Thomas J Corydon

Summary

Affiliation: University of Aarhus
Country: Denmark

Publications

  1. pmc Myoblasts generated by lentiviral mediated MyoD transduction of myotonic dystrophy type 1 (DM1) fibroblasts can be used for assays of therapeutic molecules
    Jan Larsen
    Department of Biomedicine, Aarhus University, Aarhus, Denmark
    BMC Res Notes 4:490. 2011
  2. ncbi request reprint Down-regulation of Hsp60 expression by RNAi impairs folding of medium-chain acyl-CoA dehydrogenase wild-type and disease-associated proteins
    Thomas J Corydon
    Institute of Human Genetics, University of Aarhus, DK 8000 Aarhus C, Denmark
    Mol Genet Metab 85:260-70. 2005
  3. ncbi request reprint Handling of human short-chain acyl-CoA dehydrogenase (SCAD) variant proteins in transgenic mice
    Peter M Kragh
    Institute of Human Genetics, University of Aarhus, DK 8000 Aarhus C, Denmark
    Mol Genet Metab 91:128-37. 2007
  4. ncbi request reprint Expression of the RAI gene is conducive to apoptosis: studies of induction and interference
    Magdalena J Laska
    Institute of Human Genetics, Bartholin Building, University of Aarhus, DK 8000 Aarhus C, Denmark
    Exp Cell Res 313:2611-21. 2007
  5. pmc Inactivation of the hereditary spastic paraplegia-associated Hspd1 gene encoding the Hsp60 chaperone results in early embryonic lethality in mice
    Jane H Christensen
    Research Unit for Molecular Medicine, Aarhus University Hospital, Skejby, Denmark
    Cell Stress Chaperones 15:851-63. 2010
  6. ncbi request reprint Expression of short-chain acyl-CoA dehydrogenase (SCAD) proteins in the liver of SCAD deficient mice after hydrodynamic gene transfer
    David A Holm
    Department of Human Genetics, University of Aarhus, Denmark
    Mol Genet Metab 78:250-8. 2003
  7. doi request reprint Further immunohistochemical characterization of BRD1 a new susceptibility gene for schizophrenia and bipolar affective disorder
    Carsten Reidies Bjarkam
    Institute of Anatomy, University of Aarhus, 8000 Arhus C, Denmark
    Brain Struct Funct 214:37-47. 2009
  8. ncbi request reprint Actin mutations in hypertrophic and dilated cardiomyopathy cause inefficient protein folding and perturbed filament formation
    Søren Vang
    Research Unit for Molecular Medicine, Aarhus University Hospital and Faculty of Health Sciences, Denmark
    FEBS J 272:2037-49. 2005
  9. ncbi request reprint The Y42H mutation in medium-chain acyl-CoA dehydrogenase, which is prevalent in babies identified by MS/MS-based newborn screening, is temperature sensitive
    Linda O'Reilly
    Department of Biochemistry and the Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Ireland
    Eur J Biochem 271:4053-63. 2004
  10. doi request reprint The ACADS gene variation spectrum in 114 patients with short-chain acyl-CoA dehydrogenase (SCAD) deficiency is dominated by missense variations leading to protein misfolding at the cellular level
    Christina B Pedersen
    Research Unit for Molecular Medicine, Skejby and Faculty of Health Sciences, Aarhus University Hospital, Brendstrupgaardsvej 100, 8200, Aarhus, Denmark
    Hum Genet 124:43-56. 2008

Collaborators

Detail Information

Publications10

  1. pmc Myoblasts generated by lentiviral mediated MyoD transduction of myotonic dystrophy type 1 (DM1) fibroblasts can be used for assays of therapeutic molecules
    Jan Larsen
    Department of Biomedicine, Aarhus University, Aarhus, Denmark
    BMC Res Notes 4:490. 2011
    ..abstract:..
  2. ncbi request reprint Down-regulation of Hsp60 expression by RNAi impairs folding of medium-chain acyl-CoA dehydrogenase wild-type and disease-associated proteins
    Thomas J Corydon
    Institute of Human Genetics, University of Aarhus, DK 8000 Aarhus C, Denmark
    Mol Genet Metab 85:260-70. 2005
    ..The present system can be used to study the requirement of Hsp60 for folding of other mitochondrial proteins and to assess the role of Hsp60 for the severity of genetic defects involving these proteins...
  3. ncbi request reprint Handling of human short-chain acyl-CoA dehydrogenase (SCAD) variant proteins in transgenic mice
    Peter M Kragh
    Institute of Human Genetics, University of Aarhus, DK 8000 Aarhus C, Denmark
    Mol Genet Metab 91:128-37. 2007
    ....
  4. ncbi request reprint Expression of the RAI gene is conducive to apoptosis: studies of induction and interference
    Magdalena J Laska
    Institute of Human Genetics, Bartholin Building, University of Aarhus, DK 8000 Aarhus C, Denmark
    Exp Cell Res 313:2611-21. 2007
    ..Thus, we hypothesize that RAI induction is necessary but not sufficient for apoptosis induction in non-transformed cells. Our results could be explained by a NF-kappaB mediated mechanism...
  5. pmc Inactivation of the hereditary spastic paraplegia-associated Hspd1 gene encoding the Hsp60 chaperone results in early embryonic lethality in mice
    Jane H Christensen
    Research Unit for Molecular Medicine, Aarhus University Hospital, Skejby, Denmark
    Cell Stress Chaperones 15:851-63. 2010
    ..Our results demonstrate that Hspd1 is an essential gene for early embryonic development in mice, while reducing the amount of Hsp60 by inactivation of one allele of the gene is compatible with survival to term as well as postnatal life...
  6. ncbi request reprint Expression of short-chain acyl-CoA dehydrogenase (SCAD) proteins in the liver of SCAD deficient mice after hydrodynamic gene transfer
    David A Holm
    Department of Human Genetics, University of Aarhus, Denmark
    Mol Genet Metab 78:250-8. 2003
    ..Thus, hydrodynamic gene transfer allows for functional testing of SCAD variant proteins in vivo...
  7. doi request reprint Further immunohistochemical characterization of BRD1 a new susceptibility gene for schizophrenia and bipolar affective disorder
    Carsten Reidies Bjarkam
    Institute of Anatomy, University of Aarhus, 8000 Arhus C, Denmark
    Brain Struct Funct 214:37-47. 2009
    ..These results suggest a general role of BRD1 in the cell and stress that the two BRD1 variants may play different roles in the etiology of psychiatric disease...
  8. ncbi request reprint Actin mutations in hypertrophic and dilated cardiomyopathy cause inefficient protein folding and perturbed filament formation
    Søren Vang
    Research Unit for Molecular Medicine, Aarhus University Hospital and Faculty of Health Sciences, Denmark
    FEBS J 272:2037-49. 2005
    ..We propose that effects of mutations on folding and fiber assembly may play a role in the molecular disease mechanism...
  9. ncbi request reprint The Y42H mutation in medium-chain acyl-CoA dehydrogenase, which is prevalent in babies identified by MS/MS-based newborn screening, is temperature sensitive
    Linda O'Reilly
    Department of Biochemistry and the Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Ireland
    Eur J Biochem 271:4053-63. 2004
    ..Our study suggests that Y42H is a temperature sensitive mutation, which is mild at low temperatures, but may have deleterious effects at increased temperatures...
  10. doi request reprint The ACADS gene variation spectrum in 114 patients with short-chain acyl-CoA dehydrogenase (SCAD) deficiency is dominated by missense variations leading to protein misfolding at the cellular level
    Christina B Pedersen
    Research Unit for Molecular Medicine, Skejby and Faculty of Health Sciences, Aarhus University Hospital, Brendstrupgaardsvej 100, 8200, Aarhus, Denmark
    Hum Genet 124:43-56. 2008
    ..We propose that SCAD deficiency should be considered as a disorder of protein folding that can lead to clinical disease in combination with other genetic and environmental factors...