Pernille Poulsen

Summary

Country: Denmark

Publications

  1. pmc Does zygosity influence the metabolic profile of twins? A population based cross sectional study
    P Poulsen
    Department of Endocrinology and Internal Medicine, Odense University Hospital, DK 5000 C Odense, Denmark
    BMJ 319:151-4. 1999
  2. ncbi Glucose and insulin metabolism in twins: influence of zygosity and birth weight
    P Poulsen
    Diabetes Research Center, Odense University Hospital, Odense, Denmark
    Twin Res 4:350-5. 2001
  3. ncbi The influence of zygosity status on blood pressure and on lipid profiles in male and female twins
    Pernille Poulsen
    Department of Endocrinology, Odense University Hospital, DK 5000 Odense C, Denmark
    J Hypertens 20:645-9. 2002
  4. ncbi The impact of genes and pre- and postnatal environment on the metabolic syndrome. Evidence from twin studies
    P Poulsen
    Diabetes Research Center, Department of Endocrinology, Odense University Hospital, Odense C, Denmark
    Panminerva Med 45:109-15. 2003
  5. ncbi Impact of two common polymorphisms in the PPARgamma gene on glucose tolerance and plasma insulin profiles in monozygotic and dizygotic twins: thrifty genotype, thrifty phenotype, or both?
    Pernille Poulsen
    Department of Endocrinology, Odense University Hospital, Odense C, Denmark
    Diabetes 52:194-8. 2003
  6. ncbi Metabolic and genetic influence on glucose metabolism in type 2 diabetic subjects--experiences from relatives and twin studies
    Henning Beck-Nielsen
    Odense University Hospital, Kloevervaenget 6, 4, 5000 Odense C, Denmark
    Best Pract Res Clin Endocrinol Metab 17:445-67. 2003
  7. doi The triglyceride content in skeletal muscle is associated with hepatic but not peripheral insulin resistance in elderly twins
    Louise Groth Grunnet
    Department of Endocrinology, Diabetes, and Metabolism, Rigshospitalet, Tagensvej 20, 2200 Copenhagen, Denmark
    J Clin Endocrinol Metab 97:4571-7. 2012
  8. pmc Genetic versus Non-Genetic Regulation of miR-103, miR-143 and miR-483-3p Expression in Adipose Tissue and Their Metabolic Implications-A Twin Study
    Jette Bork-Jensen
    Department of Endocrinology, Diabetes and Metabolism, Rigshospitalet, DK 2200 Copenhagen N, Denmark
    Genes (Basel) 5:508-17. 2014
  9. ncbi The diabetic phenotype is conserved in myotubes established from diabetic subjects: evidence for primary defects in glucose transport and glycogen synthase activity
    Michael Gaster
    Department of Endocrinology, Odense University Hospital, Odense, Denmark
    Diabetes 51:921-7. 2002
  10. ncbi Further studies of the influence of apolipoprotein B alleles on glucose and lipid metabolism
    Joan Bentzen
    Department of Clinical Biochemistry, Hvidovre Hospital, Denmark
    Hum Biol 75:687-703. 2003

Collaborators

Detail Information

Publications24

  1. pmc Does zygosity influence the metabolic profile of twins? A population based cross sectional study
    P Poulsen
    Department of Endocrinology and Internal Medicine, Odense University Hospital, DK 5000 C Odense, Denmark
    BMJ 319:151-4. 1999
    ..To study the influence of zygosity on the metabolic variables involved in the pathophysiology of type 2 diabetes...
  2. ncbi Glucose and insulin metabolism in twins: influence of zygosity and birth weight
    P Poulsen
    Diabetes Research Center, Odense University Hospital, Odense, Denmark
    Twin Res 4:350-5. 2001
    ..However, our present knowledge is far too insufficient to discard the results from classical twin studies concerning the relative role of genes versus environment for the development of diabetes and its metabolic effects...
  3. ncbi The influence of zygosity status on blood pressure and on lipid profiles in male and female twins
    Pernille Poulsen
    Department of Endocrinology, Odense University Hospital, DK 5000 Odense C, Denmark
    J Hypertens 20:645-9. 2002
    ..To study the influence of zygosity on blood pressure and serum lipid concentrations among male and female twins...
  4. ncbi The impact of genes and pre- and postnatal environment on the metabolic syndrome. Evidence from twin studies
    P Poulsen
    Diabetes Research Center, Department of Endocrinology, Odense University Hospital, Odense C, Denmark
    Panminerva Med 45:109-15. 2003
    ....
  5. ncbi Impact of two common polymorphisms in the PPARgamma gene on glucose tolerance and plasma insulin profiles in monozygotic and dizygotic twins: thrifty genotype, thrifty phenotype, or both?
    Pernille Poulsen
    Department of Endocrinology, Odense University Hospital, Odense C, Denmark
    Diabetes 52:194-8. 2003
    ..Accordingly, our study simultaneously supports a role for both the intrauterine environment (thrifty phenotype) and for genetics (thrifty genotype) in the etiology of insulin resistance and perhaps glucose intolerance in twins...
  6. ncbi Metabolic and genetic influence on glucose metabolism in type 2 diabetic subjects--experiences from relatives and twin studies
    Henning Beck-Nielsen
    Odense University Hospital, Kloevervaenget 6, 4, 5000 Odense C, Denmark
    Best Pract Res Clin Endocrinol Metab 17:445-67. 2003
    ..The cellular mechanism responsible for obesity/lipid-induced diabetes mellitus is discussed with specific emphasis on the role of accumulation of long-chain AcylCoA and triglycerides in liver, muscle and beta-cells...
  7. doi The triglyceride content in skeletal muscle is associated with hepatic but not peripheral insulin resistance in elderly twins
    Louise Groth Grunnet
    Department of Endocrinology, Diabetes, and Metabolism, Rigshospitalet, Tagensvej 20, 2200 Copenhagen, Denmark
    J Clin Endocrinol Metab 97:4571-7. 2012
    ..Total muscle triglyceride (MT) content has been associated with insulin resistance. We investigated the predictors and impact of MT on relevant metabolic parameters including peripheral and hepatic insulin resistance in elderly twins...
  8. pmc Genetic versus Non-Genetic Regulation of miR-103, miR-143 and miR-483-3p Expression in Adipose Tissue and Their Metabolic Implications-A Twin Study
    Jette Bork-Jensen
    Department of Endocrinology, Diabetes and Metabolism, Rigshospitalet, DK 2200 Copenhagen N, Denmark
    Genes (Basel) 5:508-17. 2014
    ....
  9. ncbi The diabetic phenotype is conserved in myotubes established from diabetic subjects: evidence for primary defects in glucose transport and glycogen synthase activity
    Michael Gaster
    Department of Endocrinology, Odense University Hospital, Odense, Denmark
    Diabetes 51:921-7. 2002
    ....
  10. ncbi Further studies of the influence of apolipoprotein B alleles on glucose and lipid metabolism
    Joan Bentzen
    Department of Clinical Biochemistry, Hvidovre Hospital, Denmark
    Hum Biol 75:687-703. 2003
    ..The effect of the polymorphisms on lipid and glucose parameters could be mediated through linkage to genes with known effect on glucose metabolism or through free fatty acids exerting their effect on glucose metabolism...
  11. ncbi Impact of genetic versus environmental factors on the control of muscle glycogen synthase activation in twins
    Pernille Poulsen
    Steno Diabetes Center, Niels Steensens Vej 2, DK 2820 Gentofte, Denmark
    Diabetes 54:1289-96. 2005
    ..Moreover, GS activity was intact with increasing age, despite a significant reduction in nonoxidative glucose metabolism...
  12. ncbi PGC-1alpha Gly482Ser polymorphism associates with hypertension among Danish whites
    Gitte Andersen
    Steno Diabetes Center, Niels Steensens Vej 2, NSH2 16, DK 2820 Gentofte, Denmark
    Hypertension 45:565-70. 2005
    ..001). In conclusion, the Ser allele of PGC-1alpha Gly482Ser confers a significantly reduced risk of hypertension in whites. Further studies are needed to elucidate the differential role of this polymorphism in men and women...
  13. ncbi Studies of variations of the cyclin-dependent kinase inhibitor 1C and the cyclin-dependent kinase 4 genes in relation to type 2 diabetes mellitus and related quantitative traits
    Eva Maria D Nielsen
    Steno Diabetes Center and Hagedorn Research Institute, Gentofte, Copenhagen, Denmark
    J Mol Med (Berl) 83:353-61. 2005
    ..02) and altered fasting plasma glucose (P=0.03). However, these later findings could not be replicated in additional studies. In conclusion, variants in CDKN1C may contribute to the inter-individual variation in birth weight...
  14. ncbi Heritability of insulin secretion, peripheral and hepatic insulin action, and intracellular glucose partitioning in young and old Danish twins
    Pernille Poulsen
    Steno Diabetes Center, Niels Steensens Vej 2, DK 2820 Gentofte, Denmark
    Diabetes 54:275-83. 2005
    ..The relative contribution of genes versus environment on in vivo insulin secretion exhibited an age dependency with a slightly greater relative impact of genes among older as compared with younger twins...
  15. pmc Periconceptional nutrition, twinning and how this impacts on current understanding of the aetiology and pathophysiology of the metabolic syndrome
    Allan Vaag
    Steno Diabetes Center, Niels Steensens Vej 2, 2820 Gentofte, Denmark
    J Physiol 586:1203-4. 2008
  16. ncbi Low birth weight and zygosity status is associated with defective muscle glycogen and glycogen synthase regulation in elderly twins
    Pernille Poulsen
    Steno Diabetes Center, Niels Steensens Vej 2, DK 2820 Gentofte, Denmark
    Diabetes 56:2710-4. 2007
    ....
  17. ncbi Twins in metabolic and diabetes research: what do they tell us?
    Allan Vaag
    Steno Diabetes Center, Gentofte, Denmark
    Curr Opin Clin Nutr Metab Care 10:591-6. 2007
    ..The purpose of this review is to provide a critical update of the impact of the 'thrifty phenotype hypothesis' on metabolism, and its implications for heritability estimates as obtained in so-called classical twin studies...
  18. ncbi Relationships of plasma adiponectin level and adiponectin receptors 1 and 2 gene expression to insulin sensitivity and glucose and fat metabolism in monozygotic and dizygotic twins
    Heidi Storgaard
    Steno Diabetes Center, 2820 Gentofte, Denmark
    J Clin Endocrinol Metab 92:2835-9. 2007
    ..Adiponectin is a key insulin-sensitizing adipokine acting on muscle metabolism via two specific receptors [adiponectin receptors 1 and 2 (AdipoR1 and AdipoR2, respectively)]...
  19. ncbi The epigenetic basis of twin discordance in age-related diseases
    Pernille Poulsen
    Steno Diabetes Center, Gentofte, Denmark
    Pediatr Res 61:38R-42R. 2007
    ..Since monozygotic twins are genetically identical they are considered ideal experimental models for studying the role of environmental factors as determinants of complex diseases and phenotypes...
  20. ncbi Total and regional fat distribution is strongly influenced by genetic factors in young and elderly twins
    Charlotte Malis
    Steno Diabetes Center, Gentofte, Denmark
    Obes Res 13:2139-45. 2005
    ..The aim of the present study was to estimate the heritability (h(2)) of total and regional fat distribution in young and elderly Danish twins...
  21. ncbi Genetic and nongenetic regulation of CAPN10 mRNA expression in skeletal muscle
    Emma Carlsson
    Department of Clinical Sciences, Diabetes and Endocrinology, Lund University, Malmo University Hospital, S 205 02 Malmo, Sweden
    Diabetes 54:3015-20. 2005
    ..Glucose-tolerant but not glucose-intolerant individuals upregulate their CAPN10 mRNA levels in response to prolonged exposure to fat...
  22. pmc Epigenetic differences arise during the lifetime of monozygotic twins
    Mario F Fraga
    Epigenetics Laboratory, Spanish National Cancer Centre CNIO, Melchor Fernandez Almagro 3, 28029 Madrid, Spain
    Proc Natl Acad Sci U S A 102:10604-9. 2005
    ..These findings indicate how an appreciation of epigenetics is missing from our understanding of how different phenotypes can be originated from the same genotype...
  23. ncbi [Etiology and physiopathology in insulin resistance and type 2 diabetes--results of twin studies]
    Allan A Vaag
    Steno Diabetes Center, Niels Steensensvej 2, DK 2820 Gentofte
    Ugeskr Laeger 164:2123-9. 2002
    ..In addition, twin studies have proved instrumental in molecular biology studies of genotype-phenotype associations and of muscle gene expression patterns in Type 2-diabetes and/or insulin resistance...
  24. ncbi The intrauterine environment as reflected by birth size and twin and zygosity status influences insulin action and intracellular glucose metabolism in an age- or time-dependent manner
    Pernille Poulsen
    Steno Diabetes Center, Niels Steensens Vej 2, DK 2820 Gentofte, Denmark
    Diabetes 55:1819-25. 2006
    ..The documented differential programming effects associated with either low birth weight and twin or zygosity status all represent known defects of glucose homeostasis in type 2 diabetes...