Jørn W Helge

Summary

Country: Denmark

Publications

  1. ncbi Partial restoration of dietary fat induced metabolic adaptations to training by 7 days of carbohydrate diet
    Jørn W Helge
    Copenhagen Muscle Research Centre, Department of Human Physiology, University of Copenhagen, DK 2100 Copenhagen Ø, Denmark
    J Appl Physiol (1985) 93:1797-805. 2002
  2. pmc Muscle metabolism during graded quadriceps exercise in man
    Jørn W Helge
    Copenhagen Muscle Research Centre, Department of Biomedical Sciences, Panum Institute, Blegdamsvej 3, DK 2200 N, Copenhagen, Denmark
    J Physiol 581:1247-58. 2007
  3. doi Interleukin-6 release is higher across arm than leg muscles during whole-body exercise
    Jørn W Helge
    Centre of Healthy Ageing, Department of Biomedical Sciences, University of Copenhagen, Denmark
    Exp Physiol 96:590-8. 2011
  4. pmc Metabolic profile in two physically active Inuit groups consuming either a western or a traditional Inuit diet
    Thor Munch-Andersen
    Copenhagen Muscle Research Centre, Rigshospitalet National University Hospital, DK 2200 Copenhagen, Denmark
    Int J Circumpolar Health 71:17342. 2012
  5. pmc Dual regulation of muscle glycogen synthase during exercise by activation and compartmentalization
    Clara Prats
    Copenhagen Muscle Research Center, Center for Healthy Ageing, Department of Biomedical Sciences, University of Copenhagen, DK 2200 Copenhagen N, Denmark
    J Biol Chem 284:15692-700. 2009
  6. ncbi Substrate availability and transcriptional regulation of metabolic genes in human skeletal muscle during recovery from exercise
    Henriette Pilegaard
    Copenhagen Muscle Research Centre, University of Copenhagen, Copenhagen, Denmark
    Metabolism 54:1048-55. 2005
  7. pmc Two weeks of metformin treatment enhances mitochondrial respiration in skeletal muscle of AMPK kinase dead but not wild type mice
    Jonas M Kristensen
    Section of Molecular Physiology Group, August Krogh Centre, Department of Nutrition, Exercise and Sport Sciences, University of Copenhagen, Denmark
    PLoS ONE 8:e53533. 2013
  8. doi Endurance training per se increases metabolic health in young, moderately overweight men
    Pernille Nordby
    Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark
    Obesity (Silver Spring) 20:2202-12. 2012
  9. doi Ceramide content is higher in type I compared to type II fibers in obesity and type 2 diabetes mellitus
    Ditte Kristensen
    Center of Healthy Aging, Department of Biomedical Sciences, University of Copenhagen, Blegdamsvej 3, 2200, Copenhagen, Denmark
    Acta Diabetol 50:705-12. 2013
  10. pmc An optimized histochemical method to assess skeletal muscle glycogen and lipid stores reveals two metabolically distinct populations of type I muscle fibers
    Clara Prats
    Center for Healthy Aging, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 8:e77774. 2013

Collaborators

Detail Information

Publications22

  1. ncbi Partial restoration of dietary fat induced metabolic adaptations to training by 7 days of carbohydrate diet
    Jørn W Helge
    Copenhagen Muscle Research Centre, Department of Human Physiology, University of Copenhagen, DK 2100 Copenhagen Ø, Denmark
    J Appl Physiol (1985) 93:1797-805. 2002
    ....
  2. pmc Muscle metabolism during graded quadriceps exercise in man
    Jørn W Helge
    Copenhagen Muscle Research Centre, Department of Biomedical Sciences, Panum Institute, Blegdamsvej 3, DK 2200 N, Copenhagen, Denmark
    J Physiol 581:1247-58. 2007
    ..These findings are in contrast to whole body measurements performed during graded exercise involving a large muscle mass during which fat oxidation peaks at around 60% of ...
  3. doi Interleukin-6 release is higher across arm than leg muscles during whole-body exercise
    Jørn W Helge
    Centre of Healthy Ageing, Department of Biomedical Sciences, University of Copenhagen, Denmark
    Exp Physiol 96:590-8. 2011
    ..The novel finding of a markedly higher IL-6 release from the exercising arm compared with the leg during whole-body exercise was not directly correlated to release or uptake of exogenous substrate, nor to muscle glycogen utilization...
  4. pmc Metabolic profile in two physically active Inuit groups consuming either a western or a traditional Inuit diet
    Thor Munch-Andersen
    Copenhagen Muscle Research Centre, Rigshospitalet National University Hospital, DK 2200 Copenhagen, Denmark
    Int J Circumpolar Health 71:17342. 2012
    ..To evaluate the effect of regular physical activity on metabolic risk factors and blood pressure in Inuit with high BMI consuming a western diet (high amount of saturated fatty acids and carbohydrates with a high glycemic index)...
  5. pmc Dual regulation of muscle glycogen synthase during exercise by activation and compartmentalization
    Clara Prats
    Copenhagen Muscle Research Center, Center for Healthy Ageing, Department of Biomedical Sciences, University of Copenhagen, DK 2200 Copenhagen N, Denmark
    J Biol Chem 284:15692-700. 2009
    ..After overnight low muscle glycogen level and/or in response to exhausting exercise-induced glycogenolysis, GS is associated with spherical structures at the I-band of sarcomeres...
  6. ncbi Substrate availability and transcriptional regulation of metabolic genes in human skeletal muscle during recovery from exercise
    Henriette Pilegaard
    Copenhagen Muscle Research Centre, University of Copenhagen, Copenhagen, Denmark
    Metabolism 54:1048-55. 2005
    ....
  7. pmc Two weeks of metformin treatment enhances mitochondrial respiration in skeletal muscle of AMPK kinase dead but not wild type mice
    Jonas M Kristensen
    Section of Molecular Physiology Group, August Krogh Centre, Department of Nutrition, Exercise and Sport Sciences, University of Copenhagen, Denmark
    PLoS ONE 8:e53533. 2013
    ..The improvement seems to be unrelated to AMPK, and does not involve changes in key mitochondrial proteins...
  8. doi Endurance training per se increases metabolic health in young, moderately overweight men
    Pernille Nordby
    Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark
    Obesity (Silver Spring) 20:2202-12. 2012
    ....
  9. doi Ceramide content is higher in type I compared to type II fibers in obesity and type 2 diabetes mellitus
    Ditte Kristensen
    Center of Healthy Aging, Department of Biomedical Sciences, University of Copenhagen, Blegdamsvej 3, 2200, Copenhagen, Denmark
    Acta Diabetol 50:705-12. 2013
    ..In human skeletal muscle, ceramide content was higher in type I than in type II fibers in patients with type 2 diabetes and in obese subjects, but overall ceramide muscle fiber content was not different compared to controls. ..
  10. pmc An optimized histochemical method to assess skeletal muscle glycogen and lipid stores reveals two metabolically distinct populations of type I muscle fibers
    Clara Prats
    Center for Healthy Aging, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 8:e77774. 2013
    ..Exhaustive exercise lead to glycogen depletion in type IIA and IIX fibers, a reduction in lipid droplets density in both type I-1 and I-2 fibers, and a decrease in the size of lipid droplets exclusively in type I-1 fibers. ..
  11. pmc The effect of graded exercise on IL-6 release and glucose uptake in human skeletal muscle
    Jørn W Helge
    Copenhagen Muscle Research Centre, Rigshospitalet, Department of Medical Physiology, Panum Institute, University of Copenhagen, Denmark
    J Physiol 546:299-305. 2003
    ..The observation of a relationship between IL-6 release and muscle glycogen store both at rest and after exercise suggests that IL-6 may act as a carbohydrate sensor...
  12. doi Adipose tissue mitochondrial respiration and lipolysis before and after a weight loss by diet and RYGB
    Merethe Hansen
    Xlab, Center for Healthy Aging, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark
    Obesity (Silver Spring) 23:2022-9. 2015
    ..To study adipose tissue mitochondrial respiration and lipolysis following a massive weight loss...
  13. doi Simvastatin effects on skeletal muscle: relation to decreased mitochondrial function and glucose intolerance
    Steen Larsen
    Center for Healthy Aging, Department of Biomedical Sciences, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    J Am Coll Cardiol 61:44-53. 2013
    ....
  14. ncbi Effect of training on muscle triacylglycerol and structural lipids: a relation to insulin sensitivity?
    Jørn W Helge
    Department of Medical Physiology, Copenhagen Muscle Research Centre, The Panum Institute, University of Copenhagen, Copenhagen, Denmark
    Diabetes 52:1881-7. 2003
    ..In contrast, training induced a minor increase in the content of phospholipid fatty acid membrane polyunsaturates, which may indicate that membrane lipids may have a role in the training-induced increase in insulin sensitivity...
  15. ncbi Skiing across the Greenland icecap: divergent effects on limb muscle adaptations and substrate oxidation
    Jørn W Helge
    Copenhagen Muscle Research Centre, National University Hospital, Denmark
    J Exp Biol 206:1075-83. 2003
    ..Although the number of subjects is limited, these results imply that the adaptation pattern after long-term, prolonged, low-intensity, whole body exercise may vary dramatically among muscles...
  16. doi Actovegin, a non-prohibited drug increases oxidative capacity in human skeletal muscle
    Stine D Søndergård
    a Xlab, Center for Healthy Aging, Department of Biomedical Sciences, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Eur J Sport Sci 16:801-7. 2016
    ..Whether this improvement translates into an ergogenic effect in athletes and thus reiterates the need to include Actovegin on the World Anti-Doping Agency's active list remains to be investigated. ..
  17. doi Cerebral autoregulation dynamics in endurance-trained individuals
    Mikkel Lind-Holst
    Bispebjerg Hospital Research Unit for Anaesthesia and Intensive Care, University of Copenhagen, Copenhagen, Denmark
    J Appl Physiol (1985) 110:1327-33. 2011
    ....
  18. pmc Ethnic differences in leptin and adiponectin levels between Greenlandic Inuit and Danish children
    Thor Munch-Andersen
    Department of Biomedical Sciences, Center for Healthy Aging, University of Copenhagen, Denmark
    Int J Circumpolar Health 72:. 2013
    ..Aerobic fitness and adiposity could only partly account for the differences. Therefore, we set out to evaluate and compare plasma leptin and adiponectin levels in Danish and Inuit children...
  19. doi Time course for the recovery of physical performance, blood hemoglobin, and ferritin content after blood donation
    Andreas K Ziegler
    Center of Healthy Aging, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark
    Transfusion 55:898-905. 2015
    ..This study aimed to elucidate the temporary impact of blood donation on endurance performance, measured as peak oxygen uptake (VO2peak ) and time trial (TT) performance...
  20. doi GAPDH and β-actin protein decreases with aging, making Stain-Free technology a superior loading control in Western blotting of human skeletal muscle
    Andreas Vigelsø
    Center for Healthy Aging, Department of Biomedical Sciences, Faculty of Health Sciences, University of Copenhagen, Denmark
    J Appl Physiol (1985) 118:386-94. 2015
    ..The novel SF technology adds lower variation to the results compared with the existing methods for correcting for loading inaccuracy in Western blotting of human skeletal muscle in applied physiology. ..
  21. doi The effect of metformin on glucose homeostasis during moderate exercise
    Merethe Hansen
    Xlab, Center for Healthy Aging, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark
    Diabetes Care 38:293-301. 2015
    ..We investigated the role of metformin on glucose kinetics during moderate exercise...
  22. doi Hypoadiponectinemia in overweight children contributes to a negative metabolic risk profile 6 years later
    Iben Kynde
    Department of Biomedical Sciences, Centre for Healthy Ageing, University of Copenhagen, 2200 Copenhagen, Denmark
    Metabolism 58:1817-24. 2009
    ..In addition, circulating plasma adiponectin may be a useful biomarker to identify overweight children at greater future risk of the cardiometabolic adverse effects of overweight...