Anne Tybjaerg-Hansen

Summary

Affiliation: Copenhagen University Hospital
Country: Denmark

Publications

  1. ncbi Phenotype of heterozygotes for low-density lipoprotein receptor mutations identified in different background populations
    Anne Tybjaerg-Hansen
    Department of Clinical Biochemistry KB 3011, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Arterioscler Thromb Vasc Biol 25:211-5. 2005
  2. ncbi Angiotensinogen gene polymorphism, plasma angiotensinogen, and risk of hypertension and ischemic heart disease: a meta-analysis
    Amar Akhtar Sethi
    Department of Clinical Biochemistry, Herlev University Hospital, Copenhagen, Denmark
    Arterioscler Thromb Vasc Biol 23:1269-75. 2003
  3. doi Prothrombin and risk of venous thromboembolism, ischemic heart disease and ischemic cerebrovascular disease in the general population
    Maren Weischer
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, Copenhagen, Denmark
    Atherosclerosis 208:480-3. 2010
  4. ncbi Combined analysis of six lipoprotein lipase genetic variants on triglycerides, high-density lipoprotein, and ischemic heart disease: cross-sectional, prospective, and case-control studies from the Copenhagen City Heart Study
    Hans H Wittrup
    Department of Clinical Biochemistry, Herlev University Hospital, Herlev Ringvej 75, DK 2730 Herlev, Denmark
    J Clin Endocrinol Metab 91:1438-45. 2006
  5. ncbi Effect of gender on phenotypic expression of the S447X mutation in LPL: the Copenhagen City Heart Study
    Hans H Wittrup
    Department of Clinical Biochemistry, Herlev University Hospital, Copenhagen, Denmark
    Atherosclerosis 165:119-26. 2002
  6. ncbi Hepatic lipase mutations,elevated high-density lipoprotein cholesterol, and increased risk of ischemic heart disease: the Copenhagen City Heart Study
    Rolf V Andersen
    Department of Clinical Biochemistry, Herlev University Hospital, Herlev Ringvej 75, DK 2730 Herlev, Denmark
    J Am Coll Cardiol 41:1972-82. 2003
  7. ncbi Blood pressure, risk of ischemic cerebrovascular and ischemic heart disease, and longevity in alpha(1)-antitrypsin deficiency: the Copenhagen City Heart Study
    Morten Dahl
    Department of Clinical Biochemistry, Herlev University Hospital, Denmark
    Circulation 107:747-52. 2003
  8. pmc Subsets of SNPs define rare genotype classes that predict ischemic heart disease
    Ruth Frikke-Schmidt
    Department of Clinical Biochemistry KB3011, Section for Molecular Genetics, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100, Copenhagen Ø, Denmark
    Hum Genet 120:865-77. 2007
  9. ncbi Angiotensinogen single nucleotide polymorphisms, elevated blood pressure, and risk of cardiovascular disease
    Amar A Sethi
    Department of Clinical Biochemistry, Herlev University Hospital, Copenhagen, Denmark
    Hypertension 41:1202-11. 2003
  10. ncbi Estrogen receptor alpha polymorphism and risk of cardiovascular disease, cancer, and hip fracture: cross-sectional, cohort, and case-control studies and a meta-analysis
    Alisa D Kjaergaard
    Department of Clinical Biochemistry, Herlev University Hospital, Herlev Ringvej 75, DK 2730 Herlev, Denmark
    Circulation 115:861-71. 2007

Collaborators

Detail Information

Publications88

  1. ncbi Phenotype of heterozygotes for low-density lipoprotein receptor mutations identified in different background populations
    Anne Tybjaerg-Hansen
    Department of Clinical Biochemistry KB 3011, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Arterioscler Thromb Vasc Biol 25:211-5. 2005
    ....
  2. ncbi Angiotensinogen gene polymorphism, plasma angiotensinogen, and risk of hypertension and ischemic heart disease: a meta-analysis
    Amar Akhtar Sethi
    Department of Clinical Biochemistry, Herlev University Hospital, Copenhagen, Denmark
    Arterioscler Thromb Vasc Biol 23:1269-75. 2003
    ....
  3. doi Prothrombin and risk of venous thromboembolism, ischemic heart disease and ischemic cerebrovascular disease in the general population
    Maren Weischer
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, Copenhagen, Denmark
    Atherosclerosis 208:480-3. 2010
    ....
  4. ncbi Combined analysis of six lipoprotein lipase genetic variants on triglycerides, high-density lipoprotein, and ischemic heart disease: cross-sectional, prospective, and case-control studies from the Copenhagen City Heart Study
    Hans H Wittrup
    Department of Clinical Biochemistry, Herlev University Hospital, Herlev Ringvej 75, DK 2730 Herlev, Denmark
    J Clin Endocrinol Metab 91:1438-45. 2006
    ..Genetic variants in lipoprotein lipase may affect triglycerides, high-density lipoprotein (HDL), and risk of ischemic heart disease (IHD)...
  5. ncbi Effect of gender on phenotypic expression of the S447X mutation in LPL: the Copenhagen City Heart Study
    Hans H Wittrup
    Department of Clinical Biochemistry, Herlev University Hospital, Copenhagen, Denmark
    Atherosclerosis 165:119-26. 2002
    ..97; P=0.98). The S447X mutation is associated with anti-atherogenic effects on TG and HDL cholesterol in both genders, and with a moderate protective effect on risk of ischemic heart disease in men...
  6. ncbi Hepatic lipase mutations,elevated high-density lipoprotein cholesterol, and increased risk of ischemic heart disease: the Copenhagen City Heart Study
    Rolf V Andersen
    Department of Clinical Biochemistry, Herlev University Hospital, Herlev Ringvej 75, DK 2730 Herlev, Denmark
    J Am Coll Cardiol 41:1972-82. 2003
    ..Our primary hypothesis was that these SNPs associate with IHD after adjustment for HDL levels...
  7. ncbi Blood pressure, risk of ischemic cerebrovascular and ischemic heart disease, and longevity in alpha(1)-antitrypsin deficiency: the Copenhagen City Heart Study
    Morten Dahl
    Department of Clinical Biochemistry, Herlev University Hospital, Denmark
    Circulation 107:747-52. 2003
    ....
  8. pmc Subsets of SNPs define rare genotype classes that predict ischemic heart disease
    Ruth Frikke-Schmidt
    Department of Clinical Biochemistry KB3011, Section for Molecular Genetics, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100, Copenhagen Ø, Denmark
    Hum Genet 120:865-77. 2007
    ..In conclusion, we present evidence that combinations of SNPs in APOE and LPL identify subgroups of individuals at substantially increased risk of IHD beyond that associated with smoking, diabetes and hypertension...
  9. ncbi Angiotensinogen single nucleotide polymorphisms, elevated blood pressure, and risk of cardiovascular disease
    Amar A Sethi
    Department of Clinical Biochemistry, Herlev University Hospital, Copenhagen, Denmark
    Hypertension 41:1202-11. 2003
    ....
  10. ncbi Estrogen receptor alpha polymorphism and risk of cardiovascular disease, cancer, and hip fracture: cross-sectional, cohort, and case-control studies and a meta-analysis
    Alisa D Kjaergaard
    Department of Clinical Biochemistry, Herlev University Hospital, Herlev Ringvej 75, DK 2730 Herlev, Denmark
    Circulation 115:861-71. 2007
    ....
  11. ncbi 164Ile allele in the beta2-Adrenergic receptor gene is associated with risk of elevated blood pressure in women. The Copenhagen City Heart Study
    Amar A Sethi
    Department of Clinical Biochemistry, Herlev University Hospital, Herlev, Denmark
    Pharmacogenet Genomics 15:633-45. 2005
    ..We tested the hypothesis that Gly16Arg, Gln27Glu, and Thr164Ile in the beta2-adrenergic receptor gene associated with elevated blood pressure...
  12. ncbi Genetically reduced antioxidative protection and increased ischemic heart disease risk: The Copenhagen City Heart Study
    Klaus Juul
    Department of Clinical Biochemistry, Herlev University Hospital, Herlev Ringvej 75, DK 2730 Herlev, Denmark
    Circulation 109:59-65. 2004
    ..The secondary hypothesis was that EC-SOD-R213G offers predictive ability with respect to IHD beyond that offered by measurements of plasma EC-SOD and autoantibodies against oxidized LDL (oxLDL)...
  13. ncbi Zinc Finger Protein 202: a new candidate gene for ischemic heart disease: The Copenhagen City Heart Study
    Maria C A Stene
    Department of Clinical Biochemistry, KB 3011, Section for Molecular Genetics, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK 2100 Copenhagen Ø, Denmark
    Atherosclerosis 188:43-50. 2006
    ..We tested the hypothesis that a common variant in ZNF202, A154V, predicts risk of ischemic heart disease (IHD), myocardial infarction (MI), and ischemic cerebrovascular disease (ICVD)...
  14. ncbi Increased risk of breast cancer associated with CHEK2*1100delC
    Maren Weischer
    Department of Clinical Biochemistry, Herlev University Hospital, Herlev, Denmark
    J Clin Oncol 25:57-63. 2007
    ..We tested the hypothesis that CHEK2*1100delC heterozygosity in the general population increases the risk of cancer in general, and breast, prostate, and colorectal cancer in particular...
  15. ncbi Polymorphism in APOB associated with increased low-density lipoprotein levels in both genders in the general population
    Marianne Benn
    Department of Clinical Biochemistry, KB3011, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK 2100 Copenhagen Ø, Denmark
    J Clin Endocrinol Metab 90:5797-803. 2005
    ..Rare mutations in APOB cause hypercholesterolemia. Whether common polymorphisms in APOB have similar effects remains controversial...
  16. doi PCSK9 R46L, low-density lipoprotein cholesterol levels, and risk of ischemic heart disease: 3 independent studies and meta-analyses
    Marianne Benn
    Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    J Am Coll Cardiol 55:2833-42. 2010
    ..The aim of this study was to examine the effect of PCSK9 R46L on low-density lipoprotein cholesterol (LDL-C), risk of ischemic heart disease (IHD), and mortality...
  17. ncbi Integrin beta3 Leu33Pro homozygosity and risk of cancer
    Stig E Bojesen
    Department of Clinical Biochemistry, Herlev University Hospital, Herlev, Denmark
    J Natl Cancer Inst 95:1150-7. 2003
    ..The Leu33Pro polymorphism of the beta3 subunit modulates the function of alpha(IIb)beta3 integrin. We examined whether this polymorphism influences cancer risk...
  18. doi C-reactive protein and the risk of cancer: a mendelian randomization study
    Kristine H Allin
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev Ringvej 75, DK 2730 Herlev, Denmark
    J Natl Cancer Inst 102:202-6. 2010
    ..The estimated causal odds ratio for cancer associated with a genetically induced doubling in CRP level was 0.94 (95% CI = 0.81 to 1.08). This finding suggests that elevated CRP levels do not cause cancer...
  19. ncbi Change in lung function and morbidity from chronic obstructive pulmonary disease in alpha1-antitrypsin MZ heterozygotes: A longitudinal study of the general population
    Morten Dahl
    Department of Clinical Biochemistry 54M1, Herlev University Hospital, Herlev Ringvej 75, DK 2730 Herlev, Denmark
    Ann Intern Med 136:270-9. 2002
    ..A deteriorating effect of severe alpha(1)-antitrypsin deficiency (ZZ genotype) on lung function is well known, whereas the role of intermediate deficiency (MZ genotype) remains uncertain...
  20. doi Promotor polymorphisms in leukotriene C4 synthase and risk of ischemic cerebrovascular disease
    Jacob J Freiberg
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev Ringvej 75, DK 2730 Herlev, Denmark
    Arterioscler Thromb Vasc Biol 28:990-6. 2008
    ..We tested the hypothesis that the -444 A/C and -1072 G/A polymorphisms of the leukotriene C(4) synthase associate with risk of ischemic cerebrovascular disease...
  21. ncbi Improving prediction of ischemic cardiovascular disease in the general population using apolipoprotein B: the Copenhagen City Heart Study
    Marianne Benn
    Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK 2100 Copenhagen Ø, Denmark
    Arterioscler Thromb Vasc Biol 27:661-70. 2007
    ..We tested the following hypotheses: apoB predicts ischemic cardiovascular events, and apoB is a better predictor of ischemic cardiovascular events than low-density lipoprotein cholesterol...
  22. pmc Nonfasting glucose, ischemic heart disease, and myocardial infarction: a Mendelian randomization study
    Marianne Benn
    Department of Clinical Biochemistry, Herlev Hospital, Denmark
    J Am Coll Cardiol 59:2356-65. 2012
    ..The purpose of this study was to test whether elevated nonfasting glucose levels associate with and cause ischemic heart disease (IHD) and myocardial infarction (MI)...
  23. doi Copy number variation in glutathione S-transferases M1 and T1 and ischemic vascular disease: four studies and meta-analyses
    Marianne S Nørskov
    Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, Denmark
    Circ Cardiovasc Genet 4:418-28. 2011
    ..We tested the hypothesis that copy number variation (CNV) in GSTM1 and GSTT1 genes, known to be associated with stepwise decreases in catalytic activity, predict risk of IVD...
  24. ncbi Genetic variation in ABCA1 predicts ischemic heart disease in the general population
    Ruth Frikke-Schmidt
    Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK 2100 Copenhagen Ø, Denmark
    Arterioscler Thromb Vasc Biol 28:180-6. 2008
    ..We tested the hypothesis that 6 nonsynonymous single nucleotide polymorphisms (SNPs) in ATP-Binding-Cassette transporter A1 (ABCA1) affect risk of ischemic heart disease (IHD) in the general population...
  25. ncbi Factor V Leiden and the risk for venous thromboembolism in the adult Danish population
    Klaus Juul
    Herlev University Hospital, Herlev, Denmark
    Ann Intern Med 140:330-7. 2004
    ..Odds ratios for venous thromboembolism (deep venous thrombosis and pulmonary embolism) derived from case-control studies range from 3 to 16 for heterozygotes compared with noncarriers and up to 79 for homozygotes compared with noncarriers...
  26. ncbi Gender- and age-specific contributions of additional DNA sequence variation in the 5' regulatory region of the APOE gene to prediction of measures of lipid metabolism
    Ruth Frikke-Schmidt
    Department of Clinical Biochemistry KB3011, Section for Molecular Genetics, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100 Copenhagen, Denmark
    Hum Genet 115:331-45. 2004
    ..2059T --> C and g.2197C --> T SNPs doubled the estimate of genetic variance of high-density lipoprotein and apolipoprotein Al in middle-aged females...
  27. doi CHEK2*1100delC genotyping for clinical assessment of breast cancer risk: meta-analyses of 26,000 patient cases and 27,000 controls
    Maren Weischer
    Department of Clinical Biochemistry, Herlev University Hospital, Herlev Ringvej 75, Herlev, Denmark
    J Clin Oncol 26:542-8. 2008
    ..CHEK2*1100delC heterozygosity may be associated with an increased risk of breast cancer; however, it is unclear whether the evidence is sufficient to recommend genotyping in clinical practice...
  28. pmc Asthma and COPD in cystic fibrosis intron-8 5T carriers. A population-based study
    Morten Dahl
    Department of Clinical Biochemistry, Herlev University Hospital, DK 2730 Herlev, Denmark
    Respir Res 6:113. 2005
    ..Carriers of cystic fibrosis intron-8 5T alleles with high exon-9 skipping could have increased annual lung function decline and increased risk for asthma or chronic obstructive pulmonary disease (COPD)...
  29. ncbi Single nucleotide polymorphism in the low-density lipoprotein receptor is associated with a threefold risk of stroke. A case-control and prospective study
    Ruth Frikke-Schmidt
    Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK 2100 Copenhagen Ø, Denmark
    Eur Heart J 25:943-51. 2004
    ..In contrast, only a single common amino acid-changing polymorphism (A370T) has been reported in this gene. The association of this polymorphism with variations in lipid levels is at present unclear...
  30. doi C-reactive protein and risk of venous thromboembolism in the general population
    Jeppe Zacho
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Arterioscler Thromb Vasc Biol 30:1672-8. 2010
    ..To examine the robustness of the association between C-reactive protein (CRP) levels and increased risk of venous thromboembolism (VTE) and to examine whether genetically elevated CRP levels cause VTE...
  31. doi Genetically elevated C-reactive protein and ischemic vascular disease
    Jeppe Zacho
    Department of Clinical Biochemistry, Herlev Hospital, Faculty of Health Sciences, University of Copenhagen, Copenhagen
    N Engl J Med 359:1897-908. 2008
    ..Elevated levels of C-reactive protein (CRP) are associated with increased risks of ischemic heart disease and ischemic cerebrovascular disease. We tested whether this is a causal association...
  32. pmc Genetic variation in ABC transporter A1 contributes to HDL cholesterol in the general population
    Ruth Frikke-Schmidt
    Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    J Clin Invest 114:1343-53. 2004
    ..In conclusion, we show that at least 10% of individuals with low HDL-C in the general population are heterozygous for mutations in ABCA1 and that both mutations and SNPs in ABCA1 contribute to HDL-C levels in the general population...
  33. ncbi Factor V Leiden: The Copenhagen City Heart Study and 2 meta-analyses
    Klaus Juul
    Department of Clinical Biochemistry, Herlev University Hospital, Herlev, Denmark
    Blood 100:3-10. 2002
    ..92 (95% CI, 0.56-1.53) and 0.68 (0.45-1.04), and for non-MI-IHD 1.01 (95% CI, 0.71-1.44) and 0.97 (0.66-1.42). Findings from The Copenhagen City Heart Study suggest that FVL is not associated with MI, IS, or non-MI-IHD...
  34. doi Angiotensinogen and ACE gene polymorphisms and risk of atrial fibrillation in the general population
    Lasse S Ravn
    Department of Cardiology, Danish Arrhythmia Research Center, Copenhagen, Denmark
    Pharmacogenet Genomics 18:525-33. 2008
    ..We hypothesized that polymorphisms in the angiotensinogen and angiotensin-converting enzyme (ACE) genes encoding proteins in this system predict risk of atrial fibrillation...
  35. doi Pentanucleotide repeat polymorphism, lipoprotein(a) levels, and risk of ischemic heart disease
    Pia R Kamstrup
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev Ringvej 75, DK 2730 Herlev, Denmark
    J Clin Endocrinol Metab 93:3769-76. 2008
    ..Lipoprotein(a) is a cardiovascular risk factor. Levels of lipoprotein(a) are predominantly determined by apolipoprotein(a) gene variation, including a pentanucleotide repeat promoter polymorphism...
  36. doi Functional promoter variant in zinc finger protein 202 predicts severe atherosclerosis and ischemic heart disease
    Maria C A Stene
    Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    J Am Coll Cardiol 52:369-77. 2008
    ..This study was designed to test the hypotheses that single nucleotide polymorphisms (SNPs), in zinc finger protein 202 (ZNF202), predict severe atherosclerosis and ischemic heart disease (IHD)...
  37. pmc A population-based study of morbidity and mortality in mannose-binding lectin deficiency
    Morten Dahl
    Department of Clinical Biochemistry 54M1, Herlev Ringvej 75, Herlev University Hospital, DK 2730 Herlev, Denmark
    J Exp Med 199:1391-9. 2004
    ..Our results suggest that MBL deficiency is not a major risk factor for morbidity or death in the adult Caucasian population...
  38. ncbi Common and rare alleles in apolipoprotein B contribute to plasma levels of low-density lipoprotein cholesterol in the general population
    Marianne Benn
    Department of Clinical Biochemistry KB3011, Section for Molecular Genetics, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK 2100 Copenhagen Ø, Denmark
    J Clin Endocrinol Metab 93:1038-45. 2008
    ..Despite this, common single-nucleotide polymorphisms (SNPs) in APOB have not convincingly been demonstrated to affect low-density lipoprotein (LDL) cholesterol levels...
  39. ncbi Hemochromatosis mutations in the general population: iron overload progression rate
    Rolf Vaern Andersen
    Department of Clinical Biochemistry, Herlev University Hospital, Copenhagen, Denmark
    Blood 103:2914-9. 2004
    ..Therefore, C282Y homozygotes identified during population screening, and not because of clinically overt hemochromatosis, at most need to be screened for manifestations of hemochromatosis every 10 to 20 years...
  40. ncbi Platelet glycoprotein IIb/IIIa Pl(A2)/Pl(A2) homozygosity associated with risk of ischemic cardiovascular disease and myocardial infarction in young men: the Copenhagen City Heart Study
    Stig E Bojesen
    Department of Clinical Biochemistry, Herlev University Hospital, Herlev, Denmark
    J Am Coll Cardiol 42:661-7. 2003
    ....
  41. ncbi Mutation in apolipoprotein B associated with hypobetalipoproteinemia despite decreased binding to the low density lipoprotein receptor
    Marianne Benn
    Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    J Biol Chem 280:21052-60. 2005
    ....
  42. pmc AT1 mutations and risk of atrial fibrillation based on genotypes from 71,000 individuals from the general population
    Sarah C W Marott
    Department of Clinical Biochemistry, Herlev Hospital, Herlev, Denmark
    Br J Clin Pharmacol 76:114-24. 2013
    ....
  43. pmc The effect of elevated body mass index on ischemic heart disease risk: causal estimates from a Mendelian randomisation approach
    Børge G Nordestgaard
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Denmark
    PLoS Med 9:e1001212. 2012
    ..We tested the hypothesis that positive observational associations between BMI and IHD are causal...
  44. ncbi Mutation in ABCA1 predicted risk of ischemic heart disease in the Copenhagen City Heart Study Population
    Ruth Frikke-Schmidt
    Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    J Am Coll Cardiol 46:1516-20. 2005
    ..We tested whether heterozygosity for the K776N mutation (frequency: 0.4%) in ATP-binding cassette transporter A1 (ABCA1) predicted ischemic heart disease (IHD) in the Copenhagen City Heart Study population...
  45. doi Nonfasting triglycerides, cholesterol, and ischemic stroke in the general population
    Anette Varbo
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark
    Ann Neurol 69:628-34. 2011
    ..We compared stepwise increasing levels of nonfasting triglycerides and cholesterol for their association with risk of ischemic stroke in the general population...
  46. doi Two novel mutations in surfactant protein-C, lung function and obstructive lung disease
    Marie Baekvad-Hansen
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Faculty of Health Sciences, Herlev Ringvej 75, DK 2730 Herlev, Copenhagen, Denmark
    Respir Med 104:418-25. 2010
    ..A53T heterozygotes had increased asthma risk, but further research is required to conclusively determine whether this mutation is associated with asthma...
  47. doi Does elevated C-reactive protein increase atrial fibrillation risk? A Mendelian randomization of 47,000 individuals from the general population
    Sarah C W Marott
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark
    J Am Coll Cardiol 56:789-95. 2010
    ..The purpose of this study was to test whether the association of C-reactive protein (CRP) with increased risk of atrial fibrillation is a robust and perhaps even causal association...
  48. doi The ABCG5/8 cholesterol transporter and myocardial infarction versus gallstone disease
    Stefan Stender
    Copenhagen University Hospitals and Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark
    J Am Coll Cardiol 63:2121-8. 2014
    ....
  49. doi Elevated body mass index as a causal risk factor for symptomatic gallstone disease: a Mendelian randomization study
    Stefan Stender
    Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital and Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
    Hepatology 58:2133-41. 2013
    ..37) overall and 1.20 (95% CI: 1.00-1.44) and 1.02 (95% CI: 0.90-1.16) in women and men, respectively. Corresponding observational HRs were 1.07 (95% CI: 1.06-1.08), 1.08 (95% CI: 1.07-1.10), and 1.04 (95% CI: 1.02-1.07), respectively...
  50. ncbi Hemochromatosis genotypes and risk of 31 disease endpoints: meta-analyses including 66,000 cases and 226,000 controls
    Christina Ellervik
    Department of Clinical Biochemistry, Herlev University Hospital, Denmark
    Hepatology 46:1071-80. 2007
    ..4 (1.1-11) for diabetes mellitus among North Europeans...
  51. doi Sterol transporter adenosine triphosphate-binding cassette transporter G8, gallstones, and biliary cancer in 62,000 individuals from the general population
    Stefan Stender
    Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark
    Hepatology 53:640-8. 2011
    ..001)...
  52. doi Association of loss-of-function mutations in the ABCA1 gene with high-density lipoprotein cholesterol levels and risk of ischemic heart disease
    Ruth Frikke-Schmidt
    Department of Clinical Biochemistry, Rigshospitalet, Herlev Hospital
    JAMA 299:2524-32. 2008
    ..Low levels of high-density lipoprotein (HDL) cholesterol are inversely related to cardiovascular risk. Whether this is a causal effect is unclear...
  53. doi Risk of cancer by ATM missense mutations in the general population
    Sarah Louise Dombernowsky
    Department of Clinical Biochemistry, Herlev University Hospital, Herlev Ringvej 75, DK 2730 Herlev, Denmark
    J Clin Oncol 26:3057-62. 2008
    ..We tested the hypotheses that ATM Ser49Cys and ATM Ser707Pro heterozygosity increase the risk of cancer overall, of breast cancer, and of 26 other cancer subtypes in the general population...
  54. doi Genetically reduced soluble epoxide hydrolase activity and risk of stroke and other cardiovascular disease
    Julie Lee
    Department of Clinical Biochemistry K54M1, Herlev Hospital, Copenhagen University Hospital, Herlev Ringvej 75, DK 2730 Herlev, Denmark
    Stroke 41:27-33. 2010
    ..We tested whether genetically reduced soluble epoxide hydrolase activity is associated with risk of ischemic stroke, myocardial infarction, and ischemic heart disease...
  55. doi Hepatic lipase, genetically elevated high-density lipoprotein, and risk of ischemic cardiovascular disease
    Trine Holm Johannsen
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark
    J Clin Endocrinol Metab 94:1264-73. 2009
    ..Hepatic lipase influences metabolism of high-density lipoprotein (HDL), a risk factor for ischemic cardiovascular disease (ICD: ischemic heart disease and ischemic cerebrovascular disease)...
  56. ncbi Zinc Finger Protein 202, genetic variation, and HDL cholesterol in the general population
    Maria C Stene
    Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Denmark
    J Lipid Res 47:944-52. 2006
    ..We show that genetic variation in ZNF202 is common in the general population. However, SNPs in the protein-coding region of ZNF202 do not make a major contribution to HDL cholesterol levels...
  57. ncbi Factor V leiden homozygosity, dyspnea, and reduced pulmonary function
    Klaus Juul
    Department of Clinical Biochemistry, Herlev University Hospital, Herlev, Denmark
    Arch Intern Med 165:2032-6. 2005
    ..We tested the hypothesis that factor V Leiden homozygosity is associated with pulmonary symptoms and signs...
  58. ncbi Extreme lipoprotein(a) levels and risk of myocardial infarction in the general population: the Copenhagen City Heart Study
    Pia R Kamstrup
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark
    Circulation 117:176-84. 2008
    ....
  59. ncbi Genetically increased antioxidative protection and decreased chronic obstructive pulmonary disease
    Klaus Juul
    Department of Clinical Biochemistry, Herlev University Hospital, Herlev, Denmark
    Am J Respir Crit Care Med 173:858-64. 2006
    ....
  60. ncbi Methylenetetrahydrofolate reductase polymorphism (C677T), hyperhomocysteinemia, and risk of ischemic cardiovascular disease and venous thromboembolism: prospective and case-control studies from the Copenhagen City Heart Study
    Jeppe Frederiksen
    Department of Clinical Biochemistry, Herlev University Hospital, Herlev Ringvej 75, DK 2730 Herlev, Denmark
    Blood 104:3046-51. 2004
    ..In conclusion, MTHFR C677T homozygosity with hyperhomocysteinemia is not associated with ICD or VTE; however, ICD/VTE is associated with hyperhomocysteinemia. Therefore, ICD and VTE may cause hyperhomocysteinemia, rather than vice versa...
  61. ncbi Alcoholism and alcohol drinking habits predicted from alcohol dehydrogenase genes
    Janne Schurmann Tolstrup
    Center for Alcohol Research, National Institute of Public Health, Copenhagen, Denmark
    Pharmacogenomics J 8:220-7. 2008
    ..1/1 genotype was 67 and 62% among the white population compared with 9 and 24% among the East Asian population...
  62. pmc Tumor suppressor p53 Arg72Pro polymorphism and longevity, cancer survival, and risk of cancer in the general population
    David Dynnes Ørsted
    Department of Clinical Biochemistry, Herlev University Hospital, University of Copenhagen, DK 2730 Herlev, Denmark
    J Exp Med 204:1295-301. 2007
    ..The increased longevity may be due to increased survival after a diagnosis of cancer or other life-threatening diseases...
  63. doi Genetically elevated lipoprotein(a) and increased risk of myocardial infarction
    Pia R Kamstrup
    Department of Clinical Biochemistry, Herlev Hospital, Herlev Ringvej 75, DK 2730 Herlev, Denmark
    JAMA 301:2331-9. 2009
    ..High levels of lipoprotein(a) are associated with increased risk of myocardial infarction (MI)...
  64. doi Surfactant protein-B 121ins2 heterozygosity, reduced pulmonary function, and chronic obstructive pulmonary disease in smokers
    Marie Baekvad-Hansen
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Denmark
    Am J Respir Crit Care Med 181:17-20. 2010
    ..Individuals heterozygous for this mutation have partial absence of surfactant protein-B and could be at risk of lung disease when exposed to additional risk factors for impaired surfactant function such as tobacco smoking...
  65. doi Missense variants in plakophilin-2 in arrhythmogenic right ventricular cardiomyopathy patients--disease-causing or innocent bystanders?
    Alex Hørby Christensen
    Department of Cardiology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    Cardiology 115:148-54. 2010
    ..We hypothesized that a Scandinavian ARVC/D population would have a different spectrum of plakophilin-2 (PKP2) mutations and that some of the reported missense mutations may not be pathogenic...
  66. doi C-reactive protein and all-cause mortality--the Copenhagen City Heart Study
    Jeppe Zacho
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev Ringvej 75, DK 2730, Herlev, Denmark
    Eur Heart J 31:1624-32. 2010
    ..We tested whether elevated levels of C-reactive protein is robustly and causally associated with all-cause mortality...
  67. ncbi Leukotriene C4 synthase and ischemic cardiovascular disease and obstructive pulmonary disease in 13,000 individuals
    Jacob J Freiberg
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Faculty of Health Sciences, University of Copenhagen, Denmark
    J Mol Cell Cardiol 46:579-86. 2009
    ..3) and 1.2 (1.0-1.5). These genotypes were not associated with risk of asthma or COPD. Leukotriene C4 synthase promoter genotypes influence risk of TIA and ischemic stroke, but not risk of IHD/coronary atherosclerosis, asthma, or COPD...
  68. ncbi Nonfasting triglycerides and risk of myocardial infarction, ischemic heart disease, and death in men and women
    Børge G Nordestgaard
    Department of Clinical Biochemistry, Herlev University Hospital, Herlev, Denmark
    JAMA 298:299-308. 2007
    ..Elevated nonfasting triglycerides indicate the presence of remnant lipoproteins, which may promote atherosclerosis...
  69. ncbi Polymorphisms in apolipoprotein B and risk of ischemic stroke
    Marianne Benn
    Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, DK 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 92:3611-7. 2007
    ..Apolipoprotein B levels associate with risk of ischemic stroke. APOB polymorphisms may influence levels of apolipoprotein B and low-density lipoprotein (LDL), but whether they associate with risk of ischemic stroke is unknown...
  70. doi High-throughput genotyping of copy number variation in glutathione S-transferases M1 and T1 using real-time PCR in 20,687 individuals
    Marianne S Nørskov
    Department of Clinical Biochemistry, KB 3011, Section for Molecular Genetics, Rigshospitalet, Copenhagen University Hospital Blegdamsvej 9, DK 2100 Copenhagen Ø, Denmark
    Clin Biochem 42:201-9. 2009
    ..We report an optimized method for the determination of copy number variation (CNV) in GST genes...
  71. doi Mitochondrial haplogroups: ischemic cardiovascular disease, other diseases, mortality, and longevity in the general population
    Marianne Benn
    Department of Clinical Biochemistry, Section for Molecular Genetics, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK 2100 Copenhagen Ø, Denmark
    Circulation 117:2492-501. 2008
    ..We tested the hypothesis that common haplogroups predict risk of ischemic cardiovascular disease, morbidity from other causes, mortality, and longevity in a general population of European descent...
  72. pmc Contribution of regulatory and structural variations in APOE to predicting dyslipidemia
    Jari H Stengård
    National Public Health Institute, Helsinki, Finland
    J Lipid Res 47:318-28. 2006
    ..Our study suggests that both regulatory and structural variations should be considered when evaluating the utility of APOE for predicting dyslipidemia in the population at large...
  73. ncbi [Prevalence of hemochromatosis-associated mutations in the hemochromatosis gene in the Danish population]
    Lisbeth Enggaard Larsen
    Medicinsk haematologisk afdeling L og klinisk biokemisk afdeling, Amtssygehuset i Herlev
    Ugeskr Laeger 164:4545-7. 2002
    ..In the present study, we determined the prevalence of the haemochromatosis-associated mutations, C282Y and H63D, in the Danish general population...
  74. ncbi A new variant with two amino acid substitutions: Hb S-Cameroon [beta6(A3)Glu-->Val;beta90(F6)Glu-->Lys]
    Jens R Bundgaard
    Department of Clinical Biochemistry, HS Rigshospitalet, Copenhagen University Hospital, Denmark
    Hemoglobin 28:131-5. 2004
  75. ncbi Promoter haplotype of a new ABCA1 mutant influences expression of familial hypoalphalipoproteinemia
    Tania L Slatter
    Department of Biochemistry, University of Otago, P O Box 56, 710 Cumberland St, Dunedin 9001, Otago, New Zealand
    Atherosclerosis 187:393-400. 2006
    ..In contrast, the maternal 1068H allele has less effect and is associated with a relatively normal HDL level. We conclude that haplotypes of mutant ABCA1 alleles may contribute to the phenotypic variance shown between FHA individuals...
  76. ncbi Integrin beta3 Leu33Pro polymorphism and risk of hip fracture: 25 years follow-up of 9233 adults from the general population
    Charlotte L Tofteng
    Osteoporosis Research Clinic, Department of Endocrinology, Hvidovre University Hospital, Hvidovre, Denmark
    Pharmacogenet Genomics 17:85-91. 2007
    ..Integrin alphavbeta3 antagonists have antiresorptive effects in bone. We tested the hypothesis that the Leu33Pro polymorphism in the integrin beta3-subunit associates with risk of hip fracture...
  77. ncbi Hereditary hemochromatosis and risk of ischemic heart disease: a prospective study and a case-control study
    Christina Ellervik
    Department of Clinical Biochemistry, Herlev University Hospital, Herlev, Denmark
    Circulation 112:185-93. 2005
    ..We tested the hypothesis that the hereditary hemochromatosis genotypes C282Y/C282Y, C282Y/H63D, or C282Y/wild-type are risk factors for ischemic heart disease (IHD) and myocardial infarction (MI)...
  78. pmc An application of the patient rule-induction method for evaluating the contribution of the Apolipoprotein E and Lipoprotein Lipase genes to predicting ischemic heart disease
    Greg Dyson
    Department of Human Genetics, University of Michigan, Ann Arbor, Michigan 48109 0618, USA, and Department of Clinical Biochemistry, Section for Molecular Genetics, Rigshospitalet, Copenhagen University Hospital, Denmark
    Genet Epidemiol 31:515-27. 2007
    ..An independent sample of 362 unrelated individuals also from the city of Copenhagen was used to test the model obtained for each of the hypothesized partitions...
  79. ncbi [Six case-control studies from the Osterbro-study (The Copenhagen City Heart Study). Angiotensinogen mutations and risk of myocardial and cerebral ischemia]
    Amar A Sethi
    Klinisk biokjemisk avd, Herlev Universitets Hospital
    Lakartidningen 99:2392-3. 2002
  80. ncbi [Morbidity and mortality in persons with mannose-binding lectin deficiency. The Osterbro study]
    Morten Dahl
    Amtssygehuset i Herlev, Klinisk Biokemisk Afdeling
    Ugeskr Laeger 166:4606-9. 2004
  81. ncbi Nanogen microelectronic chip for large-scale genotyping
    Amar Akhtar Sethi
    Department of Clinical Biochemistry, Herlev University Hospital, Copenhagen, Denmark
    Clin Chem 50:443-6. 2004
  82. ncbi [Genetically determined reduction in antioxidative protection and increased risk of ischemic heart disease--secondary publication]
    Klaus Juul
    Amtssygehuset i Herlev, Klinisk Biokemisk Afdeling
    Ugeskr Laeger 167:767-70. 2005
  83. ncbi Risk of ischemic heart and ischemic cerebrovascular disease is not increased in S, Z, and 11478A alpha1-antitrypsin carriers of the Copenhagen City Heart Study
    Morten Dahl
    Arterioscler Thromb Vasc Biol 23:e55; author reply e55. 2003
  84. doi Levels of apolipoprotein M are not associated with the risk of coronary heart disease in two independent case-control studies
    Josefin Ahnström
    Department of Laboratory Medicine, Clinical Chemistry, University of Lund, University Hospital, Malmo, Sweden
    J Lipid Res 49:1912-7. 2008
    ..97 (0.74-1.27) and 0.92 (0.84-1.02), respectively]. In conclusion, no association between apoM and CHD could be found in this study...
  85. ncbi HNPCC mutation MLH1 P648S makes the functional protein unstable, and homozygosity predisposes to mild neurofibromatosis type 1
    Tiina E Raevaara
    Department of Biosciences, Division of Genetics, University of Helsinki, Helsinki, Finland
    Genes Chromosomes Cancer 40:261-5. 2004
    ....
  86. pmc The methylenetetrahydrofolate reductase C677T genotype and the risk of obesity in three large population-based cohorts
    Sarah J Lewis
    Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol BS82PR, UK
    Eur J Endocrinol 159:35-40. 2008
    ..We sought to determine whether MTHFR C677T genotype was associated with obesity...
  87. ncbi Nose and blood pressure
    Morten Dahl
    Am J Respir Crit Care Med 169:318; author reply 319. 2004
  88. pmc Population-based resequencing of ANGPTL4 uncovers variations that reduce triglycerides and increase HDL
    Stefano Romeo
    Donald W Reynolds Cardiovascular Clinical Research Center, the Eugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
    Nat Genet 39:513-6. 2007
    ..Thus, resequencing of ANGPTL4 in a multiethnic population allowed analysis of the phenotypic effects of both rare and common variants while taking advantage of genetic variation arising from ethnic differences in population history...