Neurobiology Research Unit

Summary

Organization: Neurobiology Research Unit
Country: Denmark

Top Publications

  1. doi Radiosynthesis and evaluation of 11C-CIMBI-5 as a 5-HT2A receptor agonist radioligand for PET
    Anders Ettrup
    Neurobiology Research Unit and Center for Integrated Molecular Brain Imaging, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    J Nucl Med 51:1763-70. 2010
  2. pmc Cerebral blood flow response to functional activation
    Olaf B Paulson
    Neurobiology Research Unit 9201, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    J Cereb Blood Flow Metab 30:2-14. 2010
  3. doi Infant outcome of 957 singletons born after frozen embryo replacement: the Danish National Cohort Study 1995-2006
    Anja Pinborg
    Fertility Clinic, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Fertil Steril 94:1320-7. 2010
  4. doi Gender and the use of hormonal contraception in women are not associated with cerebral cortical 5-HT 2A receptor binding
    V G Frokjaer
    Center for Integrated Molecular Brain Imaging and Neurobiology Research Unit, Copenhagen University Hospital, Copenhagen, Denmark
    Neuroscience 163:640-5. 2009
  5. doi Brain serotonin 2A receptor binding: relations to body mass index, tobacco and alcohol use
    D Erritzoe
    Neurobiology Research Unit, University Hospital Rigshospitalet, Copenhagen, Denmark
    Neuroimage 46:23-30. 2009
  6. doi High familial risk for mood disorder is associated with low dorsolateral prefrontal cortex serotonin transporter binding
    Vibe G Frokjaer
    Neurobiology Research Unit and Center for Integrated Molecular Brain Imaging, Copenhagen University Hospital, Denmark
    Neuroimage 46:360-6. 2009
  7. doi Prospective longitudinal cohort study on cumulative 5-year delivery and adoption rates among 1338 couples initiating infertility treatment
    A Pinborg
    Fertility Clinic, The Juliane Marie Center, Copenhagen University Hospital, Rigshopitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark
    Hum Reprod 24:991-9. 2009
  8. doi Longitudinal assessment of cerebral 5-HT2A receptors in healthy elderly volunteers: an [18F]-altanserin PET study
    Lisbeth Marner
    Neurobiology Research Unit, N9201, University Hospital Rigshospitalet, Blegdamsvej 9, DK 2100, Copenhagen O, Denmark
    Eur J Nucl Med Mol Imaging 36:287-93. 2009
  9. doi Evaluation of the novel 5-HT4 receptor PET ligand [11C]SB207145 in the Göttingen minipig
    Birgitte R Kornum
    Neurobiology Research Unit and Center for Integrated Molecular Brain Imaging, Copenhagen University Hospital, Rigshospitalet, Denmark
    J Cereb Blood Flow Metab 29:186-96. 2009
  10. ncbi [Fewer twin pregnancies after fertilization in vitro. The Danish Society of Gynecology and Obstetrics]
    Anja Pinborg
    Fertilitetsklinikken, Rigshospitalet, DK 2100 København Ø
    Ugeskr Laeger 170:1047. 2008

Scientific Experts

Detail Information

Publications62

  1. doi Radiosynthesis and evaluation of 11C-CIMBI-5 as a 5-HT2A receptor agonist radioligand for PET
    Anders Ettrup
    Neurobiology Research Unit and Center for Integrated Molecular Brain Imaging, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    J Nucl Med 51:1763-70. 2010
    ..In this study, we radiolabel the high-affinity 5-HT(2A) receptor agonist 2-(4-iodo-2,5-dimethoxyphenyl)-N-(2-[(11)C-OCH(3)]methoxybenzyl)ethanamine ((11)C-CIMBI-5) and investigate its potential as a PET tracer...
  2. pmc Cerebral blood flow response to functional activation
    Olaf B Paulson
    Neurobiology Research Unit 9201, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    J Cereb Blood Flow Metab 30:2-14. 2010
    ....
  3. doi Infant outcome of 957 singletons born after frozen embryo replacement: the Danish National Cohort Study 1995-2006
    Anja Pinborg
    Fertility Clinic, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Fertil Steril 94:1320-7. 2010
    ..To examine infant outcome of singletons born after cryopreservation of embryos (Cryo)...
  4. doi Gender and the use of hormonal contraception in women are not associated with cerebral cortical 5-HT 2A receptor binding
    V G Frokjaer
    Center for Integrated Molecular Brain Imaging and Neurobiology Research Unit, Copenhagen University Hospital, Copenhagen, Denmark
    Neuroscience 163:640-5. 2009
    ..31). In conclusion, neither gender, nor the use of hormonal contraception in premenopausal women was associated with cortical 5-HT(2A) receptor binding...
  5. doi Brain serotonin 2A receptor binding: relations to body mass index, tobacco and alcohol use
    D Erritzoe
    Neurobiology Research Unit, University Hospital Rigshospitalet, Copenhagen, Denmark
    Neuroimage 46:23-30. 2009
    ..We suggest that our observation is driven by a lower central 5-HT level in overweight people, leading both to increased food intake and to a compensatory upregulation of cerebral 5-HT(2A) receptor density...
  6. doi High familial risk for mood disorder is associated with low dorsolateral prefrontal cortex serotonin transporter binding
    Vibe G Frokjaer
    Neurobiology Research Unit and Center for Integrated Molecular Brain Imaging, Copenhagen University Hospital, Denmark
    Neuroimage 46:360-6. 2009
    ..In conclusion, our data suggest that a low SERT binding in dorsolateral prefrontal cortex represents a trait marker for mood disorders...
  7. doi Prospective longitudinal cohort study on cumulative 5-year delivery and adoption rates among 1338 couples initiating infertility treatment
    A Pinborg
    Fertility Clinic, The Juliane Marie Center, Copenhagen University Hospital, Rigshopitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark
    Hum Reprod 24:991-9. 2009
    ..The objective was to assess crude 5-year delivery rates after assisted reproductive technology (ART) treatment, intrauterine inseminations (IUI), spontaneous conceptions (SC) and adoptions in a large infertile cohort...
  8. doi Longitudinal assessment of cerebral 5-HT2A receptors in healthy elderly volunteers: an [18F]-altanserin PET study
    Lisbeth Marner
    Neurobiology Research Unit, N9201, University Hospital Rigshospitalet, Blegdamsvej 9, DK 2100, Copenhagen O, Denmark
    Eur J Nucl Med Mol Imaging 36:287-93. 2009
    ....
  9. doi Evaluation of the novel 5-HT4 receptor PET ligand [11C]SB207145 in the Göttingen minipig
    Birgitte R Kornum
    Neurobiology Research Unit and Center for Integrated Molecular Brain Imaging, Copenhagen University Hospital, Rigshospitalet, Denmark
    J Cereb Blood Flow Metab 29:186-96. 2009
    ..This study validates the use of [(11)C]SB207145 as a promising PET radioligand for in vivo brain imaging of the 5-HT(4) receptor in humans...
  10. ncbi [Fewer twin pregnancies after fertilization in vitro. The Danish Society of Gynecology and Obstetrics]
    Anja Pinborg
    Fertilitetsklinikken, Rigshospitalet, DK 2100 København Ø
    Ugeskr Laeger 170:1047. 2008
  11. doi The 5-HT2A receptor binding pattern in the human brain is strongly genetically determined
    Lars H Pinborg
    Neurobiology Research Unit and Center for Integrated Molecular Brain Imaging, Copenhagen University Hospital, Rigshospitalet, N9201, 9 Blegdamsvej, DK 2100 Copenhagen, Denmark
    Neuroimage 40:1175-80. 2008
    ....
  12. pmc Proprioceptive deafferentation slows down the processing of visual hand feedback
    Daniela Balslev
    School of Psychology, University of Birmingham, UK
    J Vis 7:12.1-7. 2007
    ..We suggest that during movements intact proprioception is necessary for the rapid processing of visual feedback...
  13. doi Evaluation of the Serotonin Transporter Ligand 123I-ADAM for SPECT Studies on Humans
    Vibe G Frokjaer
    Neurobiology Research Unit, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark
    J Nucl Med 49:247-54. 2008
    ....
  14. ncbi Whole blood BDNF levels in healthy twins discordant for affective disorder: association to life events and neuroticism
    Viktorija Trajkovska
    Neurobiology Research Unit and Center for Integrated Molecular Brain Imaging, Copenhagen University Hospital, Section 9201, Blegdamsvej 9, 2100 Copenhagen, Denmark
    J Affect Disord 108:165-9. 2008
    ..Depression has been associated with decreased blood BDNF concentrations; but it is unclear if low blood BDNF levels are a state or a trait marker of depression...
  15. pmc Familial risk for mood disorder and the personality risk factor, neuroticism, interact in their association with frontolimbic serotonin 2A receptor binding
    Vibe G Frokjaer
    Neurobiology Research Unit and Center for Integrated Molecular Brain Imaging, Denmark
    Neuropsychopharmacology 35:1129-37. 2010
    ....
  16. doi Distinct neural pathways mediate α7 nicotinic acetylcholine receptor-dependent activation of the forebrain
    Morten S Thomsen
    Neurobiology Research Unit, Copenhagen University Hospital, DK2100 Copenhagen, Denmark
    Cereb Cortex 20:2092-102. 2010
    ....
  17. doi Changes in 5-HT4 receptor and 5-HT transporter binding in olfactory bulbectomized and glucocorticoid receptor heterozygous mice
    Cecilie L Licht
    Neurobiology Research Unit and Center for Integrated Molecular Brain Imaging Cimbi, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark
    Neurochem Int 56:603-10. 2010
    ..In conclusion, we have found brain regional changes in 5-HT(4) receptor and 5-HTT transporter binding in two murine models of depression-related states, characterized by 5-HT and HPA system changes...
  18. doi Systemic catechol-O-methyl transferase inhibition enables the D1 agonist radiotracer R-[11C]SKF 82957
    Mikael Palner
    Neurobiology Research Unit, Rigshospitalet and University of Copenhagen, Copenhagen, Denmark
    Nucl Med Biol 37:837-43. 2010
    ....
  19. doi α7 nicotinic receptor agonism mitigates phencyclidine-induced changes in synaptophysin and Arc gene expression in the mouse prefrontal cortex
    Morten S Thomsen
    Neurobiology Research Unit, Copenhagen University Hospital, Copenhagen, Denmark
    Neurochem Int 57:756-61. 2010
    ..These data lend support to the potential for development of α7 nAChR agonists for the treatment of cognitive deficits in schizophrenia...
  20. doi Automatic sleep scoring in normals and in individuals with neurodegenerative disorders according to new international sleep scoring criteria
    Peter S Jensen
    DTU Department of Electrical Engineering, Technical University of Denmark, Copenhagen, Denmark
    J Clin Neurophysiol 27:296-302. 2010
    ....
  21. pmc Changes in 5-HT2A-mediated behavior and 5-HT2A- and 5-HT1A receptor binding and expression in conditional brain-derived neurotrophic factor knock-out mice
    A B Klein
    Neurobiology Research Unit and Center for Integrated and Molecular Brain Imaging, Rigshospitalet and University of Copenhagen, Copenhagen, Denmark
    Neuroscience 169:1007-16. 2010
    ..These findings illustrate the context-dependent effects of deficient BDNF signaling on the 5-HT receptor system and 5-HT(2A)-receptor functional output...
  22. doi An approach for serotonin depletion in pigs: effects on serotonin receptor binding
    Anders Ettrup
    Neurobiology Research Unit and Center for Integrated Molecular Brain Imaging Cimbi, Copenhagen University Hospital, Rigshospitalet, DK 2100 Copenhagen, Denmark
    Synapse 65:136-45. 2011
    ..This porcine model of serotonin depletion will be useful in future studies of cerebral serotonergic dysfunction...
  23. ncbi [Lewy body dementia]
    Morten Ziebell
    Neurobiologisk Forskningsenhed, Afdeling N 9201, Rigshospitalet, 2100 København Ø, Denmark
    Ugeskr Laeger 172:1675-8. 2010
    ..With new clinical criteria including SPECT of dopaminergic transporters, diagnosis has become sufficiently accurate to differentiate between the two diagnoses...
  24. doi MRI-guided region-of-interest delineation is comparable to manual delineation in dopamine transporter SPECT quantification in patients: a reproducibility study
    Morten Ziebell
    Neurobiology Research Unit and Cimbi, University of Copenhagen, Rigshospitalet, Copenhagen, Denmark
    J Nucl Med Technol 38:61-8. 2010
    ..We also assessed the ability of the different approaches to identify striatal pathology in patients with parkinsonism...
  25. doi Cerebral serotonin transporter binding is inversely related to body mass index
    D Erritzoe
    Neurobiology Research Unit, Rigshospitalet and University of Copenhagen, Copenhagen, Denmark
    Neuroimage 52:284-9. 2010
    ....
  26. doi Endogenous plasma estradiol in healthy men is positively correlated with cerebral cortical serotonin 2A receptor binding
    Vibe G Frokjaer
    Center for Integrated Molecular Brain Imaging, Copenhagen University Hospital, Copenhagen, Denmark
    Psychoneuroendocrinology 35:1311-20. 2010
    ..This study was undertaken to examine if baseline levels of endogenous sex hormones are associated with cerebral serotonin 2A (5-HT(2A)) receptor binding in men...
  27. doi Aging and depression vulnerability interaction results in decreased serotonin innervation associated with reduced BDNF levels in hippocampus of rats bred for learned helplessness
    Susana Aznar
    Neurobiology Research Unit, Copenhagen University Hospital, Copenhagen, Denmark
    Synapse 64:561-5. 2010
    ....
  28. doi A nonlinear relationship between cerebral serotonin transporter and 5-HT(2A) receptor binding: an in vivo molecular imaging study in humans
    David Erritzoe
    Neurobiology Research Unit and PET and Cyclotron Unit, University Hospital Rigshospitalet, Copenhagen, Denmark
    J Neurosci 30:3391-7. 2010
    ..That is, the observed association between the 5-HT(2A) receptor and SERT binding could be driven by the projection output from the raphe nuclei, but other explanations are also at hand...
  29. doi Radiosynthesis and ex vivo evaluation of (R)-(-)-2-chloro-N-[1-11C-propyl]n-propylnorapomorphine
    Mikael Palner
    Neurobiology Research Unit, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Nucl Med Biol 37:35-40. 2010
    ..We here present the carbon-11 radiolabeling and ex vivo evaluation of 2-Cl-(-)-NPA, a novel PET-tracer candidate with high in vitro D(2)/D(3) selectivity...
  30. doi Brain imaging of serotonin 4 receptors in humans with [11C]SB207145-PET
    Lisbeth Marner
    The Neuroscience Centre, Copenhagen University Hospital Rigshospitalet, Copenhagen O, Denmark
    Neuroimage 50:855-61. 2010
    ..In conclusion, the 5-HT(4) receptor binding in human brain can be reliably assessed with [(11)C]SB207145, which is encouraging for future PET studies of drug occupancy or patients with neuropsychiatric disorders...
  31. ncbi Frontolimbic serotonin 2A receptor binding in healthy subjects is associated with personality risk factors for affective disorder
    Vibe G Frokjaer
    Center for Integrated Molecular Brain Imaging and Neurobiology Research Unit, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark
    Biol Psychiatry 63:569-76. 2008
    ..In this study we investigated whether neuroticism is associated with serotonin 2A receptor binding in brain regions of relevance for affective disorders...
  32. ncbi [Pioneering research of Niels A. Lassen]
    Olaf B Paulson
    Neurobiologisk Forskningsenhed 9201, Rigshospitalet, DK 2100 København Ø
    Ugeskr Laeger 169:2899. 2007
  33. ncbi Imaging of dopamine transporters and D2 receptors in patients with Parkinson's disease and multiple system atrophy
    G M Knudsen
    Neurobiology Research Unit 9201, Department of Neurology, University Hospital Rigshospitalet, Copenhagen, Denmark
    Eur J Nucl Med Mol Imaging 31:1631-8. 2004
    ....
  34. ncbi Significantly increased fractions of transformed to total alpha2-macroglobulin concentrations in plasma from patients with multiple sclerosis
    Poul Erik H Jensen
    The Neuroimmunology Laboratory, Section 9302, MS Research Unit, Copenhagen University Hospital, Juliane Mariesvej 20, 2100 Copenhagen, Denmark
    Biochim Biophys Acta 1690:203-7. 2004
    ..The results suggest an important involvement of alpha2M in regulation of increased proteolytic activity occurring in MS disease...
  35. ncbi Enhanced accuracy in novel mirror drawing after repetitive transcranial magnetic stimulation-induced proprioceptive deafferentation
    Daniela Balslev
    Neurobiology Research Unit, Rigshospitalet, Copenhagen University Hospital, DK 2100 Copenhagen, Denmark
    J Neurosci 24:9698-702. 2004
    ..It is thus possible, with rTMS, to enhance motor performance in tasks involving a visuoproprioceptive conflict, presumably by reducing the excitability of somatosensory cortical areas that contribute to the sense of hand position...
  36. ncbi Structural similarity and category-specificity: a refined account
    Christian Gerlach
    The Neurobiology Research Unit, N9201, Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Neuropsychologia 42:1543-53. 2004
    ..We evaluate the model based on previous evidence from both normal subjects and patients with category-specific disorders and argue that this model can help reconcile otherwise conflicting data...
  37. ncbi Right temporoparietal cortex activation during visuo-proprioceptive conflict
    Daniela Balslev
    Neurobiology Research Unit, N9201, Copenhagen University Hospital, Copenhagen, Rigshospitalet, Denmark
    Cereb Cortex 15:166-9. 2005
    ..These brain areas have previously been associated with shifts in the attended location in the visual space. These findings suggest an interaction between vision and proprioception in orienting to spatial locations...
  38. ncbi [Cellular phones--can they affect blood-brain barrier?]
    Olaf B Paulson
    H S Rigshospitalet, Neurobiologisk Forskningsenhed
    Ugeskr Laeger 166:1209-11. 2004
  39. ncbi Non-serotonergic dorsal and median raphe projection onto parvalbumin- and calbindin-containing neurons in hippocampus and septum
    S Aznar
    Neurobiology Research Unit 9201, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark
    Neuroscience 124:573-81. 2004
    ..These results indicate that the raphe nuclei may exert their control on hippocampal and septal activity not only through a serotonergic projection, but also through a significant non-serotonergic pathway...
  40. ncbi Left atrial versus left ventricular input function for quantification of the myocardial blood flow with nitrogen-13 ammonia and positron emission tomography
    Jens D Hove
    Department of Cardiology, Medical Department B, The Heart Center, Rigshospitalet, DK 2100 Copenhagen, Denmark
    Eur J Nucl Med Mol Imaging 31:71-6. 2004
    ..Spillover of activity from the left ventricular wall to the blood time-activity curve is of importance in hyperaemic flow studies using (13)NH(3). Application of a left atrial input function is a possible solution to these issues...
  41. ncbi Quantification of 5-HT2A receptors in the human brain using [18F]altanserin-PET and the bolus/infusion approach
    Lars H Pinborg
    Neurobiology Research Unit, Copenhagen University Hospital, Rigshospitalet, Denmark
    J Cereb Blood Flow Metab 23:985-96. 2003
    ..3% h-1; range -7.3-7.2% h-1) and no correlation of DV(3)' versus time was demonstrated. It is concluded that 5-HT(2A) receptor studies can be conducted within 2 h of [18F]altanserin infusion, yielding reliable results...
  42. ncbi Quantitation of the regional blood flow in the interventricular septum using positron emission tomography and nitrogen-13 ammonia
    Jens D Hove
    Department of Cardiology, The Heart Center, Rigshospitalet, Juliane Mariesvej 24, 2100 Copenhagen, Denmark
    Eur J Nucl Med Mol Imaging 30:109-16. 2003
    ..01), respectively. It is concluded that flow quantitation in the septum is significantly affected by RV spillover, resulting in a considerable underestimation of the septal blood flow unless correction is performed...
  43. ncbi The 5-HT1A serotonin receptor is located on calbindin- and parvalbumin-containing neurons in the rat brain
    Susana Aznar
    Neurobiology Research Unit, Unit 9201, Copenhagen University Hospital, Blegdamsvej 9, 2100 Copenhagen, Denmark
    Brain Res 959:58-67. 2003
    ..These results suggest a diverse function of the 5-HT(1A) receptor in modulating neuronal circuitry in different brain areas, that may depend on the type of neuron the receptor is predominantly located on...
  44. ncbi Blood-brain barrier, brain metabolism and cerebral blood flow
    O B Paulson
    Neurobiology Research Unit 9201, Rigshospitalet, Copenhagen University Hospital, 9 Blegdamsvej, DK 2100, Copenhagen, Denmark
    Eur Neuropsychopharmacol 12:495-501. 2002
    ....
  45. ncbi Cluster analysis of activity-time series in motor learning
    Daniela Balslev
    Neurobiology Research Unit, N 9201, Copenhagen University Hospital, Rigshospitalet, 9 Blegdamsvej, 2100 Copenhagen, Denmark
    Hum Brain Mapp 15:135-45. 2002
    ..These voxels were separated from a group of voxels showing an unspecific time-effect and another group of voxels, whose activation was an artifact from smoothing...
  46. ncbi Cerebral pressure autoregulation and vasoreactivity in the newborn rat
    Anders Pryds
    Department of Neonatology, Neurobiology Research Unit, Rigshospitalet, 2100 Copenhagen, Denmark
    Pediatr Res 57:294-8. 2005
    ..80). CBF pressure autoregulation and reactivity to CO2 operate in the newborn rat. This model may be useful for future investigations concerning perinatal pathophysiology in the immature brain...
  47. ncbi Alpha 7 nicotinic receptor subunit is present on serotonin neurons projecting to hippocampus and septum
    Susana Aznar
    Neurobiology Research Unit, Copenhagen University Hospital, 2100 Copenhagen, Denmark
    Synapse 55:196-200. 2005
    ..A low degree of colocalization between alpha-bungarotoxin and serotonin-positive neurons suggest that the alpha 7 subunit may be transported anterogradely to the serotonergic axonal terminals...
  48. ncbi MR-based automatic delineation of volumes of interest in human brain PET images using probability maps
    Claus Svarer
    Neurobiology Research Unit, University Hospital of Copenhagen, Rigshospitalet, N9201, 9 Blegdamsvej, DK 2100 Copenhagen, Denmark
    Neuroimage 24:969-79. 2005
    ..In addition, the method applies well in elderly subjects, even in the presence of pronounced cerebral atrophy...
  49. ncbi Vanishing twins: a predictor of small-for-gestational age in IVF singletons
    Anja Pinborg
    The Fertility Clinic, The Juliane Marie Center, Copenhagen University Hospital, Rigshopitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark
    Hum Reprod 22:2707-14. 2007
    ..The purpose of this study was to assess the effect of a vanishing twin on the risk of being small-for-gestational age (SGA) in in vitro fertilization (IVF) singletons...
  50. ncbi Reduced 5-HT2A receptor binding in patients with mild cognitive impairment
    S G Hasselbalch
    Neurobiology Research Unit N9201, The Neuroscience Centre, Rigshospitalet, Copenhagen, Denmark
    Neurobiol Aging 29:1830-8. 2008
    ..This may provide some of the pathophysiological background for the neuropsychiatric symptoms found in early AD...
  51. ncbi Measurements of brain-derived neurotrophic factor: methodological aspects and demographical data
    Viktorija Trajkovska
    Neurobiology Research Unit and Center for Integrated Molecular Brain Imaging, Rigshospitalet, Copenhagen University Hospital, Section 9201, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Brain Res Bull 73:143-9. 2007
    ..Female gender is associated with higher whole blood BDNF concentrations whereas age, thrombocyte count and BDNF Val66Met polymorphism were un-associated...
  52. ncbi Reproducibility of 5-HT2A receptor measurements and sample size estimations with [18F]altanserin PET using a bolus/infusion approach
    Steven Haugbøl
    Neurobiology Research Unit, Centre for Integrated Molecular Brain Imaging, Copenhagen University Hospital, 9 Blegdamsvej, 2100, Copenhagen, Denmark
    Eur J Nucl Med Mol Imaging 34:910-5. 2007
    ..Further, to estimate the sample size needed to detect regional differences between two groups and, finally, to evaluate how partial volume correction affects reproducibility and the required sample size...
  53. ncbi [123I]epidepride binding to cerebellar dopamine D2/D3 receptors is displaceable: implications for the use of cerebellum as a reference region
    Lars H Pinborg
    Neurobiology Research Unit, University of Copenhagen, N9201, Rigshospitalet, 9 Blegdamsvej, DK 2100 Copenhagen, Denmark
    Neuroimage 34:1450-3. 2007
    ....
  54. ncbi Reproducibility of [123I]PE2I binding to dopamine transporters with SPECT
    Morten Ziebell
    Neurobiology Research Unit, Rigshospitalet, N9201, 9 Blegdamsvej, Copenhagen, 2100, Denmark
    Eur J Nucl Med Mol Imaging 34:101-9. 2007
    ....
  55. ncbi Autonomic dysfunction and impaired cerebral autoregulation in cirrhosis
    Vibe G Frøkjaer
    Neurobiology Research Unit, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark
    Clin Auton Res 16:208-16. 2006
    ....
  56. ncbi Serotonin depletion results in a decrease of the neuronal activation caused by rivastigmine in the rat hippocampus
    Birgitte R Kornum
    Neurobiology Research Unit, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Brain Res 1073:262-8. 2006
    ..It is concluded that 5-HT mediates part of the ACh-induced hippocampal neuronal activation, possibly mediated via locally released 5-HT...
  57. ncbi Similar brain networks for detecting visuo-motor and visuo-proprioceptive synchrony
    Daniela Balslev
    Neurobiology Research Unit, N9201, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Neuroimage 31:308-12. 2006
    ..95, no brain voxel had a contrast effect above 0.11% of the whole-brain mean signal. These results do not support the hypothesis that recognition of visual feedback during active and passive movement relies on different brain areas...
  58. ncbi Central serotonin depletion affects rat brain areas differently: a qualitative and quantitative comparison between different treatment schemes
    Birgitte Rahbek Kornum
    Neurobiology Research Unit, N9201, Copenhagen University Hospital Rigshospitalet, Blegdamsvej 9, Denmark
    Neurosci Lett 392:129-34. 2006
    ..While the pattern of 5-HT depletion using pCPA alone was comparable to the one seen with the combined treatment, the 5-HT depletion using FEN alone showed a different pattern with 5-HT distributed in several brain regions...
  59. ncbi Intravenous immunoglobulin ameliorates experimental autoimmune encephalomyelitis and reduces neuropathological abnormalities when administered prophylactically
    Signe Humle Jorgensen
    Danish MS Centre, Copenhagen University Hospital, Rigshospitalet sect 9202, DK 2100 Copenhagen, Denmark
    Neurol Res 27:591-7. 2005
    ..EAE was induced in susceptible Dark Agouti rats by active immunization with a spinal cord homogenate, and infusions of 1 g/kg IVIG were given prophylactically or therapeutically...
  60. ncbi Quantification of 123I-PE2I binding to dopamine transporter with SPECT after bolus and bolus/infusion
    Lars H Pinborg
    Neurobiology Research Unit, University Hospital Rigshospitalet, Copenhagen, Denmark
    J Nucl Med 46:1119-27. 2005
    ....
  61. ncbi Intravenous immunoglobulin treatment of multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis
    Signe Humle Jorgensen
    Copenhagen MS Centre, Department of Neurology, Copenhagen University Hospital, Rigshospitalet, DK 2100 Copenhagen, Denmark
    J Neurol Sci 233:61-5. 2005
    ..IVIG is, therefore, presently regarded as a second-line therapy of MS...
  62. ncbi Cerebral metabolism of ammonia and amino acids in patients with fulminant hepatic failure
    G I Strauss
    Department of Hepatology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Gastroenterology 121:1109-19. 2001
    ..The aim of this study was to measure cerebral metabolism of ammonia and amino acids, with special emphasis on glutamine metabolism...