L Wegner

Summary

Affiliation: Steno Diabetes Center
Country: Denmark

Publications

  1. ncbi Large-scale study of the -232C > G polymorphism of PCK1 in Type 2 diabetes
    L Wegner
    Steno Diabetes Center, Gentofte, Denmark
    Diabet Med 23:1140-4. 2006
  2. ncbi Common variation in LMNA increases susceptibility to type 2 diabetes and associates with elevated fasting glycemia and estimates of body fat and height in the general population: studies of 7,495 Danish whites
    Lise Wegner
    Steno Diabetes Center, Niels Steensens Vej 2, NSP1 03, DK 2820 Gentofte, Denmark
    Diabetes 56:694-8. 2007
  3. doi Impact of TCF7L2 rs7903146 on insulin secretion and action in young and elderly Danish twins
    Lise Wegner
    Steno Diabetes Center, DK 2820 Gentofte, Denmark
    J Clin Endocrinol Metab 93:4013-9. 2008
  4. doi LMNA rs4641 and the muscle lamin A and C isoforms in twins--metabolic implications and transcriptional regulation
    L Wegner
    Hagedorn Research Institute, Niels Steensens Vej 1, DK 2820 Gentofte, Denmark
    J Clin Endocrinol Metab 95:3884-92. 2010
  5. doi A variant in the G6PC2/ABCB11 locus is associated with increased fasting plasma glucose, increased basal hepatic glucose production and increased insulin release after oral and intravenous glucose loads
    C S Rose
    Hagedorn Research Institute, Gentofte, Denmark
    Diabetologia 52:2122-9. 2009
  6. doi Polymorphisms in AHI1 are not associated with type 2 diabetes or related phenotypes in Danes: non-replication of a genome-wide association result
    J Holmkvist
    Steno Diabetes Center, Niels Steensens Vej 1, NLC2 12, 2820 Gentofte, Denmark
    Diabetologia 51:609-14. 2008
  7. pmc Evidence of an association between genetic variation of the coactivator PGC-1beta and obesity
    G Andersen
    Steno Diabetes Center, Niels Steensens Vej 2, NSH2 16, DK 2820 Gentofte, Copenhagen, Denmark
    J Med Genet 42:402-7. 2005
  8. doi The T allele of rs7903146 TCF7L2 is associated with impaired insulinotropic action of incretin hormones, reduced 24 h profiles of plasma insulin and glucagon, and increased hepatic glucose production in young healthy men
    K Pilgaard
    Steno Diabetes Center, Niels Steensens Vej 1, Gentofte, Denmark
    Diabetologia 52:1298-307. 2009
  9. ncbi Low physical activity accentuates the effect of the FTO rs9939609 polymorphism on body fat accumulation
    Camilla H Andreasen
    Steno Diabetes Center, Niels Steensens Vej 1, NLC2 13, DK 2820 Gentofte, Denmark
    Diabetes 57:95-101. 2008
  10. ncbi PGC-1alpha Gly482Ser polymorphism associates with hypertension among Danish whites
    Gitte Andersen
    Steno Diabetes Center, Niels Steensens Vej 2, NSH2 16, DK 2820 Gentofte, Denmark
    Hypertension 45:565-70. 2005

Collaborators

Detail Information

Publications11

  1. ncbi Large-scale study of the -232C > G polymorphism of PCK1 in Type 2 diabetes
    L Wegner
    Steno Diabetes Center, Gentofte, Denmark
    Diabet Med 23:1140-4. 2006
    ..Interaction studies of the PCK1-232C > G polymorphism with variants in the genes encoding peroxisome proliferator-activated receptor-gamma co-activator (PGC)-1alpha and hepatic nuclear factor (HNF)-4alpha were also performed...
  2. ncbi Common variation in LMNA increases susceptibility to type 2 diabetes and associates with elevated fasting glycemia and estimates of body fat and height in the general population: studies of 7,495 Danish whites
    Lise Wegner
    Steno Diabetes Center, Niels Steensens Vej 2, NSP1 03, DK 2820 Gentofte, Denmark
    Diabetes 56:694-8. 2007
    ....
  3. doi Impact of TCF7L2 rs7903146 on insulin secretion and action in young and elderly Danish twins
    Lise Wegner
    Steno Diabetes Center, DK 2820 Gentofte, Denmark
    J Clin Endocrinol Metab 93:4013-9. 2008
    ....
  4. doi LMNA rs4641 and the muscle lamin A and C isoforms in twins--metabolic implications and transcriptional regulation
    L Wegner
    Hagedorn Research Institute, Niels Steensens Vej 1, DK 2820 Gentofte, Denmark
    J Clin Endocrinol Metab 95:3884-92. 2010
    ..Lamins are essential for nuclear shape and function. Polymorphisms in LMNA may associate with fat and muscle development and aging...
  5. doi A variant in the G6PC2/ABCB11 locus is associated with increased fasting plasma glucose, increased basal hepatic glucose production and increased insulin release after oral and intravenous glucose loads
    C S Rose
    Hagedorn Research Institute, Gentofte, Denmark
    Diabetologia 52:2122-9. 2009
    ..Furthermore, we examined rs560887 for association with impaired fasting glycaemia (IFG), impaired glucose tolerance (IGT), type 2 diabetes and components of the metabolic syndrome...
  6. doi Polymorphisms in AHI1 are not associated with type 2 diabetes or related phenotypes in Danes: non-replication of a genome-wide association result
    J Holmkvist
    Steno Diabetes Center, Niels Steensens Vej 1, NLC2 12, 2820 Gentofte, Denmark
    Diabetologia 51:609-14. 2008
    ..The aim of the present study was to investigate the putative association between these polymorphisms and type 2 diabetes or type 2 diabetes-related metabolic traits in Danish individuals...
  7. pmc Evidence of an association between genetic variation of the coactivator PGC-1beta and obesity
    G Andersen
    Steno Diabetes Center, Niels Steensens Vej 2, NSH2 16, DK 2820 Gentofte, Copenhagen, Denmark
    J Med Genet 42:402-7. 2005
    ..PGC-1alpha is involved in adipogenesis, mitochondrial biogenesis, fatty acid beta oxidation, and hepatic gluconeogenesis...
  8. doi The T allele of rs7903146 TCF7L2 is associated with impaired insulinotropic action of incretin hormones, reduced 24 h profiles of plasma insulin and glucagon, and increased hepatic glucose production in young healthy men
    K Pilgaard
    Steno Diabetes Center, Niels Steensens Vej 1, Gentofte, Denmark
    Diabetologia 52:1298-307. 2009
    ..We studied the physiological, metabolic and hormonal mechanisms underlying the elevated risk of type 2 diabetes in carriers of TCF7L2 gene...
  9. ncbi Low physical activity accentuates the effect of the FTO rs9939609 polymorphism on body fat accumulation
    Camilla H Andreasen
    Steno Diabetes Center, Niels Steensens Vej 1, NLC2 13, DK 2820 Gentofte, Denmark
    Diabetes 57:95-101. 2008
    ..In the present study, the effect of FTO variation on metabolic traits including obesity, type 2 diabetes, and related quantitative phenotypes was examined...
  10. ncbi PGC-1alpha Gly482Ser polymorphism associates with hypertension among Danish whites
    Gitte Andersen
    Steno Diabetes Center, Niels Steensens Vej 2, NSH2 16, DK 2820 Gentofte, Denmark
    Hypertension 45:565-70. 2005
    ..001). In conclusion, the Ser allele of PGC-1alpha Gly482Ser confers a significantly reduced risk of hypertension in whites. Further studies are needed to elucidate the differential role of this polymorphism in men and women...
  11. pmc Variation in NCB5OR: studies of relationships to type 2 diabetes, maturity-onset diabetes of the young, and gestational diabetes mellitus
    Gitte Andersen
    Steno Diabetes Center and Hagedorn Research Institute, Niels Steensens Vej 2, NSH2 16, DK 2820 Gentofte, Denmark
    Diabetes 53:2992-7. 2004
    ..Thus, variation in the coding region of NCB5OR is not a major contributor in the pathogenesis of nonautoimmune diabetes...