Jeppe Romme Christensen
Affiliation: Copenhagen University Hospital
- CSF inflammation and axonal damage are increased and correlate in progressive multiple sclerosisJeppe Romme Christensen
University of Copenhagen and Department of Neurology, Copenhagen University Hospital Rigshospitalet, Denmark
Mult Scler 19:877-84. 2013..The mechanism underlying disease progression in progressive multiple sclerosis (MS) is uncertain. Pathological studies found widespread inflammation in progressive MS brains correlating with disease progression and axonal damage...
- Systemic inflammation in progressive multiple sclerosis involves follicular T-helper, Th17- and activated B-cells and correlates with progressionJeppe Romme Christensen
Department of Neurology, University of Copenhagen, Rigshospitalet, Copenhagen, Denmark
PLoS ONE 8:e57820. 2013..These observations may have implications for the treatment of progressive MS...
- Cellular sources of dysregulated cytokines in relapsing-remitting multiple sclerosisJeppe Romme Christensen
Department of Neurology, Danish Multiple Sclerosis Center, Copenhagen University Hospital Rigshospitalet, Blegdamsvej 9, Copenhagen, 2100, Denmark
J Neuroinflammation 9:215. 2012..Knowledge about the relation between blood and cerebrospinal fluid (CSF) cell expression of cytokines and the cellular source of CSF cytokines is even more scarce...
- Endogenous interferon-β-inducible gene expression and interferon-β-treatment are associated with reduced T cell responses to myelin basic protein in multiple sclerosisLars Börnsen
Danish Multiple Sclerosis Center, Department of Neurology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
PLoS ONE 10:e0118830. 2015..Reduced myelin basic protein-induced CD4+ T-cell autoreactivity in interferon-β-treated multiple sclerosis patients may be mediated by monocyte-derived interleukin-10. ..
- Natalizumab in progressive MS: results of an open-label, phase 2A, proof-of-concept trialJeppe Romme Christensen
From the Danish Multiple Sclerosis Center J R C, R R, L B, P S S, F S, Department of Neurology, Copenhagen University Hospital, Rigshospitalet, Copenhagen Danish Research Center for Magnetic Resonance M L, E G, T B D, H R S, Copenhagen University Hospital Hvidovre, Denmark
Neurology 82:1499-507. 2014..Natalizumab inhibits the migration of systemic immune cells to the CNS and may be beneficial in progressive multiple sclerosis (MS). The objective of the study was to examine the effects of natalizumab in progressive MS...