Lise Tarnow

Summary

Affiliation: Steno Diabetes Center
Country: Denmark

Publications

  1. ncbi Elevated plasma asymmetric dimethylarginine as a marker of cardiovascular morbidity in early diabetic nephropathy in type 1 diabetes
    Lise Tarnow
    Steno Diabetes Center, Gentofte, Denmark
    Diabetes Care 27:765-9. 2004
  2. pmc A prospective randomised cross-over study of the effect of insulin analogues and human insulin on the frequency of severe hypoglycaemia in patients with type 1 diabetes and recurrent hypoglycaemia (the HypoAna trial): study rationale and design
    Peter Lommer Kristensen
    Department of Cardiology, Nephrology and Endocrinology, Hillerød University Hospital, Dyrehavevej 29, DK 3400, Hillerød, Denmark
    BMC Endocr Disord 12:10. 2012
  3. pmc The CTGF -945GC polymorphism is not associated with plasma CTGF and does not predict nephropathy or outcome in type 1 diabetes
    Amélie Dendooven
    Department of Pathology, University Medical Center Utrecht, Heidelberglaan 100, 3584CX Utrecht, The Netherlands
    J Negat Results Biomed 10:4. 2011
  4. pmc Functional annotations of diabetes nephropathy susceptibility loci through analysis of genome-wide renal gene expression in rat models of diabetes mellitus
    YaoMin Hu
    The Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    BMC Med Genomics 2:41. 2009
  5. ncbi Plasma N-terminal pro-brain natriuretic peptide as an independent predictor of mortality in diabetic nephropathy
    L Tarnow
    Steno Diabetes Center, Niels Steensens Vej 2, 2820 Gentofte, Denmark
    Diabetologia 48:149-55. 2005
  6. ncbi Elevated placental growth factor (PlGF) predicts cardiovascular morbidity and mortality in type 1 diabetic patients with diabetic nephropathy
    Lise Tarnow
    Steno Diabetes Center, Gentofte, Denmark
    Scand J Clin Lab Invest Suppl 240:73-9. 2005
  7. ncbi Plasma N-terminal pro-B-type natriuretic peptide and mortality in type 2 diabetes
    L Tarnow
    Steno Diabetes Center, Niels Steensens Vej 2, DK 2820, Gentofte, Denmark
    Diabetologia 49:2256-62. 2006
  8. ncbi European rational approach for the genetics of diabetic complications--EURAGEDIC: patient populations and strategy
    Lise Tarnow
    Steno Diabetes Center, Copenhagen, Denmark
    Nephrol Dial Transplant 23:161-8. 2008
  9. ncbi Long-term renoprotective effects of losartan in diabetic nephropathy: interaction with ACE insertion/deletion genotype?
    Steen Andersen
    Steno Diabetes Center, Copenhagen, Denmark
    Diabetes Care 26:1501-6. 2003
  10. doi Impact of metformin versus repaglinide on non-glycaemic cardiovascular risk markers related to inflammation and endothelial dysfunction in non-obese patients with type 2 diabetes
    Søren S Lund
    Steno Diabetes Center, Niels Steensens Vej 2, 2820 Gentofte, Denmark
    Eur J Endocrinol 158:631-41. 2008

Detail Information

Publications108 found, 100 shown here

  1. ncbi Elevated plasma asymmetric dimethylarginine as a marker of cardiovascular morbidity in early diabetic nephropathy in type 1 diabetes
    Lise Tarnow
    Steno Diabetes Center, Gentofte, Denmark
    Diabetes Care 27:765-9. 2004
    ..This study investigated the relation between ADMA and diabetic micro- and macrovascular complications in a large cohort of type 1 diabetic patients with and without early diabetic nephropathy...
  2. pmc A prospective randomised cross-over study of the effect of insulin analogues and human insulin on the frequency of severe hypoglycaemia in patients with type 1 diabetes and recurrent hypoglycaemia (the HypoAna trial): study rationale and design
    Peter Lommer Kristensen
    Department of Cardiology, Nephrology and Endocrinology, Hillerød University Hospital, Dyrehavevej 29, DK 3400, Hillerød, Denmark
    BMC Endocr Disord 12:10. 2012
    ..This paper reports the study design of the HypoAna Trial...
  3. pmc The CTGF -945GC polymorphism is not associated with plasma CTGF and does not predict nephropathy or outcome in type 1 diabetes
    Amélie Dendooven
    Department of Pathology, University Medical Center Utrecht, Heidelberglaan 100, 3584CX Utrecht, The Netherlands
    J Negat Results Biomed 10:4. 2011
    ..In conclusion, the -945GC SNP does not affect plasma CTGF levels, incidence and prognosis of diabetic nephropathy, and cardiovascular outcome...
  4. pmc Functional annotations of diabetes nephropathy susceptibility loci through analysis of genome-wide renal gene expression in rat models of diabetes mellitus
    YaoMin Hu
    The Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    BMC Med Genomics 2:41. 2009
    ....
  5. ncbi Plasma N-terminal pro-brain natriuretic peptide as an independent predictor of mortality in diabetic nephropathy
    L Tarnow
    Steno Diabetes Center, Niels Steensens Vej 2, 2820 Gentofte, Denmark
    Diabetologia 48:149-55. 2005
    ..This study investigated the prognostic value of NT-proBNP in a large cohort of type 1 diabetic patients with and without diabetic nephropathy...
  6. ncbi Elevated placental growth factor (PlGF) predicts cardiovascular morbidity and mortality in type 1 diabetic patients with diabetic nephropathy
    Lise Tarnow
    Steno Diabetes Center, Gentofte, Denmark
    Scand J Clin Lab Invest Suppl 240:73-9. 2005
    ....
  7. ncbi Plasma N-terminal pro-B-type natriuretic peptide and mortality in type 2 diabetes
    L Tarnow
    Steno Diabetes Center, Niels Steensens Vej 2, DK 2820, Gentofte, Denmark
    Diabetologia 49:2256-62. 2006
    ..Elevated NT-proBNP predicts excess morbidity and mortality in diabetic patients with an elevated urinary albumin excretion rate. This study investigated the prognostic value of NT-proBNP in a cohort of type 2 diabetic patients...
  8. ncbi European rational approach for the genetics of diabetic complications--EURAGEDIC: patient populations and strategy
    Lise Tarnow
    Steno Diabetes Center, Copenhagen, Denmark
    Nephrol Dial Transplant 23:161-8. 2008
    ..The main objective of the EURAGEDIC study was to address these problems...
  9. ncbi Long-term renoprotective effects of losartan in diabetic nephropathy: interaction with ACE insertion/deletion genotype?
    Steen Andersen
    Steno Diabetes Center, Copenhagen, Denmark
    Diabetes Care 26:1501-6. 2003
    ..Therefore, we investigated the long-term effect of the angiotensin II subtype-1 (AT1) receptor antagonist losartan (100 mg o.d.) on kidney function in II and DD type 1 diabetic patients with diabetic nephropathy...
  10. doi Impact of metformin versus repaglinide on non-glycaemic cardiovascular risk markers related to inflammation and endothelial dysfunction in non-obese patients with type 2 diabetes
    Søren S Lund
    Steno Diabetes Center, Niels Steensens Vej 2, 2820 Gentofte, Denmark
    Eur J Endocrinol 158:631-41. 2008
    ..In T2DM patients, metformin and insulin secretagogues have demonstrated equal anti-hyperglycaemic potency. Here, we report the effect of metformin versus an insulin secretagogue, repaglinide, on CVD biomarkers in non-obese T2DM patients...
  11. ncbi Plasma concentration of asymmetric dimethylarginine (ADMA) predicts cardiovascular morbidity and mortality in type 1 diabetic patients with diabetic nephropathy
    Maria Lajer
    Steno Diabetes Center, Niels Steensens Vej 1, 2820 Gentofte, Denmark
    Diabetes Care 31:747-52. 2008
    ....
  12. doi Endothelial dysfunction and inflammation predict development of diabetic nephropathy in the Irbesartan in Patients with Type 2 Diabetes and Microalbuminuria (IRMA 2) study
    Frederik Persson
    Steno Diabetes Center, Gentofte, Denmark
    Scand J Clin Lab Invest 68:731-8. 2008
    ....
  13. pmc Combining insulin with metformin or an insulin secretagogue in non-obese patients with type 2 diabetes: 12 month, randomised, double blind trial
    Søren S Lund
    Steno Diabetes Center, Gentofte, Denmark
    BMJ 339:b4324. 2009
    ..To study the effect of insulin treatment in combination with metformin or an insulin secretagogue, repaglinide, on glycaemic regulation in non-obese patients with type 2 diabetes...
  14. pmc Effects of biphasic, basal-bolus or basal insulin analogue treatments on carotid intima-media thickness in patients with type 2 diabetes mellitus: the randomised Copenhagen Insulin and Metformin Therapy (CIMT) trial
    Louise Lundby-Christensen
    Steno Diabetes Center, Gentofte, Denmark Department of Endocrinology, Hvidovre, Copenhagen University Hospital, Hvidovre, Denmark Copenhagen Trial Unit, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark Department of Paediatrics, Hvidovre, Copenhagen University Hospital, Hvidovre, Denmark
    BMJ Open 6:e008377. 2016
    ..To assess the effect of 3 insulin analogue regimens on change in carotid intima-media thickness (IMT) in patients with type 2 diabetes...
  15. ncbi Progression of nephropathy in type 2 diabetic patients
    Kasper Rossing
    Department of Physiology, Steno Diabetes Center, Gentofte, Denmark
    Kidney Int 66:1596-605. 2004
    ....
  16. doi Relation of left ventricular function, mass, and volume to NT-proBNP in type 1 diabetic patients
    Anne Sofie Astrup
    Steno Diabetes Center, Gentofte, Denmark
    Diabetes Care 31:968-70. 2008
    ..To measure left ventricular mass (LVM), left ventricular volumes, and left ventricular function (LVF) in a cohort of type 1 diabetic patients and to correlate measures of imaging to NH(2)-terminal pro-brain natriuretic peptide (NT-proBNP)...
  17. doi Serum adiponectin predicts all-cause mortality and end stage renal disease in patients with type I diabetes and diabetic nephropathy
    Anders Jorsal
    Steno Diabetes Center, Gentofte, Denmark
    Kidney Int 74:649-54. 2008
    ..These studies show that high serum adiponectin levels predict mortality and progression to end stage renal disease in type I diabetic patients...
  18. ncbi Time course of the antiproteinuric and antihypertensive effect of losartan in diabetic nephropathy
    Steen Andersen
    Steno Diabetes Center, Niels Steensensvej 2, DK 2820 Gentofte, Denmark
    Nephrol Dial Transplant 18:293-7. 2003
    ..We evaluated the time course of the antihypertensive and antialbuminuric effect after initiation of AT1 receptor blockade by losartan in diabetic nephropathy...
  19. ncbi Angiotensin receptor blockers in diabetic nephropathy: renal and cardiovascular end points
    Hans Henrik Parving
    Steno Diabetes Center, Copenhagen, Denmark
    Semin Nephrol 24:147-57. 2004
    ..The studies mentioned here suggest that ARB represents a beneficial treatment of hypertension and proteinuria in incipient and overt diabetic nephropathy...
  20. doi Elevated NT-proBNP and coronary calcium score in relation to coronary artery disease in asymptomatic type 2 diabetic patients with elevated urinary albumin excretion rate
    Henrik Reinhard
    Steno Diabetes Centre, Gentofte, Denmark
    Nephrol Dial Transplant 26:3242-9. 2011
    ....
  21. pmc Plasma growth differentiation factor-15 independently predicts all-cause and cardiovascular mortality as well as deterioration of kidney function in type 1 diabetic patients with nephropathy
    Maria Lajer
    Steno Diabetes Center, Gentofte, Denmark
    Diabetes Care 33:1567-72. 2010
    ..The aim of this study was to investigate GDF-15 levels in relation to all-cause mortality, cardiovascular mortality and morbidity, decline in glomerular filtration rate (GFR), and progression toward end-stage renal disease (ESRD)...
  22. pmc Effect of adjunct metformin treatment in patients with type-1 diabetes and persistent inadequate glycaemic control. A randomized study
    Søren Søgaard Lund
    Steno Diabetes Center, Gentofte, Denmark
    PLoS ONE 3:e3363. 2008
    ..We investigated the effect of a one-year treatment with metformin versus placebo in patients with T1DM and persistent poor glycaemic control...
  23. ncbi Differences between nisoldipine and lisinopril on glomerular filtration rates and albuminuria in hypertensive IDDM patients with diabetic nephropathy during the first year of treatment
    P Rossing
    Steno Diabetes Center, Gentofte, Denmark
    Diabetes 46:481-7. 1997
    ..Longer follow-up is required to clarify whether these drugs have different renoprotective effects...
  24. doi Markers of endothelial dysfunction and inflammation in type 1 diabetic patients with or without diabetic nephropathy followed for 10 years: association with mortality and decline of glomerular filtration rate
    Anne Sofie Astrup
    Steno Diabetes Center, Gentofte, Denmark
    Diabetes Care 31:1170-6. 2008
    ..We evaluated the association of biomarkers of endothelial dysfunction and inflammation with all-cause mortality and cardiovascular mortality and morbidity and decline in glomerular filtration rate (GFR) in type 1 diabetic patients...
  25. ncbi [Risk factors for the development of microalbuminuria in type 1 diabetes: an incidence cohort study--a secondary publication]
    Peter Hovind
    Steno Diabetes Center, Gentofte
    Ugeskr Laeger 167:57-60. 2005
  26. doi Soluble CD40 ligand is elevated in type 1 diabetic nephropathy but not predictive of mortality, cardiovascular events or kidney function
    Maria Lajer
    Steno Diabetes Center, Gentofte, Denmark
    Platelets 21:525-32. 2010
    ..85) nor rate of decline in GFR (p = 0.69). Plasma sCD40L is elevated in T1DM nephropathy but is not a predictor of all-cause mortality, cardiovascular mortality and morbidity or deterioration of kidney function..
  27. ncbi Aldosterone synthase (CYP11B2)-344T/C polymorphism and renoprotective response to losartan treatment in diabetic nephropathy
    K J Schjoedt
    Steno Diabetes Center, Gentofte, Denmark
    Scand J Clin Lab Invest 66:173-80. 2006
    ....
  28. doi Aliskiren combined with losartan in type 2 diabetes and nephropathy
    Hans Henrik Parving
    Department of Medical Endocrinology, Rigshospitalet, Copenhagen, Denmark
    N Engl J Med 358:2433-46. 2008
    ....
  29. pmc Metformin versus placebo in combination with insulin analogues in patients with type 2 diabetes mellitus-the randomised, blinded Copenhagen Insulin and Metformin Therapy (CIMT) trial
    Louise Lundby-Christensen
    Steno Diabetes Center, Gentofte, Denmark Department of Endocrinology, Hvidovre, Copenhagen University Hospital, Hvidovre, Denmark Copenhagen Trial Unit, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark Department of Paediatrics, Hvidovre, Copenhagen University Hospital, Hvidovre, Denmark
    BMJ Open 6:e008376. 2016
    ..To assess the effect of metformin versus placebo both in combination with insulin analogue treatment on changes in carotid intima-media thickness (IMT) in patients with type 2 diabetes...
  30. ncbi Remission and regression of diabetic nephropathy
    Peter Hovind
    Steno Diabetes Center, Niels Steensens Vej 2, DK 2820 Gentofte, Denmark
    Curr Hypertens Rep 6:377-82. 2004
    ..However, to prevent development of ESRD in diabetic patients, an aggressive multifactorial approach, aiming at lowering blood pressure and albuminuria, and improving glycemic control, must be applied...
  31. ncbi Mannose-binding lectin as a predictor of microalbuminuria in type 1 diabetes: an inception cohort study
    Peter Hovind
    Steno Diabetes Center, Niels Steensens Vej 2, DK 2820 Gentofte, Denmark
    Diabetes 54:1523-7. 2005
    ....
  32. ncbi Irbesartan treatment reduces biomarkers of inflammatory activity in patients with type 2 diabetes and microalbuminuria: an IRMA 2 substudy
    Frederik Persson
    Steno Diabetes Center, Niels Steensenvej 2, DK 2820 Gentofte, Denmark
    Diabetes 55:3550-5. 2006
    ..04). There was no treatment effect on the other biomarkers. Irbesartan (300 mg once daily) reduces low-grade inflammation in this high-risk population, and this may reduce the risk of micro- and macrovascular disease...
  33. pmc Serum uric acid as a predictor for development of diabetic nephropathy in type 1 diabetes: an inception cohort study
    Peter Hovind
    Steno Diabetes Center, Gentofte, Denmark
    Diabetes 58:1668-71. 2009
    ..Whether uric acid has a causal role in the development of diabetic nephropathy is not known. The objective of the present study is to evaluate uric acid as a predictor of persistent micro- and macroalbuminuria...
  34. pmc Tubular and glomerular injury in diabetes and the impact of ACE inhibition
    Stine E Nielsen
    Steno Diabetes Center, Copenhagen, Denmark
    Diabetes Care 32:1684-8. 2009
    ..Subsequently, we evaluated the effect of ACE inhibition on U-LFABP in patients with diabetic nephropathy...
  35. ncbi Smoking and progression of diabetic nephropathy in type 1 diabetes
    Peter Hovind
    Steno Diabetes Center, Gentofte, Denmark
    Diabetes Care 26:911-6. 2003
    ..We assessed the impact of smoking on progression of diabetic nephropathy in type 1 diabetic patients enrolled in a prospective observational cohort study started in 1983...
  36. ncbi Genetic variation in the Renin-Angiotensin system and progression of diabetic nephropathy
    Peter Jacobsen
    Steno Diabetes Center, Gentofte, Denmark
    J Am Soc Nephrol 14:2843-50. 2003
    ..Interaction between polymorphisms in the renin-angiotensin system also influenced the loss of kidney function. This new genetic interaction model needs to be confirmed in future studies...
  37. ncbi Improved survival in patients obtaining remission of nephrotic range albuminuria in diabetic nephropathy
    Peter Hovind
    Steno Diabetes Center, Gentofte, Denmark
    Kidney Int 66:1180-6. 2004
    ....
  38. ncbi An IGF-I gene polymorphism modifies the risk of developing persistent microalbuminuria in type 1 diabetes
    Peter Hovind
    Steno Diabetes Center, Gentofte, Denmark
    Eur J Endocrinol 156:83-90. 2007
    ..The aim of this study was to investigate whether an IGF-I gene promoter polymorphism influenced the development of persistent MA in type 1 diabetes...
  39. pmc YKL-40, a marker of inflammation and endothelial dysfunction, is elevated in patients with type 1 diabetes and increases with levels of albuminuria
    Camilla Noelle Rathcke
    Department of Endocrinology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark
    Diabetes Care 32:323-8. 2009
    ..In the present study, YKL-40 levels were examined in patients with type 1 diabetes with increasing levels of albuminuria, known to be associated with an increased risk of cardiovascular disease...
  40. pmc Predictors for the development of microalbuminuria and macroalbuminuria in patients with type 1 diabetes: inception cohort study
    Peter Hovind
    Steno Diabetes Center, Niels Steensens Vej 2, DK 2820 Gentofte, Denmark
    BMJ 328:1105. 2004
    ..To evaluate baseline predictors for the development of persistent microalbuminuria and macroalbuminuria prospectively in patients with type 1 diabetes...
  41. ncbi Remission to normoalbuminuria during multifactorial treatment preserves kidney function in patients with type 2 diabetes and microalbuminuria
    Peter Gaede
    Steno Diabetes Center, Gentofte, Denmark
    Nephrol Dial Transplant 19:2784-8. 2004
    ..However, the long-term impact of stabilization/regression in albuminuria on decline in glomerular filtration rate (GFR) has not been established...
  42. ncbi Reduction of urinary connective tissue growth factor by Losartan in type 1 patients with diabetic nephropathy
    Steen Andersen
    Steno Diabetes Center, Gentofte, Denmark
    Kidney Int 67:2325-9. 2005
    ..The present study aimed to investigate the short- and long term effects of angiotensin II receptor blockade by Losartan on urinary CTGF levels in hypertensive type 1 diabetic patients with diabetic nephropathy...
  43. ncbi Polymorphisms in the B-type natriuretic peptide (BNP) gene are associated with NT-proBNP levels but not with diabetic nephropathy or mortality in type 1 diabetic patients
    Maria Lajer
    Steno Diabetes Center, Niels Steensens Vej 2, DK 2820 Gentofte, Denmark
    Nephrol Dial Transplant 22:3235-9. 2007
    ..Therefore, we investigated the association between two polymorphisms -381T/C and 1551G/A of the BNP gene, plasma NT-proBNP levels and mortality prognosis in 380 type 1 diabetic patients with and without diabetic nephropathy...
  44. doi Endothelial progenitor cells in long-standing asymptomatic type 1 diabetic patients with or without diabetic nephropathy
    Henrik Reinhard
    Steno Diabetes Center, Gentofte, Denmark hnri steno dk
    Nephron Clin Pract 118:c309-14. 2011
    ..Our aim was to evaluate EPC numbers in asymptomatic CVD type 1 diabetic patients with or without DN and to study the effect of CVD and medication on EPC numbers...
  45. ncbi Renoprotective effects of angiotensin II receptor blockade in type 1 diabetic patients with diabetic nephropathy
    S Andersen
    Steno Diabetes Center, Copenhagen, Denmark
    Kidney Int 57:601-6. 2000
    ..Therefore, we compared the renal and hemodynamic effects of specific intervention in the renin-angiotensin system by blockade of the angiotensin II subtype-1 receptor to the effect of ACE inhibition...
  46. ncbi Long-term renoprotective effect of nisoldipine and lisinopril in type 1 diabetic patients with diabetic nephropathy
    L Tarnow
    Steno Diabetes Center, Gentofte, Denmark
    Diabetes Care 23:1725-30. 2000
    ..To compare the long-term effect on kidney function of a long-acting calcium antagonist (nisoldipine) versus a long-acting ACE inhibitor (lisinopril) in hypertensive type 1 diabetic patients with diabetic nephropathy...
  47. doi Urinary adiponectin excretion rises with increasing albuminuria in type 1 diabetes
    Anders Jorsal
    Steno Diabetes Center, Gentofte, Denmark Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark Institute of Clinical Medicine, Faculty of Health, Aarhus University, Aarhus, Denmark Electronic address
    J Diabetes Complications 27:604-8. 2013
    ..Inspired by this, we studied the levels of u-adiponectin in type 1 diabetic patients with different levels of urinary albumin excretion (UAE)...
  48. ncbi Improved prognosis in type 1 diabetic patients with nephropathy: a prospective follow-up study
    Anne Sofie Astrup
    Steno Diabetes Center, Gentofte, Denmark
    Kidney Int 68:1250-7. 2005
    ..Furthermore, end-stage renal disease (ESRD) was the main cause of death. We prospectively assessed the impact of reno- and cardiovascular protective treatment on prognosis in type 1 diabetic patients with diabetic nephropathy...
  49. doi Impact of metformin versus the prandial insulin secretagogue, repaglinide, on fasting and postprandial glucose and lipid responses in non-obese patients with type 2 diabetes
    Søren S Lund
    Steno Diabetes Center, Niels Steensens Vej 2, 2820 Gentofte, Denmark
    Eur J Endocrinol 158:35-46. 2008
    ..Whether the same apply for postprandial glucose and lipid metabolism is unknown. Here, we compared the effect of metformin versus repaglinide on postprandial metabolism in non-obese T2DM patients...
  50. pmc Urinary proteomics in diabetes and CKD
    Kasper Rossing
    Steno Diabetes Center, Niels Steensens Vej 2, DK 2820 Gentofte, Denmark
    J Am Soc Nephrol 19:1283-90. 2008
    ..In conclusion, this study shows that analysis of the urinary proteome may allow early detection of diabetic nephropathy and may provide prognostic information...
  51. doi Finding diabetic nephropathy biomarkers in the plasma peptidome by high-throughput magnetic bead processing and MALDI-TOF-MS analysis
    Henning G Hansen
    Hagedorn Research Institute, Novo Nordisk A S, Gentofte, Denmark
    Proteomics Clin Appl 4:697-705. 2010
    ..The aim of this study was to discover candidate biomarkers for DN in the plasma peptidome in an in-house cross-sectional cohort (n=122) of type 1 diabetic patients diagnosed with normo-, micro-, and macroalbuminuria...
  52. ncbi Decreasing incidence of severe diabetic microangiopathy in type 1 diabetes
    Peter Hovind
    Steno Diabetes Center, Gentofte, Denmark
    Diabetes Care 26:1258-64. 2003
    ..To assess recent trends in the cumulative incidence of diabetic microangiopathy in type 1 diabetes, we analyzed data from long-term prospective observational studies lasting >/=20 years...
  53. ncbi PGC-1alpha Gly482Ser polymorphism associates with hypertension among Danish whites
    Gitte Andersen
    Steno Diabetes Center, Niels Steensens Vej 2, NSH2 16, DK 2820 Gentofte, Denmark
    Hypertension 45:565-70. 2005
    ..001). In conclusion, the Ser allele of PGC-1alpha Gly482Ser confers a significantly reduced risk of hypertension in whites. Further studies are needed to elucidate the differential role of this polymorphism in men and women...
  54. ncbi Beneficial impact of spironolactone in diabetic nephropathy
    Katrine Jordan Schjoedt
    Steno Diabetes Center, Gentofte, Denmark
    Kidney Int 68:2829-36. 2005
    ..We therefore aimed to evaluate the short-term effect of aldosterone antagonism with spironolactone on albuminuria and blood pressure in diabetic nephropathy...
  55. ncbi Cardiac autonomic neuropathy predicts cardiovascular morbidity and mortality in type 1 diabetic patients with diabetic nephropathy
    Anne Sofie Astrup
    Steno Diabetes Center, Niels Steensensvej 2, 2820 Gentofte, Denmark
    Diabetes Care 29:334-9. 2006
    ..Because CAN is common in patients with diabetic nephropathy, we evaluated the predictive value of CAN in type 1 diabetic patients with and without diabetic nephropathy...
  56. ncbi Progression of diabetic nephropathy
    P Hovind
    Steno Diabetes Center, Gentofte, Denmark
    Kidney Int 59:702-9. 2001
    ..The risk factors of losing filtration power (progression promoters) have not been clearly identified. Furthermore, information on optimal arterial blood pressure, glycemic control, and cholesterol levels are lacking...
  57. ncbi Remission and regression in the nephropathy of type 1 diabetes when blood pressure is controlled aggressively
    P Hovind
    Steno Diabetes Center, Gentofte, Denmark
    Kidney Int 60:277-83. 2001
    ..To examine whether remission and regression of diabetic nephropathy are possible in type 1 diabetic patients, we analyzed data from a prospective observational cohort study that was started in 1983...
  58. ncbi Preventing diabetic nephropathy: an audit
    H P Hansen
    Steno Diabetes Center, Gentofte, Denmark
    Scand J Clin Lab Invest 61:471-7. 2001
    ....
  59. ncbi PC-1 amino acid variant (K121Q) has no impact on progression of diabetic nephropathy in type 1 diabetic patients
    Peter Jacobsen
    Steno Diabetes Center, Gentofte, Denmark
    Nephrol Dial Transplant 17:1408-12. 2002
    ..We tested the impact of the PC-1 (K121Q) variant on loss of glomerular filtration rate (GFR) measured by the [(51)Cr]EDTA plasma clearance technique...
  60. pmc Screening for diabetic cardiac autonomic neuropathy using a new handheld device
    Elisabeth Gulichsen
    Steno Diabetes Center, Gentofte, Denmark
    J Diabetes Sci Technol 6:965-72. 2012
    ..The present study evaluated the prevalence of CAN diagnosed by reduced heart rate variability (HRV) using a newly developed device in a large, unselected, hospital-based population of patients with diabetes...
  61. pmc Vitamin D levels and mortality in type 2 diabetes
    Christel Joergensen
    Steno Diabetes Center, Gentofte, Denmark
    Diabetes Care 33:2238-43. 2010
    ..To evaluate vitamin D as a predictor of all-cause and cardiovascular mortality and risk of progression to micro- or macroalbuminuria in type 2 diabetic patients...
  62. ncbi Remission of nephrotic-range albuminuria in type 1 diabetic patients
    P Hovind
    Steno Diabetes Center, Gentofte, Denmark
    Diabetes Care 24:1972-7. 2001
    ..To evaluate the cumulative incidence of nephrotic-range albuminuria (NRA), the frequency of remission, and the impact on progression, we analyzed data from a prospective cohort study of type 1 diabetic patients with diabetic nephropathy...
  63. ncbi Progression of diabetic nephropathy: role of plasma homocysteine and plasminogen activator inhibitor-1
    P Hovind
    Steno Diabetes Center, Gentofte, Denmark
    Am J Kidney Dis 38:1376-80. 2001
    ..After adjustment for other well-established risk factors for progression of nephropathy in a multiple linear regression analysis, however, neither tHcy levels nor PAI-1 levels were independent predictors of rate of decline in GFR...
  64. ncbi Beneficial impact of spironolactone on nephrotic range albuminuria in diabetic nephropathy
    K J Schjoedt
    Steno Diabetes Center, Gentofte, Denmark
    Kidney Int 70:536-42. 2006
    ....
  65. doi Efficacy and safety of liraglutide for overweight adult patients with type 1 diabetes and insufficient glycaemic control (Lira-1): a randomised, double-blind, placebo-controlled trial
    Thomas Fremming Dejgaard
    Steno Diabetes Center, Gentofte, Denmark Department of Endocrinology, Hvidovre Hospital, University of Copenhagen, Hvidovre, Denmark Electronic address
    Lancet Diabetes Endocrinol 4:221-32. 2016
    ..We assessed the efficacy and safety of the GLP-1 receptor agonist liraglutide as an add-on therapy to insulin for overweight adult patients with type 1 diabetes...
  66. pmc Vitamin D, carotid intima-media thickness and bone structure in patients with type 2 diabetes
    Karoline Winckler
    Department of CardiologyNephrology and EndocrinologyDepartment of ResearchNordsjaellands Hospital, Nordsjællands University Hospital, Dyrehavevej 29, 3400 Hilleroed, DenmarkInstitute of Clinical StudiesUniversity of Aarhus, Aarhus, DenmarkClinical Research UnitSteno Diabetes Center, Gentofte, DenmarkDepartment of PaediatricsHvidovre Hospital, Copenhagen University Hospital, Hvidovre, DenmarkDepartment of MedicineCopenhagen University Hospital, Gentofte, DenmarkDepartment of Physiology and Nuclear MedicineFrederiksberg Hospital, Copenhagen University Hospital, Frederiksberg, DenmarkInstitute of Clinical MedicineUniversity of Copenhagen, Copenhagen, Denmark
    Endocr Connect 4:128-35. 2015
    ..To explore these associations and the association with other biomarkers further, multicentre studies with large numbers of patients are required. ..
  67. doi High osteoprotegerin is associated with development of foot ulcer in type 1 diabetes
    Emilie H Zobel
    Steno Diabetes Center, Gentofte, Denmark Electronic address
    J Diabetes Complications 30:1603-1608. 2016
    ..We investigated the association between osteoprotegerin and development of foot complications in persons with type 1 diabetes...
  68. doi IGFBP-4 Fragments as Markers of Cardiovascular Mortality in Type 1 Diabetes Patients With and Without Nephropathy
    Rikke Hjortebjerg
    Medical Research Laboratory R H, M B, J F, Department of Clinical Medicine, Faculty of Health, and Faculty of Health L T, H H P, P R, Aarhus University, and Departments of Heart Diseases A J and Endocrinology and Internal Medicine J F, Aarhus University Hospital, DK 8000 Aarhus, Denmark The Danish Diabetes Academy R H, DK 5000 Odense, Denmark Steno Diabetes Center L T, A J, P R, Gentofte, DK 2820 Copenhagen, Denmark Nordsjællands Hospital L T, DK 3400 Hillerød, Denmark Department of Medical Endocrinology H H P, Rigshospitalet, University of Copenhagen, DK 2100 Copenhagen, Denmark and The Novo Nordisk Foundation Center for Basic Metabolic Research P R, University of Copenhagen, DK 2300 Copenhagen, Denmark
    J Clin Endocrinol Metab 100:3032-40. 2015
    ..Pregnancy-associated plasma protein-A (PAPP-A) generated N- and C-terminal fragments of IGF binding protein-4 (NT-IGFBP-4 and CT-IGFBP-4) have been suggested as cardiac biomarkers...
  69. ncbi Renoprotective effects of losartan in diabetic nephropathy: interaction with ACE insertion/deletion genotype?
    Steen Andersen
    Steno Diabetes Center, Niels Steensensvej 2, 2820 Gentofte, Copenhagen, Denmark
    Kidney Int 62:192-8. 2002
    ..In an attempt to overcome this interaction, we evaluated the short-term renoprotective effect in diabetic nephropathy of the angiotensin II receptor antagonist losartan in patients homozygous for the insertion or the deletion allele...
  70. doi Prevalence of gastroparesis-related symptoms in an unselected cohort of patients with Type 1 diabetes
    Kristoffer Kofod-Andersen
    Steno Diabetes Center, Denmark
    J Diabetes Complications 26:89-93. 2012
    ..e. gastric emptying time, and symptoms experienced by patients. Furthermore most studies have been performed on small selected cohorts...
  71. ncbi Cardiovascular morbidity and early mortality cluster in parents of type 1 diabetic patients with diabetic nephropathy
    L Tarnow
    Steno Diabetes Center, Gentofte, Denmark
    Diabetes Care 23:30-3. 2000
    ..The aim of the present study was to evaluate these hypotheses in parents of a large group of type 1 diabetic patients with and without diabetic nephropathy...
  72. ncbi Association of aldose reductase gene Z+2 polymorphism with reduced susceptibility to diabetic nephropathy in Caucasian Type 1 diabetic patients
    M Lajer
    Steno Diabetes Centre, Gentofte, Denmark
    Diabet Med 21:867-73. 2004
    ..However data are conflicting. Therefore, we investigated whether this polymorphism is associated with diabetic nephropathy and retinopathy in Type 1 diabetes mellitus in a large case-control study and a family-based analysis...
  73. ncbi Aldosterone escape during blockade of the renin-angiotensin-aldosterone system in diabetic nephropathy is associated with enhanced decline in glomerular filtration rate
    K J Schjoedt
    Steno Diabetes Center, Niels Steensens Vej 2, 2820, Gentofte, Denmark
    Diabetologia 47:1936-9. 2004
    ..We evaluated the influence of plasma aldosterone levels on progression of diabetic nephropathy during long-term blockade of the renin-angiotensin-aldosterone system...
  74. ncbi Aldosterone synthase (CYP11B2) -344T/C polymorphism is not associated with the initiation and progression of diabetic nephropathy in Caucasian Type 1 diabetic patients
    M Lajer
    Steno Diabetes Center, Gentofte, Denmark
    Diabet Med 23:675-80. 2006
    ..Therefore, we investigated whether the -344T/C polymorphism is associated with the development and progression of diabetic nephropathy in Type 1 diabetes mellitus...
  75. ncbi Targeting hyperglycaemia with either metformin or repaglinide in non-obese patients with type 2 diabetes: results from a randomized crossover trial
    S S Lund
    Steno Diabetes Center, Gentofte, Denmark
    Diabetes Obes Metab 9:394-407. 2007
    ..In this investigator-initiated trial, we evaluated the effect of metformin vs. an insulin secretagogue, repaglinide on glycaemic regulation and markers of inflammation and insulin sensitivity in non-obese patients with T2DM...
  76. ncbi Pregnancy-associated plasma protein A in a large cohort of Type 1 diabetic patients with and without diabetic nephropathy-a prospective follow--up study
    A S Astrup
    Steno Diabetes Center, Gentofte, Denmark
    Diabet Med 24:1381-5. 2007
    ..Diabetic nephropathy is characterized by increased cardiovascular risk. We investigated the prognostic value of PAPP-A in a large cohort of Type 1 diabetic patients...
  77. doi Time course of the antiproteinuric and antihypertensive effects of direct renin inhibition in type 2 diabetes
    F Persson
    Steno Diabetes Center, Gentofte, Denmark
    Kidney Int 73:1419-25. 2008
    ..Our study shows that aliskiren reduced 24 h SBP, and this was associated with a reduction in albuminuria in type 2 diabetic patients...
  78. doi Long-term prevention of diabetic nephropathy: an audit
    K J Schjoedt
    Steno Diabetes Center, Niels Steensens Vej 1, 2820 Gentofte, Denmark
    Diabetologia 51:956-61. 2008
    ....
  79. doi The PPAR gamma 2 Pro12Ala variant predicts ESRD and mortality in patients with type 1 diabetes and diabetic nephropathy
    A Jorsal
    Steno Diabetes Center, Niels Steensens Vej 2, 2820 Gentofte, Denmark
    Mol Genet Metab 94:347-51. 2008
    ..4 years [mean+/-SD], duration of diabetes 28.3+/-8.8 years, GFR 66+/-8.8 ml/min) and 428 patients with longstanding type 1 diabetes and persistent normoalbuminuria (230 men; age 45.4+/-11.6 years, duration of diabetes 27.8+/-10.1 years)...
  80. doi Plasma osteoprotegerin levels predict cardiovascular and all-cause mortality and deterioration of kidney function in type 1 diabetic patients with nephropathy
    A Jorsal
    Steno Diabetes Center, Niels Steensens Vej 2, 2820, Gentofte, Denmark
    Diabetologia 51:2100-7. 2008
    ..The aim of this study was to investigate the predictive value of plasma levels of osteoprotegerin in relation to mortality, cardiovascular events and deterioration in kidney function in patients with type 1 diabetes...
  81. doi Optimal dose of lisinopril for renoprotection in type 1 diabetic patients with diabetic nephropathy: a randomised crossover trial
    K J Schjoedt
    Steno Diabetes Center, Gentofte, Denmark
    Diabetologia 52:46-9. 2009
    ....
  82. doi Study rationale and design of the CIMT trial: the Copenhagen Insulin and Metformin Therapy trial
    L Lundby Christensen
    Steno Diabetes Center, Gentofte, Denmark
    Diabetes Obes Metab 11:315-22. 2009
    ..0%, it is yet unknown whether a combination of metformin and insulin analogues is superior to insulin analogues alone. Nor is it known which insulin analogue regimen is the optimal...
  83. doi Effect of adjunct metformin treatment on levels of plasma lipids in patients with type 1 diabetes
    S S Lund
    Steno Diabetes Center, Niels Steensens Vej 2, 2820 Gentofte, Denmark
    Diabetes Obes Metab 11:966-77. 2009
    ..In this study, we report the effect of a 1-year treatment with metformin vs. placebo on plasma lipids in T1DM patients and persistent poor glycaemic control...
  84. doi Telomere length predicts all-cause mortality in patients with type 1 diabetes
    A S Astrup
    Steno Diabetes Center, Att Ingelise Holstein, 2820 Gentofte, Denmark
    Diabetologia 53:45-8. 2010
    ..We aimed to evaluate differences in telomere length in patients with type 1 diabetes with or without diabetic nephropathy; we also evaluated the prognostic value of telomere length...
  85. doi Neutrophil Gelatinase-Associated Lipocalin (NGAL) and Kidney Injury Molecule 1 (KIM1) in patients with diabetic nephropathy: a cross-sectional study and the effects of lisinopril
    S E Nielsen
    Steno Diabetes Center, Gentofte Hospital, Denmark
    Diabet Med 27:1144-50. 2010
    ..In addition, the effect of renoprotective treatment on urinary NGAL was evaluated in diabetic nephropathy...
  86. doi Carotid intima-media thickness is reduced 12 months after gastric bypass surgery in obese patients with type 2 diabetes or impaired glucose tolerance
    Louise Lundby-Christensen
    Steno Diabetes Center, Niels Steensens Vej 2, 2820 Gentofte, Denmark Department of Paediatrics, Copenhagen University Hospital Hvidovre, Kettegaard Alle 30, 2650 Hvidovre, Denmark Electronic address
    J Diabetes Complications 28:517-22. 2014
    ....
  87. pmc Carotid intima-media thickness in individuals with and without type 2 diabetes: a reproducibility study
    Louise Lundby-Christensen
    Steno Diabetes Center, Niels Steensens vej 2 4, 2820 Gentofte, Denmark
    Cardiovasc Diabetol 9:40. 2010
    ..The aim of this study was to quantify the variability of the measurement of carotid IMT in individuals with and without T2D...
  88. pmc Osteoprotegerin and mortality in type 2 diabetic patients
    Henrik Reinhard
    Steno Diabetes Center, Gentofte, Denmark
    Diabetes Care 33:2561-6. 2010
    ..We aimed to investigate the prognostic value of OPG in relation to all-cause and cardiovascular mortality in a cohort of type 2 diabetic patients...
  89. ncbi Diabetic microvascular complications are not associated with two polymorphisms in the GLUT-1 and PC-1 genes regulating glucose metabolism in Caucasian type 1 diabetic patients
    L Tarnow
    Steno Diabetes Center, Gentofte, Denmark
    Nephrol Dial Transplant 16:1653-6. 2001
    ....
  90. ncbi Birth weight--a risk factor for progression in diabetic nephropathy?
    P Jacobsen
    Steno Diabetes Center, Gentofte, Denmark
    J Intern Med 253:343-50. 2003
    ..Oligonephropathy has been linked to hypertension and renal disease in adult life. We tested the concept that low weight at birth acts as a risk factor for progression of diabetic nephropathy...
  91. ncbi Time to consider ACE insertion/deletion genotypes and individual renoprotective treatment in diabetic nephropathy?
    P K Jacobsen
    Steno Diabetes Center, Gentofte, Denmark
    Kidney Int 69:1293-5. 2006
    ..This Commentary summarizes the impact of the angiotensin-converting enzyme (ACE) insertion/deletion polymorphism in the ACE gene on initiation and progression of diabetic nephropathy...
  92. doi Soccer training improves cardiac function in men with type 2 diabetes
    Jakob Friis Schmidt
    1Copenhagen Centre for Team Sports and Health, Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark 2Department of Cardiology, Gentofte Hospital, Copenhagen, DENMARK 3Steno Diabetes Center, Copenhagen and Health, Aarhus University, Aarhus, Denmark 4Sport and Health Sciences, College of Life and Environmental Sciences, St Luke s Campus, University of Exeter, Devon, UNITED KINGDOM and 5Department of Cardiology, Herlev Hospital, Herlev, Denmark
    Med Sci Sports Exerc 45:2223-33. 2013
    ..Subclinical myocardial dysfunction is associated with increased risk of heart failure and impaired prognosis in T2DM; however, it is not clear if exercise training can counteract the early signs of diabetic heart disease...
  93. pmc Plasma proteome analysis of patients with type 1 diabetes with diabetic nephropathy
    Anne Julie Overgaard
    Department of Genome Biology, Hagedorn Research Institute, Gentofte, Denmark
    Proteome Sci 8:4. 2010
    ....
  94. doi Experimental testing of skin reactions to insulin detemir in diabetes patients naïve to insulin detemir
    Kenichiro O'goshi
    Department of Dermatology, Bispebjerg Hospital, Copenhagen, Denmark
    Skin Res Technol 17:411-9. 2011
    ..The purpose of this experimental study using a provocative design was to elucidate the potential mechanisms behind such skin reactions...
  95. ncbi Diabetic nephropathy. Pathogenetic aspects and cardiovascular risk factors
    Lise Tarnow
    Steno Diabetes Center, Gentofte
    Dan Med Bull 49:19-42. 2002
  96. ncbi Left ventricular hypertrophy in normoalbuminuric type 2 diabetic patients not taking antihypertensive treatment
    A Sato
    Steno Diabetes Center, Gentofte, Denmark
    QJM 98:879-84. 2005
    ..Left ventricular hypertrophy (LVH) is an independent risk factor for myocardial ischaemia, cardiac arrhythmia, sudden death, and heart failure, all common findings in patients with type 2 diabetes...
  97. ncbi Association between mannose-binding lectin and vascular complications in type 1 diabetes
    Troels K Hansen
    Immunoendocrine Research Unit, Medical Department M Endocrinology and Diabetes, Aarhus University Hospital, Norrebrogade 42 44, DK 8000 Aarhus C, Denmark
    Diabetes 53:1570-6. 2004
    ....
  98. ncbi Impact of polymorphisms in the genes encoding xylosyltransferase I and a homologue in type 1 diabetic patients with and without nephropathy
    Sylvia Schön
    Institut fur Laboratoriums und Transfusionsmedizin, Herz und Diabeteszentrum Nordrhein Westfalen, Universitatsklinik der Ruhr Universitat Bochum, Bad Oeynhausen, Germany
    Kidney Int 68:1483-90. 2005
    ....
  99. ncbi Urinary connective tissue growth factor excretion correlates with clinical markers of renal disease in a large population of type 1 diabetic patients with diabetic nephropathy
    Tri Q Nguyen
    Department of Pathology, University Medical Center Utrecht, H04 312, Heidelberglaan 100, 3584 CX, Utrecht, Netherlands
    Diabetes Care 29:83-8. 2006
    ..However, these studies addressed too small a number of patients to allow general conclusions to be drawn. Therefore, we evaluated U-CTGF in a large cross-sectional study of patients with type 1 diabetes...
  100. ncbi Plasma osteoprotegerin levels are associated with glycaemic status, systolic blood pressure, kidney function and cardiovascular morbidity in type 1 diabetic patients
    Lars Melholt Rasmussen
    Department of Clinical Biochemistry, University Hospital of Aarhus, Aarhus Amtssygehus, T Hansengade 2, DK 8000 Aarhus C, Denmark
    Eur J Endocrinol 154:75-81. 2006
    ..OPG is present in the circulation, where increased amounts have been observed in patients with diabetes. In this study, we examined whether plasma OPG is associated with the glycaemic and vascular status of patients with type 1 diabetes...
  101. ncbi The xylosyltransferase I gene polymorphism c.343G>T (p.A125S) is a risk factor for diabetic nephropathy in type 1 diabetes
    Sylvia Schön
    Institut fur Laboratoriums und Transfusionsmedizin, Herz und Diabeteszentrum Nordrhein Westfalen, 32545 Bad Oeynhausen, Germany
    Diabetes Care 29:2295-9. 2006
    ..Thus, genetic variations in the xylosyltransferase genes might be implicated in the initiation and progression of these complications...