N Grarup

Summary

Country: Denmark

Publications

  1. doi request reprint Genetic susceptibility to type 2 diabetes and obesity: from genome-wide association studies to rare variants and beyond
    Niels Grarup
    The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, DIKU Building, Universitetsparken 1, 2100, Copenhagen Ø, Denmark
    Diabetologia 57:1528-41. 2014
  2. pmc Estimation of allele frequency and association mapping using next-generation sequencing data
    Su Yeon Kim
    Departments of Integrative Biology and Statistics, UC Berkeley, Berkeley, CA 94720, USA
    BMC Bioinformatics 12:231. 2011
  3. doi request reprint The diabetogenic VPS13C/C2CD4A/C2CD4B rs7172432 variant impairs glucose-stimulated insulin response in 5,722 non-diabetic Danish individuals
    N Grarup
    Marie Krogh Center for Metabolic Research, Section of Metabolic Genetics, Faculty of Health Sciences, University of Copenhagen, Universitetsparken 1 3, 2100 Copenhagen, Denmark
    Diabetologia 54:789-94. 2011
  4. doi request reprint Type 2 diabetes risk allele near CENTD2 is associated with decreased glucose-stimulated insulin release
    T Nielsen
    Marie Krogh Center for Metabolic Research, Section of Metabolic Genetics, Faculty of Health Sciences, University of Copenhagen, Universitetsparken 1, 2100 Copenhagen, Denmark
    Diabetologia 54:1052-6. 2011
  5. doi request reprint Association studies of novel obesity-related gene variants with quantitative metabolic phenotypes in a population-based sample of 6,039 Danish individuals
    K S Burgdorf
    The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health Sciences, University of Copenhagen, Universitetsparken 1, DIKU Building, Room 1 1 N121, DK 2100 Copenhagen, Denmark
    Diabetologia 55:105-13. 2012
  6. doi request reprint A genetic risk score of 45 coronary artery disease risk variants associates with increased risk of myocardial infarction in 6041 Danish individuals
    N T Krarup
    The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark Electronic address
    Atherosclerosis 240:305-10. 2015
  7. doi request reprint Replication and meta-analysis of common variants identifies a genome-wide significant locus in migraine
    A L Esserlind
    Department of Neurology, The Danish Headache Center, Glostrup Hospital, University of Copenhagen, Glostrup, Denmark
    Eur J Neurol 20:765-72. 2013
  8. pmc Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes
    A Albrechtsen
    Centre of Bioinformatics, Faculty of Science, University of Copenhagen, Copenhagen, Denmark
    Diabetologia 56:298-310. 2013
  9. doi request reprint Homozygous carriers of the G allele of rs4664447 of the glucagon gene (GCG) are characterised by decreased fasting and stimulated levels of insulin, glucagon and glucagon-like peptide (GLP)-1
    S S Torekov
    Department of Biomedical Sciences, Faculty of Health Sciences, University of Copenhagen, 2200 Copenhagen, Denmark
    Diabetologia 54:2820-31. 2011

Collaborators

Detail Information

Publications9

  1. doi request reprint Genetic susceptibility to type 2 diabetes and obesity: from genome-wide association studies to rare variants and beyond
    Niels Grarup
    The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, DIKU Building, Universitetsparken 1, 2100, Copenhagen Ø, Denmark
    Diabetologia 57:1528-41. 2014
    ..Here we review recent progress as regards the concepts, methodologies and derived outcomes of studies of the genetics of type 2 diabetes and obesity, and discuss avenues to be investigated in the future within this research field. ..
  2. pmc Estimation of allele frequency and association mapping using next-generation sequencing data
    Su Yeon Kim
    Departments of Integrative Biology and Statistics, UC Berkeley, Berkeley, CA 94720, USA
    BMC Bioinformatics 12:231. 2011
    ..g., < 15X). However, SNP calling and allele frequency estimation in such studies is associated with substantial statistical uncertainty because of varying coverage and high error rates...
  3. doi request reprint The diabetogenic VPS13C/C2CD4A/C2CD4B rs7172432 variant impairs glucose-stimulated insulin response in 5,722 non-diabetic Danish individuals
    N Grarup
    Marie Krogh Center for Metabolic Research, Section of Metabolic Genetics, Faculty of Health Sciences, University of Copenhagen, Universitetsparken 1 3, 2100 Copenhagen, Denmark
    Diabetologia 54:789-94. 2011
    ..We looked for potential associations between the diabetogenic VPS13C/C2CD4A/C2CD4B rs7172432 variant and diabetes-related intermediary traits...
  4. doi request reprint Type 2 diabetes risk allele near CENTD2 is associated with decreased glucose-stimulated insulin release
    T Nielsen
    Marie Krogh Center for Metabolic Research, Section of Metabolic Genetics, Faculty of Health Sciences, University of Copenhagen, Universitetsparken 1, 2100 Copenhagen, Denmark
    Diabetologia 54:1052-6. 2011
    ..Here we evaluate the effect of lead variants of these loci on estimates of insulin release and insulin resistance derived from an oral glucose tolerance test...
  5. doi request reprint Association studies of novel obesity-related gene variants with quantitative metabolic phenotypes in a population-based sample of 6,039 Danish individuals
    K S Burgdorf
    The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health Sciences, University of Copenhagen, Universitetsparken 1, DIKU Building, Room 1 1 N121, DK 2100 Copenhagen, Denmark
    Diabetologia 55:105-13. 2012
    ..The aim of this study was to elucidate if any of these loci had an effect on quantitative measures of glucose homeostasis, including estimates of insulin release and insulin sensitivity in an epidemiological setting...
  6. doi request reprint A genetic risk score of 45 coronary artery disease risk variants associates with increased risk of myocardial infarction in 6041 Danish individuals
    N T Krarup
    The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark Electronic address
    Atherosclerosis 240:305-10. 2015
    ..We constructed a genetic risk score (GRS) of these variants to estimate the effect on incidence and clinical predictability of myocardial infarction (MI) and CAD...
  7. doi request reprint Replication and meta-analysis of common variants identifies a genome-wide significant locus in migraine
    A L Esserlind
    Department of Neurology, The Danish Headache Center, Glostrup Hospital, University of Copenhagen, Glostrup, Denmark
    Eur J Neurol 20:765-72. 2013
    ..We aimed to evaluate the top association single nucleotide polymorphisms (SNPs) from the discovery set by Chasman et al. in a primarily clinic-based Danish and Icelandic cohort...
  8. pmc Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes
    A Albrechtsen
    Centre of Bioinformatics, Faculty of Science, University of Copenhagen, Copenhagen, Denmark
    Diabetologia 56:298-310. 2013
    ..Here we applied exome sequencing to identify novel associations of coding polymorphisms at minor allele frequencies (MAFs) >1% with common metabolic phenotypes...
  9. doi request reprint Homozygous carriers of the G allele of rs4664447 of the glucagon gene (GCG) are characterised by decreased fasting and stimulated levels of insulin, glucagon and glucagon-like peptide (GLP)-1
    S S Torekov
    Department of Biomedical Sciences, Faculty of Health Sciences, University of Copenhagen, 2200 Copenhagen, Denmark
    Diabetologia 54:2820-31. 2011
    ..The glucagon gene (GCG) encodes several hormones important for energy metabolism: glucagon, oxyntomodulin and glucagon-like peptide (GLP)-1 and -2. Variants in GCG may associate with type 2 diabetes, obesity and/or related metabolic traits...