Peder Wolkoff

Summary

Affiliation: National Research Centre for the Working Environment
Country: Denmark

Publications

  1. doi request reprint "Healthy" eye in office-like environments
    Peder Wolkoff
    National Research Centre for the Working Environment, Copenhagen Ø, Denmark
    Environ Int 34:1204-14. 2008
  2. doi request reprint Effects by inhalation of abundant fragrances in indoor air - An overview
    Peder Wolkoff
    National Research Centre for the Working Environment, Copenhagen Ø, Denmark Electronic address
    Environ Int . 2017
  3. doi request reprint External eye symptoms in indoor environments
    P Wolkoff
    National Research Centre for the Working Environment, Copenhagen, Denmark
    Indoor Air . 2016
  4. doi request reprint Pollutant exposures and health symptoms in aircrew and office workers: Is there a link?
    Peder Wolkoff
    National Research Centre for the Working Environment, Denmark Electronic address
    Environ Int 87:74-84. 2016
  5. doi request reprint Indoor air pollutants in office environments: assessment of comfort, health, and performance
    Peder Wolkoff
    National Research Centre for the Working Environment, Copenhagen, Denmark
    Int J Hyg Environ Health 216:371-94. 2013
  6. doi request reprint Human reference values for acute airway effects of five common ozone-initiated terpene reaction products in indoor air
    Peder Wolkoff
    National Research Centre for the Working Environment, Lersø Parkallé 105, DK 2100 Copenhagen Ø, Denmark
    Toxicol Lett 216:54-64. 2013
  7. doi request reprint Airway effects of repeated exposures to ozone-initiated limonene oxidation products as model of indoor air mixtures
    Peder Wolkoff
    National Research Centre for the Working Environment, Denmark
    Toxicol Lett 209:166-72. 2012
  8. doi request reprint Problems of the "outer eyes" in the office environment: an ergophthalmologic approach
    Peder Wolkoff
    National Research Centre for the Working Environment, Copenhagen, Denmark
    J Occup Environ Med 54:621-31. 2012
  9. doi request reprint Non-cancer effects of formaldehyde and relevance for setting an indoor air guideline
    Peder Wolkoff
    National Research Centre for the Working Environment, Lersø Parkallé 105, DK 2100 Copenhagen Ø, Denmark
    Environ Int 36:788-99. 2010
  10. doi request reprint Ocular discomfort by environmental and personal risk factors altering the precorneal tear film
    Peder Wolkoff
    National Research Centre for the Working Environment, Lersø Parkallé 105, DK 2100 Copenhagen Ø, Denmark
    Toxicol Lett 199:203-12. 2010

Detail Information

Publications41

  1. doi request reprint "Healthy" eye in office-like environments
    Peder Wolkoff
    National Research Centre for the Working Environment, Copenhagen Ø, Denmark
    Environ Int 34:1204-14. 2008
    ..Sustained low relative humidity causes impairment of the PTF, while its stability, including work performance, is retained by low gaze and intermittent breaks...
  2. doi request reprint Effects by inhalation of abundant fragrances in indoor air - An overview
    Peder Wolkoff
    National Research Centre for the Working Environment, Copenhagen Ø, Denmark Electronic address
    Environ Int . 2017
    ..Limited experimental information is available on long-term effects of ozone-initiated reaction products of APN and LIM at typical indoor levels...
  3. doi request reprint External eye symptoms in indoor environments
    P Wolkoff
    National Research Centre for the Working Environment, Copenhagen, Denmark
    Indoor Air . 2016
    ..Psychological stressors may further influence the reporting behavior of eye symptoms. The impact of the risk factors may occur in a combined and exacerbating manner...
  4. doi request reprint Pollutant exposures and health symptoms in aircrew and office workers: Is there a link?
    Peder Wolkoff
    National Research Centre for the Working Environment, Denmark Electronic address
    Environ Int 87:74-84. 2016
    ..The data do not support airflow limitation effects. For ToCP, in view of the conservative approach adopted here and the rareness of reported incidents, the health risk of exposure to this compound in aircraft is considered negligible. ..
  5. doi request reprint Indoor air pollutants in office environments: assessment of comfort, health, and performance
    Peder Wolkoff
    National Research Centre for the Working Environment, Copenhagen, Denmark
    Int J Hyg Environ Health 216:371-94. 2013
    ....
  6. doi request reprint Human reference values for acute airway effects of five common ozone-initiated terpene reaction products in indoor air
    Peder Wolkoff
    National Research Centre for the Working Environment, Lersø Parkallé 105, DK 2100 Copenhagen Ø, Denmark
    Toxicol Lett 216:54-64. 2013
    ..3 ppm [corrected]would not result in airflow limitation. However, based upon the RFs for IPOH and 0.3 ppm [corrected], precautionary actions should be considered that disfavor their formation in excess...
  7. doi request reprint Airway effects of repeated exposures to ozone-initiated limonene oxidation products as model of indoor air mixtures
    Peder Wolkoff
    National Research Centre for the Working Environment, Denmark
    Toxicol Lett 209:166-72. 2012
    ..Bronchoalveolar lavage after exposures to ozone, and limonene with and without ozone, respectively, did not show airway inflammation...
  8. doi request reprint Problems of the "outer eyes" in the office environment: an ergophthalmologic approach
    Peder Wolkoff
    National Research Centre for the Working Environment, Copenhagen, Denmark
    J Occup Environ Med 54:621-31. 2012
    ..To assist health professionals dealing with the complex clinical picture of "outer" eye symptoms-among top-two in office environments--by an ergophthalmologic approach...
  9. doi request reprint Non-cancer effects of formaldehyde and relevance for setting an indoor air guideline
    Peder Wolkoff
    National Research Centre for the Working Environment, Lersø Parkallé 105, DK 2100 Copenhagen Ø, Denmark
    Environ Int 36:788-99. 2010
    ..An air quality guideline of 0.1 mg/m(3) (0.08 ppm) is considered protective against both acute and chronic sensory irritation in the airways in the general population assuming a log normal distribution of nasal sensory irritation...
  10. doi request reprint Ocular discomfort by environmental and personal risk factors altering the precorneal tear film
    Peder Wolkoff
    National Research Centre for the Working Environment, Lersø Parkallé 105, DK 2100 Copenhagen Ø, Denmark
    Toxicol Lett 199:203-12. 2010
    ....
  11. doi request reprint Acute airway effects of ozone-initiated d-limonene chemistry: importance of gaseous products
    Peder Wolkoff
    National Research Centre for the Working Environment, DK 2100 Copenhagen Ø, Denmark
    Toxicol Lett 181:171-6. 2008
    ..The result was statistically indistinguishable from clean dry air. It is concluded that ultrafine particles that are generated from ozone-initiated d-limonene chemistry and denuded are not causative of sensory effects in the airways...
  12. ncbi request reprint The dichotomy of relative humidity on indoor air quality
    Peder Wolkoff
    Indoor Environment Group, National Research Centre for the Working Environment, Lersø Parkallé 105, DK 2100 Copenhagen Ø, Denmark
    Environ Int 33:850-7. 2007
    ..Studies indicate that RH about 40% is better for the eyes and upper airways than levels below 30%. The optimal RH may differ for the eyes and the airways regarding desiccation of the mucous membranes...
  13. doi request reprint Adjuvant and inflammatory effects in mice after subchronic inhalation of allergen and ozone-initiated limonene reaction products
    Jitka Stilund Hansen
    a National Research Centre for the Working Environment, Copenhagen, Denmark
    J Toxicol Environ Health A 76:1085-95. 2013
    ..In conclusion, the study does not support an allergic inflammatory effect attributed to O3-initiated limonene reaction products in the indoor environment. ..
  14. doi request reprint Acute airway effects of airborne formaldehyde in sensitized and non-sensitized mice housed in a dry or humid environment
    Søren Thor Larsen
    The National Research Centre for the Working Environment, Lersø Parkallé 105, DK 2100 Copenhagen, Denmark
    Toxicol Appl Pharmacol 268:294-9. 2013
    ..8 and 4ppm FA. We speculate that increased mucus production in the OVA-sensitized mice has increased the "scrubber effect" in the nose, consequently protecting the conducting and lower airways...
  15. ncbi request reprint Upper airway irritation of terpene/ozone oxidation products (TOPS). Dependence on reaction time, relative humidity and initial ozone concentration
    Cornelius K Wilkins
    National Institute of Occupational Health, Lersø Parkallé 105, DK 2100 Ø, Copenhagen, Denmark
    Toxicol Lett 143:109-14. 2003
    ..5 ppm, irritation was at the same level as that for the pure terpenes, indicating that at 0.5 ppm ozone the combined irritant effect was near the no effect level for the product mixture...
  16. pmc Lung damage in mice after inhalation of nanofilm spray products: the role of perfluorination and free hydroxyl groups
    Asger W Nørgaard
    National Research Centre for the Working Environment, Copenhagen, Denmark
    Toxicol Sci 116:216-24. 2010
    ..The number of free hydroxyl groups in the silanes/alkylsiloxanes was also critical for the toxicity...
  17. doi request reprint Influence of temperature on the emission of di-(2-ethylhexyl)phthalate (DEHP) from PVC flooring in the emission cell FLEC
    Per Axel Clausen
    National Research Centre for the Working Environment, Lersø Parkallé 105, DK 2100 Copenhagen Ø, Denmark
    Environ Sci Technol 46:909-15. 2012
    ..The amount in the gas-phase increases by a factor of 24 with a corresponding decrease in the amount on the airborne particles...
  18. pmc Recent trend in risk assessment of formaldehyde exposures from indoor air
    Gunnar Damgård Nielsen
    National Research Centre for the Working Environment, Lersø Parkallé 105, 2100 Copenhagen, Denmark
    Arch Toxicol 87:73-98. 2013
    ..Reproductive and developmental toxicity are not considered relevant in the absence of sensory irritation. In conclusion, the WHO guideline has been strengthened...
  19. ncbi request reprint Mechanisms of acute inhalation effects of (+) and (-)-alpha-pinene in BALB/c mice
    Gunnar Damgård Nielsen
    National Institute of Occupational Health Denmark, Lersø Parkallé 105, DK 2100 Copenhagen O, Denmark
    Basic Clin Pharmacol Toxicol 96:420-8. 2005
    ..Overall, the enantiomers showed different time-dependent and stereoselective effects. The lower sensory irritation effect of the (-) enantiomer probably being due to less of the molecule being adsorbed to a sensory irritant receptor...
  20. ncbi request reprint The effect on human eye blink frequency of exposure to limonene oxidation products and methacrolein
    Jacob Klenø Nøjgaard
    National Institute of Occupational Health, Lersø Parkallé 105, DK 2100 Copenhagen Ø, Denmark
    Toxicol Lett 156:241-51. 2005
    ..LOPs may cause trigeminal stimulation and possibly eye irritation at O3 and limonene concentrations, which are close to high-end values measured in indoor settings. The effects may be exacerbated by low RH...
  21. ncbi request reprint Changes in eye blink frequency as a measure of trigeminal stimulation by exposure to limonene oxidation products, isoprene oxidation products and nitrate radicals
    Jacob Klenø
    National Institute of Occupational Health, Lersø Parkallé 105, 2100, Copenhagen, Denmark
    Int Arch Occup Environ Health 77:235-43. 2004
    ..Human subjects were exposed to oxidation mixtures representative of reactive indoor pollutants and clean air, from which relative changes in blink frequencies were measured...
  22. doi request reprint Formation and stability of secondary ozonides from monoterpenes studied by mass spectrometry
    Anni Vibenholt
    National Research Centre for the Working Environment, Lersø Parkallé 105, DK 2100 Copenhagen Ø, Denmark
    Chemosphere 76:572-7. 2009
    ..LimoneneSOZ and 3-careneSOZ were found to be more stable than 4-careneSOZ and isolimoneneSOZ, which corresponded well to their relative yields. 3-careneSOZ was found to be a major product from the gas-phase ozonolysis...
  23. pmc Cancer effects of formaldehyde: a proposal for an indoor air guideline value
    Gunnar Damgård Nielsen
    National Research Centre for the Working Environment, Lersø Parkallé 105, 2100, Copenhagen Ø, Denmark
    Arch Toxicol 84:423-46. 2010
    ..World Health Organization, Regional Office for Europe, Copenhagen, pp 87-91, 2000), 0.08 ppm (0.1 mg m(-3)) formaldehyde, is considered preventive of carcinogenic effects in compliance with epidemiological findings...
  24. ncbi request reprint Limonene and its ozone-initiated reaction products attenuate allergic lung inflammation in mice
    Jitka S Hansen
    a The National Research Centre for the Working Environment, Copenhagen, Denmark
    J Immunotoxicol 13:793-803. 2016
    ..In contrast, anti-inflammatory properties of the tested limonene-containing pollutants might attenuate airway allergy...
  25. ncbi request reprint Emission of di-2-ethylhexyl phthalate from PVC flooring into air and uptake in dust: emission and sorption experiments in FLEC and CLIMPAQ
    Per Axel Clausen
    National Institute of Occupational Health, Lersø Parkallé 105, DK 2100 Copenhagen O, Denmark
    Environ Sci Technol 38:2531-7. 2004
    ..About one-half of the emitted DEHP was deposited on the internal surfaces of both the FLEC and the CLIMPAQ...
  26. doi request reprint Nebulization ionization and desorption ionization analysis of reactive organofunctionalized silanes in nanofilm products
    Asger W Nørgaard
    The National Research Centre for the Working Environment, Copenhagen, Denmark
    J Mass Spectrom 46:402-10. 2011
    ..The applicabilities of each of the ionization techniques were examined, showing the advantage of utilizing more than one ionization technique for the analysis of reactive species...
  27. doi request reprint Study of ozone-initiated limonene reaction products by low temperature plasma ionization mass spectrometry
    Asger W Nørgaard
    The National Research Centre for the Working Environment, 2100, Copenhagen, Denmark
    J Am Soc Mass Spectrom 24:1090-6. 2013
    ..The use of LTP for in situ ozonolysis and ionization represents a new and versatile approach for the assessment of ozone-initiated terpene chemistry...
  28. ncbi request reprint Degradation of the adsorbent Tenax TA by nitrogen oxides, ozone, hydrogen peroxide, OH radical, and limonene oxidation products
    Jacob G Klenø
    Department of Indoor Climate, National Institute of Occupational Health, Lersø Parkallø 105, DK 2100 Copenhagen Ø, Denmark
    Environ Sci Technol 36:4121-6. 2002
    ..Nitrogen dioxide and the hydroxyl radical behave almost identically and produce 2,6-diphenyl-p-benzoquinone as the major degradation product. Reactant specific degradation products were identified for ozone (11) and nitrogen dioxide (1)...
  29. ncbi request reprint Eye irritation and environmental factors in the office environment--hypotheses, causes and a physiological model
    Peder Wolkoff
    Department of Indoor Climate, National Institute of Occupational Health, Copenhagen, Denmark
    Scand J Work Environ Health 29:411-30. 2003
    ..Personal factors (eg, use of contact lenses, eye make-up, and certain medication) may also affect destabilization of the tear film and possibly result in more eye symptoms...
  30. ncbi request reprint Sensory irritation: risk assessment approaches
    Gunnar Damgård Nielsen
    National Research Centre for the Working Environment, Copenhage Ø, Denmark
    Regul Toxicol Pharmacol 48:6-18. 2007
    ..In published studies, the combined UF is up to 300, highlighting the need of evidence-based UFs. Combined effects of sensory irritants can be considered additive as a first approximation...
  31. pmc Generation and Characterization of Indoor Fungal Aerosols for Inhalation Studies
    Anne Mette Madsen
    The National Research Centre for the Working Environment, Copenhagen, Denmark
    Appl Environ Microbiol 82:2479-93. 2016
    ..The inhalation-exposure system can be used to study responses to indoor fungi associated with water damage and the importance of fungal species composition...
  32. doi request reprint Gas chromatography interfaced with atmospheric pressure ionization-quadrupole time-of-flight-mass spectrometry by low-temperature plasma ionization
    Asger W Nørgaard
    The National Research Centre for the Working Environment, Copenhagen, Denmark
    Anal Chem 85:28-32. 2013
    ..The ion patterns seemed unique for each of the analyzed compound classes and can therefore be useful for identification of functional groups. A total of 20 different compounds within 8 functional groups were analyzed...
  33. pmc Re-evaluation of the WHO (2010) formaldehyde indoor air quality guideline for cancer risk assessment
    Gunnar Damgård Nielsen
    National Research Centre for the Working Environment, Lersø Parkallé 105, 2100, Copenhagen, Denmark
    Arch Toxicol 91:35-61. 2017
    ..6 mg/m3 and at peak exposures ≥2.5 mg/m3; both levels are above the WHO guideline. Overall, the credibility of the WHO guideline has not been challenged by new studies...
  34. doi request reprint Ozone reaction characteristics of indoor floor dust examined in the emission cell "FLEC"
    Anni Vibenholt
    National Research Centre for the Working Environment, Copenhagen, Denmark Electronic address
    Chemosphere 107:230-9. 2014
    ..Substantial increase of C7-C9 aldehydes was observed after ozone exposure...
  35. doi request reprint Ocular surface area and human eye blink frequency during VDU work: the effect of monitor position and task
    Pernille Kofoed Nielsen
    Performance and Pain Physiology Research Group, National Research Centre for the Working Environment, Lersø Parkallé 105, 2100 Copenhagen Ø, Denmark
    Eur J Appl Physiol 103:1-7. 2008
    ..This stresses that interchange of work tasks with different cognitive load is as important as the monitor position in the prevention of visual and musculoskeletal disorders...
  36. doi request reprint Characterization of nanofilm spray products by mass spectrometry
    Asger W Nørgaard
    The National Research Centre for the Working Environment, Lersø Parkallé 105, 2100 København Ø, Denmark
    Chemosphere 80:1377-86. 2010
    ..After about 1month in acidic 2-propanol substitution of the ethoxy groups with isopropoxy groups had taken place and all silane was converted to disiloxanes, trisiloxanes and tetrasiloxanes...
  37. ncbi request reprint Secondary ozonides of substituted cyclohexenes: a new class of pollutants characterized by collision-induced dissociation mass spectrometry using negative chemical ionization
    Asger W Nørgaard
    Indoor Environment Group, National Research Centre for the Working Environment, Lersø Parkallé 105, DK 2100 Copenhagen Ø, Denmark
    Chemosphere 70:2032-8. 2008
    ..Thus, negative CI-MS-MS in combination with rapid gas chromatography is the preferred method for identification of secondary ozonides of cyclohexenes...
  38. ncbi request reprint Linear alkylbenzene sulfonates in indoor floor dust
    Karl Ventzel Vejrup
    National Institute of Occupational Health, Department of Indoor Climate, Lersø Parkallé 105, DK 2100 Copenhagen, Denmark
    Sci Total Environ 300:51-8. 2002
    ..Thus, a newly washed shirt contained 2,960 microg LAS g(-1) clothing. The analysis of the office dust samples indicated that LAS (and probably other detergents) might be of importance for the indoor environment...
  39. ncbi request reprint Are we ready for indoor air pollution indices?
    Peder Wolkoff
    National Institute of Occupational Health, Denmark
    Indoor Air 13:371-2; discussion 373-6. 2003
  40. ncbi request reprint Upper airway and pulmonary effects of oxidation products of (+)-alpha-pinene, d-limonene, and isoprene in BALB/c mice
    Annette C Rohr
    EPRI, 3412 Hillview Ave, Palo Alto, CA 94304 1395, USA
    Inhal Toxicol 14:663-84. 2002
    ..This may be important in the context of the etiology or exacerbation of lower airway symptoms in office workers, or of occupational asthma in workers involved in industrial cleaning operations...
  41. ncbi request reprint [Does the modern office environment desiccate the eyes?]
    Peder Wolkoff
    Arbejdsmiljøinstituttet, Lersø Parkallé 105, DK 2100 København Ø
    Ugeskr Laeger 168:3893-6. 2006
    ..For this reason, it is important to plan the workplace and work schedule in such a way to maintain a normal eye blink frequency to minimise alterations of the precorneal tear film...