Genomes and Genes
Affiliation: Steno Diabetes Center
- Large-scale study of the -232C > G polymorphism of PCK1 in Type 2 diabetesL Wegner
Steno Diabetes Center, Gentofte, Denmark
Diabet Med 23:1140-4. 2006..Interaction studies of the PCK1-232C > G polymorphism with variants in the genes encoding peroxisome proliferator-activated receptor-gamma co-activator (PGC)-1alpha and hepatic nuclear factor (HNF)-4alpha were also performed...
- Common variation in LMNA increases susceptibility to type 2 diabetes and associates with elevated fasting glycemia and estimates of body fat and height in the general population: studies of 7,495 Danish whitesLise Wegner
Steno Diabetes Center, Niels Steensens Vej 2, NSP1 03, DK 2820 Gentofte, Denmark
Diabetes 56:694-8. 2007....
- Impact of TCF7L2 rs7903146 on insulin secretion and action in young and elderly Danish twinsLise Wegner
Steno Diabetes Center, DK 2820 Gentofte, Denmark
J Clin Endocrinol Metab 93:4013-9. 2008....
- LMNA rs4641 and the muscle lamin A and C isoforms in twins--metabolic implications and transcriptional regulationL Wegner
Hagedorn Research Institute, Niels Steensens Vej 1, DK 2820 Gentofte, Denmark
J Clin Endocrinol Metab 95:3884-92. 2010..Lamins are essential for nuclear shape and function. Polymorphisms in LMNA may associate with fat and muscle development and aging...
- A variant in the G6PC2/ABCB11 locus is associated with increased fasting plasma glucose, increased basal hepatic glucose production and increased insulin release after oral and intravenous glucose loadsC S Rose
Hagedorn Research Institute, Gentofte, Denmark
Diabetologia 52:2122-9. 2009..Furthermore, we examined rs560887 for association with impaired fasting glycaemia (IFG), impaired glucose tolerance (IGT), type 2 diabetes and components of the metabolic syndrome...
- Polymorphisms in AHI1 are not associated with type 2 diabetes or related phenotypes in Danes: non-replication of a genome-wide association resultJ Holmkvist
Steno Diabetes Center, Niels Steensens Vej 1, NLC2 12, 2820 Gentofte, Denmark
Diabetologia 51:609-14. 2008..The aim of the present study was to investigate the putative association between these polymorphisms and type 2 diabetes or type 2 diabetes-related metabolic traits in Danish individuals...
- Evidence of an association between genetic variation of the coactivator PGC-1beta and obesityG Andersen
Steno Diabetes Center, Niels Steensens Vej 2, NSH2 16, DK 2820 Gentofte, Copenhagen, Denmark
J Med Genet 42:402-7. 2005..PGC-1alpha is involved in adipogenesis, mitochondrial biogenesis, fatty acid beta oxidation, and hepatic gluconeogenesis...
- The T allele of rs7903146 TCF7L2 is associated with impaired insulinotropic action of incretin hormones, reduced 24 h profiles of plasma insulin and glucagon, and increased hepatic glucose production in young healthy menK Pilgaard
Steno Diabetes Center, Niels Steensens Vej 1, Gentofte, Denmark
Diabetologia 52:1298-307. 2009..We studied the physiological, metabolic and hormonal mechanisms underlying the elevated risk of type 2 diabetes in carriers of TCF7L2 gene...
- Low physical activity accentuates the effect of the FTO rs9939609 polymorphism on body fat accumulationCamilla H Andreasen
Steno Diabetes Center, Niels Steensens Vej 1, NLC2 13, DK 2820 Gentofte, Denmark
Diabetes 57:95-101. 2008..In the present study, the effect of FTO variation on metabolic traits including obesity, type 2 diabetes, and related quantitative phenotypes was examined...
- PGC-1alpha Gly482Ser polymorphism associates with hypertension among Danish whitesGitte Andersen
Steno Diabetes Center, Niels Steensens Vej 2, NSH2 16, DK 2820 Gentofte, Denmark
Hypertension 45:565-70. 2005..001). In conclusion, the Ser allele of PGC-1alpha Gly482Ser confers a significantly reduced risk of hypertension in whites. Further studies are needed to elucidate the differential role of this polymorphism in men and women...
- Variation in NCB5OR: studies of relationships to type 2 diabetes, maturity-onset diabetes of the young, and gestational diabetes mellitusGitte Andersen
Steno Diabetes Center and Hagedorn Research Institute, Niels Steensens Vej 2, NSH2 16, DK 2820 Gentofte, Denmark
Diabetes 53:2992-7. 2004..Thus, variation in the coding region of NCB5OR is not a major contributor in the pathogenesis of nonautoimmune diabetes...