Lars Holm

Summary

Country: Denmark

Publications

  1. doi request reprint The single-biopsy approach in determining protein synthesis in human slow-turning-over tissue: use of flood-primed, continuous infusion of amino acid tracers
    Lars Holm
    Institute of Sports Medicine Copenhagen, Department of Orthopedic Surgery, Bispebjerg Hospital and Center for Healthy Aging, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark and Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 306:E1330-9. 2014
  2. doi request reprint GH and IGF1 levels are positively associated with musculotendinous collagen expression: experiments in acromegalic and GH deficiency patients
    Simon Doessing
    Department of Orthopaedic Surgery M, Faculty of Health Sciences, Institute of Sports Medicine, Bispebjerg Hospital and Centre for Healthy Aging, University of Copenhagen, Bispebjerg Bakke 23, Copenhagen DK 2400, Denmark
    Eur J Endocrinol 163:853-62. 2010
  3. doi request reprint Assessment of satellite cell number and activity status in human skeletal muscle biopsies
    Abigail L Mackey
    Institute of Sports Medicine, Bispebjerg Hospital and Centre for Healthy Ageing, Faculty of Health Sciences, University of Copenhagen, Bispebjerg Bakke 23, 2400 Copenhagen, Denmark
    Muscle Nerve 40:455-65. 2009
  4. pmc Growth hormone stimulates the collagen synthesis in human tendon and skeletal muscle without affecting myofibrillar protein synthesis
    Simon Doessing
    Institute of Sports Medicine, Bispebjerg Hospital, Center of Healthy Aging, Faculty of Health Sciences, University of Copenhagen, Copenhagen NV, Denmark
    J Physiol 588:341-51. 2010
  5. doi request reprint Effects of estrogen replacement and lower androgen status on skeletal muscle collagen and myofibrillar protein synthesis in postmenopausal women
    Mette Hansen
    Institute of Sports Medicine, Department of Orthopaedic Surgery M, Bispebjerg Hospital and Center for Healthy Aging, Faculty of Health Sciences, University of Copenhagen, Denmark
    J Gerontol A Biol Sci Med Sci 67:1005-13. 2012
  6. doi request reprint GH receptor blocker administration and muscle-tendon collagen synthesis in humans
    Rie Harboe Nielsen
    Institute of Sports Medicine, Dept of Orthopaedic Surgery M, Bispebjerg Hospital and Center for Healthy Aging, Faculty of Health Sciences, University of Copenhagen, Denmark
    Growth Horm IGF Res 21:140-5. 2011
  7. doi request reprint Positive muscle protein net balance and differential regulation of atrogene expression after resistance exercise and milk protein supplementation
    Søren Reitelseder
    Department of Orthopedic Surgery M, Institute of Sports Medicine Copenhagen, Bispebjerg Hospital, Bispebjerg Bakke 23, Building 8, 1st Floor, 2400, Copenhagen NV, Denmark
    Eur J Nutr 53:321-33. 2014
  8. doi request reprint Contraction intensity and feeding affect collagen and myofibrillar protein synthesis rates differently in human skeletal muscle
    Lars Holm
    Institute of Sports Medicine, Bispebjerg Hospital and Center of Healthy Aging, University of Copenhagen, Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 298:E257-69. 2010
  9. doi request reprint The anabolic potential of dietary protein intake on skeletal muscle is prolonged by prior light-load exercise
    Rasmus Bechshoeft
    Institute of Sports Medicine, Dept of Orthopedic Surgery M81, Bispebjerg Hospital and Center for Healthy Aging, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Clin Nutr 32:236-44. 2013
  10. doi request reprint Whey and casein labeled with L-[1-13C]leucine and muscle protein synthesis: effect of resistance exercise and protein ingestion
    Søren Reitelseder
    Institute of Sports Medicine Copenhagen, Department of Orthopedic Surgery M, Bispebjerg Hospital and Center for Healthy Aging, University of Copenhagen, Copenhagen NV, Denmark
    Am J Physiol Endocrinol Metab 300:E231-42. 2011

Collaborators

Detail Information

Publications21

  1. doi request reprint The single-biopsy approach in determining protein synthesis in human slow-turning-over tissue: use of flood-primed, continuous infusion of amino acid tracers
    Lars Holm
    Institute of Sports Medicine Copenhagen, Department of Orthopedic Surgery, Bispebjerg Hospital and Center for Healthy Aging, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark and Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 306:E1330-9. 2014
    ....
  2. doi request reprint GH and IGF1 levels are positively associated with musculotendinous collagen expression: experiments in acromegalic and GH deficiency patients
    Simon Doessing
    Department of Orthopaedic Surgery M, Faculty of Health Sciences, Institute of Sports Medicine, Bispebjerg Hospital and Centre for Healthy Aging, University of Copenhagen, Bispebjerg Bakke 23, Copenhagen DK 2400, Denmark
    Eur J Endocrinol 163:853-62. 2010
    ..GH/IGF1 is likely to play an important role in the regulation of tendon and muscle collagen. We hypothesized that the local production of collagen is associated with the level of GH/IGF1...
  3. doi request reprint Assessment of satellite cell number and activity status in human skeletal muscle biopsies
    Abigail L Mackey
    Institute of Sports Medicine, Bispebjerg Hospital and Centre for Healthy Ageing, Faculty of Health Sciences, University of Copenhagen, Bispebjerg Bakke 23, 2400 Copenhagen, Denmark
    Muscle Nerve 40:455-65. 2009
    ..This study provides valuable tools to assess the behavior of satellite cells, both in pathological conditions and in response to physiological stimuli...
  4. pmc Growth hormone stimulates the collagen synthesis in human tendon and skeletal muscle without affecting myofibrillar protein synthesis
    Simon Doessing
    Institute of Sports Medicine, Bispebjerg Hospital, Center of Healthy Aging, Faculty of Health Sciences, University of Copenhagen, Copenhagen NV, Denmark
    J Physiol 588:341-51. 2010
    ..The results suggest that GH is more important in strengthening the matrix tissue than for muscle cell hypertrophy in adult human musculotendinous tissue...
  5. doi request reprint Effects of estrogen replacement and lower androgen status on skeletal muscle collagen and myofibrillar protein synthesis in postmenopausal women
    Mette Hansen
    Institute of Sports Medicine, Department of Orthopaedic Surgery M, Bispebjerg Hospital and Center for Healthy Aging, Faculty of Health Sciences, University of Copenhagen, Denmark
    J Gerontol A Biol Sci Med Sci 67:1005-13. 2012
    ..Nevertheless, resistance exercise in combination with ERT seems to have a counteracting effect on myofibrillar FSR in hysterectomized/oophorectomized women...
  6. doi request reprint GH receptor blocker administration and muscle-tendon collagen synthesis in humans
    Rie Harboe Nielsen
    Institute of Sports Medicine, Dept of Orthopaedic Surgery M, Bispebjerg Hospital and Center for Healthy Aging, Faculty of Health Sciences, University of Copenhagen, Denmark
    Growth Horm IGF Res 21:140-5. 2011
    ..The growth hormone (GH)/insulin-like growth factor-I (IGF-I) axis stimulates collagen synthesis in tendon and skeletal muscle, but no studies have investigated the effect of reducing IGF-I on collagen synthesis in healthy humans...
  7. doi request reprint Positive muscle protein net balance and differential regulation of atrogene expression after resistance exercise and milk protein supplementation
    Søren Reitelseder
    Department of Orthopedic Surgery M, Institute of Sports Medicine Copenhagen, Bispebjerg Hospital, Bispebjerg Bakke 23, Building 8, 1st Floor, 2400, Copenhagen NV, Denmark
    Eur J Nutr 53:321-33. 2014
    ..30 g/kg lean body mass), or a non-caloric control after heavy resistance exercise on protein turnover and mRNA expressions of forkhead homeobox type O (FOXO) isoforms, muscle RING finger 1 (MuRF1), and Atrogin1 in young healthy males...
  8. doi request reprint Contraction intensity and feeding affect collagen and myofibrillar protein synthesis rates differently in human skeletal muscle
    Lars Holm
    Institute of Sports Medicine, Bispebjerg Hospital and Center of Healthy Aging, University of Copenhagen, Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 298:E257-69. 2010
    ..Furthermore, although functionally linked, the contractile and the supportive matrix structures upregulate their protein synthesis rate quite differently in response to feeding and contractile activity and intensity...
  9. doi request reprint The anabolic potential of dietary protein intake on skeletal muscle is prolonged by prior light-load exercise
    Rasmus Bechshoeft
    Institute of Sports Medicine, Dept of Orthopedic Surgery M81, Bispebjerg Hospital and Center for Healthy Aging, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Clin Nutr 32:236-44. 2013
    ..Hyperaminoacidemia stimulates myofibrillar fractional synthesis rate (myoFSR) transiently in resting skeletal muscle. We investigated whether light-load resistance exercise can extent this responsiveness...
  10. doi request reprint Whey and casein labeled with L-[1-13C]leucine and muscle protein synthesis: effect of resistance exercise and protein ingestion
    Søren Reitelseder
    Institute of Sports Medicine Copenhagen, Department of Orthopedic Surgery M, Bispebjerg Hospital and Center for Healthy Aging, University of Copenhagen, Copenhagen NV, Denmark
    Am J Physiol Endocrinol Metab 300:E231-42. 2011
    ..05). In conclusion, whey and casein intake immediately after resistance exercise results in an overall equal MPS response despite temporal differences in insulin and amino acid concentrations and 4E-BP1...
  11. pmc Skeletal muscle myofibrillar and sarcoplasmic protein synthesis rates are affected differently by altitude-induced hypoxia in native lowlanders
    Lars Holm
    Department of Orthopaedic Surgery M and Institute of Sports Medicine, Bispebjerg Hospital, and Faculty of Health Sciences, Center of Healthy Ageing, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 5:e15606. 2010
    ..These changed responses may lead to divergent adaptation over the course of prolonged exposure...
  12. doi request reprint Nonsteroidal anti-inflammatory drug or glucosamine reduced pain and improved muscle strength with resistance training in a randomized controlled trial of knee osteoarthritis patients
    Susanne G Petersen
    Institute of Sports Medicine, Department of Orthopaedic Surgery M, Bispebjerg Hospital and Centre for Healthy Ageing, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Arch Phys Med Rehabil 92:1185-93. 2011
    ....
  13. pmc Determination of steady-state protein breakdown rate in vivo by the disappearance of protein-bound tracer-labeled amino acids: a method applicable in humans
    Lars Holm
    Institute of Sports Medicine, Department of Orthopedic Surgery M81, Bispebjerg Hospital, and Center for Healthy Aging, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 304:E895-907. 2013
    ..The applicability of this protein-specific FBR approach is suitable for human in vivo experimentation. The labeling period of deuterium oxide administration is dependent on the turnover rate of the protein of interest...
  14. doi request reprint Exercise and NSAIDs: effect on muscle protein synthesis in patients with knee osteoarthritis
    Susanne Germann Petersen
    Department of Orthopaedic Surgery, Faculty of Health Sciences, Institute of Sports Medicine, Bispebjerg Hospital and Centre for Healthy Ageing, University of Copenhagen, Copenhagen, Denmark
    Med Sci Sports Exerc 43:425-31. 2011
    ....
  15. doi request reprint Tendon protein synthesis rate in classic Ehlers-Danlos patients can be stimulated with insulin-like growth factor-I
    Rie Harboe Nielsen
    Institute of Sports Medicine, Department of Orthopaedic Surgery, Bispebjerg Hospital, and Centre for Healthy Aging, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
    J Appl Physiol (1985) 117:694-8. 2014
    ..007 ± 0.002, CTRL 0.001 ± 0.001%/h). In conclusion, baseline protein synthesis rates in connective tissue appeared normal in cEDS patients, and the patients responded with an increased tendon protein synthesis rate to IGF-I injections. ..
  16. doi request reprint Increase in tendon protein synthesis in response to insulin-like growth factor-I is preserved in elderly men
    Rie Harboe Nielsen
    Department of Orthopedic Surgery, Institute of Sports Medicine, Bispebjerg Hospital and Faculty of Health and Medical Sciences, Center for Healthy Aging, University of Copenhagen, Copenhagen, Denmark
    J Appl Physiol (1985) 116:42-6. 2014
    ..This could indicate that the changed phenotype in aging tendon is not caused by decreased fibroblast function. ..
  17. pmc Preserved skeletal muscle protein anabolic response to acute exercise and protein intake in well-treated rheumatoid arthritis patients
    Ulla Ramer Mikkelsen
    Institute of Sports Medicine, Department of Orthopaedic Surgery M, Bispebjerg Hospital and Center for Healthy Aging, Faculty of Health and Medical Sciences, University of Copenhagen, Bispebjerg Hospital Bldg 8, Bispebjerg Bakke 23, 2400, Copenhagen NV, Denmark
    Arthritis Res Ther 17:271. 2015
    ..To investigate the anabolic potential of both exercise and nutritional protein intake we investigated the muscle protein synthesis rate and anabolic signaling response in patients with RA compared to healthy controls...
  18. pmc Measuring protein breakdown rate in individual proteins in vivo
    Lars Holm
    Institute of Sports Medicine and Department of Orthopedic Surgery, Bispebjerg Hospital and Center of Healthy Aging, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Curr Opin Clin Nutr Metab Care 13:526-31. 2010
    ..To outline different approaches of how protein breakdown can be quantified and to present a new approach to determine the fractional breakdown rate of individual slow turnover proteins in vivo...
  19. doi request reprint Aquaporins 6-12 in the human eye
    Thuy Linh Tran
    Eye Pathology Institute, Department of Neuroscience and Pharmacology, University of Copenhagen, Denmark
    Acta Ophthalmol 91:557-63. 2013
    ..AQPs 0-5 have been localized at the cellular level in human eyes. We investigated the presence of the more recently discovered AQPs 6-12 in the human eye...
  20. doi request reprint Effect of estrogen on tendon collagen synthesis, tendon structural characteristics, and biomechanical properties in postmenopausal women
    Mette Hansen
    Institute of Sports Medicine, Bispebjerg Hospital, and Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    J Appl Physiol (1985) 106:1385-93. 2009
    ..These results indicate a pivotal role for estradiol in maintaining homeostasis of female connective tissue...
  21. ncbi request reprint The influence of anti-inflammatory medication on exercise-induced myogenic precursor cell responses in humans
    Abigail L Mackey
    Institute of Sports Medicine Copenhagen, Bispebjerg Hospital, Bldg 8, Bispebjerg Bakke 23, 2400 Copenhagen NV, Denmark
    J Appl Physiol (1985) 103:425-31. 2007
    ..05). These results suggest that ingestion of anti-inflammatory drugs attenuates the exercise-induced increase in satellite cell number, supporting the role of the cyclooxygenase pathway in satellite cell activity...