GHR), a genomic deletion of exon 3 (GHRd3), has been linked to increased responsiveness to GH...
  41. doi request reprint Time trends in physical activity in leisure time in the Danish population from 1987 to 2005
    Christina Bjørk Petersen
    National Institute of Public Health, University of Southern Denmark, Øster Farimagsgade, Copenhagen, Denmark
    Scand J Public Health 38:121-8. 2010
    ..To examine time trends in leisure-time physical activity in the Danish population from 1987 to 2005...
  42. doi request reprint Human skeletal muscle ceramide content is not a major factor in muscle insulin sensitivity
    M Skovbro
    Department of Biomedical Sciences, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Diabetologia 51:1253-60. 2008
    ..This study investigated total skeletal muscle ceramide fatty acid content in participants exhibiting a wide range of insulin sensitivities...
  43. ncbi request reprint Eccentric contractions affect muscle membrane phospholipid fatty acid composition in rats
    J W Helge
    Copenhagen Muscle Research Centre, Department of Human Physiology, University of Copenhagen, Denmark
    Exp Physiol 86:599-604. 2001
    ..Thus one severe bout of eccentric contractions modulates the fatty acid composition of the muscle membrane phospholipids when compared to a control leg, and supplemental intake of fish oil or vitamin C did not attenuate this effect...
  44. ncbi request reprint Training and natural immunity: effects of diets rich in fat or carbohydrate
    B K Pedersen
    Copenhagen Muscle Research Centre, Department of Infectious Diseases M7721, Rigshospitalet, Denmark
    Eur J Appl Physiol 82:98-102. 2000
    ....
  45. ncbi request reprint Interrelationships between muscle fibre type, substrate oxidation and body fat
    J W Helge
    Copenhagen Muscle Research Centre, August Krogh Institute, University of Copenhagen, Denmark
    Int J Obes Relat Metab Disord 23:986-91. 1999
    ..To investigate interrelationships between muscle fibre type, respiratory exchange ratio (RER) during exercise at a fixed workload and adiposity...
  46. doi request reprint Maintaining a clinical weight loss after intensive lifestyle intervention is the key to cardiometabolic health
    Sune Dandanell
    Center for Healthy Aging, Department of Biomedical Sciences, Xlab, University of Copenhagen, Denmark Department for Physiotherapy and Occupational Therapy, Metropolitan University College, Copenhagen, Denmark Electronic address
    Obes Res Clin Pract . 2016
    ..The aim was to study the effect of different magnitudes of weight loss maintenance after ILI on cardiometabolic health...
  47. pmc Preoperative β-cell function in patients with type 2 diabetes is important for the outcome of Roux-en-Y gastric bypass surgery
    Michael Taulo Lund
    Xlab, Center for Healthy Aging, Department of Biomedical Sciences, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3b, Copenhagen, Denmark
    J Physiol 593:3123-33. 2015
    ..Postoperative postprandial GLP-1 concentrations increased markedly, but did not differ between the groups. Our findings emphasize the importance of the preoperative of β-cell function for remission of diabetes after RYGB...
  48. doi request reprint Meal induced gut hormone secretion is altered in aerobically trained compared to sedentary young healthy males
    Michael Taulo Lund
    Department of Biomedical Sciences, Center for Healthy Aging, Xlab, University of Copenhagen, Blegdamsvej 3b, 2200, Copenhagen, Denmark
    Eur J Appl Physiol 113:2737-47. 2013
    ..Satiety measures did not differ between groups throughout the test. It is possible that in aerobically T subjects, a lower GIP release is partly responsible for a lower postprandial incretin stimulated insulin secretion...
  49. doi request reprint Insulin resistance and mitochondrial function in skeletal muscle
    Flemming Dela
    Xlab, Center for Healthy Aging, Faculty of Medicine, University of Copenhagen, Denmark
    Int J Biochem Cell Biol 45:11-5. 2013
    ..In this review we will present the prevailing view-points and argue for the unlikelihood of this scenario being instrumental in human insulin resistance. This article is part of a Directed Issue entitled: Bioenergetic dysfunction...
  50. pmc Effect of a Web-based intervention to promote physical activity and improve health among physically inactive adults: a population-based randomized controlled trial
    Andreas Wolff Hansen
    National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark
    J Med Internet Res 14:e145. 2012
    ..Web-based interventions provide cost- and time-efficient means of delivering individually targeted lifestyle modification at a population level...
  51. doi request reprint Fat oxidation at rest predicts peak fat oxidation during exercise and metabolic phenotype in overweight men
    M Rosenkilde
    Department of Biomedical Sciences, Center for Healthy Aging, University of Copenhagen, Copenhagen, Denmark
    Int J Obes (Lond) 34:871-7. 2010
    ..To elucidate if fat oxidation at rest predicts peak fat oxidation during exercise and/or metabolic phenotype in moderately overweight, sedentary men...
  52. ncbi request reprint Training affects muscle phospholipid fatty acid composition in humans
    J W Helge
    Copenhagen Muscle Research Centre, August Krogh Institute, University of Copenhagen, DK 2100 DK Copenhagen, Denmark
    J Appl Physiol (1985) 90:670-7. 2001
    ..Regular exercise training per se influences the phospholipid fatty acid composition of muscle membranes but has no effect on the composition of fatty acids stored in triacylglycerols within the muscle...
  53. pmc Training Does Not Alter Muscle Ceramide and Diacylglycerol in Offsprings of Type 2 Diabetic Patients Despite Improved Insulin Sensitivity
    Ditte Søgaard
    Xlab, Centre of Healthy Aging, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark
    J Diabetes Res 2016:2372741. 2016
    ..05). This study showed no relation between insulin sensitivity and ceramide or DAG content suggesting that ceramide and DAG are not major players in the early phase of insulin resistance in human muscle...
  54. doi request reprint Effects of an 8-weeks erythropoietin treatment on mitochondrial and whole body fat oxidation capacity during exercise in healthy males
    Amelia Guadalupe-Grau
    a Xlab, Center for Healthy Aging, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark
    J Sports Sci 33:570-8. 2015
    ..Eight weeks of recombinant erythropoietin treatment increases mitochondrial fatty acid oxidation capacity and myoglobin concentration without any effect on whole body maximal fat oxidation...
  55. doi request reprint Acute exercise improves motor memory: exploring potential biomarkers
    Kasper Skriver
    Department of Neuroscience and Pharmacology, University of Copenhagen, Copenhagen, Blegdamsvej 3, DK 2200 Copenhagen N, Denmark Department of Nutrition, Exercise and Sports, University of Copenhagen, Universitetsparken, DK 2300 Copenhagen N, Denmark Electronic address
    Neurobiol Learn Mem 116:46-58. 2014
    ..More mechanistic studies are required to elucidate the specific role of each biomarker in the formation of motor memory...
  56. doi request reprint Exercise interventions to prevent and manage type 2 diabetes: physiological mechanisms
    Flemming Dela
    Xlab, Center for Healthy Aging, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
    Med Sport Sci 60:36-47. 2014
    ..Rather, either no change or an increase is seen in the few studies that have been conducted. The mechanism for this opposite response is unknown, and this area needs high-quality intervention as well as cross-sectional studies...
  57. ncbi request reprint Regular exercise modulates muscle membrane phospholipid profile in rats
    J W Helge
    Copenhagen Muscle Research Centre, August Krogh Institute, University of Copenhagen, Denmark
    J Nutr 129:1636-42. 1999
    ..This change likely reflects an increased utilization of highly unsaturated fatty acids for energy, an effect which may have deleterious effects on insulin action...