Jakob Ek

Summary

Affiliation: Steno Diabetes Center
Country: Denmark

Publications

  1. ncbi request reprint The functional Thr130Ile and Val255Met polymorphisms of the hepatocyte nuclear factor-4alpha (HNF4A): gene associations with type 2 diabetes or altered beta-cell function among Danes
    Jakob Ek
    Steno Diabetes Center and Hagedorn Research Institute, Niels Steensens Vej 6, NSK1 14, DK 2820 Gentofte, Denmark
    J Clin Endocrinol Metab 90:3054-9. 2005
  2. ncbi request reprint A -30G>A polymorphism of the beta-cell-specific glucokinase promoter associates with hyperglycemia in the general population of whites
    Christian S Rose
    Steno Diabetes Center, DK 2820 Gentofte, Denmark
    Diabetes 54:3026-31. 2005
  3. ncbi request reprint A novel -192c/g mutation in the proximal P2 promoter of the hepatocyte nuclear factor-4 alpha gene (HNF4A) associates with late-onset diabetes
    Jakob Ek
    Steno Diabetes Center and Hagedorn Research Institute, Gentofte, Denmark
    Diabetes 55:1869-73. 2006
  4. ncbi request reprint PGC-1alpha Gly482Ser polymorphism associates with hypertension among Danish whites
    Gitte Andersen
    Steno Diabetes Center, Niels Steensens Vej 2, NSH2 16, DK 2820 Gentofte, Denmark
    Hypertension 45:565-70. 2005
  5. ncbi request reprint Analysis of separate and combined effects of common variation in KCNJ11 and PPARG on risk of type 2 diabetes
    Sara K Hansen
    Steno Diabetes Center and Hagedorn Research Institute, Niels Steensens Vej 2, DK 2820 Gentofte, Denmark
    J Clin Endocrinol Metab 90:3629-37. 2005
  6. pmc Genetic evidence that HNF-1alpha-dependent transcriptional control of HNF-4alpha is essential for human pancreatic beta cell function
    Sara K Hansen
    Steno Diabetes Center and Hagedorn Research Institute, Gentofte, Denmark
    J Clin Invest 110:827-33. 2002
  7. pmc Variation in NCB5OR: studies of relationships to type 2 diabetes, maturity-onset diabetes of the young, and gestational diabetes mellitus
    Gitte Andersen
    Steno Diabetes Center and Hagedorn Research Institute, Niels Steensens Vej 2, NSH2 16, DK 2820 Gentofte, Denmark
    Diabetes 53:2992-7. 2004
  8. ncbi request reprint Maturity-onset diabetes of the young with end-stage nephropathy: a new indication for simultaneous pancreas and kidney transplantation?
    Frantisek Saudek
    Diabetes Center, Institute for Clinical and Experimental Medicine, Praha, Czech Republic
    Transplantation 77:1298-301. 2004
  9. ncbi request reprint Novel variants in the putative peroxisome proliferator-activated receptor {gamma} promoter and relationships with obesity in men
    Thomas M Larsen
    Department of Human Nutrition, LMC Royal Veterinary and Agricultural University, Rolighedsvej 30, 1958 Frederiksberg C, Denmark
    Obes Res 13:953-8. 2005

Collaborators

Detail Information

Publications9

  1. ncbi request reprint The functional Thr130Ile and Val255Met polymorphisms of the hepatocyte nuclear factor-4alpha (HNF4A): gene associations with type 2 diabetes or altered beta-cell function among Danes
    Jakob Ek
    Steno Diabetes Center and Hagedorn Research Institute, Niels Steensens Vej 6, NSK1 14, DK 2820 Gentofte, Denmark
    J Clin Endocrinol Metab 90:3054-9. 2005
    ....
  2. ncbi request reprint A -30G>A polymorphism of the beta-cell-specific glucokinase promoter associates with hyperglycemia in the general population of whites
    Christian S Rose
    Steno Diabetes Center, DK 2820 Gentofte, Denmark
    Diabetes 54:3026-31. 2005
    ..24]). In conclusion, the GCK -30G>A polymorphism associates with elevated fasting and post-OGTT glycemia in the middle-aged general population of whites, as well as with IGR and other features of the WHO-defined metabolic syndrome...
  3. ncbi request reprint A novel -192c/g mutation in the proximal P2 promoter of the hepatocyte nuclear factor-4 alpha gene (HNF4A) associates with late-onset diabetes
    Jakob Ek
    Steno Diabetes Center and Hagedorn Research Institute, Gentofte, Denmark
    Diabetes 55:1869-73. 2006
    ..In conclusion, a rare, novel mutation that disrupts a protein binding site in the pancreatic HNF4A promoter associates with late-onset diabetes...
  4. ncbi request reprint PGC-1alpha Gly482Ser polymorphism associates with hypertension among Danish whites
    Gitte Andersen
    Steno Diabetes Center, Niels Steensens Vej 2, NSH2 16, DK 2820 Gentofte, Denmark
    Hypertension 45:565-70. 2005
    ..001). In conclusion, the Ser allele of PGC-1alpha Gly482Ser confers a significantly reduced risk of hypertension in whites. Further studies are needed to elucidate the differential role of this polymorphism in men and women...
  5. ncbi request reprint Analysis of separate and combined effects of common variation in KCNJ11 and PPARG on risk of type 2 diabetes
    Sara K Hansen
    Steno Diabetes Center and Hagedorn Research Institute, Niels Steensens Vej 2, DK 2820 Gentofte, Denmark
    J Clin Endocrinol Metab 90:3629-37. 2005
    ..In conclusion, our results showed no evidence of a synergistic interaction between the KCNJ11 Glu(23)Lys and PPARG Pro(12)Ala polymorphisms, but indicated that they may act in an additive manner to increase the risk of type 2 diabetes...
  6. pmc Genetic evidence that HNF-1alpha-dependent transcriptional control of HNF-4alpha is essential for human pancreatic beta cell function
    Sara K Hansen
    Steno Diabetes Center and Hagedorn Research Institute, Gentofte, Denmark
    J Clin Invest 110:827-33. 2002
    ..Furthermore, they indicate that this regulation is essential to maintain normal pancreatic function...
  7. pmc Variation in NCB5OR: studies of relationships to type 2 diabetes, maturity-onset diabetes of the young, and gestational diabetes mellitus
    Gitte Andersen
    Steno Diabetes Center and Hagedorn Research Institute, Niels Steensens Vej 2, NSH2 16, DK 2820 Gentofte, Denmark
    Diabetes 53:2992-7. 2004
    ..Thus, variation in the coding region of NCB5OR is not a major contributor in the pathogenesis of nonautoimmune diabetes...
  8. ncbi request reprint Maturity-onset diabetes of the young with end-stage nephropathy: a new indication for simultaneous pancreas and kidney transplantation?
    Frantisek Saudek
    Diabetes Center, Institute for Clinical and Experimental Medicine, Praha, Czech Republic
    Transplantation 77:1298-301. 2004
    ..A hyperglycemic clamp test showed a normal beta-cell function. CONCLUSION: Identification of MODY3 among all C-peptide-positive patients with advanced diabetic nephropathy might help to select a specific group profiting from SPK...
  9. ncbi request reprint Novel variants in the putative peroxisome proliferator-activated receptor {gamma} promoter and relationships with obesity in men
    Thomas M Larsen
    Department of Human Nutrition, LMC Royal Veterinary and Agricultural University, Rolighedsvej 30, 1958 Frederiksberg C, Denmark
    Obes Res 13:953-8. 2005
    ..In conclusion, the identified novel variants in the PPARgamma2 promoter region do not explain the reported discrepancies in the association of previously identified variants with obesity and type 2 diabetes...