H Langberg

Summary

Country: Denmark

Publications

  1. ncbi request reprint Eccentric rehabilitation exercise increases peritendinous type I collagen synthesis in humans with Achilles tendinosis
    H Langberg
    Institute of Sports Medicine Copenhagen, Bispebjerg Hospital, Copenhagen, Denmark
    Scand J Med Sci Sports 17:61-6. 2007
  2. pmc Cyclo-oxygenase-2 mediated prostaglandin release regulates blood flow in connective tissue during mechanical loading in humans
    H Langberg
    Sports Medicine Research Unit, Department of Rheumatology, Copenhagen University Hospital at Bispebjerg, DK 2400 Copenhagen NV, Denmark
    J Physiol 551:683-9. 2003
  3. pmc Substantial elevation of interleukin-6 concentration in peritendinous tissue, in contrast to muscle, following prolonged exercise in humans
    Henning Langberg
    Sports Medicine Research Unit, Department of Rheumatology H, Bispebjerg Hospital, Copenhagen, Denmark
    J Physiol 542:985-90. 2002
  4. pmc Exercise-induced increase in interstitial bradykinin and adenosine concentrations in skeletal muscle and peritendinous tissue in humans
    H Langberg
    Sports Medicine Research Unit, Copenhagen Muscle Research Centre, Bispebjerg Hospital, DK 2400 Copenhagen NV, Denmark
    J Physiol 542:977-83. 2002
  5. ncbi request reprint Age related blood flow around the Achilles tendon during exercise in humans
    H Langberg
    Sports Medicine Research Unit, Department of Rheumatology H, Bispebjerg Hospital, Bispebjerg Bakke 23, 2400 Copenhagen NV, Denmark
    Eur J Appl Physiol 84:246-8. 2001
  6. doi request reprint Effect of administration of oral contraceptives in vivo on collagen synthesis in tendon and muscle connective tissue in young women
    M Hansen
    Institute of Sports Medicine, Bispebjerg Hospital and Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    J Appl Physiol (1985) 106:1435-43. 2009
  7. doi request reprint Effect of administration of oral contraceptives on the synthesis and breakdown of myofibrillar proteins in young women
    M Hansen
    Institute of Sports Medicine, Bispebjerg Hospital, Copenhagen, Denmark
    Scand J Med Sci Sports 21:62-72. 2011
  8. pmc Type I collagen synthesis and degradation in peritendinous tissue after exercise determined by microdialysis in humans
    H Langberg
    Sports Medicine Research Unit, Department of Rheumatology H and Department of Clinical Physiology, Bispebjerg Hospital, Copenhagen, Denmark
    J Physiol 521:299-306. 1999
  9. doi request reprint Novel methods for tendon investigations
    M Kjaer
    Institute of Sports Medicine, Department of Rheumatology, Bispebjerg Hospital, Copenhagen University Hospital, Copenhagen, Denmark
    Disabil Rehabil 30:1514-22. 2008
  10. pmc Blood flow and oxygenation in peritendinous tissue and calf muscle during dynamic exercise in humans
    R Boushel
    Sports Medicine Research Unit, Department of Rheumatology H and Department of Clinical Physiology, Bispebjerg Hospital, The Copenhagen Muscle Research Centre, Copenhagen, Denmark
    J Physiol 524:305-13. 2000

Detail Information

Publications70

  1. ncbi request reprint Eccentric rehabilitation exercise increases peritendinous type I collagen synthesis in humans with Achilles tendinosis
    H Langberg
    Institute of Sports Medicine Copenhagen, Bispebjerg Hospital, Copenhagen, Denmark
    Scand J Med Sci Sports 17:61-6. 2007
    ..In contrast, the collagen metabolism in healthy control tendons seems not to be affected by eccentric training. These findings could indicate a relation between collagen metabolism and recovery from injury in human tendons...
  2. pmc Cyclo-oxygenase-2 mediated prostaglandin release regulates blood flow in connective tissue during mechanical loading in humans
    H Langberg
    Sports Medicine Research Unit, Department of Rheumatology, Copenhagen University Hospital at Bispebjerg, DK 2400 Copenhagen NV, Denmark
    J Physiol 551:683-9. 2003
    ....
  3. pmc Substantial elevation of interleukin-6 concentration in peritendinous tissue, in contrast to muscle, following prolonged exercise in humans
    Henning Langberg
    Sports Medicine Research Unit, Department of Rheumatology H, Bispebjerg Hospital, Copenhagen, Denmark
    J Physiol 542:985-90. 2002
    ....
  4. pmc Exercise-induced increase in interstitial bradykinin and adenosine concentrations in skeletal muscle and peritendinous tissue in humans
    H Langberg
    Sports Medicine Research Unit, Copenhagen Muscle Research Centre, Bispebjerg Hospital, DK 2400 Copenhagen NV, Denmark
    J Physiol 542:977-83. 2002
    ..These findings support a role for bradykinin and adenosine in exercise-induced hyperaemia in skeletal muscle and suggest that bradykinin and adenosine are potential regulators of blood flow in peritendinous tissue...
  5. ncbi request reprint Age related blood flow around the Achilles tendon during exercise in humans
    H Langberg
    Sports Medicine Research Unit, Department of Rheumatology H, Bispebjerg Hospital, Bispebjerg Bakke 23, 2400 Copenhagen NV, Denmark
    Eur J Appl Physiol 84:246-8. 2001
    ....
  6. doi request reprint Effect of administration of oral contraceptives in vivo on collagen synthesis in tendon and muscle connective tissue in young women
    M Hansen
    Institute of Sports Medicine, Bispebjerg Hospital and Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    J Appl Physiol (1985) 106:1435-43. 2009
    ..In conclusion, synthetic female sex hormones administered as OC had an inhibiting effect on collagen synthesis in tendon, bone, and muscle connective tissue, which may be related to a lower bioavailability of IGF-I...
  7. doi request reprint Effect of administration of oral contraceptives on the synthesis and breakdown of myofibrillar proteins in young women
    M Hansen
    Institute of Sports Medicine, Bispebjerg Hospital, Copenhagen, Denmark
    Scand J Med Sci Sports 21:62-72. 2011
    ..In contrast, there was no effect of OC on myofibrillar protein breakdown in the fed state...
  8. pmc Type I collagen synthesis and degradation in peritendinous tissue after exercise determined by microdialysis in humans
    H Langberg
    Sports Medicine Research Unit, Department of Rheumatology H and Department of Clinical Physiology, Bispebjerg Hospital, Copenhagen, Denmark
    J Physiol 521:299-306. 1999
    ..This suggests an adaptation to acute physical loading also in non-bone-related collagen in humans...
  9. doi request reprint Novel methods for tendon investigations
    M Kjaer
    Institute of Sports Medicine, Department of Rheumatology, Bispebjerg Hospital, Copenhagen University Hospital, Copenhagen, Denmark
    Disabil Rehabil 30:1514-22. 2008
    ....
  10. pmc Blood flow and oxygenation in peritendinous tissue and calf muscle during dynamic exercise in humans
    R Boushel
    Sports Medicine Research Unit, Department of Rheumatology H and Department of Clinical Physiology, Bispebjerg Hospital, The Copenhagen Muscle Research Centre, Copenhagen, Denmark
    J Physiol 524:305-13. 2000
    ..However, peak exercise peritendinous blood flow reaches only approximately 20 % of its maximal blood flow capacity...
  11. doi request reprint From mechanical loading to collagen synthesis, structural changes and function in human tendon
    M Kjaer
    Department of Orthopaedics, Institute of Sports Medicine, Bispebjerg Hospital, Copenhagen, Denmark
    Scand J Med Sci Sports 19:500-10. 2009
    ..An intimate interplay between mechanical signalling and biochemical changes in the matrix is needed in tendon, such that chemical changes can be converted into adaptations in the morphology, structure and material properties...
  12. doi request reprint Effects of transdermal estrogen on collagen turnover at rest and in response to exercise in postmenopausal women
    J Pingel
    Institute of Sports Medicine, Department of Orthopedic Surgery M81, Bispebjerg Hospital and Center for Healthy Aging, Faculty of Health Sciences, University of Copenhagen, Bispebjerg Bakke 23, Copenhagen, Denmark
    J Appl Physiol (1985) 113:1040-7. 2012
    ..In perspective, this indicates that the availability of estrogen in postmenopausal women is important for repair of muscle damage or remodeling of the connective tissue within the skeletal muscle after exercise...
  13. pmc Expression of collagen and related growth factors in rat tendon and skeletal muscle in response to specific contraction types
    K M Heinemeier
    Institute of Sports Medicine, Bispebjerg Hospital Building 8, 1st Floor, 23 Bispebjerg Bakke, DK 2400 Copenhagen NV, Denmark
    J Physiol 582:1303-16. 2007
    ....
  14. doi request reprint Local NSAID infusion does not affect protein synthesis and gene expression in human muscle after eccentric exercise
    U R Mikkelsen
    Institute of Sports Medicine, Bispebjerg Hospital and Center for Healthy Aging, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Scand J Med Sci Sports 21:630-44. 2011
    ..Although NSAIDs inhibit the exercise-induced satellite cell proliferation, we observed only limited effects on gene expression, and on post-exercise protein synthesis...
  15. pmc Interstitial and arterial-venous [K+] in human calf muscle during dynamic exercise: effect of ischaemia and relation to muscle pain
    S Green
    Copenhagen Muscle Research Centre, Rigshospitalet, Copenhagen, Denmark
    J Physiol 529:849-61. 2000
    ....
  16. pmc Metabolism and inflammatory mediators in the peritendinous space measured by microdialysis during intermittent isometric exercise in humans
    H Langberg
    Sports Medicine Research Unit, Department of Rheumatology H, Bispebjerg Hospital, Copenhagen, Denmark
    J Physiol 515:919-27. 1999
    ..5. This study indicates that both lipid and carbohydrate metabolism as well as inflammatory activity is accelerated in the peritendinous region of the human Achilles tendon with dynamic loading...
  17. doi request reprint Local administration of insulin-like growth factor-I (IGF-I) stimulates tendon collagen synthesis in humans
    M Hansen
    Institute of Sports Medicine, Department of Orthopedic Surgery M81, Bispebjerg Hospital and Center for Healthy Aging, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark Department of Endocrinology and Internal Medicine, Aarhus University Hospital and The Medical Research Laboratories, Institute of Clinical Medicine, Faculty of Health Sciences, Aarhus University, Aarhus, Denmark
    Scand J Med Sci Sports 23:614-9. 2013
    ..05). In conclusion, local IGF-I administration can directly enhance tendon collagen synthesis both within and around the human tendon tissue...
  18. doi request reprint Myofibrillar proteolysis in response to voluntary or electrically stimulated muscle contractions in humans
    M Hansen
    Copenhagen Muscle Research Center, Institute of Sports Medicine, Bispebjerg Hospital, Copenhagen, Denmark
    Scand J Med Sci Sports 19:75-82. 2009
    ..These results indicate that the local myofibrillar breakdown is accelerated after ES associated with severe myofiber damage...
  19. ncbi request reprint Regional blood flow during exercise in humans measured by near-infrared spectroscopy and indocyanine green
    R Boushel
    Sports Medicine Research Unit, Copenhagen Muscle Research Centre, Bispebjerg Hospital, Copenhagen, Denmark
    J Appl Physiol (1985) 89:1868-78. 2000
    ..Due to its high spatial and temporal resolution, the technique may be useful for determining regional blood flow distribution and regulation during exercise in humans...
  20. doi request reprint Effect of growth hormone on aging connective tissue in muscle and tendon: gene expression, morphology, and function following immobilization and rehabilitation
    A P Boesen
    Department of Ortopaedic Surgery M, Institute of Sports Medicine Copenhagen, Bispebjerg Hospital, and Center for Healthy Aging, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
    J Appl Physiol (1985) 116:192-203. 2014
    ..In conclusion, in elderly humans, GH seems to have a matrix stabilizing effect during inactivity and rehabilitation by stimulating collagen expression in the musculotendinous tissue and increasing tendon CSA and stiffness...
  21. doi request reprint The heat shock protein response following eccentric exercise in human skeletal muscle is unaffected by local NSAID infusion
    U R Mikkelsen
    Institute of Sports Medicine, Department of Orthopedic Surgery M, Bispebjerg Hospital and Center for Healthy Aging, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
    Eur J Appl Physiol 113:1883-93. 2013
    ..Increased expression of HSPs was observed on mRNA and protein level following eccentric exercise; however, this response was unaffected by local intramuscular infusion of NSAIDs...
  22. ncbi request reprint Monitoring tissue oxygen availability with near infrared spectroscopy (NIRS) in health and disease
    R Boushel
    Sports Medicine Research Unit, Bispebjerg University Hospital, Copenhagen Muscle Research Center, Denmark
    Scand J Med Sci Sports 11:213-22. 2001
    ..These various measurements provide the opportunity to evaluate several important metabolic and circulatory patterns in very localized regions of tissue and may be fruitful in the study of occupational syndromes and a variety of diseases...
  23. pmc Training-induced changes in peritendinous type I collagen turnover determined by microdialysis in humans
    H Langberg
    Sports Medicine Research Unit, Department of Rheumatology H, Bispebjerg Hospital, Copenhagen, Denmark
    J Physiol 534:297-302. 2001
    ..Early in the process both synthesis and degradation are elevated, whereas later, the anabolic processes are dominating causing a net synthesis of type I collagen in tendon-related tissue in humans...
  24. ncbi request reprint Negative interstitial pressure in the peritendinous region during exercise
    H Langberg
    Sports Medicine Research Unit, Department of Rheumatology H, Bispebjerg Hospital, DK 2400 Copenhagen, Denmark
    J Appl Physiol (1985) 87:999-1002. 1999
    ..Langberg, J. Bülow, and M. Kjaer. Acta Physiol. Scand. 163: 149-153, 1998; H. Langberg, J. Bülow, and M. Kjaer. Clin. Physiol. 19: 89-93, 1999)...
  25. pmc Myofibre damage in human skeletal muscle: effects of electrical stimulation versus voluntary contraction
    R M Crameri
    Department of Exercise Science, Concordia University, Montreal, Canada, and Institute of Sports Medicine, Copenhagen, Bispebjerg Hospital, Denmark
    J Physiol 583:365-80. 2007
    ..An increase in tenascin C expression in the midbelly of the skeletal muscle in both legs provides further evidence of a potential role for the extracellular matrix in the phenomenon of delayed onset of muscle soreness...
  26. ncbi request reprint Interstitial muscle lactate, pyruvate and potassium dynamics in the trapezius muscle during repetitive low-force arm movements, measured with microdialysis
    L Rosendal
    National Institute of Occupational Health, Copenhagen, Denmark
    Acta Physiol Scand 182:379-88. 2004
    ..Local muscle metabolic responses to repetitive low-force contractions and to intense static contractions were studied by microdialysis in humans...
  27. doi request reprint Early osteoarthritis and microdialysis: a novel in vivo approach for measurements of biochemical markers in the perisynovium and intraarticularly
    Ida Carøe Helmark
    Institute of Sports Medicine, Department of Orthopedic Surgery, Center for Healthy Aging, Bispebjerg Hospital, Bispebjerg Bakke 23, Copenhagen NV, Denmark
    Knee Surg Sports Traumatol Arthrosc 18:1617-23. 2010
    ..The present methodology displays a potential for future studies of simultaneous biochemical changes within and around joints...
  28. ncbi request reprint Determination of markers for collagen type I turnover in peritendinous human tissue by microdialysis: effect of catheter types and insertion trauma
    J L Olesen
    Institute of Sports Medicine, Bispebjerg Hospital, DK 2400 Copenhagen, Denmark
    Scand J Rheumatol 35:312-7. 2006
    ..However, exclusion of the observed elevation as a response to trauma from inserting the microdialysis catheters or a possible influence from the collagen production in skin was not determined...
  29. ncbi request reprint Decline eccentric squats increases patellar tendon loading compared to standard eccentric squats
    M Kongsgaard
    Institute of Sports Medicine, Bispebjerg Hospital, Department 8 Bispebjerg bakke 23, 2400 Copenhagen, Denmark
    Clin Biomech (Bristol, Avon) 21:748-54. 2006
    ..This study aimed to compare electromyography activity, patellar tendon strain and joint angle kinematics during standard and decline eccentric squats...
  30. ncbi request reprint Short-term strength training and the expression of myostatin and IGF-I isoforms in rat muscle and tendon: differential effects of specific contraction types
    K M Heinemeier
    Institute of Sports Medicine, Bispebjerg Hospital Bldg 8, 1st Floor, 23 Bispebjerg Bakke, DK 2400 Copenhagen NV, Denmark
    J Appl Physiol (1985) 102:573-81. 2007
    ....
  31. pmc Increased mast cell numbers in a calcaneal tendon overuse model
    J Pingel
    Institute of Sports Medicine, Department of Orthopaedic Surgery M Bispebjerg Hospital and Center for Healthy Aging, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Scand J Med Sci Sports 23:e353-60. 2013
    ..The current study demonstrates that 7-week HIUR causes structural changes in the calcaneal tendon, and further that these changes are associated with an increased mast cell density...
  32. pmc Local NSAID infusion inhibits satellite cell proliferation in human skeletal muscle after eccentric exercise
    U R Mikkelsen
    Institute of Sports Medicine, Bispebjerg Hospital, Bispebjerg Bakke 23, Copenhagen DK 2400, Denmark
    J Appl Physiol (1985) 107:1600-11. 2009
    ..These results suggest that NSAIDs negatively affect satellite cell activity after unaccustomed eccentric exercise...
  33. pmc Tendon and skeletal muscle matrix gene expression and functional responses to immobilisation and rehabilitation in young males: effect of growth hormone administration
    A P Boesen
    A P Boesen Institute of Sports Medicine, Department of Orthopaedic Surgery M, Bispebjerg Hospital, Bispebjerg Bakke 23, DK 2400 Copenhagen, Denmark
    J Physiol 591:6039-52. 2013
    ..GH has a matrix-stabilising effect during periods of inactivity and rehabilitation in humans...
  34. doi request reprint Sonoelastography as a diagnostic tool in the assessment of musculoskeletal alterations: a systematic review
    M Pedersen
    Bispebjerg Hospital and Centre for Healthy Ageing, Faculty of Health Sciences, University of Copenhagen, Institute of Sports Medicine Copenhagen, Denmark
    Ultraschall Med 33:441-6. 2012
    ..Sonoelastography (SEL), the most commonly used technique, allows determination of the elastic properties of tissue by applying pressure...
  35. doi request reprint The influence of training status on the drop in muscle strength after acute exercise
    Jessica Pingel
    Institute for Sports Medicine, Bispebjerg Hospital, Bispebjerg Bakke 23, Build 8, 1st Floor, 2400 Copenhagen NV, Denmark
    Eur J Appl Physiol 106:605-11. 2009
    ..05). The present study highlights the importance of determining the muscle endurance when evaluating the effect of immobilization on muscle parameters...
  36. ncbi request reprint Physical exercise can influence local levels of matrix metalloproteinases and their inhibitors in tendon-related connective tissue
    S O A Koskinen
    Sports Medicine Research Unit, Bispebjerg Hospital, Copenhagen, Denmark
    J Appl Physiol (1985) 96:861-4. 2004
    ....
  37. ncbi request reprint Metabolic activity and collagen turnover in human tendon in response to physical activity
    M Kjaer
    Institute of Sports Medicine and Copenhagen Muscle Research Centre, Bispebjerg Hospital, Copenhagen NV, Denmark
    J Musculoskelet Neuronal Interact 5:41-52. 2005
    ..Understanding of such changes is a pre-requisite in the development of measures aimed at prevention of overuse tendon injuries occurring during sport, work or leisure-related activities...
  38. ncbi request reprint Tendinopathy and Doppler activity: the vascular response of the Achilles tendon to exercise
    M I Boesen
    The Parker Institute, Frederiksberg Hospital, Frederiksberg, Copenhagen, Denmark
    Scand J Med Sci Sports 16:463-9. 2006
    ..Intratendinous Doppler activity has been interpreted as an equivalent of neovessels in the Achilles tendon and as a sign of tendinosis (AT)...
  39. ncbi request reprint Eccentric exercise in treatment of Achilles tendinopathy
    J Nørregaard
    Institute of Sports Medicine, Bispebjerg Hospital, Copenhagen, Denmark
    Scand J Med Sci Sports 17:133-8. 2007
    ..The purpose of the present study was to examine the long-term effect of eccentric exercises compared with stretching exercises on patients with achillodynia...
  40. pmc Ultrasound guided electrocoagulation in patients with chronic non-insertional Achilles tendinopathy: a pilot study
    M Ilum Boesen
    Parker Institute, Frederiksberg, Denmark
    Br J Sports Med 40:761-6. 2006
    ..Treatment of this neovascularisation with sclerosing therapy seems to relieve the pain. However, the procedure often has to be repeated...
  41. doi request reprint Effect of range of motion in heavy load squatting on muscle and tendon adaptations
    K Bloomquist
    The University Hospitals Centre for Health Research, Copenhagen University Hospital, Copenhagen, Denmark
    Eur J Appl Physiol 113:2133-42. 2013
    ..Training deep squats elicited favourable adaptations on knee extensor muscle size and function compared to training shallow squats...
  42. doi request reprint Measurement of skeletal muscle collagen breakdown by microdialysis
    B F Miller
    Department of Health and Exercise Science, Colorado State University, Fort Collins, Colorado 80523 1582, USA
    Scand J Med Sci Sports 21:e1-8. 2011
    ....
  43. ncbi request reprint Intra- and peri-tendinous microdialysis determination of glucose and lactate in pigs
    H Langberg
    Sports Medicine Research Unit, Department of Rheumatology H, Bispebjerg Hospital, Bispebjerg Bakke 23, DK 2400 Copenhagen NV, Denmark
    Acta Physiol Scand 174:377-80. 2002
  44. doi request reprint Concomitant changes in cross-sectional area and water content in skeletal muscle after resistance exercise
    M S Kristiansen
    Institute of Sports Medicine, Department of Orthopedic Surgery M, Bispebjerg Hospital and Center for Healthy Ageing, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Scand J Med Sci Sports 24:e260-8. 2014
    ....
  45. pmc Coordinated collagen and muscle protein synthesis in human patella tendon and quadriceps muscle after exercise
    Benjamin F Miller
    Institute of Sports Medicine, Copenhagen, Bispebjerg Hospital, Denmark
    J Physiol 567:1021-33. 2005
    ..The similar time course of changes of protein synthetic rates in different cell types supports the idea of coordinated musculotendinous adaptation...
  46. pmc Combined inhibition of nitric oxide and prostaglandins reduces human skeletal muscle blood flow during exercise
    Robert Boushel
    Department of Exercise Science, Concordia University, Montreal, Quebec, Canada
    J Physiol 543:691-8. 2002
    ..These findings demonstrate an important synergistic role of NO and PG for skeletal muscle vasodilatation and hyperaemia during muscular contraction...
  47. ncbi request reprint Muscle interstitial potassium kinetics during intense exhaustive exercise: effect of previous arm exercise
    Nikolai Nordsborg
    The August Krogh Institute, IFI, Universitetsparken 13, DK 2100 Copenhagen Ø, Denmark
    Am J Physiol Regul Integr Comp Physiol 285:R143-8. 2003
    ..The high [K+]i levels reached at exhaustion can be expected to cause fatigue, which is supported by the finding that a faster accumulation of interstitial K+, induced by prior arm exercise, was associated with a reduced time to fatigue...
  48. ncbi request reprint [Overuse injuries in tendon tissue: insight into adaptation mechanisms]
    Michael Kjaer
    H S Bispebjerg Hospital, Medicinsk Center, Reumatologisk Klinik H, Idraetsmedicinsk Forskningsenhed, DK 2400 København NV
    Ugeskr Laeger 165:1438-43. 2003
    ..Newly developed in-vivo techniques open new possibilities for a deeper understanding of the pathogenesis behind tendon overuse injuries...
  49. pmc Exercise but not prostanoids enhance levels of vascular endothelial growth factor and other proliferative agents in human skeletal muscle interstitium
    Lotte Höffner
    Copenhagen Muscle Research Centre, Institute for Exercise and Sport Science, Copenhagen University, and Sports Medicine Research Unit, Bispebjerg Hospital, Denmark
    J Physiol 550:217-25. 2003
    ..Products of cyclooxygenase do not appear to have an effect on the release of VEGF or other proliferative agents in human skeletal muscle...
  50. pmc Ethinyl oestradiol administration in women suppresses synthesis of collagen in tendon in response to exercise
    Mette Hansen
    Institute of Sports Medicine, Copenhagen, Build 8, Bispebjerg Hospital, Bispebjerg Bakke 23, DK 2400 Copenhagen NV, Denmark
    J Physiol 586:3005-16. 2008
    ..The mechanism behind this is either a direct effect of oestradiol, or an indirect effect via a reduction in levels of free IGF-I. However, the data did not indicate any long-term effect on tendon size associated with chronic OC use...
  51. doi request reprint Effects of long-term immobilization and recovery on human triceps surae and collagen turnover in the Achilles tendon in patients with healing ankle fracture
    Britt Christensen
    Institute of Sports Medicine, Bispebjerg Hospital, University of Copenhagen, Bispebjerg Bakke 23, 2400 Copenhagen NV, Denmark
    J Appl Physiol (1985) 105:420-6. 2008
    ..Remobilization increased muscle size and strength and tendon synthesis and degradation decreased to baseline levels. These dynamic changes in tendon connective tissue turnover were not associated with macroscopic changes in tendon size...
  52. ncbi request reprint Incidence of injury and physical performance adaptations during military training
    Lars Rosendal
    Sports Medicine Research Unit, Bispebjerg Hospital, Copenhagen, Denmark
    Clin J Sport Med 13:157-63. 2003
    ....
  53. ncbi request reprint Enhanced procollagen processing in skeletal muscle after a single bout of eccentric loading in humans
    Regina M Crameri
    Sports Medicine Research Unit, Bispebjerg Hospital, DK 2400, Copenhagen NV, Denmark
    Matrix Biol 23:259-64. 2004
    ..This study shows that following a single bout of high intensity eccentric exercise there is an increase in procollagen processing within skeletal muscle in humans...
  54. ncbi request reprint Increase in interstitial interleukin-6 of human skeletal muscle with repetitive low-force exercise
    Lars Rosendal
    National Institute of Occupational Health, Lersø Parkallé 105, DK 2100 Copenhagen, Denmark
    J Appl Physiol (1985) 98:477-81. 2005
    ..We conclude that upper extremity, low-intensity exercise results in a substantial increase in IL-6 in the interstitium of the stabilizing trapezius muscle, whereas no change is seen for plasma IL-6...
  55. pmc Extracellular matrix adaptation of tendon and skeletal muscle to exercise
    Michael Kjaer
    Institute of Sports Medicine, Bispebjerg Hospital, Copenhagen, Denmark
    J Anat 208:445-50. 2006
    ..These findings may provide the basis for understanding tissue overloading and injury in both tendons and skeletal muscle...
  56. ncbi request reprint Expression of insulin-like growth factor I, insulin-like growth factor binding proteins, and collagen mRNA in mechanically loaded plantaris tendon
    Jens L Olesen
    Institute of Sports Medicine, Bispebjerg Hospital, DK 2400 Copenhagen, Denmark
    J Appl Physiol (1985) 101:183-8. 2006
    ..Also, MGF is expressed with an early upregulation in loaded tendon tissue. We suggest that the IGF-I system could be involved in collagen synthesis in tendon in response to mechanical loading...
  57. ncbi request reprint Exercise-induced changes in circulating levels of transforming growth factor-beta-1 in humans: methodological considerations
    Katja Heinemeier
    Sports Medicine Research Unit, Bispebjerg Hospital, Building 8, 1st Floor, 23 Bispebjerg Bakke, 2400 Copenhagen NV, Denmark
    Eur J Appl Physiol 90:171-7. 2003
    ..Exercise increased the plasma concentration, perhaps indicating a release from mechanically loaded tissues...
  58. ncbi request reprint Exercise-dependent IGF-I, IGFBPs, and type I collagen changes in human peritendinous connective tissue determined by microdialysis
    Jens L Olesen
    Institute of Sports Medicine, Bispebjerg Hospital, DK 2400 Copenhagen, Denmark
    J Appl Physiol (1985) 102:214-20. 2007
    ..The local increased collagen synthesis was preceded by an elevation of local concentration of IGFBP-4, suggesting that IGFBP-4 may have a key role in the IGF-axis effect on the human collagen synthesis in vivo...
  59. ncbi request reprint Colour doppler ultrasonography and sclerosing therapy in diagnosis and treatment of tendinopathy in horses-a research model for human medicine
    Morten Ilum Boesen
    Parker Institute, Frederiksberg Hospital, Nordre Fasanvej 57, 2000 Frederiksberg, Denmark
    Knee Surg Sports Traumatol Arthrosc 15:935-9. 2007
    ..The animal model will allow experimental studies including substantial tissue sampling for mechanical and molecular biological analysis...
  60. ncbi request reprint Role of TGF-beta1 in relation to exercise-induced type I collagen synthesis in human tendinous tissue
    Katja Heinemeier
    Department of Rheumatology H, Bispebjerg Hospital, DK 2400 Copenhagen, Denmark
    J Appl Physiol (1985) 95:2390-7. 2003
    ..Although not conclusive, changes in circulating and local TGF-beta1, in response to exercise, suggest a role for TGF-beta1 in mechanical regulation of local collagen type I synthesis in tendon-related connective tissue in vivo...
  61. ncbi request reprint Prostaglandin synthesis can be inhibited locally by infusion of NSAIDS through microdialysis catheters in human skeletal muscle
    Ulla Ramer Mikkelsen
    Institute of Sports Medicine, Bispebjerg Hospital, DK 2400 Copenhagen NV, Copenhagen, Denmark
    J Appl Physiol (1985) 104:534-7. 2008
    ..In conclusion, the present study shows that infusion of NSAIDs into human muscle via microdialysis catheters results in a graded blockade of prostaglandin synthesis...
  62. pmc The adaptability of tendon to loading differs in men and women
    S Peter Magnusson
    Institute of Sports Medicine Copenhagen, Bispebjerg Hospital, Copenhagen, Denmark
    Int J Exp Pathol 88:237-40. 2007
    ..These data indicate that tendons in women have a lower rate of new connective tissue formation, respond less to mechanical loading, and have a lower mechanical strength, which may leave the tissue more susceptible to injury...
  63. ncbi request reprint The influence of anti-inflammatory medication on exercise-induced myogenic precursor cell responses in humans
    Abigail L Mackey
    Institute of Sports Medicine Copenhagen, Bispebjerg Hospital, Bldg 8, Bispebjerg Bakke 23, 2400 Copenhagen NV, Denmark
    J Appl Physiol (1985) 103:425-31. 2007
    ..05). These results suggest that ingestion of anti-inflammatory drugs attenuates the exercise-induced increase in satellite cell number, supporting the role of the cyclooxygenase pathway in satellite cell activity...
  64. ncbi request reprint The effect of running, strength, and vibration strength training on the mechanical, morphological, and biochemical properties of the Achilles tendon in rats
    Kirsten Legerlotz
    Institute of Biomechanics and Orthopaedics, German Sport University Cologne, Cologne, Germany
    J Appl Physiol (1985) 102:564-72. 2007
    ..However, the RT group had a higher TIMP-1 mRNA concentration in the Achilles tendon in contrast to AMC group (P < 0.05), which suggests that this exercise mode may have an influence on tendon adaptation...
  65. ncbi request reprint Nitric oxide and prostaglandins influence local skeletal muscle blood flow during exercise in humans: coupling between local substrate uptake and blood flow
    Kari K Kalliokoski
    Copenhagen Muscle Research Centre, Bispebjerg Hospital, Denmark
    Am J Physiol Regul Integr Comp Physiol 291:R803-9. 2006
    ..The findings suggest that local substrate uptake in skeletal muscle can be regulated independently of regional changes in blood flow...
  66. ncbi request reprint Expression, content, and localization of insulin-like growth factor I in human achilles tendon
    Jens L Olesen
    Institute of Sports Medicine, Bispebjerg Hospital, Copenhagen, Denmark
    Connect Tissue Res 47:200-6. 2006
    ..The present study adds support for the roles of IGF-I and IGFBP-4 in the regulation of tendon adaptive responses to mechanical loading...
  67. pmc Changes in satellite cells in human skeletal muscle after a single bout of high intensity exercise
    Regina M Crameri
    Sports Medicine Research Unit, Bispebjerg Hospital, Copenhagen, Denmark
    J Physiol 558:333-40. 2004
    ..However, a single bout of exercise is not sufficient for the satellite cell to undergo terminal differentiation...
  68. ncbi request reprint Corticosteroids reduce the tensile strength of isolated collagen fascicles
    Bjarki Thor Haraldsson
    Institute of Sports Medicine Copenhagen, Bispebjerg Hospital, Bispebjerg Bakke 23, 2400 Copenhagen NV, Denmark
    Am J Sports Med 34:1992-7. 2006
    ..Overuse tendon injuries are frequent. Corticosteroid injections are commonly used as treatment, although their direct effects on the material properties of the tendon are poorly understood...
  69. ncbi request reprint The effect of dynamic knee-extension exercise on patellar tendon and quadriceps femoris muscle glucose uptake in humans studied by positron emission tomography
    Kari K Kalliokoski
    Copenhagen Muscle Research Centre, Institute of Sports Medicine, Bispebjerg Hospital, Denmark
    J Appl Physiol (1985) 99:1189-92. 2005
    ..Thus tendon glucose uptake is likely to be regulated by mechanisms independently of those regulating skeletal muscle glucose uptake...
  70. ncbi request reprint Physical capacity influences the response of insulin-like growth factor and its binding proteins to training
    Lars Rosendal
    Sports Medicine Research Unit and Copenhagen Muscle Research Centre, Bispebjerg Hospital, DK 2400 Copenhagen, Denmark
    J Appl Physiol (1985) 93:1669-75. 2002
    ..Also, prolonged physical training resulted in increased IGFBP-3 proteolysis in previously untrained individuals only, indicating that intense physical training affects trained and untrained individuals differently...