Niels H Secher

Summary

Country: Denmark

Publications

  1. pmc Central command and the onset of exercise
    Niels H Secher
    Department of Anaesthesia, The Copenhagen Muscle Research Centre, Rigshospitalet, University of Copenhagen, Denmark
    J Physiol 578:375-6. 2007
  2. ncbi request reprint [Patients with kidney disease]
    Niels H Secher
    H S Rigshospitalet, Abdominalcenteret, Anaestersiologisk og Nefrologisk Klinik, København Ø
    Ugeskr Laeger 168:4309-11. 2006
  3. ncbi request reprint [The muscles work, but the brain gets tired]
    Niels H Secher
    H S Rigshospitalet, Abdominalcenteret, Anaestesiologisk Klinik, København Ø
    Ugeskr Laeger 168:4503-6. 2006
  4. doi request reprint Glycopyrrolate abolishes the exercise-induced increase in cerebral perfusion in humans
    Thomas Seifert
    Department of Anaesthesia, The Copenhagen Muscle Research Centre, University of Copenhagen, Copenhagen Ø, Denmark
    Exp Physiol 95:1016-25. 2010
  5. doi request reprint Thigh oxygen uptake at the onset of intense exercise is not affected by a reduction in oxygen delivery caused by hypoxia
    Peter M Christensen
    Department of Exercise and Sport Sciences, University of Copenhagen, Denmark
    Am J Physiol Regul Integr Comp Physiol 303:R843-9. 2012
  6. ncbi request reprint Capillary-oxygenation-level-dependent near-infrared spectrometry in frontal lobe of humans
    Peter Rasmussen
    Copenhagen Muscle Research Centre, Department of Anaesthesia, University of Copenhagen, Rigshospitalet, Copenhagen, Denmark
    J Cereb Blood Flow Metab 27:1082-93. 2007
  7. doi request reprint Coupling between the blood lactate-to-pyruvate ratio and MCA Vmean at the onset of exercise in humans
    Peter Rasmussen
    1Department of Anesthesia, Copenhagen Muscle Research Center, Rigshospitalet, Copenhagen, Denmark
    J Appl Physiol (1985) 107:1799-805. 2009
  8. doi request reprint Leg oxygen uptake in the initial phase of intense exercise is slowed by a marked reduction in oxygen delivery
    Peter M Christensen
    Department of Nutrition, Exercise and Sports, Section of Integrated Physiology, University of Copenhagen, Copenhagen, Denmark
    Am J Physiol Regul Integr Comp Physiol 305:R313-21. 2013
  9. ncbi request reprint Cutaneous vasoconstriction affects near-infrared spectroscopy determined cerebral oxygen saturation during administration of norepinephrine
    Henrik Sørensen
    Department of Anesthesia, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Anesthesiology 117:263-70. 2012
  10. pmc Glucose ingestion attenuates interleukin-6 release from contracting skeletal muscle in humans
    Mark A Febbraio
    Copenhagen Muscle Research Centre, Department of Infectious Diseases, University of Copenhagen, DK 2100, Copenhagen Ø, Denmark
    J Physiol 549:607-12. 2003

Detail Information

Publications110 found, 100 shown here

  1. pmc Central command and the onset of exercise
    Niels H Secher
    Department of Anaesthesia, The Copenhagen Muscle Research Centre, Rigshospitalet, University of Copenhagen, Denmark
    J Physiol 578:375-6. 2007
  2. ncbi request reprint [Patients with kidney disease]
    Niels H Secher
    H S Rigshospitalet, Abdominalcenteret, Anaestersiologisk og Nefrologisk Klinik, København Ø
    Ugeskr Laeger 168:4309-11. 2006
    ..Surgical procedures for the kidney patient are dominated by providing an i.v. access. The internal jugular vein is preferred after identification of its lumen by ultrasound...
  3. ncbi request reprint [The muscles work, but the brain gets tired]
    Niels H Secher
    H S Rigshospitalet, Abdominalcenteret, Anaestesiologisk Klinik, København Ø
    Ugeskr Laeger 168:4503-6. 2006
    ..This imbalance between oxygen and glucose plus lactate uptake remains unsolved, but glycogen and accumulation of intermediates of metabolism are likely to play a key role...
  4. doi request reprint Glycopyrrolate abolishes the exercise-induced increase in cerebral perfusion in humans
    Thomas Seifert
    Department of Anaesthesia, The Copenhagen Muscle Research Centre, University of Copenhagen, Copenhagen Ø, Denmark
    Exp Physiol 95:1016-25. 2010
    ..05). Thus, during both cycling and static handgrip, a cholinergic receptor mechanism is important for the exercise-induced increase in cerebral perfusion without affecting the cerebral metabolic rate for oxygen...
  5. doi request reprint Thigh oxygen uptake at the onset of intense exercise is not affected by a reduction in oxygen delivery caused by hypoxia
    Peter M Christensen
    Department of Exercise and Sport Sciences, University of Copenhagen, Denmark
    Am J Physiol Regul Integr Comp Physiol 303:R843-9. 2012
    ..35 ± 0.07 and 0.36 ± 0.07 mmol·kg dry wt(-1)·s(-1) in NOR and HYP). Thus the increase in thigh Vo2 was not attenuated at the onset of intense knee-extensor exercise despite a reduction in oxygen delivery and pressure...
  6. ncbi request reprint Capillary-oxygenation-level-dependent near-infrared spectrometry in frontal lobe of humans
    Peter Rasmussen
    Copenhagen Muscle Research Centre, Department of Anaesthesia, University of Copenhagen, Rigshospitalet, Copenhagen, Denmark
    J Cereb Blood Flow Metab 27:1082-93. 2007
    ....
  7. doi request reprint Coupling between the blood lactate-to-pyruvate ratio and MCA Vmean at the onset of exercise in humans
    Peter Rasmussen
    1Department of Anesthesia, Copenhagen Muscle Research Center, Rigshospitalet, Copenhagen, Denmark
    J Appl Physiol (1985) 107:1799-805. 2009
    ..These findings support brain tissue redox state and oxygenation as potential modulators of an increase in cerebral blood flow at the onset of exercise...
  8. doi request reprint Leg oxygen uptake in the initial phase of intense exercise is slowed by a marked reduction in oxygen delivery
    Peter M Christensen
    Department of Nutrition, Exercise and Sports, Section of Integrated Physiology, University of Copenhagen, Copenhagen, Denmark
    Am J Physiol Regul Integr Comp Physiol 305:R313-21. 2013
    ..This is in contrast to previous observations during moderate-intensity exercise using the same DB procedure, which suggests that fast-twitch muscle fibers are more sensitive to a reduction in oxygen delivery than slow-twitch fibers. ..
  9. ncbi request reprint Cutaneous vasoconstriction affects near-infrared spectroscopy determined cerebral oxygen saturation during administration of norepinephrine
    Henrik Sørensen
    Department of Anesthesia, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Anesthesiology 117:263-70. 2012
    ..We hypothesized that norepinephrine-induced reduction in scO2 is influenced by cutaneous vasoconstriction...
  10. pmc Glucose ingestion attenuates interleukin-6 release from contracting skeletal muscle in humans
    Mark A Febbraio
    Copenhagen Muscle Research Centre, Department of Infectious Diseases, University of Copenhagen, DK 2100, Copenhagen Ø, Denmark
    J Physiol 549:607-12. 2003
    ..05) glucose uptake and a reduced (P < 0.05) FFA uptake in GLU. These results demonstrate that glucose ingestion during exercise attenuates leg IL-6 release but does not decrease intramuscular expression of IL-6 mRNA...
  11. doi request reprint Skeletal muscle signaling and the heart rate and blood pressure response to exercise: insight from heart rate pacing during exercise with a trained and a deconditioned muscle group
    Stefan P Mortensen
    Centre of Inflammation and Metabolism, Rigshospitalet, Copenhagen, Denmark
    Hypertension 61:1126-33. 2013
    ..These results demonstrate that skeletal muscle training reduces the cardioventilatory response to exercise without compromising O2 delivery, and it can therefore be used to reduce the load on the heart during physical activity...
  12. doi request reprint Hypoxia and exercise provoke both lactate release and lactate oxidation by the human brain
    Morten Overgaard
    Department of Anesthesia, The Copenhagen Muscle Research Center, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    FASEB J 26:3012-20. 2012
    ..These results support the existence of a cell-cell lactate shuttle that may involve neurons and astrocytes...
  13. pmc Limitations to systemic and locomotor limb muscle oxygen delivery and uptake during maximal exercise in humans
    Stefan P Mortensen
    The Copenhagen Muscle Research Centre, Rigshospitalet, University of Copenhagan, Section 7652, Blegdamsvej 9, DK 2100 Copenhagen Ø, Denmark
    J Physiol 566:273-85. 2005
    ..The similar impairment in SV and O2 delivery during incremental and constant load cycling provides evidence for a central limitation to aerobic power and capacity in humans...
  14. ncbi request reprint Frontal lobe oxygenation is maintained during hypotension following propofol-fentanyl anesthesia
    Peter Nissen
    Department of Anesthesia, Rigshospitalet, University of Copenhagen, Denmark
    AANA J 77:271-6. 2009
    ..The findings implicate that even an approximately 30% drop in MAP at the induction of anesthesia does not typically affect cerebral oxygenation...
  15. doi request reprint Phenylephrine but not ephedrine reduces frontal lobe oxygenation following anesthesia-induced hypotension
    Peter Nissen
    Department of Anesthesia, Rigshospitalet 2041, University of Copenhagen, Blegdamsvej 9, 2100, Copenhagen Ø, Denmark
    Neurocrit Care 12:17-23. 2010
    ..Vasopressor agents are used to correct anesthesia-induced hypotension. We describe the effect of phenylephrine and ephedrine on frontal lobe oxygenation (S(c)O(2)) following anesthesia-induced hypotension...
  16. doi request reprint Interindividual variation in platelets and the cardiovascular response to haemorrhage in the pig
    Morten Zaar
    Department of Anaesthesia, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Blood Coagul Fibrinolysis 22:92-7. 2011
    ..These results support that platelets exert functions during bleeding beyond their importance for clot formation...
  17. ncbi request reprint [Anaesthesia in connection with liver transplantation]
    Niels H Secher
    Rigshospitalet, Anaestesiologisk Klinik, København Ø
    Ugeskr Laeger 170:1335-8. 2008
    ..Treatment quality is expressed as a maintained central blood volume evaluated by transthoratic electrical impedance and a stable cerebral oxygenation (71% (67-82%)) as determined by near-infrared spectroscopy...
  18. doi request reprint Endurance training enhances BDNF release from the human brain
    Thomas Seifert
    Department of Anesthesia, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen Ø, Denmark
    Am J Physiol Regul Integr Comp Physiol 298:R372-7. 2010
    ..4.6 + or - 1.4 mRNA/ssDNA) compared with untrained mice. The increased BDNF expression in the hippocampus and the enhanced release of BDNF from the human brain following training suggest that endurance training promotes brain health...
  19. doi request reprint Hydroxyethyl starch reduces coagulation competence and increases blood loss during major surgery: results from a randomized controlled trial
    Kirsten C Rasmussen
    Department of Anesthesiology, The Abdominal Centre Section for Transfusion Medicine Department of Urology and Center of Head and Ortopaedic Surgery, Rigshospitalet, University of Copenhagen, Denmark
    Ann Surg 259:249-54. 2014
    ..This study evaluated whether administration of hydroxyethyl starch (HES) 130/0.4 affects coagulation competence and influences the perioperative blood loss...
  20. ncbi request reprint MCA Vmean and the arterial lactate-to-pyruvate ratio correlate during rhythmic handgrip
    Peter Rasmussen
    Deapartment of Anesthesia, Copenhagen Muscle Center, University of Copenhagen, Denmark
    J Appl Physiol (1985) 101:1406-11. 2006
    ..These results support that the arterial plasma L/P ratio modulates cerebral blood flow during cerebral activation independently from the plasma glucose concentration...
  21. ncbi request reprint Are the arms and legs in competition for cardiac output?
    Niels H Secher
    The Copenhagen Muscle Research Center, Department of Anesthesia, Rigshospitalet, University of Copenhagen, Denmark
    Med Sci Sports Exerc 38:1797-803. 2006
    ....
  22. doi request reprint Partial neuromuscular blockade in humans enhances muscle blood flow during exercise independently of muscle oxygen uptake and acetylcholine receptor blockade
    Ylva Hellsten
    Department of Exercise and Sport Sciences, University of Copenhagen, Universitetsparken 13, DK 2100 Copenhagen Ø, Denmark
    Am J Physiol Regul Integr Comp Physiol 296:R1106-12. 2009
    ..The enhanced exercise hyperemia during partial neuromuscular blockade may be related to a greater recruitment of fast-twitch muscle fibers...
  23. doi request reprint Near-infrared spectroscopy for evaluation of cerebral autoregulation during orthotopic liver transplantation
    Peter Nissen
    Department of Anesthesia, Rigshospitalet 2041, University of Copenhagen, Blegdamsvej 9, 2100 Copenhagen Ø, Denmark
    Neurocrit Care 11:235-41. 2009
    ..The present study evaluated whether frontal lobe cerebral oxygenation (S(c)O(2)), as assessed by near-infrared spectroscopy (NIRS), can detect cerebral autoregulation in patients undergoing orthotopic liver transplantation...
  24. doi request reprint Phenylephrine decreases frontal lobe oxygenation at rest but not during moderately intense exercise
    Patrice Brassard
    Department of Anesthesia, The Copenhagen Muscle Research Center, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    J Appl Physiol (1985) 108:1472-8. 2010
    ..05) and CMRO2 increased 17% (P<0.05). These results suggest that the administration of phenylephrine reduced ScO2 but that the increased cerebral metabolism needed for moderately intense exercise eliminated that effect...
  25. pmc Plasma pro-atrial natriuretic peptide to indicate fluid balance during cystectomy: a prospective observational study
    Kirsten C Rasmussen
    Departments of Anaesthesiology, Rigshospitalet, Copenhagen, Denmark
    BMJ Open 6:e010323. 2016
    ..During surgery the volume of administered fluid is debated. Pro-atrial natriuretic peptide (proANP) is released by atrial distension, and we evaluated the relationship between changes in proANP associated with perioperative fluid balance...
  26. pmc Restrictions in systemic and locomotor skeletal muscle perfusion, oxygen supply and VO2 during high-intensity whole-body exercise in humans
    Stefan P Mortensen
    The Copenhagen Muscle Research Centre, Rigshospitalet, University of Copenhagen, Denmark
    J Physiol 586:2621-35. 2008
    ....
  27. ncbi request reprint Cerebral metabolism is influenced by muscle ischaemia during exercise in humans
    Mads K Dalsgaard
    Department of Anaesthesia and The Copenhagen Muscle Research Centre, Rigshospitalet, University of Copenhagen, Denmark
    Exp Physiol 88:297-302. 2003
    ..5 +/- 0.3 (P < 0.05). The results support the hypothesis that during exercise, cerebral metabolism is influenced both by the mental effort to exercise and by sensory input from skeletal muscles...
  28. pmc Brain and central haemodynamics and oxygenation during maximal exercise in humans
    Jose Gonzalez-Alonso
    The Copenhagen Muscle Research Centre, Department of Anaesthesia, Rigshospitalet, University of Copenhagen, Denmark
    J Physiol 557:331-42. 2004
    ..Furthermore, fatigue during maximal exercise, with or without heat stress, in healthy humans is associated with an enhanced rather than impaired brain uptake of O(2) and substrates...
  29. ncbi request reprint Cerebral metabolism during upper and lower body exercise
    Mads K Dalsgaard
    Department of Anesthesia, The Copenhagen Muscle Research Center, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    J Appl Physiol (1985) 97:1733-9. 2004
    ..However, the comparatively small reduction in the cerebral metabolic ratio during arm cranking suggests that it is influenced by the exercise paradigm...
  30. doi request reprint Techniques of cardiac output measurement during liver transplantation: arterial pulse wave versus thermodilution
    Peter Nissen
    Department of Anesthesia Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Denmark
    Liver Transpl 15:287-91. 2009
    ..Thus, for CO, this less invasive method appears to provide a reliable uninterrupted measurement during orthotopic liver transplantation...
  31. pmc Brain nonoxidative carbohydrate consumption is not explained by export of an unknown carbon source: evaluation of the arterial and jugular venous metabolome
    Peter Rasmussen
    Department of Anaesthesia, University of Copenhagen, Copenhagen, Denmark
    J Cereb Blood Flow Metab 30:1240-6. 2010
    ..We conclude that during exercise, the surplus carbohydrate uptake by the brain cannot be accounted for by changes in the NMR-derived plasma metabolome across the brain...
  32. doi request reprint Normovolemia defined according to cardiac stroke volume in healthy supine humans
    Morten Bundgaard-Nielsen
    Department of Anesthesiology, Rigshospitalet, University of Copenhagen, Denmark
    Clin Physiol Funct Imaging 30:318-22. 2010
    ..However, it is unknown whether stroke volume (SV) responds to an increase in preload induced by fluid administration...
  33. doi request reprint Central and peripheral blood flow during exercise with a continuous-flow left ventricular assist device: constant versus increasing pump speed: a pilot study
    Patrice Brassard
    Department of Anesthesia, The Heart Centre, Rigshospitalet, University of Copenhagen, Denmark
    Circ Heart Fail 4:554-60. 2011
    ....
  34. doi request reprint Nitrite and S-Nitrosohemoglobin Exchange Across the Human Cerebral and Femoral Circulation: Relationship to Basal and Exercise Blood Flow Responses to Hypoxia
    Damian M Bailey
    From Faculty of Medicine, Reichwald Health Sciences Centre, University of British Columbia Okanagan, Kelowna, BC, Canada D M B Neurovascular Research Laboratory, Faculty of Life Sciences and Education, University of South Wales, Glamorgan, UK K A E Department of Anesthesia, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark P R, M D, A M B, T S, P B, M Z, H B N, N H S Université Laval, Quebec, QC, Canada P B and Department of Integrative Physiology and Anatomy, University of North Texas, Health Science Center, Ft Worth P B R
    Circulation 135:166-176. 2017
    ....
  35. doi request reprint Endotoxemia reduces cerebral perfusion but enhances dynamic cerebrovascular autoregulation at reduced arterial carbon dioxide tension
    Patrice Brassard
    Department of Anesthesia, The Copenhagen Muscle Research Center, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Crit Care Med 40:1873-8. 2012
    ..We considered that a reduction in arterial carbon dioxide tension would attenuate cerebral perfusion and improve dynamic cerebral autoregulation in healthy subjects exposed to endotoxemia...
  36. doi request reprint Sympathetic influence on cerebral blood flow and metabolism during exercise in humans
    Thomas Seifert
    Department of Anaesthesia and The Copenhagen Muscle Research Centre, Rigshospitalet 2041, University of Copenhagen, Blegdamsvej 9, DK 2100 Copenhagen Ø, Denmark
    Prog Neurobiol 95:406-26. 2011
    ..This is possibly related to an attenuated catecholamine response. Finally, exercise promotes brain health as evidenced by increased release of brain-derived neurotrophic factor (BDNF) from the brain...
  37. ncbi request reprint Maintained cerebral and skeletal muscle oxygenation during maximal exercise in patients with liver cirrhosis
    Henning Bay Nielsen
    Department of Hepatology, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, 2100 København O, Denmark
    J Hepatol 43:266-71. 2005
    ..In cirrhotic patients, insufficient redistribution of blood from splanchnic organs to the central circulation could limit blood supply to skeletal muscles and the brain during exercise...
  38. pmc Brain glucose and lactate uptake during exhaustive exercise
    Niels H Secher
    The Copenhagen Muscle Research Centre, Department of Anaesthesia, Rigshospitalet, and Department of Biochemistry and Genetics, The Panum Institute, University of Copenhagen, Denmark
    J Physiol 568:3. 2005
  39. ncbi request reprint Normovolaemia defined by central blood volume and venous oxygen saturation
    Niels H Secher
    Copenhagen Muscle Research Centre, Department of Anaesthesia, Rigshospitalet, University of Copenhagen, Denmark
    Clin Exp Pharmacol Physiol 32:901-10. 2005
    ..It is suggested that, in supine humans and guided by Svo2, normovolaemia may be established to an accuracy of approximately 100 mL and that its adequacy is controlled by recording cerebral oxygenation...
  40. pmc Cerebral non-oxidative carbohydrate consumption in humans driven by adrenaline
    Thomas S Seifert
    Department of Anaesthesia, The Copenhagen Muscle Research Centre, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Denmark
    J Physiol 587:285-93. 2009
    ..05). These results support that non-oxidative carbohydrate consumption for the brain is driven by a beta(2)-adrenergic mechanism, giving neurons an abundant provision of energy when plasma adrenaline increases...
  41. doi request reprint Facial immersion in cold water enhances cerebral blood velocity during breath-hold exercise in humans
    Thomas Kjeld
    Department of Aneasthesiology, Rigshospitalet, Blegdamsvej 9, University of Copenhagen, Copenhagen, Denmark
    J Appl Physiol (1985) 106:1243-8. 2009
    ....
  42. doi request reprint Extra-cerebral oxygenation influence on near-infrared-spectroscopy-determined frontal lobe oxygenation in healthy volunteers: a comparison between INVOS-4100 and NIRO-200NX
    Henrik Sørensen
    Department of Anaesthesia, The Copenhagen Muscle Research Centre, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark Zurich Centre for Integrative Human Physiology, University of Zurich, Zurich, Switzerland
    Clin Physiol Funct Imaging 35:177-84. 2015
    ..We aimed to quantify the impact of extra-cerebral oxygenation on two SR-NIRS derived Sc O2 ...
  43. ncbi request reprint Understanding central fatigue: where to go?
    Peter Rasmussen
    Copenhagen Muscle Research Centre, Department of Anaesthesia, Rigshospitalet, AN2041, Blegdamsvej 9, DK2100 Copenhagen, Denmark
    Exp Physiol 92:369-70. 2007
  44. doi request reprint Blood lactate is an important energy source for the human brain
    Gerrit van Hall
    Copenhagen Muscle Research Centre, University of Copenhagen, Copenhagen, Denmark
    J Cereb Blood Flow Metab 29:1121-9. 2009
    ..In conclusion, systemic lactate is taken up and oxidized by the human brain and is an important substrate for the brain both under basal and hyperlactatemic conditions...
  45. doi request reprint Maintained cerebral metabolic ratio during exercise in patients with beta-adrenergic blockade
    Christiane M B Gam
    Department of Anaesthesia, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Clin Physiol Funct Imaging 29:420-6. 2009
    ..We evaluated to what extent cirrhotic patients in oral treatment with propranolol are able to mobilize brain non-oxidative carbohydrate metabolism...
  46. doi request reprint Reduced gluconeogenesis and lactate clearance in Huntington's disease
    Knud Josefsen
    The Bartholin Institute, Rigshospitalet, Copenhagen, Denmark
    Neurobiol Dis 40:656-62. 2010
    ..We propose that blood glucose concentration in the recovery from exercise can be applied as a liver function test in HD patients...
  47. pmc Coagulation competence for predicting perioperative hemorrhage in patients treated with lactated Ringer's vs. Dextran--a randomized controlled trial
    Kirsten C Rasmussen
    Departments of Anesthesiology, Transfusion Medicine, University of Copenhagen, Copenhagen, Denmark
    BMC Anesthesiol 15:178. 2015
    ..Perioperative hemorrhage may depend on coagulation competence and this study evaluated the influence of coagulation competence on blood loss during cystectomy due to bladder cancer...
  48. pmc Interleukin-6 release from the human brain during prolonged exercise
    Lars Nybo
    Department of Human Physiology, Institute of Exercise and Sport Sciences, University of Copenhagen, Denmark
    J Physiol 542:991-5. 2002
    ..In conclusion, IL-6 is released from the brain during prolonged exercise in humans and it appears that the duration of the exercise rather than the increase in body temperature dictates the cerebral IL-6 response...
  49. ncbi request reprint Bicarbonate attenuates arterial desaturation during maximal exercise in humans
    Henning B Nielsen
    The Copenhagen Muscle Research Center, Department of Anesthesia, Rigshospitalet, DK 2100 Copenhagen, Denmark
    J Appl Physiol (1985) 93:724-31. 2002
    ..The enlarged blood-buffering capacity after infusion of Bic attenuated acidosis and in turn arterial desaturation during maximal exercise...
  50. pmc Inadequate heat release from the human brain during prolonged exercise with hyperthermia
    Lars Nybo
    Department of Human Physiology, Institute of Exercise and Sport Sciences, University of Copenhagen, Denmark
    J Physiol 545:697-704. 2002
    ..20 +/- 0.06 J g(-1) min(-1). The present results indicate that the average brain temperature is at least 0.2 degrees C higher than that of the body core during exercise with or without hyperthermia...
  51. ncbi request reprint Middle cerebral artery blood velocity during intense static exercise is dominated by a Valsalva maneuver
    Frank Pott
    The Copenhagen Muscle Research Center and Department of Anesthesia, Rigshospitalet, University of Copenhagen, DK 2100 Copenhagen, Denmark
    J Appl Physiol (1985) 94:1335-44. 2003
    ..On the other hand, blackout during and after intense static exercise may reflect a reduction in cerebral blood flow due to expiratory straining and/or hyperventilation...
  52. pmc A reduced cerebral metabolic ratio in exercise reflects metabolism and not accumulation of lactate within the human brain
    Mads K Dalsgaard
    Department of Anaesthesia, Rigshospitalet 2041, Blegdamsvej 9, DK 2100 Copenhagen Ø, Denmark
    J Physiol 554:571-8. 2004
    ..5 mM. The finding that an increase in lactate could not be detected in the CSF or within the brain rules out accumulation in a distribution volume and indicates that the lactate taken up by the brain is metabolized...
  53. ncbi request reprint The CSF and arterial to internal jugular venous hormonal differences during exercise in humans
    Mads K Dalsgaard
    Department of Anaesthesia, Rigshospitalet 2041, Blegdamsvej 9, DK 2100 Copenhagen Ø, Denmark
    Exp Physiol 89:271-7. 2004
    ..The results support the notion that the exercise-induced changes in brain metabolism are controlled by factors intrinsic to the brain...
  54. ncbi request reprint Cerebrospinal fluid IL-6, HSP72, and TNF-alpha in exercising humans
    Adam Steensberg
    Centre of Inflammation and Metabolism, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Denmark
    Brain Behav Immun 20:585-9. 2006
    ....
  55. pmc Beta-adrenergic receptor desensitization in man: insight into post-exercise attenuation of cardiac function
    Emma Hart
    Centre for Sports Medicine and Human Performance, Brunel University, Uxbridge, Middlesex UB8 3PH, UK, and Copenhagen Muscle Research Centre, Department of Anaesthesia, Rigshospitalet, University of Copenhagen, Denmark
    J Physiol 577:717-25. 2006
    ..05). Desensitization of the beta-AR contributes to an attenuated left ventricular systolic but not diastolic function following prolonged exercise...
  56. pmc Non-selective beta-adrenergic blockade prevents reduction of the cerebral metabolic ratio during exhaustive exercise in humans
    Thomas Seifert Larsen
    Department of Anaesthesia, Rigshospitalet 2041, Blegdamsvej 9, DK 2100, Copenhagen Ø, Denmark
    J Physiol 586:2807-15. 2008
    ....
  57. doi request reprint Lactate fuels the human brain during exercise
    Bjørn Quistorff
    Department of Biomedical Sciences, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    FASEB J 22:3443-9. 2008
    ..Thus, the notion of the human brain as an obligatory glucose consumer is not without exceptions...
  58. pmc Pulmonary artery perfusion versus no pulmonary perfusion during cardiopulmonary bypass in patients with COPD: a randomised clinical trial
    Katrine B Buggeskov
    Department of Cardiothoracic Anesthesiology, The Heart Centre, Rigshospitalet, Copenhagen, Denmark
    BMJ Open Respir Res 3:e000146. 2016
    ..Effects of active pulmonary artery perfusion were explored in patients with chronic obstructive pulmonary disease (COPD) undergoing cardiac surgery...
  59. pmc Thoracic epidural analgesia reduces gastric microcirculation in the pig
    Rikard Ambrus
    Department of Surgical Gastroenterology C, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, DK 2100, Copenhagen Ø, Denmark
    BMC Anesthesiol 16:86. 2016
    ..Thoracic epidural analgesia (TEA) is used for pain relief during and after abdominal surgery, but the effect of TEA on the splanchnic microcirculation remains debated. We evaluated whether TEA affects splanchnic microcirculation in the pig...
  60. ncbi request reprint Thermodilution-determined Internal Jugular Venous Flow
    Peter Rasmussen
    1Zurich Center of Integrative Human Physiology, University of Zurich, Switzerland 2Institute of Human Movement Sciences and Sport, ETH Zurich, Switzerland 3Medical Intensive Care Unit, University Hospital of Zurich, Switzerland 4Department of Anesthesia, The Copenhagen Muscle Research Center, Rigshospitalet, University of Copenhagen, Denmark 5Department of Biomedical Engineering, Toyo University, Japan 6Research Institute of Physical Fitness, Japan Women s College of Physical Education, Tokyo, Japan
    Med Sci Sports Exerc . 2016
    ..internal jugular venous (IJV) flow and/or that CBF is influenced by posture. Here we test the hypothesis that IJV flow, as determined by retrograde thermodilution increases during exercise when body position is maintained...
  61. doi request reprint Cerebral water and ion balance remains stable when humans are exposed to acute hypoxic exercise
    Magnus B Avnstorp
    1 Department of Anesthesia, The Copenhagen Muscle Research Center, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    High Alt Med Biol 16:18-25. 2015
    ..This study evaluated whether disturbed cerebral water and ion homeostasis can be detected when intense exercise is carried out in hypoxia and monitored the influence of muscle metabolism for changes in arterial variables...
  62. doi request reprint Does goal-directed fluid therapy affect postoperative orthostatic intolerance?: A randomized trial
    Morten Bundgaard-Nielsen
    Research Fellow, Research Assistant, Section of Surgical Pathophysiology, The Juliane Marie Center, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark, and Department of Anesthesiology, The Abdominal Center, Copenhagen University Hospital, Rigshospitalet Research Fellow, Professor, Section of Surgical Pathophysiology, The Juliane Marie Center, Copenhagen University Hospital, Rigshospitalet Staff Anesthesiologist, Head of Department, Professor, Department of Anesthesiology, The Abdominal Center, Copenhagen University Hospital, Rigshospitalet Professor, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark
    Anesthesiology 119:813-23. 2013
    ....
  63. ncbi request reprint Can haemodialysis-induced hypotension be predicted?
    Yan Cai
    Department of Anaesthesia, Rigshospitalet, University of Copenhagen, Denmark
    Nephron 92:582-8. 2002
    ..Thoracic electrical impedance (TI) is applied to monitor the central blood volume and we evaluated if it can be used to predict HD-induced hypotension...
  64. ncbi request reprint High glycogen levels in the hippocampus of patients with epilepsy
    Mads K Dalsgaard
    Department of Anaesthesia, The Copenhagen Muscle Research Centre, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    J Cereb Blood Flow Metab 27:1137-41. 2007
    ....
  65. doi request reprint G16R single nucleotide polymorphism but not haplotypes of the β(2)-adrenergic receptor gene alters cardiac output in humans
    Kim Z Rokamp
    Department of Anaesthesia, Rigshospitalet, University of Copenhagen, 9 Blegdamsvej, DK 2100 Copenhagen, Denmark
    Clin Sci (Lond) 125:191-8. 2013
    ..0 -1.0) l/min greater in ACE I/I carriers compared with I/D and D/D subjects (P=0.054). In conclusion, the ADRB2 Arg16 allele in humans is associated with a lower Q both at rest and during exercise, overriding the effects of haplotypes...
  66. ncbi request reprint Effects of hyperthermia on cerebral blood flow and metabolism during prolonged exercise in humans
    Lars Nybo
    Department of Human Physiology, Institute of Exercise and Sport Sciences, University of Copenhagen, Denmark
    J Appl Physiol 93:58-64. 2002
    ....
  67. ncbi request reprint Supraorbital cutaneous blood flow rate during carotid endarterectomy
    Jens D Hove
    Department of Anaesthesia, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Clin Physiol Funct Imaging 26:323-7. 2006
    ..The supraorbital cutaneous blood flow rate may therefore be influenced by changes in the internal carotid artery flow during carotid endarterectomy...
  68. pmc The intent to exercise influences the cerebral O(2)/carbohydrate uptake ratio in humans
    Mads K Dalsgaard
    Department of Anaesthesia, The Panum Institute, University of Copenhagen, Denmark
    J Physiol 540:681-9. 2002
    ..We speculate that the uptake ratio for the brain may serve as a metabolic indicator of 'central fatigue'...
  69. doi request reprint Human investigations into the exercise pressor reflex
    Niels H Secher
    The Copenhagen Muscle Research Centre, Department of Anaesthesia, Rigshospitalet, University of Copenhagen, Denmark
    Exp Physiol 97:59-69. 2012
    ....
  70. pmc Baroreflex-mediated changes in cardiac output and vascular conductance in response to alterations in carotid sinus pressure during exercise in humans
    Shigehiko Ogoh
    Department of Integrative Physiology, University of North Texas Health Science Center at Fort Worth, TX, USA and Copenhagen Muscle Research Centre, Department of Anaesthesia, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    J Physiol 550:317-24. 2003
    ..017) during heavy exercise. Collectively, these findings indicate that alterations in vasomotion are the primary means by which the CBR regulates blood pressure during mild to heavy exercise...
  71. ncbi request reprint "Central command" and insular activation during attempted foot lifting in paraplegic humans
    Markus Nowak
    The Copenhagen Muscle Research Center, Rigshospitalet, Copenhagen, Denmark
    Hum Brain Mapp 25:259-65. 2005
    ..A conjunction analysis showing responses common to handgrip and attempted foot lifting revealed activation in the right central insula (P < 0.05, corrected) in concordance with the concept of a central command feed-forward hypothesis...
  72. ncbi request reprint The brain at work: a cerebral metabolic manifestation of central fatigue?
    Mads K Dalsgaard
    Department of Anaesthesia, The Copenhagen Muscle Research Centre, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    J Neurosci Res 85:3334-9. 2007
    ..Depletion of glycogen stores and subsequent supercompensation during periods of low neuronal activity may not only play a role but also link brain metabolism to its function...
  73. doi request reprint Transfusion packages for massively bleeding patients: the effect on clot formation and stability as evaluated by Thrombelastograph (TEG)
    Pär I Johansson
    Transfusion Service, Department of Clinical Immunology, University of Copenhagen, Rigshospitalet 2034, Blegdamsvej 9, Copenhagen, Denmark
    Transfus Apher Sci 39:3-8. 2008
    ..01). In 8 patients damage control surgery was successful and 6 of these patients survived. The result indicates that an early balanced transfusion strategy maintains haemostatic competence in massively bleeding patients...
  74. pmc Pulmonary artery and intestinal temperatures during heat stress and cooling
    James Pearson
    Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital of Dallas, Dallas, TX, USA
    Med Sci Sports Exerc 44:857-62. 2012
    ..However, it is unknown whether intestinal temperature accurately tracks pulmonary artery blood temperature, the gold standard, during thermal stimuli in resting humans, which is the investigated hypothesis...
  75. pmc Exercise induces hepatosplanchnic release of heat shock protein 72 in humans
    Mark A Febbraio
    Copenhagen Muscle Research Centre, University of Copenhagen, Denmark
    J Physiol 544:957-62. 2002
    ..2 +/- 0.2 pg min(-1) after 120 min. These data demonstrate that the splanchnic tissues release HSP72 during exercise and this release is responsible, in part, for the elevated systemic concentration of this protein during exercise...
  76. ncbi request reprint Proactive administration of platelets and plasma for patients with a ruptured abdominal aortic aneurysm: evaluating a change in transfusion practice
    Pär I Johansson
    Department of Clinical Immunology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Transfusion 47:593-8. 2007
    ..It was considered that early substitution with PLTs and fresh-frozen plasma (FFP) would prevent development of coagulopathy and thus improve survival...
  77. ncbi request reprint [Should cerebral autoregulation be reassessed?]
    Niels H Secher
    Anaestesiologisk Klinik, Rigshospitalet, DK 2100 København Ø
    Ugeskr Laeger 171:2291-3. 2009
    ..Thereby, ScO2 is maintained even when the mean arterial pressure is < 40 mm Hg. However, for some patients, ScO2 decreases with a small reduction in blood pressure and it is recommended that ScO2 be monitored...
  78. pmc Tracheal tube and laryngeal mask cuff pressure during anaesthesia - mandatory monitoring is in need
    Kim Z Rokamp
    Department of Anaesthesia, University of Copenhagen, Herlev Hospital, Herlev Ringvej 7, DK 2730 Herlev, Denmark
    BMC Anesthesiol 10:20. 2010
    ..To prevent endothelium and nerve lesions, tracheal tube and laryngeal mask cuff pressure is to be maintained at a low level and yet be high enough to secure air sealing...
  79. ncbi request reprint [Strategy for peroperative fluid therapy--balancing the central blood volume]
    Niels H Secher
    H S Rigshospitalet, Abdominalcentret, Anaestesiafdelingen
    Ugeskr Laeger 164:1489-93. 2002
    ..It is concluded that the deviations reflect the CBV accurately in both experimental and clinical studies. A strategy that maintains the CBV ensures cerebral oxygenation even during extensive haemorrhage...
  80. ncbi request reprint Cardiovascular control during exercise: insights from spinal cord-injured humans
    Flemming Dela
    Department of Medical Physiology, The Panum Institute, Building 12 4 7, Blegdamsvej 3, DK 2200 Copenhagen N, Denmark
    Circulation 107:2127-33. 2003
    ..We studied the role of the central nervous system, neural feedback from contracting skeletal muscles, and sympathetic activity to the heart in the control of heart rate and blood pressure during 2 levels of dynamic exercise...
  81. pmc Carotid baroreflex responsiveness to head-up tilt-induced central hypovolaemia: effect of aerobic fitness
    Shigehiko Ogoh
    Department of Integrative Physiology, University of North Texas Health Science Center at Fort Worth, TX 76107, USA
    J Physiol 551:601-8. 2003
    ..These findings provide an explanation for the predisposition to orthostatic hypotension and intolerance in well-trained athletes...
  82. pmc Partial blockade of skeletal muscle somatosensory afferents attenuates baroreflex resetting during exercise in humans
    Scott A Smith
    University of North Texas Health Science Center, Department of Integrative Physiology, Fort Worth, TX, USA
    J Physiol 551:1013-21. 2003
    ..However, this neural input appears to modify baroreflex control of blood pressure to a greater extent than heart rate...
  83. ncbi request reprint Glucose ingestion blunts hormone-sensitive lipase activity in contracting human skeletal muscle
    Matthew J Watt
    Skeletal Muscle Research Laboratory, School of Medical Sciences, Royal Melbourne Institute of Technology University, PO Box 71, Bundoora 3083, Victoria, Australia
    Am J Physiol Endocrinol Metab 286:E144-50. 2004
    ..16 +/- 0.59, GLU, 1.37 +/- 0.37 mmol/min) in GLU compared with CON. These results demonstrate that circulating insulin and epinephrine play a role in HSLa in contracting skeletal muscle...
  84. pmc Central command is capable of modulating sweating from non-glabrous human skin
    Manabu Shibasaki
    Department of Human Environmental Health, Nara Women s University, Japan
    J Physiol 553:999-1004. 2003
    ..These results suggest that central command is capable of modulating sweating rate in all thermal conditions, however its effect is reduced when body temperatures and/or sweating rate are substantially elevated...
  85. ncbi request reprint Are the lungs built for rowing?
    Niels H Secher
    Scand J Med Sci Sports 13:337-8. 2003
  86. ncbi request reprint Carotid baroreflex function ceases during vasovagal syncope
    Shigehiko Ogoh
    Department of Integrative Physiology, University of North Texas, Health Science Centre, Fort Worth, Texas, USA
    Clin Auton Res 14:30-3. 2004
    ..In addition, during the vasovagal syncope, baroreflex control was suppressed as blood pressure remained low during neck pressure stimuli. In conclusion, arterial baroreflex function ceases during vasovagal syncope...
  87. ncbi request reprint Cerebral perturbations provoked by prolonged exercise
    Lars Nybo
    Department of Human Physiology, Institute of Exercise and Sport Sciences, August Krogh Institute, Universitetsparken 13, DK 2100 Copenhagen, Denmark
    Prog Neurobiol 72:223-61. 2004
    ..Therefore, strenuous exercise is a challenge not only to the cardiorespiratory and locomotive systems but also to the brain...
  88. ncbi request reprint Cerebral carbohydrate cost of physical exertion in humans
    Mads K Dalsgaard
    Department of Anesthesia, Rigshospitalet 2041, Blegdamsvej 9, DK 2100 Copenhagen Ø, Denmark
    Am J Physiol Regul Integr Comp Physiol 287:R534-40. 2004
    ..08). A time-dependent cerebral surplus uptake of carbohydrate was not substantiated and, consequently, exhaustive exercise involves a brain surplus carbohydrate uptake of a magnitude comparable with its glycogen content...
  89. ncbi request reprint Dynamic cerebral autoregulation during exhaustive exercise in humans
    Shigehiko Ogoh
    Department of Integrative Physiology, University of North Texas Health Science Center, Fort Worth, Texas 76107, USA
    Am J Physiol Heart Circ Physiol 288:H1461-7. 2005
    ..05), whereas the phase shift tended to decrease. These findings suggest that dynamic cerebral autoregulation was impaired by exhaustive exercise despite a hyperventilation-induced reduction in Pa(CO(2))...
  90. ncbi request reprint Middle cerebral artery flow velocity and pulse pressure during dynamic exercise in humans
    Shigehiko Ogoh
    Dept of Integrative Physiology, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX 76107, USA
    Am J Physiol Heart Circ Physiol 288:H1526-31. 2005
    ..However, dynamic CA remains able to modulate blood flow around the exercise-induced increase in MCA V(m), even during high-intensity exercise...
  91. pmc Central command and the cutaneous vascular response to isometric exercise in heated humans
    Manabu Shibasaki
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, 7232 Greenville Ave Suite 435, Dallas, TX 75231, USA
    J Physiol 565:667-73. 2005
    ..These findings suggest that central command, as well as muscle metabo-sensitive afferent stimulation, contributes to forearm cutaneous vascular responses in heat stressed humans...
  92. pmc Autonomic nervous system influence on arterial baroreflex control of heart rate during exercise in humans
    Shigehiko Ogoh
    Department of Integrative Physiology, University of North Texas Health Science Center at Fort Worth, TX 76107, USA
    J Physiol 566:599-611. 2005
    ..These findings suggest that during exercise the reduction of arterial baroreceptor reflex sensitivity at the operating point was a result of vagal withdrawal rather than an increase in sympathetic activity...
  93. ncbi request reprint Kidneys extract BNP and NT-proBNP in healthy young men
    Morten Schou
    Dept of Endocrinology and Cardiology, Frederiksberg Univ Hospital, Ndr Fasanvej 57 59, DK 2000 Frederiksberg, Denmark
    J Appl Physiol (1985) 99:1676-80. 2005
    ..15-0.20. There is no cerebral extraction, and short-term moderate exercise does not affect these values. Our findings suggest that the kidneys extract BNP and NT-proBNP to a similar extent in healthy young men...
  94. ncbi request reprint The interaction of central command and the exercise pressor reflex in mediating baroreflex resetting during exercise in humans
    Kevin M Gallagher
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390 9034, USA
    Exp Physiol 91:79-87. 2006
    ..Therefore, we suggest that central command and the exercise pressor reflex interact such that signals from one input facilitate signals from the other, resulting in an enhanced resetting of the baroreflex during exercise...
  95. pmc Cardiac and vasomotor components of the carotid baroreflex control of arterial blood pressure during isometric exercise in humans
    James P Fisher
    School of Sport and Exercise Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    J Physiol 572:869-80. 2006
    ..These data suggest that alterations in vasomotor tone are the primary mechanism by which the CBR modulates blood pressure during low intensity isometric exercise...
  96. ncbi request reprint "In health and in a normoxic environment, VO2 max is/is not limited primarily by cardiac output and locomotor muscle blood flow"
    Niels H Secher
    J Appl Physiol 100:1415. 2006
  97. ncbi request reprint Cerebral autoregulation and CO2 responsiveness of the brain
    Rogier V Immink
    Am J Physiol Heart Circ Physiol 291:H2018; author reply H2019. 2006
  98. ncbi request reprint Metabolism of perfused pig intercostal muscles evaluated by 31P-magnetic resonance spectroscopy
    Brian Lindegaard Pedersen
    Nuclear Magnetic Resonance Centre, Department of Medical Biochemistry and Genetics, The Panum Institute, Blegdamsvej 3, 2200 Copenhagen N, Denmark
    Exp Physiol 91:755-63. 2006
    ..The preparation can also be applied to human intercostal muscles, as demonstrated in one preliminary experiment. The results demonstrate a stable and functional in vitro preparation of intact perfused intercostal muscles in the pig...
  99. ncbi request reprint Effects of hyperglycemia on the cerebrovascular response to rhythmic handgrip exercise
    Yu Sok Kim
    Medium Care Unit, Department of Internal Medicine, F7 205 Academic Medical Center, University of Amsterdam, 1100 DE Amsterdam, The Netherlands
    Am J Physiol Heart Circ Physiol 293:H467-73. 2007
    ..These findings suggest that elevated blood glucose does not explain that dynamic CA is affected during intense exercise...
  100. doi request reprint Point:Counterpoint: Sympathetic activity does/does not influence cerebral blood flow. Point: Sympathetic activity does influence cerebral blood flow
    Johannes J van Lieshout
    Department of Internal Medicine, Medium Care Unit, AMC Center for Heart Failure Research, Academic Medical Center, University of Amerstdam, The Netherlands
    J Appl Physiol 105:1364-6. 2008
  101. ncbi request reprint Syncope, cerebral perfusion, and oxygenation
    Johannes J van Lieshout
    Cardiovascular Research Institute Amsterdam and Departments of Medicine and Physiology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    J Appl Physiol (1985) 94:833-48. 2003
    ..Redistribution of cardiac output may affect cerebral perfusion by increased cerebral vascular resistance, supporting the view that cerebral perfusion depends on arterial inflow pressure provided that there is a sufficient cardiac output...