Christian Frøsig

Summary

Affiliation: University of Copenhagen
Country: Denmark

Publications

  1. pmc AMPK and insulin action--responses to ageing and high fat diet
    Christian Frøsig
    Section of Molecular Physiology, The August Krogh Centre, Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 8:e62338. 2013
  2. ncbi request reprint 5'-AMP-activated protein kinase activity and protein expression are regulated by endurance training in human skeletal muscle
    Christian Frøsig
    Copenhagen Muscle Research Centre, Department of Human Physiology, Institute of Exercise and Sport Sciences, University of Copenhagen, DK 2100 Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 286:E411-7. 2004
  3. pmc Exercise-induced TBC1D1 Ser237 phosphorylation and 14-3-3 protein binding capacity in human skeletal muscle
    Christian Frøsig
    Molecular Physiology Group, Department of Exercise and Sport Sciences, University of Copenhagen, DK 2100 Copenhagen, Denmark
    J Physiol 588:4539-48. 2010
  4. doi request reprint Improved insulin sensitivity after exercise: focus on insulin signaling
    Christian Frøsig
    The Copenhagen Muscle Research Centre, Molecular Physiology Group, Section of Human Physiology, Department of Exercise and Sport Sciences, University of Copenhagen, Copenhagen, Denmark
    Obesity (Silver Spring) 17:S15-20. 2009
  5. doi request reprint Reduced malonyl-CoA content in recovery from exercise correlates with improved insulin-stimulated glucose uptake in human skeletal muscle
    Christian Frøsig
    Copenhagen Muscle Research Centre, Molecular Physiology Group, Section of Human Physiology, Department of Exercise and Sport Sciences, University of Copenhagen, DK 2100 Copenhagen Ø, Denmark
    Am J Physiol Endocrinol Metab 296:E787-95. 2009
  6. pmc Exercise improves phosphatidylinositol-3,4,5-trisphosphate responsiveness of atypical protein kinase C and interacts with insulin signalling to peptide elongation in human skeletal muscle
    Christian Frøsig
    Copenhagen Muscle Research Centre, Section of Human Physiology, Department of Exercise and Sport Sciences, University of Copenhagen, 13, Universitetsparken, DK 2100, Copenhagen, Denmark
    J Physiol 582:1289-301. 2007
  7. ncbi request reprint Knockout of the alpha2 but not alpha1 5'-AMP-activated protein kinase isoform abolishes 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranosidebut not contraction-induced glucose uptake in skeletal muscle
    Sebastian B Jørgensen
    Copenhagen Muscle Research Centre, Department of Human Physiology, 13 Universitetsparken, University of Copenhagen, DK 2100 Copenhagen, Denmark
    J Biol Chem 279:1070-9. 2004
  8. pmc Lipid-induced insulin resistance affects women less than men and is not accompanied by inflammation or impaired proximal insulin signaling
    Louise D Høeg
    Copenhagen Muscle Research Centre, Department of Exercise and Sport Sciences, University of Copenhagen, Denmark
    Diabetes 60:64-73. 2011
  9. pmc Effect of endurance exercise training on Ca2+ calmodulin-dependent protein kinase II expression and signalling in skeletal muscle of humans
    Adam J Rose
    Copenhagen Muscle Research Centre, Department of Exercise and Sport Sciences, Section of Human Physiology, University of Copenhagen, Universitetsparken 13, Copenhagen, Denmark 2100
    J Physiol 583:785-95. 2007
  10. ncbi request reprint Exercise signalling to glucose transport in skeletal muscle
    Erik A Richter
    Copenhagen Muscle Research Centre, Department of Human Physiology, Institute of Exercise and Sport Sciences, University of Copenhagen, Universitetsparken 13, 2100 Copenhagen Ø, Denmark
    Proc Nutr Soc 63:211-6. 2004

Collaborators

Detail Information

Publications16

  1. pmc AMPK and insulin action--responses to ageing and high fat diet
    Christian Frøsig
    Section of Molecular Physiology, The August Krogh Centre, Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 8:e62338. 2013
    ....
  2. ncbi request reprint 5'-AMP-activated protein kinase activity and protein expression are regulated by endurance training in human skeletal muscle
    Christian Frøsig
    Copenhagen Muscle Research Centre, Department of Human Physiology, Institute of Exercise and Sport Sciences, University of Copenhagen, DK 2100 Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 286:E411-7. 2004
    ..Except for the increase in gamma1 protein, all observed adaptations to training could be ascribed to local contraction-induced mechanisms, since they did not occur in the contralateral untrained muscle...
  3. pmc Exercise-induced TBC1D1 Ser237 phosphorylation and 14-3-3 protein binding capacity in human skeletal muscle
    Christian Frøsig
    Molecular Physiology Group, Department of Exercise and Sport Sciences, University of Copenhagen, DK 2100 Copenhagen, Denmark
    J Physiol 588:4539-48. 2010
    ..Furthermore, we show that the catalytic α2 AMPK subunit is the main (but probably not the only) donor of AMPK activity regulating TBC1D1 Ser237 phosphorylation in mouse EDL muscle...
  4. doi request reprint Improved insulin sensitivity after exercise: focus on insulin signaling
    Christian Frøsig
    The Copenhagen Muscle Research Centre, Molecular Physiology Group, Section of Human Physiology, Department of Exercise and Sport Sciences, University of Copenhagen, Copenhagen, Denmark
    Obesity (Silver Spring) 17:S15-20. 2009
    ..Although the functional interpretation is lacking, these novel observations may present a breakthrough in understanding the beneficial interplay between exercise and insulin action...
  5. doi request reprint Reduced malonyl-CoA content in recovery from exercise correlates with improved insulin-stimulated glucose uptake in human skeletal muscle
    Christian Frøsig
    Copenhagen Muscle Research Centre, Molecular Physiology Group, Section of Human Physiology, Department of Exercise and Sport Sciences, University of Copenhagen, DK 2100 Copenhagen Ø, Denmark
    Am J Physiol Endocrinol Metab 296:E787-95. 2009
    ..Collectively, this study indicates that reduced muscle MCoA content in recovery from exercise may be part of the adaptive response leading to improved insulin action on glucose uptake after exercise in human muscle...
  6. pmc Exercise improves phosphatidylinositol-3,4,5-trisphosphate responsiveness of atypical protein kinase C and interacts with insulin signalling to peptide elongation in human skeletal muscle
    Christian Frøsig
    Copenhagen Muscle Research Centre, Section of Human Physiology, Department of Exercise and Sport Sciences, University of Copenhagen, 13, Universitetsparken, DK 2100, Copenhagen, Denmark
    J Physiol 582:1289-301. 2007
    ..Furthermore, endurance exercise increased the responsiveness of aPKC to PIP3 providing a possible link to improved insulin-stimulated glucose uptake after exercise...
  7. ncbi request reprint Knockout of the alpha2 but not alpha1 5'-AMP-activated protein kinase isoform abolishes 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranosidebut not contraction-induced glucose uptake in skeletal muscle
    Sebastian B Jørgensen
    Copenhagen Muscle Research Centre, Department of Human Physiology, 13 Universitetsparken, University of Copenhagen, DK 2100 Copenhagen, Denmark
    J Biol Chem 279:1070-9. 2004
    ..Alternatively, neither alpha-isoform of AMPK is involved in contraction-induced muscle glucose uptake...
  8. pmc Lipid-induced insulin resistance affects women less than men and is not accompanied by inflammation or impaired proximal insulin signaling
    Louise D Høeg
    Copenhagen Muscle Research Centre, Department of Exercise and Sport Sciences, University of Copenhagen, Denmark
    Diabetes 60:64-73. 2011
    ..Women also express higher muscle mRNA levels of proteins related to lipid metabolism than men. We therefore hypothesized that women would be less prone to lipid-induced insulin resistance...
  9. pmc Effect of endurance exercise training on Ca2+ calmodulin-dependent protein kinase II expression and signalling in skeletal muscle of humans
    Adam J Rose
    Copenhagen Muscle Research Centre, Department of Exercise and Sport Sciences, Section of Human Physiology, University of Copenhagen, Universitetsparken 13, Copenhagen, Denmark 2100
    J Physiol 583:785-95. 2007
    ..This may contribute to greater Ca(2+) mediated regulation during exercise and the altered muscle phenotype with training...
  10. ncbi request reprint Exercise signalling to glucose transport in skeletal muscle
    Erik A Richter
    Copenhagen Muscle Research Centre, Department of Human Physiology, Institute of Exercise and Sport Sciences, University of Copenhagen, Universitetsparken 13, 2100 Copenhagen Ø, Denmark
    Proc Nutr Soc 63:211-6. 2004
    ..Furthermore, the p38 mitogen-activated protein kinase may be involved in activating the GLUT4 translocated to the surface membrane. Nevertheless, the picture is incomplete, and fibre type differences also seem to be involved...
  11. ncbi request reprint Effects of endurance exercise training on insulin signaling in human skeletal muscle: interactions at the level of phosphatidylinositol 3-kinase, Akt, and AS160
    Christian Frøsig
    Copenhagen Muscle Research Centre, Section of Human Physiology, Department of Exercise and Sport Sciences, University of Copenhagen, Copenhagen, Denmark
    Diabetes 56:2093-102. 2007
    ....
  12. pmc 5'AMP activated protein kinase expression in human skeletal muscle: effects of strength training and type 2 diabetes
    Jørgen F P Wojtaszewski
    The Institute of Exercise and Sport Sciences, The Copenhagen Muscle Research Centre, University of Copenhagen, 13 Universitetsparken, 2100 Copenhagen, Denmark
    J Physiol 564:563-73. 2005
    ....
  13. ncbi request reprint Increased atypical PKC activity in endurance-trained human skeletal muscle
    Jakob N Nielsen
    Copenhagen Muscle Research Centre, Department of Human Physiology, Institute of Exercise and Sport Sciences, University of Copenhagen, DK 2100, Copenhagen, Denmark
    Biochem Biophys Res Commun 312:1147-53. 2003
    ..Protein expression of the kinases was similar in trained and sedentary muscle. The increased aPKC activity in exercise-trained subjects could be important in explaining the enhanced insulin action in these individuals...
  14. doi request reprint Role of AMPK in regulation of LC3 lipidation as a marker of autophagy in skeletal muscle
    Andreas Mæchel Fritzen
    Section of Molecular Physiology, Department of Nutrition, Exercise and Sports, The August Krogh Centre, Faculty of Science, University of Copenhagen, Copenhagen, Denmark
    Cell Signal 28:663-74. 2016
    ..Furthermore, LC3 lipidation is increased in muscle lacking functional AMPKα2 during fasting and aging. Moreover, LC3 lipidation seems not to be a universal response to muscle contraction in mice...
  15. doi request reprint Regulation of autophagy in human skeletal muscle: effects of exercise, exercise training and insulin stimulation
    Andreas M Fritzen
    Section of Molecular Physiology, Department of Nutrition, Exercise and Sports, The August Krogh Centre, Faculty of Science, University of Copenhagen, Copenhagen, Denmark
    J Physiol 594:745-61. 2016
    ..Moreover, AMPK activation during exercise may not be sufficient to regulate autophagy in muscle, while mTORC1 signalling via ULK1 probably mediates the autophagy-inhibiting effect of insulin...
  16. ncbi request reprint Skeletal muscle insulin signaling defects downstream of phosphatidylinositol 3-kinase at the level of Akt are associated with impaired nonoxidative glucose disposal in HIV lipodystrophy
    Steen B Haugaard
    Department of Infectious Diseases, Clinical Research Unit 136, Hvidovre University Hospital, DK 2650 Hvidovre, Copenhagen, Denmark
    Diabetes 54:3474-83. 2005
    ..These results suggest mechanisms for the insulin resistance greatly enhancing the risk of type 2 diabetes in HIV lipodystrophy...