Genomes and Genes
Affiliation: Novo Nordisk A/S
- IL-1RL2 and its ligands contribute to the cytokine network in psoriasisHal Blumberg
Amgen, Seattle, WA 98119, USA
J Immunol 185:4354-62. 2010..Blockade of IL-1F6 receptor also resolves the inflammatory changes in human psoriatic lesional skin transplanted onto immunodeficient mice. These data suggest a role for IL-1F family members in psoriasis...
- Opposing activities of two novel members of the IL-1 ligand family regulate skin inflammationHal Blumberg
Department of Inflammation, 2Department of Pathology, 3Department of Biostatistics, Amgen, Seattle, WA 98119, USA
J Exp Med 204:2603-14. 2007..In summary, dysregulated expression of novel agonistic and antagonistic IL-1 family member ligands can promote cutaneous inflammation, revealing potential novel targets for the treatment of inflammatory skin disorders...
- RIP4 regulates epidermal differentiation and cutaneous inflammationRyan B Rountree
Department of Oncology, Amgen, Seattle, Washington, USA
J Invest Dermatol 130:102-12. 2010..These data suggest that RIP4 functions in the epidermis through PKC-specific signaling pathways to regulate differentiation and inflammation...
- RANK overexpression in transgenic mice with mouse mammary tumor virus promoter-controlled RANK increases proliferation and impairs alveolar differentiation in the mammary epithelia and disrupts lumen formation in cultured epithelial aciniEva Gonzalez-Suarez
Department of Cancer Biology, AW2 D2262, Amgen Inc, 1201 Amgen Court West, Seattle, WA 98119, USA
Mol Cell Biol 27:1442-54. 2007..Moreover, the increased proliferation and survival observed in a three-dimensional culture system suggests a role for aberrant RANK signaling during breast tumorigenesis...