- Aging and the human neocortexBente Pakkenberg
Research Laboratory for Stereology and Neuroscience, Bispebjerg Hospital, Bispebjerg Bakke, Copenhagen NV 2400, Denmark
Exp Gerontol 38:95-9. 2003..15 quadrillion). Although the effect of aging is seen in all estimated structural elements, the effect of sex is actually higher. The functional relevance of these differences in neuron numbers in both age and gender is not known...
- Communication among neuronsLisbeth Marner
PET and Cyclotron Unit, University Hospital of Copenhagen, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark
Dan Med J 59:B4427. 2012..Possible confounders are considered and the relation to the prevailing beta-amyloid hypothesis is discussed...
- Marked loss of myelinated nerve fibers in the human brain with ageLisbeth Marner
Research Laboratory for Stereology and Neuroscience, Bispebjerg Hospital, 2400 Copenhagen N, Denmark
J Comp Neurol 462:144-52. 2003..The marked loss of myelinated nerve fibers with age could explain some of the cognitive decline seen in the elderly...
- Total length of nerve fibers in prefrontal and global white matter of chronic schizophrenicsLisbeth Marner
Research Laboratory for Stereology and Neuroscience, Bispebjerg Hospital, Bispebjerg Bakke 23, 2400 Copenhagen N, Copenhagen, Denmark
J Psychiatr Res 37:539-47. 2003..Our results do not show a larger loss of nerve fibers in neither the white matter globally or in the prefrontal white matter of schizophrenics...
- Loss of serotonin 2A receptors exceeds loss of serotonergic projections in early Alzheimer's disease: a combined [11C]DASB and [18F]altanserin-PET studyLisbeth Marner
Neurobiology Research Unit, The Neuroscience Centre, Copenhagen, Denmark Center for Integrated Molecular Brain Imaging, Copenhagen, Denmark
Neurobiol Aging 33:479-87. 2012..0005). No change in [(11)C]DASB binding was found in the midbrain. We conclude that the prominent reduction in neocortical 5-HT(2A) receptor binding in early AD is not caused by a primary loss of serotonergic neurons or their projections...
- Age and sex effects on 5-HT(4) receptors in the human brain: a [(11)C]SB207145 PET studyKarine Madsen
Neurobiology Research Unit, Department of Neurology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark
J Cereb Blood Flow Metab 31:1475-81. 2011..The relatively stable 5-HT(4) receptor binding with aging contrasts others in subtypes of receptors, which generally decrease with aging...
- The 5-HT4 receptor levels in hippocampus correlates inversely with memory test performance in humansMette Ewers Haahr
Neurobiology Research Unit and Center of Integrated Molecular Brain Imaging, University Hospital Rigshospitalet, 24 Juliane Maries Vej, 2100 Copenhagen, Denmark Danish Research Centre for Magnetic Resonance, University Hospital Hvidovre, 30 Kettegard Alle, 2650 Hvidovre, Denmark
Hum Brain Mapp 34:3066-74. 2013..014). These findings provide evidence that the 5-HT4 R is associated with memory functions in the human hippocampus and potentially pharmacological stimulation of the receptor may improve episodic memory...
- Cerebral serotonin 4 receptors and amyloid-β in early Alzheimer's diseaseKarine Madsen
Neurobiology Research Unit and Center for Integrated Molecular Brain Imaging, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark
J Alzheimers Dis 26:457-66. 2011..We speculate that this may either be a compensatory effect of decreased levels of interstitial 5-HT, an attempt to improve cognitive function, increase acetylcholine release or to counteract Aβ accumulation...
- Increased volume of the pigmented neurons in the locus coeruleus of schizophrenic subjects: a stereological studyLisbeth Marner
Research Laboratory for Stereology and Neuroscience, Bispebjerg University Hospital, 2400 Copenhagen NV, Denmark
J Psychiatr Res 39:337-45. 2005..No relation was found between total numbers or geometric mean volume of the pigmented cells and fixation time...
- No global loss of neocortical neurons in Parkinson's disease: a quantitative stereological studyKamilla M Pedersen
Research Laboratory for Stereology and Neuroscience, H S Bispebjerg University Hospital, Copenhagen, Denmark
Mov Disord 20:164-71. 2005....
- Mass dose effects and in vivo affinity in brain PET receptor studies--a study of cerebral 5-HT4 receptor binding with [11C]SB207145Karine Madsen
Neurobiology Research Unit, The Neuroscience Center, Rigshospitalet, Blegdamsvej 9, Copenhagen, Denmark
Nucl Med Biol 38:1085-91. 2011..In this study, we devise a method for determining receptor occupancy of the mass dose of the radioligand itself and the in vivo affinity...
- The reduction of baseline serotonin 2A receptors in mild cognitive impairment is stable at two-year follow-upLisbeth Marner
Neurobiology Research Unit, The Neuroscience Center, University Hospital Rigshospitalet, Copenhagen, Denmark
J Alzheimers Dis 23:453-9. 2011..Our finding suggests that profoundly reduced cortical 5-HT2A receptor binding is an early feature in MCI whereas the clinical progression from MCI to AD is less associated with further decrease in binding...