Ulla Vogel

Summary

Affiliation: National Research Centre for the Working Environment
Country: Denmark

Publications

  1. pmc Interaction between interleukin-10 (IL-10) polymorphisms and dietary fibre in relation to risk of colorectal cancer in a Danish case-cohort study
    Vibeke Andersen
    Medical Department, SHS Aabenraa, Aabenraa, Denmark
    BMC Cancer 12:183. 2012
  2. pmc Carbon black nanoparticle instillation induces sustained inflammation and genotoxicity in mouse lung and liver
    Julie A Bourdon
    Health Canada, Environmental and Radiation Health Sciences Directorate, Mechanistic Studies Division, Tunney s Pasture, Ottawa, Canada
    Part Fibre Toxicol 9:5. 2012
  3. ncbi request reprint Prospective study of interaction between alcohol, NSAID use and polymorphisms in genes involved in the inflammatory response in relation to risk of colorectal cancer
    Ulla Vogel
    National Research Centre for the Working Environment, Copenhagen, Denmark
    Mutat Res 624:88-100. 2007
  4. pmc The NFKB1 ATTG ins/del polymorphism and risk of coronary heart disease in three independent populations
    Ulla Vogel
    National Research Centre for the Working Environment, Copenhagen, Denmark
    Atherosclerosis 219:200-4. 2011
  5. ncbi request reprint Polymorphisms in COX-2, NSAID use and risk of basal cell carcinoma in a prospective study of Danes
    Ulla Vogel
    National Research Centre for Working Environment, DK 2100 Copenhagen O, Denmark
    Mutat Res 617:138-46. 2007
  6. doi request reprint Polymorphisms in genes involved in the inflammatory response and interaction with NSAID use or smoking in relation to lung cancer risk in a prospective study
    Ulla Vogel
    National Research Centre for the Working Environment, DK 2100 Copenhagen O, Denmark
    Mutat Res 639:89-100. 2008
  7. pmc Modest effect on plaque progression and vasodilatory function in atherosclerosis-prone mice exposed to nanosized TiO(2)
    Lone Mikkelsen
    Department of Public Health, University of Copenhagen, 1014 Copenhagen K, Denmark
    Part Fibre Toxicol 8:32. 2011
  8. pmc Distribution of silver in rats following 28 days of repeated oral exposure to silver nanoparticles or silver acetate
    Katrin Loeschner
    Division of Food Chemistry, National Food Institute, Technical University of Denmark, Søborg, Denmark
    Part Fibre Toxicol 8:18. 2011
  9. pmc Kupffer cells are central in the removal of nanoparticles from the organism
    Evaldas Sadauskas
    Department of Neurobiology, Institute of Anatomy, University of Aarhus, Building 1233 1234, Wilhelm Meyers Alle, DK 8000 Aarhus C, Denmark
    Part Fibre Toxicol 4:10. 2007
  10. pmc Effects of prenatal exposure to diesel exhaust particles on postnatal development, behavior, genotoxicity and inflammation in mice
    Karin S Hougaard
    National Research Centre of the Working Environment, Lersø Parkallé 105, DK 2100 Copenhagen Ø, Denmark
    Part Fibre Toxicol 5:3. 2008

Detail Information

Publications82

  1. pmc Interaction between interleukin-10 (IL-10) polymorphisms and dietary fibre in relation to risk of colorectal cancer in a Danish case-cohort study
    Vibeke Andersen
    Medical Department, SHS Aabenraa, Aabenraa, Denmark
    BMC Cancer 12:183. 2012
    ..Diet and lifestyle may be linked to cancer through inflammation. Interleukin-10 (IL-10) is an anti-inflammatory cytokine. We wanted to test if dietary factors and IL10 polymorphisms interact in relation to colorectal carcinogenesis...
  2. pmc Carbon black nanoparticle instillation induces sustained inflammation and genotoxicity in mouse lung and liver
    Julie A Bourdon
    Health Canada, Environmental and Radiation Health Sciences Directorate, Mechanistic Studies Division, Tunney s Pasture, Ottawa, Canada
    Part Fibre Toxicol 9:5. 2012
    ..Widespread occupational exposure to carbon black nanoparticles (CBNPs) raises concerns over their safety. CBNPs are genotoxic in vitro but less is known about their genotoxicity in various organs in vivo...
  3. ncbi request reprint Prospective study of interaction between alcohol, NSAID use and polymorphisms in genes involved in the inflammatory response in relation to risk of colorectal cancer
    Ulla Vogel
    National Research Centre for the Working Environment, Copenhagen, Denmark
    Mutat Res 624:88-100. 2007
    ..02). Moreover, an interaction between DLG5 R30Q and NSAID use was found (P for interaction=0.02). Our results do not suggest that inborn variations in the inflammatory response play any major role in risk of colorectal cancer...
  4. pmc The NFKB1 ATTG ins/del polymorphism and risk of coronary heart disease in three independent populations
    Ulla Vogel
    National Research Centre for the Working Environment, Copenhagen, Denmark
    Atherosclerosis 219:200-4. 2011
    ..We aimed to investigate the association of the functional ATTG NFKB1 insertion/deletion variant with risk of CHD in three independent prospective studies of generally healthy men and women...
  5. ncbi request reprint Polymorphisms in COX-2, NSAID use and risk of basal cell carcinoma in a prospective study of Danes
    Ulla Vogel
    National Research Centre for Working Environment, DK 2100 Copenhagen O, Denmark
    Mutat Res 617:138-46. 2007
    ..While it cannot be ruled out that the present findings are due to chance, the results indicate that high COX-2 expression may increase risk of BCC while NSAID use may be protective...
  6. doi request reprint Polymorphisms in genes involved in the inflammatory response and interaction with NSAID use or smoking in relation to lung cancer risk in a prospective study
    Ulla Vogel
    National Research Centre for the Working Environment, DK 2100 Copenhagen O, Denmark
    Mutat Res 639:89-100. 2008
    ..p for interaction was 3 x 10(-6) for COX-2 A-1195G and 9 x 10(-5) for PPARgamma2 Pro(12)Ala. The results suggest that NSAID use may modify risk of lung cancer differently depending on the genotype...
  7. pmc Modest effect on plaque progression and vasodilatory function in atherosclerosis-prone mice exposed to nanosized TiO(2)
    Lone Mikkelsen
    Department of Public Health, University of Copenhagen, 1014 Copenhagen K, Denmark
    Part Fibre Toxicol 8:32. 2011
    ..There is growing evidence that exposure to small size particulate matter increases the risk of developing cardiovascular disease...
  8. pmc Distribution of silver in rats following 28 days of repeated oral exposure to silver nanoparticles or silver acetate
    Katrin Loeschner
    Division of Food Chemistry, National Food Institute, Technical University of Denmark, Søborg, Denmark
    Part Fibre Toxicol 8:18. 2011
    ..Oral administration is a relevant route of exposure because of the use of silver nanoparticles in products related to food and food contact materials...
  9. pmc Kupffer cells are central in the removal of nanoparticles from the organism
    Evaldas Sadauskas
    Department of Neurobiology, Institute of Anatomy, University of Aarhus, Building 1233 1234, Wilhelm Meyers Alle, DK 8000 Aarhus C, Denmark
    Part Fibre Toxicol 4:10. 2007
    ..Gold nanoparticles were chosen as a model because these particles have been found to be chemically inert and at the same time are easily traced by autometallography (AMG) at both ultrastructural and light microscopic levels...
  10. pmc Effects of prenatal exposure to diesel exhaust particles on postnatal development, behavior, genotoxicity and inflammation in mice
    Karin S Hougaard
    National Research Centre of the Working Environment, Lersø Parkallé 105, DK 2100 Copenhagen Ø, Denmark
    Part Fibre Toxicol 5:3. 2008
    ..Pregnant mice (C57BL/6; BomTac) were exposed to 19 mg/m3 DEP (~1.106 particles/cm3; mass median diameter congruent with 240 nm) on gestational days 9-19, for 1 h/day...
  11. pmc Assessment of heterogeneity between European Populations: a Baltic and Danish replication case-control study of SNPs from a recent European ulcerative colitis genome wide association study
    Vibeke Andersen
    Medical Department, Viborg Regional Hospital, Denmark
    BMC Med Genet 12:139. 2011
    ....
  12. pmc Polymorphisms in NFkB, PXR, LXR and risk of colorectal cancer in a prospective study of Danes
    Vibeke Andersen
    Medical Department, Viborg Regional Hospital, Heibergs Alle 4, DK 8800 Viborg, Denmark
    BMC Cancer 10:484. 2010
    ....
  13. pmc The INSIG2 rs7566605 polymorphism is not associated with body mass index and breast cancer risk
    Daniele Campa
    German Cancer Research Center DKFZ, Heidelberg, Germany
    BMC Cancer 10:563. 2010
    ..BMI is considered to be one of the measures of choice to evaluate body fatness and there is evidence that body fatness is related with an increased risk of breast cancer (BC)...
  14. pmc No influence of the polymorphisms CYP2C19 and CYP2D6 on the efficacy of cyclophosphamide, thalidomide, and bortezomib in patients with Multiple Myeloma
    Annette J Vangsted
    Dept of Oncology and Haematology, Roskilde Hospital, Copenhagen University, DK 4000 Roskilde, Denmark
    BMC Cancer 10:404. 2010
    ..We explored the potential influence of different polymorphisms in the CYP enzymes on the outcome of treatment...
  15. ncbi request reprint Repeated inhalations of diesel exhaust particles and oxidatively damaged DNA in young oxoguanine DNA glycosylase (OGG1) deficient mice
    Lotte Risom
    Department of Occupational and Environmental Health, Institute of Public Health, University of Copenhagen, Copenhagen, Denmark
    Free Radic Res 41:172-81. 2007
    ..In conclusion, Ogg1-/- mice have elevated pulmonary levels of FPG sites and accumulate genomic 8-oxodG after repeated inhalations of DEP...
  16. pmc A haplotype of polymorphisms in ASE-1, RAI and ERCC1 and the effects of tobacco smoking and alcohol consumption on risk of colorectal cancer: a Danish prospective case-cohort study
    Rikke D Hansen
    National Research Centre for the Working Environment, Lersø Parkallé 105, 2100 Copenhagen, Denmark
    BMC Cancer 8:54. 2008
    ....
  17. ncbi request reprint XPA A23G, XPC Lys939Gln, XPD Lys751Gln and XPD Asp312Asn polymorphisms, interactions with smoking, alcohol and dietary factors, and risk of colorectal cancer
    Rikke Dalgaard Hansen
    National Research Centre for the Working Environment, Lersø Parkallé 105, 2100 Copenhagen, Denmark
    Mutat Res 619:68-80. 2007
    ..Overall, the results of the present study indicate that the four polymorphisms are not of major importance in colorectal cancer carcinogenesis...
  18. ncbi request reprint OGG1 expression and OGG1 Ser326Cys polymorphism and risk of lung cancer in a prospective study
    Lotte Hatt
    Institute of Public Health, Department of Environmental Health, Copenhagen, Denmark
    Mutat Res 639:45-54. 2008
    ..The results suggest that OGG1 mRNA levels should be regarded as a biomarker of exposure to oxidative stress with induction of DNA rather than a marker of inborn DNA repair capacity...
  19. pmc Pulmonary exposure to carbon black by inhalation or instillation in pregnant mice: effects on liver DNA strand breaks in dams and offspring
    Petra Jackson
    National Research Centre for the Working Environment, Copenhagen, Denmark
    Nanotoxicology 6:486-500. 2012
    ..Neither inhalation nor instillation affected gestation and lactation. Maternal inhalation exposure to Printex 90-induced liver DNA damage in the mothers and the in utero exposed offspring...
  20. doi request reprint Inflammatory and genotoxic effects of sanding dust generated from nanoparticle-containing paints and lacquers
    Anne Thoustrup Saber
    The National Research Centre for the Working Environment, Lersø Parkallé 105, DK 2100 Copenhagen, Denmark
    Nanotoxicology 6:776-88. 2012
    ....
  21. ncbi request reprint Effect of increased intake of dietary animal fat and fat energy on oxidative damage, mutation frequency, DNA adduct level and DNA repair in rat colon and liver
    Ulla Vogel
    National Institute of Occupational Health, Lersø Parkallé 105, DK 2100, Copenhagen, Denmark
    Free Radic Res 37:947-56. 2003
    ....
  22. doi request reprint Lifestyle, environmental, and genetic predictors of bulky DNA adducts in a study population nested within a prospective Danish cohort
    Kirsten Thorup Eriksen
    Danish Cancer Society, Institute of Cancer Epidemiology, Copenhagen, Denmark
    J Toxicol Environ Health A 73:583-95. 2010
    ..Overall, our study showed only few associations between dietary, environmental, and genetic factors and levels of bulky DNA adducts measured in peripheral leukocytes in a general Danish population...
  23. ncbi request reprint DNA damage in rats after a single oral exposure to diesel exhaust particles
    Pernille Høgh Danielsen
    Institute of Public Health, Department of Occupational and Environmental Health, University of Copenhagen, Copenhagen, Denmark
    Mutat Res 637:49-55. 2008
    ..The oral exposure route should be taken into account in risk assessment of particulate matter...
  24. doi request reprint Inflammatory and genotoxic effects of nanoparticles designed for inclusion in paints and lacquers
    Anne Thoustrup Saber
    The National Research Centre for the Working Environment, Copenhagen, Denmark
    Nanotoxicology 6:453-71. 2012
    ..The uncoated titanium dioxide was not DNA damaging by the comet assay 24 h after exposure despite being highly inflammogenic. This suggests that inflammation is not a prerequisite to DNA damage in titanium dioxide-based products...
  25. ncbi request reprint Dietary elevated sucrose modulation of diesel-induced genotoxicity in the colon and liver of Big Blue rats
    Lotte Risom
    Institute of Public Health c o Department of Pharmacology, University of Copenhagen, Blegdamsvej 3, 2200, Copenhagen, Denmark
    Arch Toxicol 77:651-6. 2003
    ..In conclusion, sucrose feeding did not increase DEP-induced DNA damage in colon or liver...
  26. doi request reprint Maternal inhalation of surface-coated nanosized titanium dioxide (UV-Titan) in C57BL/6 mice: effects in prenatally exposed offspring on hepatic DNA damage and gene expression
    Petra Jackson
    National Research Centre for the Working Environment, DK 2100 Copenhagen Ø, Denmark
    Nanotoxicology 7:85-96. 2013
    ..Changes may be a secondary response to maternal inflammation although no direct link was evident through gene expression analysis...
  27. ncbi request reprint Effect of polymorphisms in XPD, RAI, ASE-1 and ERCC1 on the risk of basal cell carcinoma among Caucasians after age 50
    Ulla Vogel
    National Institute of Occupational Health, DK 2100 Copenhagen O, Denmark
    Cancer Detect Prev 29:209-14. 2005
    ..While it cannot be ruled out that the present findings are due to chance, the present results are consistent with previous findings that XPD Arg156Arg is a weak risk factor for basal cell carcinoma...
  28. ncbi request reprint X-ray-induced oxidative stress: DNA damage and gene expression of HO-1, ERCC1 and OGG1 in mouse lung
    Lotte Risom
    Institute of Public Health, University of Copenhagen, Blegdamsvej 3, DK 2200, Copenhagen, Denmark
    Free Radic Res 37:957-66. 2003
    ..In conclusion, this study shows the feasibility of partial-body X-ray irradiation as an in vivo model for induction and repair of oxidative DNA damage, and expression of relevant DNA repair and antioxidant defense genes...
  29. ncbi request reprint Peroxisome proliferator-activated [corrected] receptor-gamma2 [corrected] Pro12Ala, interaction with alcohol intake and NSAID use, in relation to risk of breast cancer in a prospective study of Danes
    Ulla Vogel
    National Institute of Occupational Health, Copenhagen, Denmark
    Carcinogenesis 28:427-34. 2007
    ..We also observe interaction between NSAID, alcohol consumption and PPARgamma2 Pro12Ala genotype in relation to breast cancer risk...
  30. doi request reprint Association between 8-oxo-7,8-dihydroguanine excretion and risk of lung cancer in a prospective study
    Steffen Loft
    Department of Public Health, Section of Environmental Health, University of Copenhagen, Copenhagen, Denmark
    Free Radic Biol Med 52:167-72. 2012
    ..14 (0.98-1.34) among subjects homozygous for Cys326. The association between urinary 8-oxoGua excretion and lung cancer risk among former and never-smokers suggests that oxidative stress with damage to DNA is important in this group...
  31. pmc Particle-induced pulmonary acute phase response correlates with neutrophil influx linking inhaled particles and cardiovascular risk
    Anne Thoustrup Saber
    The National Research Centre for the Working Environment, Copenhagen, Denmark
    PLoS ONE 8:e69020. 2013
    ..Acute phase response is causally linked to cardiovascular disease. Here, we propose that particle-induced pulmonary acute phase response provides an underlying mechanism for particle-induced cardiovascular risk...
  32. pmc Nanotitanium dioxide toxicity in mouse lung is reduced in sanding dust from paint
    Anne Thoustrup Saber
    The National Research Centre for the Working Environment, Lersø Parkallé 105, Copenhagen, Denmark
    Part Fibre Toxicol 9:4. 2012
    ..We compared the toxic effects of the titanium dioxide nanoparticle UV-Titan L181 (NanoTiO2), pure or embedded in a paint matrix. We also compared the effects of the same paint with and without NanoTiO2...
  33. doi request reprint Mutation spectrum in FE1-MUTA(TM) Mouse lung epithelial cells exposed to nanoparticulate carbon black
    Nicklas Raun Jacobsen
    National Research Centre for the Working Environment, Lersø Parkallé 105, DK 2100 Copenhagen Ø, Denmark
    Environ Mol Mutagen 52:331-7. 2011
    ....
  34. ncbi request reprint Combinations of polymorphisms in XPD, XPC and XPA in relation to risk of lung cancer
    Ulla Vogel
    National Institute of Occupational Health, Lersoe Parkalle 105, DK 2100 Copenhagen O, Denmark
    Cancer Lett 222:67-74. 2005
    ..We found that XPA A23G and XPC Lys939Gln polymorphisms may be risk factors for lung cancer and evidence that positive interactions between the polymorphisms in XPA/XPD and XPC/XPD may occur...
  35. ncbi request reprint No association between base excision repair gene polymorphisms and risk of lung cancer
    Ulla Vogel
    National Institute of Occupational Health, Copenhagen, Denmark
    Biochem Genet 42:453-60. 2004
    ..This is the first study of polymorphisms in base excision repair genes in relation to lung cancer among Danes...
  36. pmc Validation of freezing tissues and cells for analysis of DNA strand break levels by comet assay
    Petra Jackson
    National Research Centre for the Working Environment, Lersø Parkallé 105, Copenhagen Ø DK 2100, Denmark
    Mutagenesis 28:699-707. 2013
    ..The use of frozen tissues; however, requires great care during preparation before analysis, with handling as a major risk factor. ..
  37. doi request reprint Exposure of pregnant mice to carbon black by intratracheal instillation: toxicogenomic effects in dams and offspring
    Petra Jackson
    National Research Centre for the Working Environment, Copenhagen DK 2100, Denmark
    Mutat Res 745:73-83. 2012
    ..Further investigation is required to determine the long-term health consequences of the gene expression changes in offspring and response to environmental stresses...
  38. ncbi request reprint Tumor necrosis factor is not required for particle-induced genotoxicity and pulmonary inflammation
    Anne T Saber
    National Institute of Occupational Health, Lersø Parkallé 105, 2100, Copenhagen, Denmark
    Arch Toxicol 79:177-82. 2005
    ..The data indicate that an inflammatory response was not a prerequisite for DNA damage, and TNF was not required for the induction of inflammation by DEP and CB particles...
  39. ncbi request reprint Interactions between the OGG1 Ser326Cys polymorphism and intake of fruit and vegetables in relation to lung cancer
    Mette Sørensen
    Institute of Cancer Epidemiology, Danish Cancer Society, Strandboulevarden 49, 2100, Copenhagen, Denmark
    Free Radic Res 40:885-91. 2006
    ..The same tendency was seen in relation to intake of fruit. There were no statistically significant interactions between the OGG1 polymorphism and smoking...
  40. ncbi request reprint Mutagenicity of carbon nanomaterials
    Hakan Wallin
    National Research Centre for the Working Environment, Copenhagen 2100, Denmark
    J Biomed Nanotechnol 7:29. 2011
    ....
  41. ncbi request reprint Bulky DNA adducts as risk indicator of lung cancer in a Danish case-cohort study
    Helle Bak
    Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark
    Int J Cancer 118:1618-22. 2006
    ..Our results indicate that bulky DNA adducts may have a weak association with lung cancer risk...
  42. doi request reprint Diesel exhaust particles are mutagenic in FE1-MutaMouse lung epithelial cells
    Nicklas Raun Jacobsen
    National Research Centre for the Working Environment, Lersø Parkallé 105, DK 2100 Copenhagen Ø, Denmark
    Mutat Res 641:54-7. 2008
    ....
  43. doi request reprint Effects of lung exposure to carbon nanotubes on female fertility and pregnancy. A study in mice
    Karin S Hougaard
    National Research Centre for the Working Environment, Copenhagen Ø, Denmark
    Reprod Toxicol 41:86-97. 2013
    ..Exposure was not associated with changes in the assessed gestational or offspring parameters. ..
  44. doi request reprint Daily sperm production: application in studies of prenatal exposure to nanoparticles in mice
    Zdenka Orabi Kyjovska
    National Research Centre for the Working Environment, Lersø Parkallé 105, DK 2100 Copenhagen Ø, Denmark
    Reprod Toxicol 36:88-97. 2013
    ..F2 offspring, whose fathers were prenatally exposed to Printex90, showed lowered sperm production. Furthermore, we report statistically significant differences in sperm production between mouse strains...
  45. doi request reprint Prenatal exposure to carbon black (printex 90): effects on sexual development and neurofunction
    Petra Jackson
    National Research Centre for the Working Environment, Copenhagen, Denmark
    Basic Clin Pharmacol Toxicol 109:434-7. 2011
    ..The female offspring prenatally exposed to 268 μg Printex 90/animal displayed altered habituation pattern during the Open field test...
  46. ncbi request reprint Inflammatory response and genotoxicity of seven wood dusts in the human epithelial cell line A549
    Jette Bornholdt
    National Research Centre for the Working Environment, Lersø Park Alle 105, DK 2100 Copenhagen, Denmark
    Mutat Res 632:78-88. 2007
    ..Although hardwoods are often considered more harmful than softwoods by regulatory agencies, the current experiments do not provide evidence for a clear-cut distinction between toxicities of hardwood and softwood dust...
  47. doi request reprint An experimental protocol for maternal pulmonary exposure in developmental toxicology
    Petra Jackson
    National Research Centre for the Working Environment, Lersø Parkallé 105, Copenhagen Ø, Denmark
    Basic Clin Pharmacol Toxicol 108:202-7. 2011
    ..We suggest that this procedure can be used as a means of exposure through the airways in studies of developmental toxicity...
  48. ncbi request reprint Two regions in chromosome 19q13.2-3 are associated with risk of lung cancer
    Ulla Vogel
    National Institute of Occupational Health, DK 2100 Copenhagen O, Denmark
    Mutat Res 546:65-74. 2004
    ..We found no interaction between genotypes and duration of smoking. In conclusion, two regions of chromosome 19q13.2-3 seem to be associated with risk of lung cancer...
  49. doi request reprint Polymorphisms in inflammation genes, tobacco smoke and furred pets and wheeze in children
    Mette Sørensen
    Institute of Cancer Epidemiology, Danish Cancer Society, Strandboulevarden, Copenhagen, Denmark
    Pediatr Allergy Immunol 20:614-23. 2009
    ..Polymorphisms in IL-8 affected the association between pet-keeping and risk of wheeze. Polymorphisms in inflammation genes might affect the association between environmental exposures and risk of recurrent wheeze in early childhood...
  50. ncbi request reprint Inflammation but no DNA (deoxyribonucleic acid) damage in mice exposed to airborne dust from a biofuel plant
    Anne Mette Madsen
    National Research Centre for the Working Environment, Lersø Parkallé 105, Copenhagen, Denmark
    Scand J Work Environ Health 34:278-7. 2008
    ..This study investigated whether exposure to dust from biofuel plants induces DNA (deoxyribonucleic acid) damage and inflammation in exposed mice...
  51. doi request reprint In utero exposure to nanosized carbon black (Printex90) does not induce tandem repeat mutations in female murine germ cells
    Anne Mette Zenner Boisen
    National Research Centre for the Working Environment, DK 2100 Copenhagen, Denmark
    Reprod Toxicol 41:45-8. 2013
    ..ESTR mutation rates in CB-exposed F2 female offspring were not statistically different from those of F2 female control offspring. ..
  52. pmc NanoTIO(2) (UV-Titan) does not induce ESTR mutations in the germline of prenatally exposed female mice
    Anne Mette Zenner Boisen
    The National Research Centre for the Working Environment, Copenhagen, Denmark
    Part Fibre Toxicol 9:19. 2012
    ..Here we investigate the effects of nanoparticles on the female germline. Since pulmonary exposure to nanosized titanium dioxide (nanoTiO(2)) produces a long-lasting inflammatory response in mice, it was chosen for the present study...
  53. ncbi request reprint DNA adduct formation and oxidative stress in colon and liver of Big Blue rats after dietary exposure to diesel particles
    Marianne Dybdahl
    Department of Chemical Work Environment, National Institute of Occupational Health, Copenhagen, Denmark
    Carcinogenesis 24:1759-66. 2003
    ....
  54. doi request reprint Alcohol drinking habits, alcohol dehydrogenase genotypes and risk of acute coronary syndrome
    Janne S Tolstrup
    Center for Alcohol Research, National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark
    Scand J Public Health 38:489-94. 2010
    ..We aimed to test this hypothesis, including alcohol as both the amount of alcohol and the frequency of drinking...
  55. doi request reprint Interaction between ADH1C Arg(272)Gln and alcohol intake in relation to breast cancer risk suggests that ethanol is the causal factor in alcohol related breast cancer
    Signe Benzon Larsen
    National Research Centre for the Working Environment, Copenhagen, Denmark
    Cancer Lett 295:191-7. 2010
    ..04-1.24) per 10g alcohol/day, but not among homozygous wild type carriers (p for interaction=0.06). Thus, slow oxidation of ethanol seemed to be associated with breast cancer risk...
  56. doi request reprint Nonsteroidal anti-inflammatory drug use and breast cancer risk: a Danish cohort study
    Søren Friis
    Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark
    Eur J Cancer Prev 17:88-96. 2008
    ..The increased breast cancer incidence among NSAID users may reflect a noncausal association, but our study provides no evidence of a chemopreventive effect of NSAIDs against breast cancer over the durations studied...
  57. ncbi request reprint GPX Pro198Leu and OGG1 Ser326Cys polymorphisms and risk of development of colorectal adenomas and colorectal cancer
    Rikke Hansen
    National Institute of Occupational Health, Copenhagen, Denmark
    Cancer Lett 229:85-91. 2005
    ..56 (95% confidence interval 0.33-0.95), while no association were found with risk of adenomas. This indicates that a low repair capacity of oxidative DNA damage may not be a risk factor for development of colorectal adenomas or carcinoma...
  58. pmc Genetic Variations in Pattern Recognition Receptor Loci Are Associated with Anti-TNF Response in Patients with Rheumatoid Arthritis
    Jacob Sode
    Department of Autoimmunology and Biomarkers, Statens Serum Institut, Copenhagen, Denmark Department of Rheumatology, Frederiksberg Hospital, Frederiksberg, Denmark Institute of Regional Health Research Center Sønderjylland, University of Southern Denmark, Odense, Denmark OPEN Odense Patient Data Explorative Network, Odense University Hospital, Odense, Denmark
    PLoS ONE 10:e0139781. 2015
    ....
  59. pmc Particle-induced pulmonary acute phase response may be the causal link between particle inhalation and cardiovascular disease
    Anne T Saber
    National Research Centre for the Working Environment, Copenhagen, Denmark
    Wiley Interdiscip Rev Nanomed Nanobiotechnol 6:517-31. 2014
    ..We discuss the implications of these findings in relation to occupational exposure to nanoparticles...
  60. pmc Effects of prenatal exposure to surface-coated nanosized titanium dioxide (UV-Titan). A study in mice
    Karin S Hougaard
    National Research Centre for the Working Environment, Copenhagen Ø, Denmark
    Part Fibre Toxicol 7:16. 2010
    ..Consequently, also toxicological properties may change compared to the parent compound. We examined developmental and neurobehavioral effects following maternal exposure to a nanoparticulate UV-filter (UV-titan L181)...
  61. ncbi request reprint Increased mutant frequency by carbon black, but not quartz, in the lacZ and cII transgenes of muta mouse lung epithelial cells
    Nicklas Raun Jacobsen
    National Research Centre for the Working Environment, Lersø Parkallé 105, DK 2100 Copenhagen Ø, Denmark
    Environ Mol Mutagen 48:451-61. 2007
    ..More studies are essential for understanding the biological significance of these findings, and clearly documenting DNA sequence changes. The results do not necessarily imply that other carbonaceous nano materials are genotoxic...
  62. doi request reprint Biodistribution of Carbon Nanotubes in Animal Models
    Nicklas Raun Jacobsen
    The National Research Centre for the Working Environment, Copenhagen, Denmark
    Basic Clin Pharmacol Toxicol . 2016
    ..Overall, there is evidence that CNT will primarily be distributed to the liver where they appear to be present one year after exposure. This article is protected by copyright. All rights reserved...
  63. pmc Surface modification does not influence the genotoxic and inflammatory effects of TiO2 nanoparticles after pulmonary exposure by instillation in mice
    Hakan Wallin
    National Research Centre for the Working Environment, Lersø Parkallé 105, DK 2100 Copenhagen Ø, Denmark
    Mutagenesis 32:47-57. 2017
    ..In conclusion, functionalisation of reactive negatively charged rutile TiO2 to positively charged did not consistently influence pulmonary toxicity of the studied TiO2 NPs...
  64. doi request reprint DNA strand breaks, acute phase response and inflammation following pulmonary exposure by instillation to the diesel exhaust particle NIST1650b in mice
    Zdenka O Kyjovska
    National Research Centre for the Working Environment, Lersø Parkallé 105, DK 2100 Copenhagen Ø, Denmark
    Mutagenesis 30:499-507. 2015
    ..The observed long-term pulmonary genotoxicity by DEP was less than the previously observed genotoxicity for CB using identical experimental set-up. ..
  65. doi request reprint Physical-chemical and microbiological characterization, and mutagenic activity of airborne PM sampled in a biomass-fueled electrical production facility
    Corey A Cohn
    National Research Centre for the Working Environment, Copenhagen, Denmark
    Environ Mol Mutagen 52:319-30. 2011
    ..The results suggest that exposure to combustion PM in a biomass-fueled facility, which likely includes PM from biomass combustion as well as internal combustion vehicles, may contribute to an elevated risk of adverse health effects...
  66. doi request reprint The association of polymorphisms in 5-fluorouracil metabolism genes with outcome in adjuvant treatment of colorectal cancer
    Shoaib Afzal
    Rigshospitalet, Copenhagen, Denmark
    Pharmacogenomics 12:1257-67. 2011
    ..The purpose of this study was to investigate whether specific combinations of polymorphisms in 5-fluorouracil (5-FU) metabolism-related genes were associated with outcome in 5-FU-based adjuvant treatment of colorectal cancer...
  67. pmc Bioaccumulation and ecotoxicity of carbon nanotubes
    Petra Jackson
    National Research Centre for the Working Environment, Lersø Parkallé 105, Copenhagen Ø, DK 2100, Denmark
    Chem Cent J 7:154. 2013
    ..Studies have to include better characterization of the starting materials, of the dispersions and of the biological fate, to obtain better knowledge of the exposure/effect relationships. ..
  68. pmc DNA damage following pulmonary exposure by instillation to low doses of carbon black (Printex 90) nanoparticles in mice
    Zdenka O Kyjovska
    Danish Centre for Nanosafety, National Research Centre for the Working Environment, Copenhagen Ø, Denmark
    Environ Mol Mutagen 56:41-9. 2015
    ..We interpret the increased DNA strand breaks occurring following these low exposure doses of NPCB as DNA damage caused by primary genotoxicity in the absence of substantial inflammation, cell damage, and acute phase response...
  69. pmc K-ras mutations in sinonasal cancers in relation to wood dust exposure
    Jette Bornholdt
    National Research Centre for the Working Environment, Lersø Parkallé 105, DK 2100 Copenhagen, Denmark
    BMC Cancer 8:53. 2008
    ..In previous small studies of this cancer, ras mutations were suggested to be related to wood dust exposure, but these studies were too limited to detect statistically significant associations...
  70. doi request reprint Genetic variation in the hTAS2R38 taste receptor and brassica vegetable intake
    Nela Gorovic
    Laboratory of Clinical Pharmacology Q7642, Rigshospitalet, Department of Clinical Pharmacology, Copenhagen University Hospital, Bispebjerg, Copenhagen, Denmark
    Scand J Clin Lab Invest 71:274-9. 2011
    ..This indicates that non-genetic factors may have more influence on dietary choice than genetics...
  71. pmc No cytotoxicity or genotoxicity of graphene and graphene oxide in murine lung epithelial FE1 cells in vitro
    Stefan Bengtson
    National Research Centre for the Working Environment, Lersø Parkallé 105, DK 2100, Copenhagen Ø, Denmark
    Environ Mol Mutagen 57:469-82. 2016
    ..Environ. Mol. Mutagen. 57:469-482, 2016. © 2016 The Authors. Environmental and Molecular Mutagenesis Published by Wiley Periodicals, Inc. ..
  72. doi request reprint Characterization of genotoxic response to 15 multiwalled carbon nanotubes with variable physicochemical properties including surface functionalizations in the FE1-Muta(TM) mouse lung epithelial cell line
    Petra Jackson
    Danish Centre for Nanosafety, National Research Centre for the Working Environment, Copenhagen Ø, Denmark
    Environ Mol Mutagen 56:183-203. 2015
    ..Significantly, increased levels of SB were only observed at 200 µg/ml of MWCNT-042. Overall, the MWCNT were not cytotoxic and weakly genotoxic after 24 hr exposure to doses up to 200 µg/ml...
  73. pmc Lung inflammation and genotoxicity following pulmonary exposure to nanoparticles in ApoE-/- mice
    Nicklas Raun Jacobsen
    National Research Centre for the Working Environment, Lersø Parkallé 105, DK 2100 Copenhagen Ø, Denmark
    Part Fibre Toxicol 6:2. 2009
    ..Three and 24 h after pulmonary exposure, inflammation was assessed by mRNA levels of cytokines in lung tissue, cell composition, genotoxicity, protein and lactate dehydrogenase activity in broncho-alveolar lavage (BAL) fluid...
  74. pmc Lack of acute phase response in the livers of mice exposed to diesel exhaust particles or carbon black by inhalation
    Anne T Saber
    National Research Centre for the Working Environment, DK 2100 Copenhagen, Denmark
    Part Fibre Toxicol 6:12. 2009
    ..In this study we test the hypothesis that diesel exhaust particles (DEP) - or carbon black (CB)-induced lung inflammation initiates an acute phase response in the liver...
  75. doi request reprint PPARgamma-PGC-1alpha activity is determinant of alcohol related breast cancer
    Rasmus Koefoed Petersen
    Department of Biology, University of Copenhagen, Denmark
    Cancer Lett 315:59-68. 2012
    ..Our results suggest that PPARγ and PGC-1α activity is an important determinant of alcohol related breast cancer...
  76. pmc Transcriptomic analysis reveals novel mechanistic insight into murine biological responses to multi-walled carbon nanotubes in lungs and cultured lung epithelial cells
    Sarah Søs Poulsen
    National Research Centre for the Working Environment, Copenhagen, Denmark Department of Science, Systems and Models, Roskilde University, Roskilde, Denmark
    PLoS ONE 8:e80452. 2013
    ..Our results suggest that careful consideration should be given in selecting relevant endpoints when substituting animal with in vitro testing. ..
  77. doi request reprint Variation in the measurement of DNA damage by comet assay measured by the ECVAG inter-laboratory validation trial
    Lykke Forchhammer
    Department of Public Health, Section of Environmental Health, University of Copenhagen, Copenhagen, Denmark
    Mutagenesis 25:113-23. 2010
    ..In summary, adjustment of primary comet assay results by reference standards reduces inter-laboratory variation in the level of DNA damage measured by the alkaline version of the comet assay...
  78. pmc Intestinal PTGS2 mRNA levels, PTGS2 gene polymorphisms, and colorectal carcinogenesis
    Lotte K Vogel
    Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 9:e105254. 2014
    ..Prostaglandin synthase cyclooxygenase-2 (COX-2) encoded by the PTGS2 gene is the rate limiting enzyme in prostaglandin synthesis and therefore plays a distinct role as regulator of inflammation...
  79. doi request reprint Common variants in CYP2R1 and GC genes are both determinants of serum 25-hydroxyvitamin D concentrations after UVB irradiation and after consumption of vitamin D₃-fortified bread and milk during winter in Denmark
    Janna Nissen
    From the Divisions of Nutrition JN, KHM, RA, hm, and LBR and Toxicology and Risk Assessment GR H, Technical University of Denmark, Søborg, Denmark the Department of Applied Mathematics and Computer Science, Technical University of Denmark, Lyngby, Denmark EWA the National Research Centre for the Working Environment, Copenhagen, Denmark UV the Department of Biomedicine, Aarhus University, Aarhus, Denmark BAN the Clinical Biochemical Department, Holbæk Hospital, Holbæk, Denmark PJB and the Department of Dermatology, Copenhagen University Hospital, Bispebjerg, Copenhagen, Denmark HCW
    Am J Clin Nutr 101:218-27. 2015
    ....
  80. doi request reprint FADS single-nucleotide polymorphisms are associated with behavioral outcomes in children, and the effect varies between sexes and is dependent on PPAR genotype
    Heidi A R Jensen
    From the Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark HARJ, LBSH, MSN, LBC, CR, KFM, and LL, and the National Research Centre for the Working Environment, Copenhagen, Denmark UV
    Am J Clin Nutr 100:826-32. 2014
    ..Results regarding a potential programming effect on cognitive function and behavior in humans are inconclusive...
  81. pmc Anti-TNF treatment response in rheumatoid arthritis patients is associated with genetic variation in the NLRP3-inflammasome
    Jacob Sode
    Clinical Biochemistry, Immunology and Genetics, Statens Serum Institut, Copenhagen, Denmark Department of Rheumatology, Frederiksberg Hospital, Frederiksberg, Denmark Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark
    PLoS ONE 9:e100361. 2014
    ..The objective of this study was to replicate and extend previously found associations between anti-TNF treatment response and genetic variation in the TNF-, NF-κB- and pattern recognition receptor signalling pathways...
  82. ncbi request reprint Inhalation of ozone induces DNA strand breaks and inflammation in mice
    Jette Bornholdt
    National Institute of Occupational Health, Lersø Park Alle 105, DK 2100, Copenhagen, Denmark
    Mutat Res 520:63-71. 2002
    ..This was not reflected by an induction of mutations in the lung of Muta Mice...