Affiliation: Novo Nordisk A/S
- Insulin-like growth factor I (IGF-I) is a more potent regulator of gene expression than insulin in primary human myoblasts and myotubesJane Palsgaard
Receptor Systems Biology Laboratory, Hagedorn Research Institute, Niels Steensens Vej 6, 2820 Gentofte, Denmark
Growth Horm IGF Res 19:168-78. 2009..This was true for genes involved in both mitogenic and metabolic regulations. The data suggest that IGF-I is a more important metabolic regulator in skeletal muscle than previously estimated...
- Gene expression in skeletal muscle biopsies from people with type 2 diabetes and relatives: differential regulation of insulin signaling pathwaysJane Palsgaard
Receptor Systems Biology Laboratory, Hagedorn Research Institute, Novo Nordisk, Gentofte, Denmark
PLoS ONE 4:e6575. 2009..As healthy first degree relatives of people with type 2 diabetes have an increased risk of developing type 2 diabetes, they provide a good model in the search for primary causes of the disease...
- Activation of the insulin receptor (IR) by insulin and a synthetic peptide has different effects on gene expression in IR-transfected L6 myoblastsMaja Jensen
Receptor Systems Biology Laboratory, Hagedorn Research Institute, Niels Steensensvej 6, 2820 Gentofte, Denmark
Biochem J 412:435-45. 2008..In conclusion, we show that insulin and S597 acting via the same receptor differentially affect gene expression in cells, resulting in a different mitogenicity of the two ligands, a finding which has critical therapeutic implications...