Gianni Panagiotou

Summary

Country: Denmark

Publications

  1. pmc Linking genotype and phenotype of Saccharomyces cerevisiae strains reveals metabolic engineering targets and leads to triterpene hyper-producers
    Karina M Madsen
    Center for Microbial Biotechnology, Department of Systems Biology, Technical University of Denmark, Kgs Lyngby, Denmark
    PLoS ONE 6:e14763. 2011
  2. pmc Yeast biological networks unfold the interplay of antioxidants, genome and phenotype, and reveal a novel regulator of the oxidative stress response
    Jose M Otero
    Department of Systems Biology, Center for Microbial Biotechnology, Technical University of Denmark, Lyngby, Denmark
    PLoS ONE 5:e13606. 2010
  3. pmc Combining substrate specificity analysis with support vector classifiers reveals feruloyl esterase as a phylogenetically informative protein group
    Roberto Olivares-Hernández
    Department of Chemical and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden
    PLoS ONE 5:e12781. 2010
  4. pmc Studies of the production of fungal polyketides in Aspergillus nidulans by using systems biology tools
    Gianni Panagiotou
    Center for Microbial Biotechnology, Department of Systems Biology, Building 223, Technical University of Denmark, DK 2800 Kongens Lyngby, Denmark
    Appl Environ Microbiol 75:2212-20. 2009
  5. ncbi Penicillium brasilianum as an enzyme factory; the essential role of feruloyl esterases for the hydrolysis of the plant cell wall
    Gianni Panagiotou
    Center for Microbial Biotechnology, BioCentrum DTU, Building 223, Technical University of Denmark, 2800 Lyngby, Denmark
    J Biotechnol 130:219-28. 2007
  6. ncbi Production and partial characterization of arabinoxylan-degrading enzymes by Penicillium brasilianum under solid-state fermentation
    Gianni Panagiotou
    Center for Microbial Biotechnology, BioCentrum DTU, Building 223, Technical University of Denmark, DK 2800, Kgs Lyngby, Denmark
    Appl Microbiol Biotechnol 72:1117-24. 2006
  7. ncbi Engineering of the redox imbalance of Fusarium oxysporum enables anaerobic growth on xylose
    Gianni Panagiotou
    Center for Microbial Biotechnology, Technical University of Denmark, BioCentrum DTU, Building 223, DK 2800 Kgs Lyngby, Denmark
    Metab Eng 8:474-82. 2006
  8. doi The interplay of descriptor-based computational analysis with pharmacophore modeling builds the basis for a novel classification scheme for feruloyl esterases
    D B R K Gupta Udatha
    Department of Chemical and Biological Engineering, Industrial Biotechnology, Chalmers University of Technology, Kemivagen 10, SE 412 96, Gothenburg, Sweden
    Biotechnol Adv 29:94-110. 2011
  9. doi Uncovering transcriptional regulation of glycerol metabolism in Aspergilli through genome-wide gene expression data analysis
    Margarita Salazar
    Department of Chemical and Biological Engineering, Chalmers University of Technology, 412 96, Goteborg, Sweden
    Mol Genet Genomics 282:571-86. 2009
  10. doi Overexpression of a novel endogenous NADH kinase in Aspergillus nidulans enhances growth
    Gianni Panagiotou
    Center for Microbial Biotechnology, Department of Systems Biology, Building 223, Technical University of Denmark, DK 2800 Kgs Lyngby, Denmark
    Metab Eng 11:31-9. 2009

Collaborators

Detail Information

Publications25

  1. pmc Linking genotype and phenotype of Saccharomyces cerevisiae strains reveals metabolic engineering targets and leads to triterpene hyper-producers
    Karina M Madsen
    Center for Microbial Biotechnology, Department of Systems Biology, Technical University of Denmark, Kgs Lyngby, Denmark
    PLoS ONE 6:e14763. 2011
    ..A systematic experimental or computational survey of all feasible gene modifications to determine the genotype yielding the optimal triterpene production phenotype is a laborious and time-consuming process...
  2. pmc Yeast biological networks unfold the interplay of antioxidants, genome and phenotype, and reveal a novel regulator of the oxidative stress response
    Jose M Otero
    Department of Systems Biology, Center for Microbial Biotechnology, Technical University of Denmark, Lyngby, Denmark
    PLoS ONE 5:e13606. 2010
    ....
  3. pmc Combining substrate specificity analysis with support vector classifiers reveals feruloyl esterase as a phylogenetically informative protein group
    Roberto Olivares-Hernández
    Department of Chemical and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden
    PLoS ONE 5:e12781. 2010
    ..The diversity of substrate specificities found in the FAE family shows that this family is old enough to have experienced the emergence and loss of many activities...
  4. pmc Studies of the production of fungal polyketides in Aspergillus nidulans by using systems biology tools
    Gianni Panagiotou
    Center for Microbial Biotechnology, Department of Systems Biology, Building 223, Technical University of Denmark, DK 2800 Kongens Lyngby, Denmark
    Appl Environ Microbiol 75:2212-20. 2009
    ....
  5. ncbi Penicillium brasilianum as an enzyme factory; the essential role of feruloyl esterases for the hydrolysis of the plant cell wall
    Gianni Panagiotou
    Center for Microbial Biotechnology, BioCentrum DTU, Building 223, Technical University of Denmark, 2800 Lyngby, Denmark
    J Biotechnol 130:219-28. 2007
    ..While total release of phenolic acids and pentoses was not observed, the synergistic enhancement of hydrolysis in the presence of feruloyl esterase was clearly demonstrated...
  6. ncbi Production and partial characterization of arabinoxylan-degrading enzymes by Penicillium brasilianum under solid-state fermentation
    Gianni Panagiotou
    Center for Microbial Biotechnology, BioCentrum DTU, Building 223, Technical University of Denmark, DK 2800, Kgs Lyngby, Denmark
    Appl Microbiol Biotechnol 72:1117-24. 2006
    ..The P. brasilianum CE produced in this work contains a balance of cell wall-modifying enzymes capable of degrading arabinoxylan of BSG by more than 40%...
  7. ncbi Engineering of the redox imbalance of Fusarium oxysporum enables anaerobic growth on xylose
    Gianni Panagiotou
    Center for Microbial Biotechnology, Technical University of Denmark, BioCentrum DTU, Building 223, DK 2800 Kgs Lyngby, Denmark
    Metab Eng 8:474-82. 2006
    ..It was demonstrated that dissimilatory nitrate reduction allows F. oxysporum to exhibit typical respiratory metabolic behaviour with a highly active TCA cycle and a large demand for NADPH...
  8. doi The interplay of descriptor-based computational analysis with pharmacophore modeling builds the basis for a novel classification scheme for feruloyl esterases
    D B R K Gupta Udatha
    Department of Chemical and Biological Engineering, Industrial Biotechnology, Chalmers University of Technology, Kemivagen 10, SE 412 96, Gothenburg, Sweden
    Biotechnol Adv 29:94-110. 2011
    ..Knowing the pharmacophoric features of a small molecule that are essential for binding to the members of a certain family opens a window of opportunities for tailored applications of FAEs...
  9. doi Uncovering transcriptional regulation of glycerol metabolism in Aspergilli through genome-wide gene expression data analysis
    Margarita Salazar
    Department of Chemical and Biological Engineering, Chalmers University of Technology, 412 96, Goteborg, Sweden
    Mol Genet Genomics 282:571-86. 2009
    ..cerevisiae. Our study clearly demonstrates that cross-species evolutionary comparisons among filamentous fungi, using comparative genomics and transcriptomics, are a powerful tool for uncovering regulatory systems...
  10. doi Overexpression of a novel endogenous NADH kinase in Aspergillus nidulans enhances growth
    Gianni Panagiotou
    Center for Microbial Biotechnology, Department of Systems Biology, Building 223, Technical University of Denmark, DK 2800 Kgs Lyngby, Denmark
    Metab Eng 11:31-9. 2009
    ..This conclusion may impact the design of new strains capable of generating reducing power in the form of NADPH, which is crucial for efficient production of many industrially important metabolites and enzymes...
  11. pmc Systems analysis unfolds the relationship between the phosphoketolase pathway and growth in Aspergillus nidulans
    Gianni Panagiotou
    Center for Microbial Biotechnology, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark
    PLoS ONE 3:e3847. 2008
    ..niger and A. oryzae. Here we identified the gene coding for a novel metabolic pathway in A. nidulans, namely the phosphoketolase pathway, and investigated the role of an increased phosphoketolase activity...
  12. ncbi Effect of compounds released during pretreatment of wheat straw on microbial growth and enzymatic hydrolysis rates
    Gianni Panagiotou
    Center for Microbial Biotechnology, BioCentrum DTU, Building 223, Technical University of Denmark, DK 2800 Lyngby, Denmark
    Biotechnol Bioeng 96:250-8. 2007
    ..From all the potential inhibiting compounds that were tested, formic acid had the most severe influence on the hydrolysis rate resulting in a complete inactivation of the two enzyme mixtures...
  13. pmc Common and distant structural characteristics of feruloyl esterase families from Aspergillus oryzae
    D B R K Gupta Udatha
    Department of Chemical and Biological Engineering, Industrial Biotechnology, Chalmers University of Technology, Gothenburg, Sweden
    PLoS ONE 7:e39473. 2012
    ..Following the increasing attention on these enzymes, a novel descriptor based classification system has been proposed for FAEs resulting into 12 distinct families and pharmacophore models for three FAE sub-families have been developed...
  14. pmc A trispecies Aspergillus microarray: comparative transcriptomics of three Aspergillus species
    Mikael R Andersen
    Center for Microbial Biotechnology, BioCentrum DTU, Technical University of Denmark, DK 2800 Kgs Lyngby, Denmark
    Proc Natl Acad Sci U S A 105:4387-92. 2008
    ..With this case example, we present a validated tool for transcriptome analysis of three Aspergillus species and a methodology for conducting cross-species evolutionary studies within a genus using comparative transcriptomics...
  15. doi Fermentation characteristics of Fusariumoxysporum grown on acetate
    Gianni Panagiotou
    Center for Microbial Biotechnology, BioCentrum DTU, Building 223, Technical University of Denmark, DK 2800 Kgs Lyngby, Denmark
    Bioresour Technol 99:7397-401. 2008
    ....
  16. ncbi The influence of different cultivation conditions on the metabolome of Fusarium oxysporum
    Gianni Panagiotou
    Center for Microbial Biotechnology, BioCentrum DTU, Building 223, Technical University of Denmark, DK 2800 Kgs Lyngby, Denmark
    J Biotechnol 118:304-15. 2005
    ....
  17. pmc Identification of biomarkers for genotyping Aspergilli using non-linear methods for clustering and classification
    Irene Kouskoumvekaki
    Center for Microbial Biotechnology, BioCentrum DTU, Building 223, Technical University of Denmark, DK 2800 Kgs Lyngby, Denmark
    BMC Bioinformatics 9:59. 2008
    ....
  18. ncbi Targeted metabolic engineering guided by computational analysis of single-nucleotide polymorphisms (SNPs)
    D B R K Gupta Udatha
    Department of Chemical and Biological Engineering, Industrial Biotechnology, Chalmers University of Technology, Gothenburg, Sweden
    Methods Mol Biol 985:409-28. 2013
    ..Since measuring the effects of amino acid mutations experimentally is a laborious process, a variety of computational methods have been discussed here that aid to extract direct genotype to phenotype information...
  19. pmc The chemical interactome space between the human host and the genetically defined gut metabotypes
    Ulrik Plesner Jacobsen
    Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark
    ISME J 7:730-42. 2013
    ..Furthermore, we established connections between the systemic effects of non-antibiotic drugs and the gut microbiome of relevance to drug side effects and health-care solutions...
  20. doi Mapping the genome of Plasmodium falciparum on the drug-like chemical space reveals novel anti-malarial targets and potential drug leads
    Kasper Jensen
    Department of Systems Biology, Technical University of Denmark, Kgs Lyngby 2800, Denmark
    Mol Biosyst 8:1678-85. 2012
    ..At the same time, prioritized compounds from the GSK library could serve as lead compounds to medicinal chemists for further optimization...
  21. pmc Integrated text mining and chemoinformatics analysis associates diet to health benefit at molecular level
    Kasper Jensen
    Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Kemitorvet, Lyngby, Denmark
    PLoS Comput Biol 10:e1003432. 2014
    ..This works represents a systematized approach to the association of food with health effect, and provides the phytochemical layer of information for nutritional systems biology research. ..
  22. ncbi Fueling industrial biotechnology growth with bioethanol
    Jose Manuel Otero
    Center for Microbial Biotechnology, BioCentrum, Technical University of Denmark, BioCentrum DTU, 2800, Kgs Lyngby, Denmark
    Adv Biochem Eng Biotechnol 108:1-40. 2007
    ..Biofuel will continue to be the keystone of any industrial biotechnology-based economy whereby biorefineries leverage common raw materials and unit operations to integrate diverse processes to produce demand-driven product portfolios...
  23. ncbi Nutritional systems biology: definitions and approaches
    Gianni Panagiotou
    Department of Systems Biology, Center for Microbial Biotechnology, Technical University of Denmark, Kgs Lyngby, Denmark
    Annu Rev Nutr 29:329-39. 2009
    ....
  24. ncbi Intracellular metabolite profiling of Fusarium oxysporum converting glucose to ethanol
    Gianni Panagiotou
    Center for Microbial Biotechnology, BioCentrum DTU, Technical University of Denmark, Soltofts Plads, Building 223, 2800 Lyngby, Denmark
    J Biotechnol 115:425-34. 2005
    ..On the other hand, the presence of high levels of gamma-amino-n-butyric acid (GABA) under anaerobic conditions suggests a functional GABA bypass and a possible block in the TCA cycle at these conditions...