Affiliation: University of Southern Denmark
- High prevalence of autoantibodies among Danish centenariansK Andersen-Ranberg
Department of Geriatrics, Odense University Hospital, Odense, Denmark
Clin Exp Immunol 138:158-63. 2004..Non-organ specific autoantibodies are evenly distributed irrespective of the level of disability or comorbidity, suggesting underlying, undiagnosed pathological processes which may be part of the processes involved in frailty...
- Dementia is not inevitable: a population-based study of Danish centenariansK Andersen-Ranberg
Aging Research Centre, University of Southern Denmark, Odense University, Odense, Denmark
J Gerontol B Psychol Sci Soc Sci 56:P152-9. 2001..Dementia is common but not inevitable in centenarians. Cerebro- and cardiovascular diseases are equally common in demented and nondemented persons...
- Healthy centenarians do not exist, but autonomous centenarians do: a population-based study of morbidity among Danish centenariansK Andersen-Ranberg
Aging Research Center, Epidemiology, Institute of Public Health, University of Southern Denmark, Odense, Denmark
J Am Geriatr Soc 49:900-8. 2001..CONCLUSION: Because they have a high prevalence of several common diseases and chronic conditions, Danish centenarians are not healthy. However, a minor proportion was identified as being cognitively intact and functioning well...
- Declining physical abilities with age: a cross-sectional study of older twins and centenarians in DenmarkK Andersen-Ranberg
Ageing Research Centre and Epidemiology, Institute of Public Health, Odense, Denmark
Age Ageing 28:373-7. 1999..To evaluate whether physical disability reaches a plateau in the oldest age groups...
- Low activity of superoxide dismutase and high activity of glutathione reductase in erythrocytes from centenariansH R Andersen
Department of Environmental Medicine, Odense University, Winsløwparken 17, DK 5000 Odense C, Denmark
Age Ageing 27:643-8. 1998..to compare the activities of antioxidative enzymes in erythrocytes between centenarians and a younger group of elderly subjects...
- Modest implication of interleukin-6 promoter polymorphisms in longevityL Christiansen
Department of Epidemiology, Institute of Public Health, University of Southern Denmark, Odense, Denmark
Mech Ageing Dev 125:391-5. 2004..We found a modest, but significant, increase in the frequency of interleukin-6 -174GG homozygotes with age suggesting that this genotype is advantageous for longevity...
- Increased plasma concentration of serum amyloid P component in centenarians with impaired cognitive performanceM Nybo
Department of Medical Microbiology, Odense University, Denmark
Dement Geriatr Cogn Disord 9:126-9. 1998..We conclude that the centenarians with impaired cognitive performance had significantly increased plasma concentrations of SAP, while the values for cognitive intact centenarians were within the normal range...
- Is ageing associated with a shift in the balance between Type 1 and Type 2 cytokines in humans?M Sandmand
The Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Denmark
Clin Exp Immunol 127:107-14. 2002..Furthermore, the percentage of T cells with cytokine expression was closely correlated to the in vivo expression of CD95 and CD45RO. In conclusion, we found some evidence for an age-related shift towards a Type 2 cytokine profile...
- Replication studies in longevity: puzzling findings in Danish centenarians at the 3'APOB-VNTR locusO Varcasia
Cell Biology Department, University of Calabria, Rende, Italy
Ann Hum Genet 65:371-6. 2001..The different findings in Denmark and Italy suggest that gene/longevity associations are population-specific, and heavily affected by the population-specific genetic and environmental history...
- Variations of cardiovascular disease associated genes exhibit sex-dependent influence on human longevityQ Tan
Max-Planck Institute for Demographic Research, Rostock, Germany
Exp Gerontol 36:1303-15. 2001..However, the presence of sex-dependent effects and the fact that major CVD-associated genes failed to impose detrimental influence on longevity lead us to concur that the aging process is highly complicated...