Michael Didriksen

Summary

Affiliation: H. Lundbeck A/S
Country: Denmark

Publications

  1. ncbi request reprint The heterozygous reeler mouse: behavioural phenotype
    Jana Podhorna
    Department of Psychopharmacology, Psychosis, H Lundbeck A S, Ottiliavej 9, 2500 Copenhagen Valby, Denmark
    Behav Brain Res 153:43-54. 2004
  2. ncbi request reprint Reversal of PCP-induced learning and memory deficits in the Morris' water maze by sertindole and other antipsychotics
    Michael Didriksen
    Disease Pharmacology, H Lundbeck A S, Ottiliavej 9, 2500 Valby, Denmark
    Psychopharmacology (Berl) 193:225-33. 2007
  3. pmc Hippocampal CA1 region shows differential regulation of gene expression in mice displaying extremes in behavioral sensitization to amphetamine: relevance for psychosis susceptibility?
    Nicole A Datson
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research LACDR and Leiden University Medical Center, Leiden University, P O Box 9502, 2300 RA Leiden, The Netherlands
    Psychopharmacology (Berl) 217:525-38. 2011
  4. pmc Genome-wide scans using archived neonatal dried blood spot samples
    Mads V Hollegaard
    Section of Neonatal Screening and Hormones, Statens Serum Institut, Copenhagen, Denmark
    BMC Genomics 10:297. 2009
  5. ncbi request reprint Sertindole, in contrast to clozapine and olanzapine, does not disrupt water maze performance after acute or chronic treatment
    Michael Didriksen
    Pharmacology Target Research, H Lundbeck A S Ottiliavej 9, 2500 Valby, Denmark
    Eur J Pharmacol 542:108-15. 2006
  6. ncbi request reprint Lu 35-138 ((+)-(S)-3-{1-[2-(1-acetyl-2,3-dihydro-1H-indol-3-yl)ethyl]-3,6-dihydro-2H-pyridin-4-yl}-6-chloro-1H-indole), a dopamine D4 receptor antagonist and serotonin reuptake inhibitor: characterisation of its in vitro profile and pre-clinical antipsych
    Peter Hertel
    Research and Development, H Lundbeck A S, Copenhagen Valby, Denmark
    Eur J Pharmacol 573:148-60. 2007
  7. doi request reprint Negative modulation of GABAA α5 receptors by RO4938581 attenuates discrete sub-chronic and early postnatal phencyclidine (PCP)-induced cognitive deficits in rats
    John P Redrobe
    Synaptic Transmission I, Neuroscience Research DK, H Lundbeck A S, Ottiliavej 9, 2500 Valby, Denmark
    Psychopharmacology (Berl) 221:451-68. 2012
  8. ncbi request reprint Cognitive deficits caused by late gestational disruption of neurogenesis in rats: a preclinical model of schizophrenia
    Peter Flagstad
    Department of Pharmacology Target Research, H Lundbeck A S, Copenhagen Valby, Denmark
    Neuropsychopharmacology 30:250-60. 2005
  9. ncbi request reprint Positive modulation of glutamatergic receptors potentiates the suppressive effects of antipsychotics on conditioned avoidance responding in rats
    Christina Kurre Olsen
    Department of Psychopharmacology, Pharmacological Research, H Lundbeck A S, Ottiliavej 9, DK 2500 Valby Copenhagen, Denmark
    Pharmacol Biochem Behav 84:259-65. 2006
  10. ncbi request reprint Decrease in parvalbumin-expressing neurons in the hippocampus and increased phencyclidine-induced locomotor activity in the rat methylazoxymethanol (MAM) model of schizophrenia
    Silke Penschuck
    Department of Neuroscience, 900, Lundbeck Research USA, Inc, 215 College Road, Paramus, NJ 07652 1431, USA
    Eur J Neurosci 23:279-84. 2006

Collaborators

Detail Information

Publications13

  1. ncbi request reprint The heterozygous reeler mouse: behavioural phenotype
    Jana Podhorna
    Department of Psychopharmacology, Psychosis, H Lundbeck A S, Ottiliavej 9, 2500 Copenhagen Valby, Denmark
    Behav Brain Res 153:43-54. 2004
    ....
  2. ncbi request reprint Reversal of PCP-induced learning and memory deficits in the Morris' water maze by sertindole and other antipsychotics
    Michael Didriksen
    Disease Pharmacology, H Lundbeck A S, Ottiliavej 9, 2500 Valby, Denmark
    Psychopharmacology (Berl) 193:225-33. 2007
    ..In clinic, the cognitive deficits are closely associated with functional outcome. Thus, improvement of cognition may have high impact on patients' daily life...
  3. pmc Hippocampal CA1 region shows differential regulation of gene expression in mice displaying extremes in behavioral sensitization to amphetamine: relevance for psychosis susceptibility?
    Nicole A Datson
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research LACDR and Leiden University Medical Center, Leiden University, P O Box 9502, 2300 RA Leiden, The Netherlands
    Psychopharmacology (Berl) 217:525-38. 2011
    ..We hypothesize that the same genes and pathways underlying behavioral sensitization in mice are also involved in the vulnerability to psychosis...
  4. pmc Genome-wide scans using archived neonatal dried blood spot samples
    Mads V Hollegaard
    Section of Neonatal Screening and Hormones, Statens Serum Institut, Copenhagen, Denmark
    BMC Genomics 10:297. 2009
    ..Whole-genome amplified DNA from 24 neonatal dried blood spot samples stored between 15 to 25 years was tested, and high-quality genomic DNA from 8 of the same individuals was used as reference...
  5. ncbi request reprint Sertindole, in contrast to clozapine and olanzapine, does not disrupt water maze performance after acute or chronic treatment
    Michael Didriksen
    Pharmacology Target Research, H Lundbeck A S Ottiliavej 9, 2500 Valby, Denmark
    Eur J Pharmacol 542:108-15. 2006
    ..Clearly further studies are needed to assess the potential cognition-enhancing effects of sertindole vs. other antipsychotics in a relevant animal model of schizophrenia...
  6. ncbi request reprint Lu 35-138 ((+)-(S)-3-{1-[2-(1-acetyl-2,3-dihydro-1H-indol-3-yl)ethyl]-3,6-dihydro-2H-pyridin-4-yl}-6-chloro-1H-indole), a dopamine D4 receptor antagonist and serotonin reuptake inhibitor: characterisation of its in vitro profile and pre-clinical antipsych
    Peter Hertel
    Research and Development, H Lundbeck A S, Copenhagen Valby, Denmark
    Eur J Pharmacol 573:148-60. 2007
    ..Collectively, these results suggest that Lu 35-138 possesses antipsychotic activity combined with a low extrapyramidal and cognitive side effect liability...
  7. doi request reprint Negative modulation of GABAA α5 receptors by RO4938581 attenuates discrete sub-chronic and early postnatal phencyclidine (PCP)-induced cognitive deficits in rats
    John P Redrobe
    Synaptic Transmission I, Neuroscience Research DK, H Lundbeck A S, Ottiliavej 9, 2500 Valby, Denmark
    Psychopharmacology (Berl) 221:451-68. 2012
    ....
  8. ncbi request reprint Cognitive deficits caused by late gestational disruption of neurogenesis in rats: a preclinical model of schizophrenia
    Peter Flagstad
    Department of Pharmacology Target Research, H Lundbeck A S, Copenhagen Valby, Denmark
    Neuropsychopharmacology 30:250-60. 2005
    ..No deficits were observed in the reference memory version of the Morris water maze and in a non-match-to position experiment, showing that the deficits are limited to certain aspects of cognition...
  9. ncbi request reprint Positive modulation of glutamatergic receptors potentiates the suppressive effects of antipsychotics on conditioned avoidance responding in rats
    Christina Kurre Olsen
    Department of Psychopharmacology, Pharmacological Research, H Lundbeck A S, Ottiliavej 9, DK 2500 Valby Copenhagen, Denmark
    Pharmacol Biochem Behav 84:259-65. 2006
    ..Consequently, our data lend further support to the potential use of the CAR test in the investigation of augmentation strategies involving the addition of non-dopaminergic target compounds to existing atypical antipsychotics...
  10. ncbi request reprint Decrease in parvalbumin-expressing neurons in the hippocampus and increased phencyclidine-induced locomotor activity in the rat methylazoxymethanol (MAM) model of schizophrenia
    Silke Penschuck
    Department of Neuroscience, 900, Lundbeck Research USA, Inc, 215 College Road, Paramus, NJ 07652 1431, USA
    Eur J Neurosci 23:279-84. 2006
    ....
  11. ncbi request reprint Disruption of neurogenesis on gestational day 17 in the rat causes behavioral changes relevant to positive and negative schizophrenia symptoms and alters amphetamine-induced dopamine release in nucleus accumbens
    Peter Flagstad
    Department of Psychopharmacology, H Lundbeck A S, Copenhagen Valby, Denmark
    Neuropsychopharmacology 29:2052-64. 2004
    ..This study contributes to the evaluation of the validity of the prenatal MAM GD17 treatment in rats as an animal model for schizophrenia...
  12. doi request reprint Nest building performance following MPTP toxicity in mice
    Thomas Nikolaj Sager
    H Lundbeck A S, Ottiliavej 9, DK 2500 Valby, Denmark
    Behav Brain Res 208:444-9. 2010
    ..However, after 28 days the change in behavior was no longer detected, which may reflect the plasticity of the tyrosine hydroxylase positive neurons in the dorsolateral part of striatum...
  13. pmc Antagonism of dopamine D2 receptor/beta-arrestin 2 interaction is a common property of clinically effective antipsychotics
    Bernard Masri
    Departments of Cell Biology, Medicine and Neurobiology, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 105:13656-61. 2008
    ..Thus, selective targeting of D2(L)R/beta-arrestin 2 interaction and related signaling pathways may provide new opportunities for antipsychotic development...